MOC PCSF Pipeline

Description

The genes in this pipeline are those identified to be differentially expressed (DE) in stage_I, stage_II, stage_III and stage_IV samples. Run with interaction data from DE gene list in STRING. In this run, no cutoff is used for DE genes i.e. -3 to 3 (used all DE genes).

See end of doc for gene subset summary

Show Kylie raw data treatment

sample_info <- read.csv("data/All survival_CN_Aug18.csv")
sample_info <- subset(sample_info, select = c("GAMUT_ID", "Grade", "Stage"))

kylie_counts <- read.csv("data/analysis_set_raw_counts.csv", row.names = 1)

# Extract column names
column_names <- colnames(kylie_counts)

# Remove "GAMuT_" part from column names
gamut_ids <- sub("^GAMuT_", "", column_names)


# create list of stage ids 
stage_I <- c("I","IA","IB","IC")
stage_II <- c("II", "IIA", "IIB", "IIC")
stage_III <- c("III", "IIIA", "IIIB", "IIIC", "IIIc")
stage_IV <- c("IV")
stage_ids <- list(stage_I, stage_II, stage_III, stage_IV)

# common GAMuT IDs between sample_info and kylie_counts
matching_ids <- intersect(gamut_ids, sample_info$GAMUT_ID)

stage_df <- list()

for (stage in stage_ids) {
  # sanity check
  print(stage)
  # retrieve GAMuT ID for the stage
  stage_id <- sample_info[sample_info$Stage %in% stage, 1]
  # common GAMuT IDs between stage and matching_ids
  matching_stage_id <- intersect(matching_ids, stage_id)
  # subset the kylie_counts df based on the IDs from matching_stage_id
  subset_stage_counts <- kylie_counts[, paste0("GAMuT_", matching_stage_id)]
  # add it to the df list
  stage_df <- c(stage_df, list(subset_stage_counts))
}

# retrieve each df from the list and save a separate variable
stage_I <- stage_df[[1]]
stage_II <- stage_df[[2]]
stage_III <- stage_df[[3]]
stage_IV <- as.data.frame(stage_df[[4]])
colnames(stage_IV) <- paste0("GAMuT_", matching_stage_id)
rownames(stage_IV) <- rownames(kylie_counts)


write.csv(stage_I, "data/stage_I_master_df.csv")
write.csv(stage_II, "data/stage_II_master_df.csv")
write.csv(stage_III, "data/stage_III_master_df.csv")
write.csv(stage_IV, "data/stage_IV_master_df.csv")


## subset benign samples
ben_rows <- subset(sample_info, Grade == "BEN")
ben_id <- ben_rows$GAMUT_ID
matching_ben_id <- intersect(matching_ids, ben_id)
subset_ben_counts <- kylie_counts[, paste0("GAMuT_", matching_ben_id)]

write.csv(subset_ben_counts, "data/ben_master_df.csv")

#bdl_rows <- subset(sample_info, Grade == "BDL")

Gene Subset Progression

The raw data consists of 14,889 genes which was subject to removal of low acitvity genes by subsetting those that have a CPM of more than 1 in at least 50% of the samples.

• Stage_I = 36

• Stage_II = 2 files

• Stage_III = 5 files

• Stage_IV = 1 files

• Benign = 11

FALSE = Failed genes

##    Mode   FALSE    TRUE 
## logical      21   14868

Show low acitivty genes

Low count genes

ensembl_gene_id	external_gene_name
ENSG00000078549	ADCYAP1R1
ENSG00000089199	CHGB
ENSG00000096006	CRISP3
ENSG00000105877	DNAH11
ENSG00000112818	MEP1A
ENSG00000137745	MMP13
ENSG00000141469	SLC14A1
ENSG00000141837	CACNA1A
ENSG00000154646	TMPRSS15
ENSG00000156234	CXCL13
ENSG00000157551	KCNJ15
ENSG00000163631	ALB
ENSG00000166405	RIC3
ENSG00000169245	CXCL10
ENSG00000170893	TRH
ENSG00000174992	ZG16
ENSG00000175084	DES
ENSG00000197888	UGT2B17
ENSG00000198483	ANKRD35
ENSG00000256713	PGA5
ENSG00000263961	RHEX

Step 1: Differential expression analysis using edgeR

## Disp = 0.38941 , BCV = 0.624

##        groupcancer
## Down           125
## NotSig       14078
## Up             665

Step 2: PCSF file prep - Create score file and format STRING interaction data

• Convert gene ensembl to gene symbol

• Create score file from logFC values

• Feed list of proteins into STRING/Cytoscape

• Format output and create interaction file

Show code

## convert to gene names and create list for STRING

# read in the data
kylie_data <- read.csv("intermediate/edgeR/edgeR_dif_exp_genes.csv")

# subset the gene_id and logFC columns
kylie_data <- subset(kylie_data, select = c("gene_id", "logFC"))

# convert to gene symbol
gene_id <- getBM(attributes = c("ensembl_gene_id", "external_gene_name"), 
                       filters = "ensembl_gene_id", 
                       values = kylie_data$gene_id, 
                       mart = ensembl)

# remove empty rows
gene_id <- subset(gene_id, external_gene_name != "") # uniprot_gn_symbol = 772

# check for duplicate uniprot ids
gene_id <- distinct(gene_id)

# merge back with original data
colnames(gene_id)[1] <- "gene_id"

kylie_gene_data <- merge(gene_id, kylie_data, by = "gene_id")

kylie_gene_data <- subset(kylie_gene_data, select = c("external_gene_name", "logFC"))

# check to see if genes that at all genes were converted at least once
missing_genes <- anti_join(kylie_data, gene_id, by = "gene_id")

# create score file
write.csv(kylie_gene_data, "intermediate/PCSF_data/pcsf_kylie_score.csv")

## create ensemble protein list for interaction db
write.table(kylie_gene_data$external_gene_name, "intermediate/cytoscape/kylie_gene_list.txt", row.names = F, col.names = F, quote = F)

string_edge_data <- read.table("intermediate/cytoscape/STRING network (physical) default edge.csv", header = T, sep = ",", stringsAsFactors = F)
ppi_list <- subset(string_edge_data, select = c("name", "stringdb..score"))
ppi_list <- ppi_list %>% 
  separate(name, sep = " ", into = c("node_1", "del", "node_2"))
ppi_list <- subset(ppi_list, select = c("node_1", "node_2", "stringdb..score"))
ppi_list$node_1 <- gsub(".*.\\.", "", ppi_list$node_1)
ppi_list$node_2 <- gsub(".*.\\.", "", ppi_list$node_2)

string_node_data <- read.table("intermediate/cytoscape/STRING network (physical) default node.csv", header = T, sep = ",", stringsAsFactors = F)
node_list <- subset(string_node_data, select = c("name", "query.term"))
node_list$name <- gsub(".*.\\.", "", node_list$name)
ppi_list$original_order <- seq_len(nrow(ppi_list))
merged_df <- merge(ppi_list, node_list, by.x = "node_1", by.y = "name", all.x = TRUE)
merged_df <- merge(merged_df, node_list, by.x = "node_2", by.y = "name", all.x = TRUE)
merged_df <- merged_df[order(merged_df$original_order), ]

final_df <- merged_df[, c("query.term.x", "query.term.y", "stringdb..score")]
colnames(final_df) <- c("node_1", "node_2", "score")

write.csv(final_df, "intermediate/PCSF_data/STRING_data.csv")


# create gene_id uniprot_id ref list.
ref_list <- getBM(attributes = c("external_gene_name","uniprot_gn_id"),
                  filters = "external_gene_name", 
                  values = node_list$query.term, 
                  mart = ensembl)

Step 3: Run PCSF and create cross reference results with AF structures for durggability

##   45.42% of your terminal nodes are included in the interactome
##   Solving the PCSF by adding random noise to the edge costs...

## Time difference of 3.818044 secs

PCSF Nertwork Metrics

	gene_id	cluster	betweenness	degree_centrality
1	A4GALT	1	0	1
115	GLA	1	0	1
12	ATAD5	2	0	1
22	BOP1	2	0	1
23	BRAT1	2	0	1
28	C4B	2	0	1
34	CCNE2	2	0	1
39	CDC25C	2	0	1
44	CDCA5	2	0	1
47	CDH3	2	0	1
49	CDKN3	2	0	1
52	CENPE	2	0	1
60	CHAF1B	2	0	1
63	CIT	2	0	1
64	CKS2	2	0	1
74	DEPDC1	2	0	1
75	DEPDC1B	2	0	1
80	DNAH9	2	0	1
81	DNM1	2	0	1
83	DSCC1	2	0	1
86	E2F2	2	0	1
88	E2F8	2	0	1
89	EME1	2	0	1
90	ENO1	2	0	1
93	ERCC6L	2	0	1
94	ESPL1	2	0	1
95	ESPN	2	0	1
97	FABP1	2	0	1
99	FANCA	2	0	1
100	FANCB	2	0	1
103	FBXL19	2	0	1
105	FGFR4	2	0	1
110	GAS2L1	2	0	1
112	GINS1	2	0	1
113	GINS2	2	0	1
114	GINS4	2	0	1
118	GRB7	2	0	1
119	GTSE1	2	0	1
123	H2AC11	2	0	1
127	H2AC15	2	0	1
128	H2AC16	2	0	1
130	H2AC4	2	0	1
157	HMGA1	2	0	1
158	HMMR	2	0	1
160	IGFBP3	2	0	1
162	IL32	2	0	1
163	IQGAP3	2	0	1
166	JAG2	2	0	1
189	LMNB2	2	0	1
197	MELK	2	0	1
200	MRPL12	2	0	1
201	MTTP	2	0	1
204	MYBL2	2	0	1
206	MZT2B	2	0	1
207	NCAPG	2	0	1
211	NECTIN1	2	0	1
217	NRARP	2	0	1
219	NUF2	2	0	1
230	PCLAF	2	0	1
231	PDE3A	2	0	1
232	PDLIM4	2	0	1
238	PHLDA1	2	0	1
239	PIF1	2	0	1
248	POLQ	2	0	1
249	PPFIA3	2	0	1
250	PRAME	2	0	1
251	PRC1	2	0	1
252	PSMD3	2	0	1
253	PTGS1	2	0	1
260	RAD54L	2	0	1
263	RAVER1	2	0	1
266	RPL39L	2	0	1
272	S100A9	2	0	1
274	SGO1	2	0	1
276	SHCBP1	2	0	1
283	SLC3A1	2	0	1
285	SPAG4	2	0	1
287	SPC24	2	0	1
288	SPC25	2	0	1
290	SPRY1	2	0	1
292	SPTBN5	2	0	1
293	STIL	2	0	1
294	TACC3	2	0	1
295	TEAD4	2	0	1
296	TGM2	2	0	1
297	TICRR	2	0	1
304	TRAIP	2	0	1
305	TRIB3	2	0	1
306	TRIP13	2	0	1
310	UBE2T	2	0	1
312	USP44	2	0	1
313	WDR18	2	0	1
316	XPR1	2	0	1
111	GGT1	3	0	1
159	ICAM1	3	0	1
161	IGSF8	3	0	1
203	MUC17	3	0	1
240	PITX1	3	0	1
246	PODXL	3	0	1
279	SLC19A3	3	0	1
318	ZNRF3	3	0	1
5	ABCD1	4	0	1
281	SLC27A2	4	0	1
18	BCAM	5	0	1
71	CP	6	0	1
155	HEPH	6	0	1
78	DNAH3	7	0	1
79	DNAH7	7	0	1
101	FBLN1	8	0	1
102	FBLN2	8	0	1
168	KHDRBS3	9	0	1
262	RARRES1	9	0	1
183	KRT15	10	0	1
184	KRT23	10	0	1
186	LDHA	11	0	1
236	PFKFB4	11	0	1
195	MDK	12	0	1
282	SLC2A1	12	0	1
226	PCDHGA4	13	0	1
227	PCDHGA5	13	0	1
228	PCDHGB1	14	0	1
229	PCDHGB2	14	0	1
245	PLXNA4	15	0	1
273	SEMA6A	15	0	1
268	RTKN	16	0	1
271	S100A4	16	0	1
2	ABCA2	2	3430	2
16	AURKB	2	0	2
17	BAMBI	2	130	2
19	BCL6	2	260	2
21	BLM	2	0	2
35	CCNF	2	1	2
41	CDC6	2	2	2
42	CDC7	2	0	2
43	CDCA2	2	0	2
46	CDH24	2	260	2
59	CEP55	2	6	2
62	CHTF18	2	260	2
73	DBN1	2	147	2
76	DLGAP5	2	774	2
84	DTL	2	10	2
87	E2F7	2	260	2
91	EPHB2	2	260	2
98	FAM83D	2	0	2
107	FZD2	2	0	2
109	GAPDH	2	774	2
116	GPC1	2	1028	2
117	GPI	2	260	2
121	H1-3	2	0	2
125	H2AC13	2	0	2
167	JUP	2	518	2
171	KIF15	2	10	2
172	KIF18A	2	0	2
173	KIF18B	2	0	2
176	KIF20B	2	0	2
177	KIF23	2	0	2
179	KIF4A	2	0	2
192	MCM2	2	0	2
202	MUC16	2	260	2
205	MZT2A	2	260	2
208	NCAPH	2	260	2
210	NEB	2	518	2
213	NEK2	2	0	2
218	NRCAM	2	260	2
220	NUSAP1	2	257	2
223	ORC6	2	0	2
225	PBK	2	0	2
242	PLEKHG2	2	260	2
254	PTGS2	2	260	2
267	RRM2	2	260	2
270	RUNX3	2	260	2
275	SGO2	2	0	2
277	SKA1	2	0	2
278	SKA3	2	0	2
280	SLC1A5	2	2988	2
291	SPTBN2	2	518	2
298	TK1	2	12	2
299	TMOD1	2	774	2
303	TPX2	2	518	2
314	WDR62	2	260	2
3	ABCC2	3	0	2
4	ABCC4	3	57	2
7	ANPEP	3	76	2
69	CLDN7	3	76	2
187	LGR5	3	22	2
199	MME	3	112	2
269	RTN4R	3	60	2
300	TNFRSF19	3	42	2
165	ITGB8	5	0	2
185	LAMA5	5	3	2
224	PARVB	5	1	2
235	PFKFB3	11	1	2
11	ATAD2	2	0	3
13	ATP1A1	2	4150	3
14	ATP1B3	2	3224	3
38	CDC25A	2	5900	3
40	CDC45	2	263	3
50	CDT1	2	260	3
53	CENPF	2	0	3
61	CHEK1	2	260	3
72	CYBA	2	1284	3
96	EXO1	2	251	3
104	FGFR3	2	519	3
120	H1-10	2	160	3
153	H4C13	2	4	3
156	HJURP	2	0	3
182	KPNA2	2	400	3
188	LMNB1	2	260	3
191	MCM10	2	412	3
198	MKI67	2	0	3
209	NDC80	2	606	3
233	PDLIM7	2	519	3
241	PKMYT1	2	280	3
244	PLK4	2	299	3
258	RAD51	2	19	3
284	SLC7A5	2	260	3
317	XRCC2	2	0	3
66	CLDN2	3	0	3
67	CLDN3	3	1	3
68	CLDN4	3	21	3
82	DPP4	3	107	3
164	ITGA7	5	4	3
8	APOB	2	777	4
9	ASF1B	2	0	4
10	ASPM	2	639	4
20	BIRC5	2	260	4
26	BUB1	2	519	4
32	CCNB2	2	259	4
106	FOXM1	2	510	4
108	FZD7	2	776	4
149	H3C11	2	481	4
169	KIF11	2	48	4
178	KIF2C	2	1267	4
180	KIFC1	2	1277	4
190	MAD2L1	2	1535	4
255	PTTG1	2	726	4
265	RPL19	2	519	4
301	TONSL	2	21	4
307	TTK	2	1031	4
308	UBE2C	2	18	4
315	WDR76	2	4995	4
65	CLDN15	3	60	4
214	NHERF1	3	107	4
234	PDZK1	3	44	4
6	ANLN	2	1633	5
25	BRCA2	2	769	5
27	BUB1B	2	521	5
37	CDC20	2	623	5
77	DNA2	2	3554	5
85	E2F1	2	530	5
122	H1-5	2	1287	5
170	KIF14	2	861	5
247	POLD1	2	1287	5
256	RAC3	2	2787	5
259	RAD51AP1	2	614	5
286	SPAG5	2	1766	5
289	SPINDOC	2	0	5
15	AURKA	2	260	6
33	CCNE1	2	969	6
45	CDCA8	2	260	6
70	CLSPN	2	776	6
141	H2BC21	2	1	6
148	H3C10	2	497	6
175	KIF20A	2	1070	6
215	NOTCH1	2	5773	6
257	RACGAP1	2	847	6
264	RECQL4	2	103	6
36	CD9	3	194	6
30	CCNA2	2	14369	7
51	CENPA	2	1242	7
129	H2AC21	2	777	7
140	H2BC18	2	34	7
151	H3C13	2	6617	7
181	KNL1	2	0	7
193	MCM4	2	366	7
194	MCM6	2	529	7
221	OIP5	2	260	7
29	CBX2	2	4	8
54	CENPH	2	858	8
56	CENPK	2	0	8
92	ERBB2	2	4747	8
124	H2AC12	2	0	8
150	H3C12	2	4161	8
154	H4C4	2	81	8
196	MED1	2	1287	8
222	ORC1	2	15590	8
57	CENPM	2	464	9
58	CENPW	2	64	9
131	H2AC8	2	5209	9
139	H2BC17	2	260	9
143	H2BC4	2	213	9
174	KIF1A	2	2485	9
302	TOP2A	2	1844	9
309	UBE2S	2	18196	9
311	UHRF1	2	270	9
55	CENPI	2	1240	10
134	H2BC11	2	233	10
135	H2BC12	2	20	10
152	H4C1	2	847	10
243	PLK1	2	2733	10
142	H2BC3	2	269	11
212	NEIL3	2	47	11
237	PHF19	2	430	11
133	H2BC10	2	288	12
145	H2BC7	2	2530	12
146	H2BC8	2	801	12
147	H3C1	2	1350	12
31	CCNB1	2	2056	13
144	H2BC6	2	4200	13
126	H2AC14	2	5614	14
132	H2AX	2	5479	14
137	H2BC14	2	766	14
216	NR5A2	2	5443	14
48	CDK1	2	18044	16
261	RARA	2	5107	16
138	H2BC15	2	1247	18
136	H2BC13	2	1475	19
24	BRCA1	2	10810	25

Step 4: Combine Structural and Citation data

Note: The citation scores for this data were generated using PubMed API

Show raw table

PCSF Druggability Results

external_gene_name	uniprot_gn_id	cluster	betweenness	degree_centrality	file_id	ID	pocket	druggability	num_drug_pockets	struct_score	logFC	regulation	citation_score
MUC17	Q685J3	3	0	1	AF-Q685J3-F5-model_v4	Q685J3-F5	0.317	1.000	7	50.38741	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F12-model_v4	Q685J3-F12	0.130	1.000	3	55.24057	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F3-model_v4	Q685J3-F3	0.321	1.000	5	57.04810	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F2-model_v4	Q685J3-F2	0.338	0.999	8	53.74200	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F10-model_v4	Q685J3-F10	0.303	0.998	8	57.31370	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F11-model_v4	Q685J3-F11	0.223	0.998	4	55.80117	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F13-model_v4	Q685J3-F13	0.184	0.998	9	52.17108	2.932704	up_reg	99
CENPE	Q02224	2	0	1	AF-Q02224-F6-model_v4	Q02224-F6	0.135	0.997	5	72.55249	1.272231	up_reg	439
MUC17	Q685J3	3	0	1	AF-Q685J3-F7-model_v4	Q685J3-F7	0.253	0.996	7	51.47074	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F1-model_v4	Q685J3-F1	0.162	0.996	6	51.86692	2.932704	up_reg	99
CD9	P21926	3	194	6	AF-P21926-F1-model_v4	P21926-F1	0.063	0.994	1	88.11915	1.203438	up_reg	2729
MELK	Q14680	2	0	1	AF-Q14680-F1-model_v4	Q14680-F1	0.159	0.993	1	70.64372	1.755936	up_reg	669
MUC17	Q685J3	3	0	1	AF-Q685J3-F6-model_v4	Q685J3-F6	0.273	0.993	5	57.70932	2.932704	up_reg	99
MUC17	Q685J3	3	0	1	AF-Q685J3-F17-model_v4	Q685J3-F17	0.018	0.993	2	52.40577	2.932704	up_reg	99
XPR1	Q9UBH6	2	0	1	AF-Q9UBH6-F1-model_v4	Q9UBH6-F1	0.207	0.993	3	83.73372	1.318176	up_reg	180
KIF11	P52732	2	48	4	AF-P52732-F1-model_v4	P52732-F1	0.141	0.991	1	74.76864	1.239185	up_reg	827
PTGS2	P35354	2	260	2	AF-P35354-F1-model_v4	P35354-F1	0.262	0.987	1	93.32770	2.338946	up_reg	41309
TEAD4	Q15561	2	0	1	AF-Q15561-F1-model_v4	Q15561-F1	0.243	0.986	2	76.58312	1.597999	up_reg	388
FABP1	P07148	2	0	1	AF-P07148-F1-model_v4	P07148-F1	-0.023	0.981	1	94.95010	7.464763	up_reg	900
ABCA2	Q9BZC7	2	3430	2	AF-Q9BZC7-F1-model_v4	Q9BZC7-F1	0.258	0.976	5	72.33891	1.262028	up_reg	138
PRC1	O43663	2	0	1	AF-O43663-F1-model_v4	O43663-F1	0.226	0.975	2	80.11427	1.458330	up_reg	1534
SPAG4	Q9NPE6	2	0	1	AF-Q9NPE6-F1-model_v4	Q9NPE6-F1	0.378	0.975	1	71.56424	1.521158	up_reg	51
KIF20B	Q96Q89	2	0	2	AF-Q96Q89-F1-model_v4	Q96Q89-F1	0.232	0.971	4	63.74834	1.021659	up_reg	57
H2BC10	P62807	2	288	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.200574	up_reg	0
H2BC4	P62807	2	213	9	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.124252	up_reg	0
H2BC6	P62807	2	4200	13	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.513907	up_reg	0
H2BC7	P62807	2	2530	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.650740	up_reg	0
H2BC8	P62807	2	801	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.316050	up_reg	1
CENPE	Q02224	2	0	1	AF-Q02224-F2-model_v4	Q02224-F2	0.126	0.960	2	70.76444	1.272231	up_reg	439
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F4-model_v4	Q8TD57-F4	0.164	0.960	4	85.66639	2.305663	up_reg	16
RARA	P10276	2	5107	16	AF-P10276-F1-model_v4	P10276-F1	0.362	0.958	1	79.41892	1.490980	up_reg	4411
CYBA	P13498	2	1284	3	AF-P13498-F1-model_v4	P13498-F1	0.480	0.957	1	77.02989	1.275871	up_reg	1045
H2BC17	P23527	2	260	9	AF-P23527-F1-model_v4	P23527-F1	0.371	0.957	2	88.00099	1.844521	up_reg	0
TTK	P33981	2	1031	4	AF-P33981-F1-model_v4	P33981-F1	0.087	0.956	1	63.95435	1.457472	up_reg	2071
SLC19A3	Q9BZV2	3	0	1	AF-Q9BZV2-F1-model_v4	Q9BZV2-F1	0.137	0.955	2	82.16840	3.205348	up_reg	180
FZD7	O75084	2	776	4	AF-O75084-F1-model_v4	O75084-F1	0.435	0.953	3	84.14906	1.548584	up_reg	390
PLK1	P53350	2	2733	10	AF-P53350-F1-model_v4	P53350-F1	0.175	0.953	2	85.16989	1.603519	up_reg	3003
IL32	P24001	2	0	1	AF-P24001-F1-model_v4	P24001-F1	0.099	0.950	2	71.19002	1.544145	up_reg	628
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F10-model_v4	Q8IZT6-F10	0.434	0.949	4	62.64048	1.477836	up_reg	518
CENPE	Q02224	2	0	1	AF-Q02224-F3-model_v4	Q02224-F3	0.416	0.949	1	70.84160	1.272231	up_reg	439
LAMA5	O15230	5	3	2	AF-O15230-F12-model_v4	O15230-F12	0.086	0.946	2	79.24314	2.198114	up_reg	155
PDE3A	Q14432	2	0	1	AF-Q14432-F1-model_v4	Q14432-F1	0.272	0.945	3	61.48643	1.816074	up_reg	371
H2BC13	Q99880	2	1475	19	AF-Q99880-F1-model_v4	Q99880-F1	0.414	0.944	2	87.44870	1.723938	up_reg	0
PTGS1	P23219	2	0	1	AF-P23219-F1-model_v4	P23219-F1	0.142	0.943	1	94.11557	1.691682	up_reg	3045
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F9-model_v4	Q9NRC6-F9	0.088	0.942	1	80.58407	1.859882	up_reg	17
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F14-model_v4	Q8TD57-F14	0.099	0.941	1	85.25115	2.305663	up_reg	16
H2BC3	P33778	2	269	11	AF-P33778-F1-model_v4	P33778-F1	0.423	0.941	2	87.64271	1.429227	up_reg	2
FBLN2	P98095	8	0	1	AF-P98095-F1-model_v4	P98095-F1	0.228	0.938	1	67.61607	2.431256	up_reg	74
H2BC12	O60814	2	20	10	AF-O60814-F1-model_v4	O60814-F1	0.241	0.937	1	88.05779	1.128966	up_reg	3
RAC3	P60763	2	2787	5	AF-P60763-F1-model_v4	P60763-F1	0.341	0.937	1	93.83371	1.213210	up_reg	301
NR5A2	O00482	2	5443	14	AF-O00482-F1-model_v4	O00482-F1	0.203	0.936	2	72.86144	1.943734	up_reg	569
H2BC15	Q99877	2	1247	18	AF-Q99877-F1-model_v4	Q99877-F1	0.313	0.935	1	87.69131	1.134114	up_reg	0
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F12-model_v4	Q9NYC9-F12	0.087	0.930	2	85.79432	3.112720	up_reg	75
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F13-model_v4	Q9NYC9-F13	0.158	0.928	1	84.31003	3.112720	up_reg	75
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F7-model_v4	Q8IZT6-F7	0.335	0.927	1	64.38947	1.477836	up_reg	518
CDC45	O75419	2	263	3	AF-O75419-F1-model_v4	O75419-F1	0.323	0.926	1	92.88743	1.483786	up_reg	603
SLC27A2	O14975	4	0	1	AF-O14975-F1-model_v4	O14975-F1	0.206	0.925	1	92.73940	1.659103	up_reg	79
CDC6	Q99741	2	2	2	AF-Q99741-F1-model_v4	Q99741-F1	0.244	0.922	2	69.83948	3.355449	up_reg	1062
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F5-model_v4	Q8WXX0-F5	0.424	0.921	2	88.31141	1.516270	up_reg	21
LAMA5	O15230	5	3	2	AF-O15230-F10-model_v4	O15230-F10	0.241	0.919	3	79.99285	2.198114	up_reg	155
LAMA5	O15230	5	3	2	AF-O15230-F1-model_v4	O15230-F1	0.244	0.918	2	82.41367	2.198114	up_reg	155
CENPI	Q92674	2	1240	10	AF-Q92674-F1-model_v4	Q92674-F1	0.058	0.915	3	72.79816	1.176172	up_reg	68
CENPF	P49454	2	0	3	AF-P49454-F7-model_v4	P49454-F7	0.122	0.906	1	71.41875	1.543658	up_reg	391
PBK	Q96KB5	2	0	2	AF-Q96KB5-F1-model_v4	Q96KB5-F1	0.152	0.901	1	84.90700	1.610733	up_reg	788
TOP2A	P11388	2	1844	9	AF-P11388-F1-model_v4	P11388-F1	0.045	0.897	1	76.40832	2.033427	up_reg	1351
ITGB8	P26012	5	0	2	AF-P26012-F1-model_v4	P26012-F1	0.085	0.896	1	76.46707	1.652867	up_reg	134
HEPH	Q9BQS7	6	0	1	AF-Q9BQS7-F1-model_v4	Q9BQS7-F1	0.288	0.895	2	89.66272	1.676420	up_reg	201
H2BC14	Q99879	2	766	14	AF-Q99879-F1-model_v4	Q99879-F1	0.365	0.888	2	86.12243	1.594661	up_reg	1
SPAG5	Q96R06	2	1766	5	AF-Q96R06-F1-model_v4	Q96R06-F1	0.223	0.887	2	63.81311	1.534844	up_reg	127
ANPEP	P15144	3	76	2	AF-P15144-F1-model_v4	P15144-F1	0.232	0.886	1	93.75126	6.652030	up_reg	193
HMMR	O75330	2	0	1	AF-O75330-F1-model_v4	O75330-F1	0.192	0.886	2	76.10490	1.783138	up_reg	255
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F15-model_v4	Q8TD57-F15	0.172	0.885	2	86.96104	2.305663	up_reg	16
ESPL1	Q14674	2	0	1	AF-Q14674-F1-model_v4	Q14674-F1	0.619	0.885	1	75.77835	1.914072	up_reg	146
ABCD1	P33897	4	0	1	AF-P33897-F1-model_v4	P33897-F1	0.179	0.884	1	81.73405	1.260959	up_reg	675
CIT	O14578	2	0	1	AF-O14578-F1-model_v4	O14578-F1	0.129	0.882	1	70.15278	1.119051	up_reg	8694
CENPE	Q02224	2	0	1	AF-Q02224-F8-model_v4	Q02224-F8	0.191	0.880	2	74.15316	1.272231	up_reg	439
ABCC2	Q92887	3	0	2	AF-Q92887-F1-model_v4	Q92887-F1	0.256	0.879	6	81.43685	1.508199	up_reg	2209
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F5-model_v4	Q8TD57-F5	0.312	0.878	4	88.06644	2.305663	up_reg	16
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F11-model_v4	Q9NRC6-F11	0.288	0.878	4	81.48643	1.859882	up_reg	17
MTTP	P55157	2	0	1	AF-P55157-F1-model_v4	P55157-F1	0.279	0.871	2	86.91982	3.185389	up_reg	434
H2BC11	P06899	2	233	10	AF-P06899-F1-model_v4	P06899-F1	0.250	0.870	2	85.69804	1.482316	up_reg	1
KIF15	Q9NS87	2	10	2	AF-Q9NS87-F1-model_v4	Q9NS87-F1	0.241	0.869	1	72.02130	1.354129	up_reg	161
SLC1A5	Q15758	2	2988	2	AF-Q15758-F1-model_v4	Q15758-F1	0.051	0.866	2	79.59138	1.291235	up_reg	544
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F13-model_v4	Q8TD57-F13	0.156	0.864	1	85.29108	2.305663	up_reg	16
SLC7A5	Q01650	2	260	3	AF-Q01650-F1-model_v4	Q01650-F1	0.097	0.862	2	86.24003	2.711656	up_reg	872
WDR76	Q9H967	2	4995	4	AF-Q9H967-F1-model_v4	Q9H967-F1	0.272	0.861	1	75.38044	1.087175	up_reg	22
NRCAM	Q92823	2	260	2	AF-Q92823-F1-model_v4	Q92823-F1	0.090	0.859	2	78.95628	3.487392	up_reg	325
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F2-model_v4	Q9NRC6-F2	0.193	0.859	2	82.12636	1.859882	up_reg	17
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F16-model_v4	Q9NYC9-F16	0.142	0.858	3	85.56208	3.112720	up_reg	75
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F15-model_v4	Q9NYC9-F15	0.197	0.856	2	86.26959	3.112720	up_reg	75
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F15-model_v4	Q8WXX0-F15	0.086	0.848	3	89.77931	1.516270	up_reg	21
BUB1B	O60566	2	521	5	AF-O60566-F1-model_v4	O60566-F1	0.211	0.846	2	64.72058	1.529523	up_reg	478
POLD1	P28340	2	1287	5	AF-P28340-F1-model_v4	P28340-F1	0.097	0.843	2	86.95676	1.347636	up_reg	323
SLC2A1	P11166	12	0	1	AF-P11166-F1-model_v4	P11166-F1	0.190	0.839	1	89.61531	1.425517	up_reg	3575
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F3-model_v4	Q8IZT6-F3	0.121	0.835	1	67.46659	1.477836	up_reg	518
LAMA5	O15230	5	3	2	AF-O15230-F11-model_v4	O15230-F11	0.204	0.833	5	78.94328	2.198114	up_reg	155
CENPF	P49454	2	0	3	AF-P49454-F9-model_v4	P49454-F9	0.372	0.826	1	72.00170	1.543658	up_reg	391
H2BC18	Q5QNW6	2	34	7	AF-Q5QNW6-F1-model_v4	Q5QNW6-F1	0.422	0.825	2	87.95688	1.297057	up_reg	0
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F11-model_v4	Q8IZT6-F11	0.163	0.820	2	68.83865	1.477836	up_reg	518
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F3-model_v4	Q8WXX0-F3	0.157	0.817	2	87.36839	1.516270	up_reg	21
GPI	P06744	2	260	2	AF-P06744-F1-model_v4	P06744-F1	0.383	0.816	2	97.84077	1.548803	up_reg	20988
CENPA	P49450	2	1242	7	AF-P49450-F1-model_v4	P49450-F1	0.140	0.815	2	82.07836	1.774299	up_reg	1099
KIF20A	O95235	2	1070	6	AF-O95235-F1-model_v4	O95235-F1	0.333	0.814	3	67.30456	1.472619	up_reg	306
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F6-model_v4	Q8TD57-F6	0.199	0.807	4	87.74512	2.305663	up_reg	16
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F3-model_v4	Q9NRC6-F3	0.204	0.805	3	81.97984	1.859882	up_reg	17
LAMA5	O15230	5	3	2	AF-O15230-F13-model_v4	O15230-F13	0.150	0.804	1	81.67851	2.198114	up_reg	155
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F2-model_v4	Q8IZT6-F2	0.163	0.803	2	63.49329	1.477836	up_reg	518
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F58-model_v4	Q8WXI7-F58	0.180	0.798	1	55.96839	4.631299	up_reg	1358
BRCA2	P51587	2	769	5	AF-P51587-F12-model_v4	P51587-F12	0.083	0.796	1	65.83808	1.000504	up_reg	14413
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F10-model_v4	Q9NRC6-F10	0.205	0.796	1	80.95462	1.859882	up_reg	17
RECQL4	O94761	2	103	6	AF-O94761-F1-model_v4	O94761-F1	0.125	0.793	1	69.03096	2.366331	up_reg	335
RTKN	Q9BST9	16	0	1	AF-Q9BST9-F1-model_v4	Q9BST9-F1	0.115	0.793	1	72.73822	1.286409	up_reg	70
CENPF	P49454	2	0	3	AF-P49454-F8-model_v4	P49454-F8	0.307	0.792	6	71.55613	1.543658	up_reg	391
FGFR4	P22455	2	0	1	AF-P22455-F1-model_v4	P22455-F1	0.145	0.792	3	74.61047	1.878331	up_reg	1205
AURKB	Q96GD4	2	0	2	AF-Q96GD4-F1-model_v4	Q96GD4-F1	0.060	0.789	2	79.85404	1.350410	up_reg	1380
CHAF1B	Q13112	2	0	1	AF-Q13112-F1-model_v4	Q13112-F1	0.173	0.789	1	75.38529	1.009863	up_reg	92
MZT2A	Q6P582	2	260	2	AF-Q6P582-F1-model_v4	Q6P582-F1	0.264	0.788	1	65.50284	1.098928	up_reg	5
ATP1A1	P05023	2	4150	3	AF-P05023-F1-model_v4	P05023-F1	0.200	0.787	1	88.69918	1.217536	up_reg	574
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F10-model_v4	Q9NYC9-F10	0.090	0.786	2	87.22307	3.112720	up_reg	75
BRCA2	P51587	2	769	5	AF-P51587-F11-model_v4	P51587-F11	0.066	0.783	2	62.08251	1.000504	up_reg	14413
LAMA5	O15230	5	3	2	AF-O15230-F7-model_v4	O15230-F7	0.102	0.782	2	78.13025	2.198114	up_reg	155
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F10-model_v4	Q8WXX0-F10	0.212	0.781	3	85.95119	1.516270	up_reg	21
TGM2	P21980	2	0	1	AF-P21980-F1-model_v4	P21980-F1	0.245	0.781	1	92.78304	1.904023	up_reg	595
CDC25C	P30307	2	0	1	AF-P30307-F1-model_v4	P30307-F1	0.362	0.777	1	64.18249	1.552450	up_reg	1464
ATP1B3	P54709	2	3224	3	AF-P54709-F1-model_v4	P54709-F1	0.329	0.776	1	89.52136	1.755640	up_reg	52
TRAIP	Q9BWF2	2	0	1	AF-Q9BWF2-F1-model_v4	Q9BWF2-F1	0.303	0.770	1	74.95434	1.048263	up_reg	59
WDR62	O43379	2	260	2	AF-O43379-F1-model_v4	O43379-F1	0.088	0.770	2	61.36502	1.688680	up_reg	124
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F1-model_v4	Q8IZT6-F1	0.107	0.769	2	62.01828	1.477836	up_reg	518
CENPF	P49454	2	0	3	AF-P49454-F10-model_v4	P49454-F10	0.416	0.769	3	73.15360	1.543658	up_reg	391
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F4-model_v4	Q9NYC9-F4	0.401	0.767	4	85.33799	3.112720	up_reg	75
FZD2	Q14332	2	0	2	AF-Q14332-F1-model_v4	Q14332-F1	0.544	0.766	4	84.43777	1.655708	up_reg	255
LGR5	O75473	3	22	2	AF-O75473-F1-model_v4	O75473-F1	0.267	0.766	4	80.74472	3.555059	up_reg	2038
ORC1	Q13415	2	15590	8	AF-Q13415-F1-model_v4	Q13415-F1	0.154	0.765	1	67.97461	1.802587	up_reg	378
PHF19	Q5T6S3	2	430	11	AF-Q5T6S3-F1-model_v4	Q5T6S3-F1	0.257	0.765	1	69.88708	1.211096	up_reg	70
PPFIA3	O75145	2	0	1	AF-O75145-F1-model_v4	O75145-F1	0.306	0.764	3	69.92988	2.010150	up_reg	8
ANLN	Q9NQW6	2	1633	5	AF-Q9NQW6-F1-model_v4	Q9NQW6-F1	0.121	0.760	1	59.87419	1.600614	up_reg	232
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F4-model_v4	Q9NRC6-F4	0.332	0.758	3	80.26262	1.859882	up_reg	17
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F12-model_v4	Q8IZT6-F12	0.305	0.756	1	71.82009	1.477836	up_reg	518
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F1-model_v4	Q9NYC9-F1	0.154	0.754	1	83.21812	3.112720	up_reg	75
LMNB1	P20700	2	260	3	AF-P20700-F1-model_v4	P20700-F1	0.275	0.754	2	82.63466	1.294937	up_reg	202
CENPE	Q02224	2	0	1	AF-Q02224-F7-model_v4	Q02224-F7	0.304	0.741	2	72.44087	1.272231	up_reg	439
DNA2	P51530	2	3554	5	AF-P51530-F1-model_v4	P51530-F1	0.216	0.741	2	87.56204	1.114640	up_reg	607
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F7-model_v4	Q8WXX0-F7	0.146	0.736	2	88.36956	1.516270	up_reg	21
SPTBN2	O15020	2	518	2	AF-O15020-F1-model_v4	O15020-F1	0.242	0.736	3	76.77521	2.161117	up_reg	98
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F3-model_v4	Q8TD57-F3	0.165	0.733	3	84.86977	2.305663	up_reg	16
CHEK1	O14757	2	260	3	AF-O14757-F1-model_v4	O14757-F1	0.067	0.732	1	78.13441	1.188158	up_reg	2110
MME	P08473	3	112	2	AF-P08473-F1-model_v4	P08473-F1	0.377	0.727	3	96.22472	2.634423	up_reg	2311
BCAM	P50895	5	0	1	AF-P50895-F1-model_v4	P50895-F1	0.182	0.725	3	84.58449	2.892853	up_reg	431
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F2-model_v4	Q9NYC9-F2	0.275	0.722	1	84.32226	3.112720	up_reg	75
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F66-model_v4	Q8WXI7-F66	0.177	0.720	2	77.36666	4.631299	up_reg	1358
POLQ	O75417	2	0	1	AF-O75417-F1-model_v4	O75417-F1	0.104	0.717	1	59.48627	1.691706	up_reg	186
KPNA2	P52292	2	400	3	AF-P52292-F1-model_v4	P52292-F1	0.024	0.711	1	86.10732	1.245351	up_reg	315
SHCBP1	Q8NEM2	2	0	1	AF-Q8NEM2-F1-model_v4	Q8NEM2-F1	0.180	0.711	1	73.69646	1.170171	up_reg	66
SPC25	Q9HBM1	2	0	1	AF-Q9HBM1-F1-model_v4	Q9HBM1-F1	0.390	0.708	1	90.25548	1.320553	up_reg	108
FANCA	O15360	2	0	1	AF-O15360-F1-model_v4	O15360-F1	0.135	0.707	1	74.56587	1.028733	up_reg	697
RARRES1	P49788	9	0	1	AF-P49788-F1-model_v4	P49788-F1	0.423	0.702	3	79.94364	2.923580	up_reg	102
FOXM1	Q08050	2	510	4	AF-Q08050-F1-model_v4	Q08050-F1	0.173	0.701	1	51.07629	1.648781	up_reg	2285
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F8-model_v4	Q8TD57-F8	0.127	0.700	3	86.03215	2.305663	up_reg	16
PFKFB3	Q16875	11	1	2	AF-Q16875-F1-model_v4	Q16875-F1	0.182	0.700	1	87.13527	1.551414	up_reg	668
CCNB1	P14635	2	2056	13	AF-P14635-F1-model_v4	P14635-F1	0.078	0.699	1	77.77241	1.801033	up_reg	2303
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F12-model_v4	Q9NRC6-F12	0.288	0.697	2	78.32663	1.859882	up_reg	17
MCM6	Q14566	2	529	7	AF-Q14566-F1-model_v4	Q14566-F1	0.032	0.695	2	77.33923	1.041344	up_reg	384
STIL	Q15468	2	0	1	AF-Q15468-F1-model_v4	Q15468-F1	0.163	0.693	1	53.64950	1.037125	up_reg	476
LDHA	P00338	11	0	1	AF-P00338-F1-model_v4	P00338-F1	0.089	0.690	1	96.06050	1.071241	up_reg	2265
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F11-model_v4	Q9NYC9-F11	0.048	0.687	2	87.78923	3.112720	up_reg	75
ABCC4	O15439	3	57	2	AF-O15439-F1-model_v4	O15439-F1	0.139	0.684	3	83.59147	1.197058	up_reg	845
ITGA7	Q13683	5	4	3	AF-Q13683-F1-model_v4	Q13683-F1	0.119	0.684	2	79.47519	1.441251	up_reg	231
NCAPH	Q15003	2	260	2	AF-Q15003-F1-model_v4	Q15003-F1	0.198	0.683	1	60.71979	1.728427	up_reg	73
SKA3	Q8IX90	2	0	2	AF-Q8IX90-F1-model_v4	Q8IX90-F1	0.354	0.683	1	64.75869	1.526244	up_reg	99
LAMA5	O15230	5	3	2	AF-O15230-F6-model_v4	O15230-F6	0.157	0.682	2	80.88889	2.198114	up_reg	155
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F10-model_v4	Q8TD57-F10	0.134	0.681	1	85.22852	2.305663	up_reg	16
LAMA5	O15230	5	3	2	AF-O15230-F8-model_v4	O15230-F8	0.061	0.679	2	75.26612	2.198114	up_reg	155
BRCA2	P51587	2	769	5	AF-P51587-F10-model_v4	P51587-F10	0.092	0.678	3	62.85491	1.000504	up_reg	14413
TRIP13	Q15645	2	0	1	AF-Q15645-F1-model_v4	Q15645-F1	0.249	0.677	2	86.97940	1.912157	up_reg	205
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F8-model_v4	Q8IZT6-F8	0.448	0.675	3	63.92800	1.477836	up_reg	518
PKMYT1	Q99640	2	280	3	AF-Q99640-F1-model_v4	Q99640-F1	0.142	0.674	1	75.59028	2.415277	up_reg	108
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F17-model_v4	Q9NYC9-F17	0.200	0.671	1	88.35441	3.112720	up_reg	75
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F6-model_v4	Q8IZT6-F6	0.197	0.670	3	66.25757	1.477836	up_reg	518
CENPE	Q02224	2	0	1	AF-Q02224-F1-model_v4	Q02224-F1	0.308	0.670	2	71.07051	1.272231	up_reg	439
LAMA5	O15230	5	3	2	AF-O15230-F4-model_v4	O15230-F4	0.172	0.670	2	84.35481	2.198114	up_reg	155
DLGAP5	Q15398	2	774	2	AF-Q15398-F1-model_v4	Q15398-F1	0.128	0.669	1	56.37102	1.477999	up_reg	184
RAD54L	Q92698	2	0	1	AF-Q92698-F1-model_v4	Q92698-F1	0.171	0.669	1	80.51223	1.511108	up_reg	181
BCL6	P41182	2	260	2	AF-P41182-F1-model_v4	P41182-F1	0.071	0.668	1	50.10971	1.124834	up_reg	4242
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F9-model_v4	Q8TD57-F9	0.115	0.668	1	84.68082	2.305663	up_reg	16
KIF4A	O95239	2	0	2	AF-O95239-F1-model_v4	O95239-F1	0.244	0.668	3	72.17122	1.626611	up_reg	229
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F1-model_v4	Q8TD57-F1	0.199	0.662	1	78.29482	2.305663	up_reg	16
FANCB	Q8NB91	2	0	1	AF-Q8NB91-F1-model_v4	Q8NB91-F1	0.127	0.662	3	71.98628	1.300126	up_reg	87
GPC1	P35052	2	1028	2	AF-P35052-F1-model_v4	P35052-F1	0.159	0.659	1	82.89746	2.018276	up_reg	268
XRCC2	O43543	2	0	3	AF-O43543-F1-model_v4	O43543-F1	0.516	0.659	1	87.09828	1.514626	up_reg	432
MCM4	P33991	2	366	7	AF-P33991-F1-model_v4	P33991-F1	0.217	0.658	3	73.74330	1.169478	up_reg	450
NEK2	P51955	2	0	2	AF-P51955-F1-model_v4	P51955-F1	0.136	0.658	2	78.74819	1.921272	up_reg	497
LAMA5	O15230	5	3	2	AF-O15230-F2-model_v4	O15230-F2	0.026	0.656	1	82.86351	2.198114	up_reg	155
TPX2	Q9ULW0	2	518	2	AF-Q9ULW0-F1-model_v4	Q9ULW0-F1	0.402	0.656	1	64.23851	1.659036	up_reg	689
NCAPG	Q9BPX3	2	0	1	AF-Q9BPX3-F1-model_v4	Q9BPX3-F1	0.163	0.655	1	82.50230	1.672671	up_reg	258
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F9-model_v4	Q8WXX0-F9	0.177	0.654	2	86.45957	1.516270	up_reg	21
CENPH	Q9H3R5	2	858	8	AF-Q9H3R5-F1-model_v4	Q9H3R5-F1	0.285	0.649	1	83.39197	1.363394	up_reg	90
BAMBI	Q13145	2	130	2	AF-Q13145-F1-model_v4	Q13145-F1	0.346	0.648	1	64.85375	1.519035	up_reg	578
H2BC21	Q16778	2	1	6	AF-Q16778-F1-model_v4	Q16778-F1	0.458	0.645	2	88.04314	1.311310	up_reg	2
PODXL	O00592	3	0	1	AF-O00592-F1-model_v4	O00592-F1	0.288	0.644	1	53.92824	1.533310	up_reg	212
RAD51	Q06609	2	19	3	AF-Q06609-F1-model_v4	Q06609-F1	0.282	0.640	1	91.59067	1.172608	up_reg	5877
GINS4	Q9BRT9	2	0	1	AF-Q9BRT9-F1-model_v4	Q9BRT9-F1	0.324	0.635	1	90.74832	1.344926	up_reg	38
MYBL2	P10244	2	0	1	AF-P10244-F1-model_v4	P10244-F1	0.066	0.633	1	58.45051	2.299187	up_reg	483
CLDN3	O15551	3	1	3	AF-O15551-F1-model_v4	O15551-F1	0.271	0.631	1	81.42759	4.740731	up_reg	487
H1-5	P16401	2	1287	5	AF-P16401-F1-model_v4	P16401-F1	0.282	0.629	1	64.55596	1.583736	up_reg	139
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F6-model_v4	Q8WXX0-F6	0.352	0.626	2	89.35613	1.516270	up_reg	21
PCDHGB1	Q9Y5G3	14	0	1	AF-Q9Y5G3-F1-model_v4	Q9Y5G3-F1	0.109	0.624	2	75.21973	3.070102	up_reg	3
H3C1	P68431	2	1350	12	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.099690	up_reg	5
H3C10	P68431	2	497	6	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.831417	up_reg	0
H3C11	P68431	2	481	4	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.514423	up_reg	1
H3C12	P68431	2	4161	8	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	2.005020	up_reg	0
NUF2	Q9BZD4	2	0	1	AF-Q9BZD4-F1-model_v4	Q9BZD4-F1	0.317	0.622	2	89.42833	1.255478	up_reg	201
BLM	P54132	2	0	2	AF-P54132-F1-model_v4	P54132-F1	0.161	0.616	1	60.95775	1.054300	up_reg	5467
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F1-model_v4	Q9NRC6-F1	0.103	0.613	1	80.83881	1.859882	up_reg	17
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F11-model_v4	Q8TD57-F11	0.286	0.612	4	84.67000	2.305663	up_reg	16
BRCA2	P51587	2	769	5	AF-P51587-F8-model_v4	P51587-F8	0.270	0.607	2	50.76375	1.000504	up_reg	14413
PFKFB4	Q16877	11	0	1	AF-Q16877-F1-model_v4	Q16877-F1	0.267	0.607	1	92.10892	1.207471	up_reg	142
PRAME	P78395	2	0	1	AF-P78395-F1-model_v4	P78395-F1	0.372	0.605	1	81.57775	2.811976	up_reg	566
IQGAP3	Q86VI3	2	0	1	AF-Q86VI3-F1-model_v4	Q86VI3-F1	0.181	0.604	2	79.62675	1.151973	up_reg	86
MZT2B	Q6NZ67	2	0	1	AF-Q6NZ67-F1-model_v4	Q6NZ67-F1	0.256	0.603	1	65.75364	1.516884	up_reg	3
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F14-model_v4	Q8WXX0-F14	0.080	0.600	3	86.98711	1.516270	up_reg	21
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F5-model_v4	Q9NYC9-F5	0.350	0.600	1	85.96167	3.112720	up_reg	75
NOTCH1	P46531	2	5773	6	AF-P46531-F1-model_v4	P46531-F1	0.203	0.600	2	57.49833	1.622551	up_reg	9140
CENPK	Q9BS16	2	0	8	AF-Q9BS16-F1-model_v4	Q9BS16-F1	0.253	0.599	1	81.70731	1.268209	up_reg	51
ICAM1	P05362	3	0	1	AF-P05362-F1-model_v4	P05362-F1	0.208	0.596	2	88.57488	1.791348	up_reg	31229
PHLDA1	Q8WV24	2	0	1	AF-Q8WV24-F1-model_v4	Q8WV24-F1	0.396	0.593	1	62.40043	1.124484	up_reg	193
NRARP	Q7Z6K4	2	0	1	AF-Q7Z6K4-F1-model_v4	Q7Z6K4-F1	0.142	0.584	1	82.92880	1.755765	up_reg	46
RACGAP1	Q9H0H5	2	847	6	AF-Q9H0H5-F1-model_v4	Q9H0H5-F1	0.133	0.584	2	69.86318	1.059365	up_reg	177
NUSAP1	Q9BXS6	2	257	2	AF-Q9BXS6-F1-model_v4	Q9BXS6-F1	0.144	0.583	1	63.08720	1.230911	up_reg	186
H4C1	P62805	2	847	10	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.351587	up_reg	1
H4C13	P62805	2	4	3	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.732810	up_reg	0
H4C4	P62805	2	81	8	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.036836	up_reg	19
PDZK1	Q5T2W1	3	44	4	AF-Q5T2W1-F1-model_v4	Q5T2W1-F1	0.169	0.577	2	78.65569	2.855962	up_reg	291
CENPE	Q02224	2	0	1	AF-Q02224-F5-model_v4	Q02224-F5	0.235	0.575	2	73.06951	1.272231	up_reg	439
ERBB2	P04626	2	4747	8	AF-P04626-F1-model_v4	P04626-F1	0.179	0.572	1	74.90918	2.810506	up_reg	37036
SEMA6A	Q9H2E6	15	0	1	AF-Q9H2E6-F1-model_v4	Q9H2E6-F1	0.163	0.564	1	70.78297	2.534740	up_reg	133
E2F8	A0AVK6	2	0	1	AF-A0AVK6-F1-model_v4	A0AVK6-F1	0.140	0.562	1	53.69316	1.322877	up_reg	153
DSCC1	Q9BVC3	2	0	1	AF-Q9BVC3-F1-model_v4	Q9BVC3-F1	0.206	0.558	1	92.16572	1.280364	up_reg	21
KIF2C	Q99661	2	1267	4	AF-Q99661-F1-model_v4	Q99661-F1	0.070	0.558	2	74.65762	1.874636	up_reg	302
TK1	P04183	2	12	2	AF-P04183-F1-model_v4	P04183-F1	0.284	0.554	2	82.30998	1.559659	up_reg	784
EXO1	Q9UQ84	2	251	3	AF-Q9UQ84-F1-model_v4	Q9UQ84-F1	0.203	0.552	1	63.63935	1.723281	up_reg	931
UBE2S	Q16763	2	18196	9	AF-Q16763-F1-model_v4	Q16763-F1	0.168	0.552	1	81.85029	2.280124	up_reg	119
MCM10	Q7L590	2	412	3	AF-Q7L590-F1-model_v4	Q7L590-F1	0.080	0.549	2	66.88891	1.989976	up_reg	234
CCNA2	P20248	2	14369	7	AF-P20248-F1-model_v4	P20248-F1	0.256	0.547	2	74.74787	1.423933	up_reg	784
ERCC6L	Q2NKX8	2	0	1	AF-Q2NKX8-F1-model_v4	Q2NKX8-F1	0.048	0.546	1	62.79458	1.585961	up_reg	64
MDK	P21741	12	0	1	AF-P21741-F1-model_v4	P21741-F1	0.343	0.543	1	73.10764	1.614032	up_reg	962
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F13-model_v4	Q9NRC6-F13	0.316	0.537	2	80.36086	1.859882	up_reg	17
NDC80	O14777	2	606	3	AF-O14777-F1-model_v4	O14777-F1	0.161	0.532	2	78.60958	1.647925	up_reg	596
MRPL12	P52815	2	0	1	AF-P52815-F1-model_v4	P52815-F1	0.472	0.530	1	69.51532	1.804467	up_reg	36
CCNE2	O96020	2	0	1	AF-O96020-F1-model_v4	O96020-F1	0.296	0.527	1	77.76399	1.400035	up_reg	308
CENPF	P49454	2	0	3	AF-P49454-F1-model_v4	P49454-F1	0.399	0.524	2	72.41199	1.543658	up_reg	391
MCM2	P49736	2	0	2	AF-P49736-F1-model_v4	P49736-F1	0.139	0.522	3	76.52259	1.728739	up_reg	1566
S100A4	P26447	16	0	1	AF-P26447-F1-model_v4	P26447-F1	0.313	0.516	1	85.18673	2.611786	up_reg	1720
CENPM	Q9NSP4	2	464	9	AF-Q9NSP4-F1-model_v4	Q9NSP4-F1	0.181	0.514	1	89.76468	1.643556	up_reg	49
ATAD2	Q6PL18	2	0	3	AF-Q6PL18-F1-model_v4	Q6PL18-F1	0.186	0.513	1	62.52127	1.359788	up_reg	168
KRT15	P19012	10	0	1	AF-P19012-F1-model_v4	P19012-F1	0.359	0.513	1	77.14245	2.098460	up_reg	232
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F2-model_v4	Q8TD57-F2	0.407	0.511	1	85.57752	2.305663	up_reg	16
DTL	Q9NZJ0	2	10	2	AF-Q9NZJ0-F1-model_v4	Q9NZJ0-F1	0.101	0.511	2	63.43932	1.403031	up_reg	635
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F5-model_v4	Q8IZT6-F5	0.281	0.507	2	68.95596	1.477836	up_reg	518
DBN1	Q16643	2	147	2	AF-Q16643-F1-model_v4	Q16643-F1	0.135	0.507	1	63.03875	1.667269	up_reg	49
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F7-model_v4	Q8TD57-F7	0.093	0.507	1	88.96404	2.305663	up_reg	16
MED1	Q15648	2	1287	8	AF-Q15648-F1-model_v4	Q15648-F1	0.111	0.507	1	51.29562	1.306109	up_reg	1104
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F59-model_v4	Q8WXI7-F59	0.129	0.507	3	61.67421	4.631299	up_reg	1358
KIF14	Q15058	2	861	5	AF-Q15058-F1-model_v4	Q15058-F1	0.127	0.506	1	66.04636	1.571041	up_reg	164
PTTG1	O95997	2	726	4	AF-O95997-F1-model_v4	O95997-F1	0.339	0.504	1	64.54399	1.771144	up_reg	440
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F14-model_v4	Q9NYC9-F14	0.124	0.503	1	86.18666	3.112720	up_reg	75
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F5-model_v4	Q9NRC6-F5	0.167	0.499	2	79.92004	1.859882	up_reg	17
TMOD1	P28289	2	774	2	AF-P28289-F1-model_v4	P28289-F1	0.096	0.499	1	84.79803	2.356395	up_reg	153
KIF23	Q02241	2	0	2	AF-Q02241-F1-model_v4	Q02241-F1	0.314	0.498	1	73.07353	1.531319	up_reg	207
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F7-model_v4	Q9NRC6-F7	0.063	0.494	2	80.47958	1.859882	up_reg	17
FGFR3	P22607	2	519	3	AF-P22607-F1-model_v4	P22607-F1	0.127	0.488	1	75.36964	1.507694	up_reg	3446
CENPE	Q02224	2	0	1	AF-Q02224-F4-model_v4	Q02224-F4	0.168	0.487	1	72.31956	1.272231	up_reg	439
CLDN15	P56746	3	60	4	AF-P56746-F1-model_v4	P56746-F1	0.406	0.485	1	81.81001	1.946830	up_reg	38
CENPF	P49454	2	0	3	AF-P49454-F6-model_v4	P49454-F6	0.437	0.484	2	70.99553	1.543658	up_reg	391
CDCA8	Q53HL2	2	260	6	AF-Q53HL2-F1-model_v4	Q53HL2-F1	0.388	0.483	1	68.78919	1.145697	up_reg	210
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F7-model_v4	Q9NYC9-F7	0.145	0.480	1	86.92646	3.112720	up_reg	75
CDK1	P06493	2	18044	16	AF-P06493-F1-model_v4	P06493-F1	0.514	0.471	1	89.31551	1.580437	up_reg	6002
CHTF18	Q8WVB6	2	260	2	AF-Q8WVB6-F1-model_v4	Q8WVB6-F1	0.162	0.470	1	64.97510	1.599515	up_reg	19
JAG2	Q9Y219	2	0	1	AF-Q9Y219-F1-model_v4	Q9Y219-F1	0.248	0.470	1	72.67450	2.132090	up_reg	322
DEPDC1B	Q8WUY9	2	0	1	AF-Q8WUY9-F1-model_v4	Q8WUY9-F1	0.107	0.469	1	77.36351	2.451811	up_reg	55
GLA	P06280	1	0	1	AF-P06280-F1-model_v4	P06280-F1	0.368	0.468	1	94.50382	1.121088	up_reg	12907
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F63-model_v4	Q8WXI7-F63	0.089	0.463	1	74.65565	4.631299	up_reg	1358
FBLN1	P23142	8	0	1	AF-P23142-F1-model_v4	P23142-F1	0.382	0.461	1	79.64933	5.288778	up_reg	150
TRIB3	Q96RU7	2	0	1	AF-Q96RU7-F1-model_v4	Q96RU7-F1	0.175	0.461	2	78.02088	1.928480	up_reg	514
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F12-model_v4	Q8TD57-F12	0.143	0.459	1	85.20082	2.305663	up_reg	16
FAM83D	Q9H4H8	2	0	2	AF-Q9H4H8-F1-model_v4	Q9H4H8-F1	0.140	0.459	1	64.42717	1.177234	up_reg	60
DPP4	P27487	3	107	3	AF-P27487-F1-model_v4	P27487-F1	0.321	0.453	1	96.40635	3.510087	up_reg	5935
CENPF	P49454	2	0	3	AF-P49454-F4-model_v4	P49454-F4	0.416	0.452	1	70.50561	1.543658	up_reg	391
LAMA5	O15230	5	3	2	AF-O15230-F3-model_v4	O15230-F3	0.132	0.448	1	83.31297	2.198114	up_reg	155
DEPDC1	Q5TB30	2	0	1	AF-Q5TB30-F1-model_v4	Q5TB30-F1	0.111	0.445	1	61.05036	1.835268	up_reg	92
NEIL3	Q8TAT5	2	47	11	AF-Q8TAT5-F1-model_v4	Q8TAT5-F1	0.015	0.445	1	70.00855	1.452700	up_reg	153
KIF18B	Q86Y91	2	0	2	AF-Q86Y91-F1-model_v4	Q86Y91-F1	0.200	0.437	1	62.74387	1.922124	up_reg	78
DNM1	Q05193	2	0	1	AF-Q05193-F1-model_v4	Q05193-F1	0.166	0.433	1	79.06586	1.800731	up_reg	263
BRAT1	Q6PJG6	2	0	1	AF-Q6PJG6-F1-model_v4	Q6PJG6-F1	0.415	0.432	1	85.19003	1.099328	up_reg	53
CDH24	Q86UP0	2	260	2	AF-Q86UP0-F1-model_v4	Q86UP0-F1	0.296	0.432	1	76.24933	1.247597	up_reg	8
AURKA	O14965	2	260	6	AF-O14965-F1-model_v4	O14965-F1	0.139	0.431	1	75.90579	1.275528	up_reg	2494
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F12-model_v4	Q8WXX0-F12	0.146	0.431	2	86.67860	1.516270	up_reg	21
CDC7	O00311	2	0	2	AF-O00311-F1-model_v4	O00311-F1	0.307	0.427	1	72.36204	1.012901	up_reg	661
PLXNA4	Q9HCM2	15	0	1	AF-Q9HCM2-F1-model_v4	Q9HCM2-F1	0.090	0.426	1	83.61456	2.486699	up_reg	108
ORC6	Q9Y5N6	2	0	2	AF-Q9Y5N6-F1-model_v4	Q9Y5N6-F1	0.216	0.425	1	81.54463	1.147588	up_reg	103
PDLIM4	P50479	2	0	1	AF-P50479-F1-model_v4	P50479-F1	0.362	0.420	1	70.90770	2.084414	up_reg	71
CDKN3	Q16667	2	0	1	AF-Q16667-F1-model_v4	Q16667-F1	0.472	0.413	1	91.05949	1.590039	up_reg	184
GAPDH	P04406	2	774	2	AF-P04406-F1-model_v4	P04406-F1	0.345	0.413	1	98.17071	1.126776	up_reg	8565
RPL19	P84098	2	519	4	AF-P84098-F1-model_v4	P84098-F1	0.402	0.406	1	94.64079	1.191137	up_reg	131
BUB1	O43683	2	519	4	AF-O43683-F1-model_v4	O43683-F1	0.138	0.403	1	64.12427	1.883874	up_reg	1290
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F61-model_v4	Q8WXI7-F61	0.196	0.403	1	73.85441	4.631299	up_reg	1358
TACC3	Q9Y6A5	2	0	1	AF-Q9Y6A5-F1-model_v4	Q9Y6A5-F1	0.259	0.400	1	58.34000	1.257585	up_reg	373
LMNB2	Q03252	2	0	1	AF-Q03252-F1-model_v4	Q03252-F1	0.194	0.394	0	80.02784	1.018836	up_reg	73
BOP1	Q14137	2	0	1	AF-Q14137-F1-model_v4	Q14137-F1	0.149	0.393	0	80.78432	1.427766	up_reg	122
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F3-model_v4	Q9NYC9-F3	0.216	0.391	0	84.04318	3.112720	up_reg	75
IGSF8	Q969P0	3	0	1	AF-Q969P0-F1-model_v4	Q969P0-F1	0.093	0.389	0	88.38596	1.008061	up_reg	49
CEP55	Q53EZ4	2	6	2	AF-Q53EZ4-F1-model_v4	Q53EZ4-F1	0.284	0.386	0	82.79305	1.774115	up_reg	279
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F6-model_v4	Q9NYC9-F6	0.184	0.385	0	86.20007	3.112720	up_reg	75
CENPF	P49454	2	0	3	AF-P49454-F5-model_v4	P49454-F5	0.219	0.384	0	70.83409	1.543658	up_reg	391
UBE2T	Q9NPD8	2	0	1	AF-Q9NPD8-F1-model_v4	Q9NPD8-F1	0.273	0.383	0	86.02709	1.200009	up_reg	149
KRT23	Q9C075	10	0	1	AF-Q9C075-F1-model_v4	Q9C075-F1	0.182	0.382	0	78.43096	6.327604	up_reg	48
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F6-model_v4	Q9NRC6-F6	0.247	0.380	0	79.57389	1.859882	up_reg	17
RRM2	P31350	2	260	2	AF-P31350-F1-model_v4	P31350-F1	0.276	0.377	0	80.12601	1.559305	up_reg	923
CDCA5	Q96FF9	2	0	1	AF-Q96FF9-F1-model_v4	Q96FF9-F1	0.258	0.376	0	63.50505	1.762388	up_reg	158
KIF1A	Q12756	2	2485	9	AF-Q12756-F1-model_v4	Q12756-F1	0.106	0.373	0	71.01825	2.921797	up_reg	354
SPC24	Q8NBT2	2	0	1	AF-Q8NBT2-F1-model_v4	Q8NBT2-F1	0.345	0.372	0	91.39337	1.231117	up_reg	80
PCDHGA5	Q9Y5G8	13	0	1	AF-Q9Y5G8-F1-model_v4	Q9Y5G8-F1	0.102	0.371	0	75.39293	1.810726	up_reg	0
PIF1	Q9H611	2	0	1	AF-Q9H611-F1-model_v4	Q9H611-F1	0.062	0.368	0	77.97936	1.521154	up_reg	478
CBX2	Q14781	2	4	8	AF-Q14781-F1-model_v4	Q14781-F1	0.412	0.367	0	57.18264	2.495511	up_reg	194
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F9-model_v4	Q8IZT6-F9	0.161	0.360	0	63.08517	1.477836	up_reg	518
CLDN4	O14493	3	21	3	AF-O14493-F1-model_v4	O14493-F1	0.511	0.360	0	84.52154	1.539998	up_reg	632
GRB7	Q14451	2	0	1	AF-Q14451-F1-model_v4	Q14451-F1	0.214	0.360	0	78.88878	3.704094	up_reg	311
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F4-model_v4	Q8IZT6-F4	0.271	0.359	0	70.40001	1.477836	up_reg	518
CENPW	Q5EE01	2	64	9	AF-Q5EE01-F1-model_v4	Q5EE01-F1	0.310	0.353	0	89.69919	1.259111	up_reg	61
KIFC1	Q9BW19	2	1277	4	AF-Q9BW19-F1-model_v4	Q9BW19-F1	0.202	0.353	0	77.88326	1.653350	up_reg	190
NECTIN1	Q15223	2	0	1	AF-Q15223-F1-model_v4	Q15223-F1	0.115	0.351	0	75.94298	1.035554	up_reg	389
PCDHGB2	Q9Y5G2	14	0	1	AF-Q9Y5G2-F1-model_v4	Q9Y5G2-F1	0.338	0.351	0	75.75001	1.612896	up_reg	2
RUNX3	Q13761	2	260	2	AF-Q13761-F1-model_v4	Q13761-F1	0.403	0.350	0	62.21557	1.969305	up_reg	1565
ASF1B	Q9NVP2	2	0	4	AF-Q9NVP2-F1-model_v4	Q9NVP2-F1	0.391	0.346	0	85.64720	1.543374	up_reg	114
ENO1	P06733	2	0	1	AF-P06733-F1-model_v4	P06733-F1	0.465	0.346	0	97.62715	1.253482	up_reg	881
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F67-model_v4	Q8WXI7-F67	0.102	0.344	0	76.30687	4.631299	up_reg	1358
RPL39L	Q96EH5	2	0	1	AF-Q96EH5-F1-model_v4	Q96EH5-F1	0.319	0.343	0	94.09941	1.340365	up_reg	19
CENPF	P49454	2	0	3	AF-P49454-F2-model_v4	P49454-F2	0.173	0.336	0	71.95028	1.543658	up_reg	391
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F13-model_v4	Q8WXX0-F13	0.129	0.335	0	86.47365	1.516270	up_reg	21
TONSL	Q96HA7	2	21	4	AF-Q96HA7-F1-model_v4	Q96HA7-F1	0.187	0.335	0	76.48871	1.661091	up_reg	54
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F8-model_v4	Q9NRC6-F8	0.157	0.332	0	80.45226	1.859882	up_reg	17
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F4-model_v4	Q8WXX0-F4	0.226	0.331	0	87.83695	1.516270	up_reg	21
FBXL19	Q6PCT2	2	0	1	AF-Q6PCT2-F1-model_v4	Q6PCT2-F1	0.073	0.327	0	67.83220	1.264427	up_reg	65
C4B	P0C0L5	2	0	1	AF-P0C0L5-F1-model_v4	P0C0L5-F1	0.182	0.325	0	83.46925	2.001316	up_reg	3359
OIP5	O43482	2	260	7	AF-O43482-F1-model_v4	O43482-F1	0.193	0.324	0	76.32641	1.591730	up_reg	272
CLSPN	Q9HAW4	2	776	6	AF-Q9HAW4-F1-model_v4	Q9HAW4-F1	0.285	0.322	0	51.81036	1.270376	up_reg	151
GINS2	Q9Y248	2	0	1	AF-Q9Y248-F1-model_v4	Q9Y248-F1	0.258	0.318	0	93.40448	1.567400	up_reg	87
EME1	Q96AY2	2	0	1	AF-Q96AY2-F1-model_v4	Q96AY2-F1	0.155	0.315	0	67.90349	1.276116	up_reg	191
SLC3A1	Q07837	2	0	1	AF-Q07837-F1-model_v4	Q07837-F1	0.216	0.312	0	87.82102	2.729605	up_reg	278
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F65-model_v4	Q8WXI7-F65	0.065	0.305	0	75.39936	4.631299	up_reg	1358
RTN4R	Q9BZR6	3	60	2	AF-Q9BZR6-F1-model_v4	Q9BZR6-F1	0.240	0.303	0	77.06296	2.208875	up_reg	341
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F11-model_v4	Q8WXX0-F11	0.151	0.298	0	86.66137	1.516270	up_reg	21
E2F1	Q01094	2	530	5	AF-Q01094-F1-model_v4	Q01094-F1	0.159	0.295	0	63.73504	1.335481	up_reg	5151
GINS1	Q14691	2	0	1	AF-Q14691-F1-model_v4	Q14691-F1	0.241	0.287	0	93.30269	1.666886	up_reg	69
UBE2C	O00762	2	18	4	AF-O00762-F1-model_v4	O00762-F1	0.355	0.286	0	89.69871	1.857549	up_reg	444
CCNE1	P24864	2	969	6	AF-P24864-F1-model_v4	P24864-F1	0.101	0.284	0	79.97658	1.823919	up_reg	1067
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F1-model_v4	Q8WXX0-F1	0.347	0.283	0	81.86191	1.516270	up_reg	21
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F9-model_v4	Q9NYC9-F9	0.145	0.275	0	89.10942	3.112720	up_reg	75
LAMA5	O15230	5	3	2	AF-O15230-F5-model_v4	O15230-F5	0.171	0.274	0	83.83144	2.198114	up_reg	155
SPRY1	O43609	2	0	1	AF-O43609-F1-model_v4	O43609-F1	0.224	0.267	0	61.61950	1.240669	up_reg	317
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F8-model_v4	Q8WXX0-F8	0.046	0.258	0	86.25343	1.516270	up_reg	21
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F2-model_v4	Q8WXX0-F2	0.207	0.256	0	87.78350	1.516270	up_reg	21
KIF18A	Q8NI77	2	0	2	AF-Q8NI77-F1-model_v4	Q8NI77-F1	0.186	0.256	0	67.74104	1.821786	up_reg	147
E2F7	Q96AV8	2	260	2	AF-Q96AV8-F1-model_v4	Q96AV8-F1	0.108	0.254	0	51.27249	1.708301	up_reg	226
PDLIM7	Q9NR12	2	519	3	AF-Q9NR12-F1-model_v4	Q9NR12-F1	0.079	0.251	0	71.03190	1.532650	up_reg	175
WDR18	Q9BV38	2	0	1	AF-Q9BV38-F1-model_v4	Q9BV38-F1	0.095	0.251	0	86.10082	1.125611	up_reg	14
BRCA2	P51587	2	769	5	AF-P51587-F9-model_v4	P51587-F9	0.072	0.246	0	55.07728	1.000504	up_reg	14413
GGT1	P19440	3	0	1	AF-P19440-F1-model_v4	P19440-F1	0.391	0.244	0	94.94071	1.800705	up_reg	180
CENPF	P49454	2	0	3	AF-P49454-F3-model_v4	P49454-F3	0.328	0.243	0	70.33298	1.543658	up_reg	391
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F8-model_v4	Q9NYC9-F8	0.233	0.242	0	87.95375	3.112720	up_reg	75
PARVB	Q9HBI1	5	1	2	AF-Q9HBI1-F1-model_v4	Q9HBI1-F1	0.063	0.242	0	82.45817	1.248136	up_reg	81
RAD51AP1	Q96B01	2	614	5	AF-Q96B01-F1-model_v4	Q96B01-F1	0.122	0.242	0	58.79844	1.425452	up_reg	101
IGFBP3	P17936	2	0	1	AF-P17936-F1-model_v4	P17936-F1	0.282	0.235	0	67.73329	2.109532	up_reg	8159
KHDRBS3	O75525	9	0	1	AF-O75525-F1-model_v4	O75525-F1	0.467	0.235	0	69.77844	1.649271	up_reg	64
CDT1	Q9H211	2	260	3	AF-Q9H211-F1-model_v4	Q9H211-F1	0.393	0.234	0	74.90779	2.404285	up_reg	661
H2AC11	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.789297	up_reg	1
H2AC13	P0C0S8	2	0	2	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.687352	up_reg	1
H2AC15	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.300878	up_reg	0
H2AC16	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	2.102910	up_reg	0
H2AC12	Q96KK5	2	0	8	AF-Q96KK5-F1-model_v4	Q96KK5-F1	0.413	0.233	0	91.90792	1.694176	up_reg	0
H2AC4	P04908	2	0	1	AF-P04908-F1-model_v4	P04908-F1	0.384	0.231	0	91.08903	2.125754	up_reg	1
H2AC8	P04908	2	5209	9	AF-P04908-F1-model_v4	P04908-F1	0.384	0.231	0	91.08903	1.236545	up_reg	1
H2AC14	Q99878	2	5614	14	AF-Q99878-F1-model_v4	Q99878-F1	0.443	0.230	0	91.90550	1.611322	up_reg	0
CDC25A	P30304	2	5900	3	AF-P30304-F1-model_v4	P30304-F1	0.261	0.229	0	63.57967	1.351055	up_reg	1245
H3C13	Q71DI3	2	6617	7	AF-Q71DI3-F1-model_v4	Q71DI3-F1	0.089	0.228	0	87.30418	2.440964	up_reg	1
UHRF1	Q96T88	2	270	9	AF-Q96T88-F1-model_v4	Q96T88-F1	0.210	0.221	0	81.26714	1.647277	up_reg	703
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F64-model_v4	Q8WXI7-F64	0.085	0.220	0	75.54095	4.631299	up_reg	1358
PSMD3	O43242	2	0	1	AF-O43242-F1-model_v4	O43242-F1	0.208	0.219	0	73.48985	2.626656	up_reg	45
CDC20	Q12834	2	623	5	AF-Q12834-F1-model_v4	Q12834-F1	0.319	0.217	0	84.85435	2.104143	up_reg	1658
NHERF1	O14745	3	107	4	AF-O14745-F1-model_v4	O14745-F1	0.202	0.212	0	72.47472	1.164937	up_reg	466
PLK4	O00444	2	299	3	AF-O00444-F1-model_v4	O00444-F1	0.133	0.199	0	66.92294	1.179010	up_reg	487
EPHB2	P29323	2	260	2	AF-P29323-F1-model_v4	P29323-F1	0.129	0.198	0	80.12099	1.875976	up_reg	851
LAMA5	O15230	5	3	2	AF-O15230-F9-model_v4	O15230-F9	0.149	0.195	0	79.60429	2.198114	up_reg	155
CKS2	P33552	2	0	1	AF-P33552-F1-model_v4	P33552-F1	0.368	0.194	0	92.87122	1.091549	up_reg	172
S100A9	P06702	2	0	1	AF-P06702-F1-model_v4	P06702-F1	0.328	0.187	0	94.90595	5.148571	up_reg	2221
PCDHGA4	Q9Y5G9	13	0	1	AF-Q9Y5G9-F1-model_v4	Q9Y5G9-F1	0.100	0.184	0	74.38778	2.483945	up_reg	4
ZNRF3	Q9ULT6	3	0	1	AF-Q9ULT6-F1-model_v4	Q9ULT6-F1	0.232	0.183	0	51.30892	1.455680	up_reg	160
HMGA1	P17096	2	0	1	AF-P17096-F1-model_v4	P17096-F1	0.159	0.181	0	65.46237	1.407994	up_reg	1303
H1-3	P16402	2	0	2	AF-P16402-F1-model_v4	P16402-F1	0.228	0.176	0	63.95611	1.231820	up_reg	153
H2AC21	Q8IUE6	2	777	7	AF-Q8IUE6-F1-model_v4	Q8IUE6-F1	0.379	0.174	0	91.07137	1.668757	up_reg	0
PCLAF	Q15004	2	0	1	AF-Q15004-F1-model_v4	Q15004-F1	0.264	0.167	0	66.12640	1.296453	up_reg	103
TNFRSF19	Q9NS68	3	42	2	AF-Q9NS68-F1-model_v4	Q9NS68-F1	0.228	0.160	0	60.38073	2.426988	up_reg	118
CLDN7	O95471	3	76	2	AF-O95471-F1-model_v4	O95471-F1	0.254	0.152	0	82.24946	1.355505	up_reg	303
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F62-model_v4	Q8WXI7-F62	0.095	0.146	0	75.51818	4.631299	up_reg	1358
ESPN	B1AK53	2	0	1	AF-B1AK53-F1-model_v4	B1AK53-F1	0.114	0.144	0	68.30997	2.798276	up_reg	203
PITX1	P78337	3	0	1	AF-P78337-F1-model_v4	P78337-F1	0.326	0.132	0	63.26645	1.889320	up_reg	481
USP44	Q9H0E7	2	0	1	AF-Q9H0E7-F1-model_v4	Q9H0E7-F1	0.101	0.131	0	72.70601	2.218077	up_reg	63
SPINDOC	Q9BUA3	2	0	5	AF-Q9BUA3-F1-model_v4	Q9BUA3-F1	0.062	0.118	0	51.19178	1.089261	up_reg	9
SKA1	Q96BD8	2	0	2	AF-Q96BD8-F1-model_v4	Q96BD8-F1	0.218	0.102	0	85.82242	1.714548	up_reg	115
CLDN2	P57739	3	0	3	AF-P57739-F1-model_v4	P57739-F1	0.093	0.091	0	78.67346	3.466479	up_reg	415
E2F2	Q14209	2	0	1	AF-Q14209-F1-model_v4	Q14209-F1	0.180	0.079	0	64.08260	1.719613	up_reg	642
H2AX	P16104	2	5479	14	AF-P16104-F1-model_v4	P16104-F1	0.328	0.078	0	87.32992	1.814395	up_reg	7263
CCNB2	O95067	2	259	4	AF-O95067-F1-model_v4	O95067-F1	0.089	0.073	0	80.38333	1.681702	up_reg	456
H1-10	Q92522	2	160	3	AF-Q92522-F1-model_v4	Q92522-F1	0.065	0.060	0	66.41116	1.405241	up_reg	41
CCNF	P41002	2	1	2	AF-P41002-F1-model_v4	P41002-F1	0.276	0.059	0	72.44700	1.358114	up_reg	185
A4GALT	Q9NPC4	1	0	1	AF-Q9NPC4-F1-model_v4	Q9NPC4-F1	0.089	0.056	0	89.56960	2.317881	up_reg	69
CDH3	P22223	2	0	1	AF-P22223-F1-model_v4	P22223-F1	0.256	0.053	0	76.62218	1.560149	up_reg	267
SGO1	Q5FBB7	2	0	1	AF-Q5FBB7-F1-model_v4	Q5FBB7-F1	0.108	0.050	0	55.17324	1.452157	up_reg	255
JUP	P14923	2	518	2	AF-P14923-F1-model_v4	P14923-F1	0.091	0.021	0	81.10563	2.379501	up_reg	491
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F60-model_v4	Q8WXI7-F60	0.186	0.021	0	67.43678	4.631299	up_reg	1358
MAD2L1	Q13257	2	1535	4	AF-Q13257-F1-model_v4	Q13257-F1	0.178	0.019	0	93.75853	1.487082	up_reg	687

PCSF Druggability Results

external_gene_name	uniprot_gn_id	cluster	betweenness	degree_centrality	file_id	ID	pocket	druggability	num_drug_pockets	struct_score	logFC	regulation	citation_score
MUC17	Q685J3	3	0	1	AF-Q685J3-F5-model_v4	Q685J3-F5	0.317	1.000	7	50.38741	2.932704	up_reg	99
CENPE	Q02224	2	0	1	AF-Q02224-F6-model_v4	Q02224-F6	0.135	0.997	5	72.55249	1.272231	up_reg	439
CD9	P21926	3	194	6	AF-P21926-F1-model_v4	P21926-F1	0.063	0.994	1	88.11915	1.203438	up_reg	2729
MELK	Q14680	2	0	1	AF-Q14680-F1-model_v4	Q14680-F1	0.159	0.993	1	70.64372	1.755936	up_reg	669
XPR1	Q9UBH6	2	0	1	AF-Q9UBH6-F1-model_v4	Q9UBH6-F1	0.207	0.993	3	83.73372	1.318176	up_reg	180
KIF11	P52732	2	48	4	AF-P52732-F1-model_v4	P52732-F1	0.141	0.991	1	74.76864	1.239185	up_reg	827
PTGS2	P35354	2	260	2	AF-P35354-F1-model_v4	P35354-F1	0.262	0.987	1	93.32770	2.338946	up_reg	41309
TEAD4	Q15561	2	0	1	AF-Q15561-F1-model_v4	Q15561-F1	0.243	0.986	2	76.58312	1.597999	up_reg	388
FABP1	P07148	2	0	1	AF-P07148-F1-model_v4	P07148-F1	-0.023	0.981	1	94.95010	7.464763	up_reg	900
ABCA2	Q9BZC7	2	3430	2	AF-Q9BZC7-F1-model_v4	Q9BZC7-F1	0.258	0.976	5	72.33891	1.262028	up_reg	138
PRC1	O43663	2	0	1	AF-O43663-F1-model_v4	O43663-F1	0.226	0.975	2	80.11427	1.458330	up_reg	1534
SPAG4	Q9NPE6	2	0	1	AF-Q9NPE6-F1-model_v4	Q9NPE6-F1	0.378	0.975	1	71.56424	1.521158	up_reg	51
KIF20B	Q96Q89	2	0	2	AF-Q96Q89-F1-model_v4	Q96Q89-F1	0.232	0.971	4	63.74834	1.021659	up_reg	57
H2BC10	P62807	2	288	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.200574	up_reg	0
H2BC4	P62807	2	213	9	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.124252	up_reg	0
H2BC6	P62807	2	4200	13	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.513907	up_reg	0
H2BC7	P62807	2	2530	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.650740	up_reg	0
H2BC8	P62807	2	801	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.316050	up_reg	1
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F4-model_v4	Q8TD57-F4	0.164	0.960	4	85.66639	2.305663	up_reg	16
RARA	P10276	2	5107	16	AF-P10276-F1-model_v4	P10276-F1	0.362	0.958	1	79.41892	1.490980	up_reg	4411
CYBA	P13498	2	1284	3	AF-P13498-F1-model_v4	P13498-F1	0.480	0.957	1	77.02989	1.275871	up_reg	1045
H2BC17	P23527	2	260	9	AF-P23527-F1-model_v4	P23527-F1	0.371	0.957	2	88.00099	1.844521	up_reg	0
TTK	P33981	2	1031	4	AF-P33981-F1-model_v4	P33981-F1	0.087	0.956	1	63.95435	1.457472	up_reg	2071
SLC19A3	Q9BZV2	3	0	1	AF-Q9BZV2-F1-model_v4	Q9BZV2-F1	0.137	0.955	2	82.16840	3.205348	up_reg	180
FZD7	O75084	2	776	4	AF-O75084-F1-model_v4	O75084-F1	0.435	0.953	3	84.14906	1.548584	up_reg	390
PLK1	P53350	2	2733	10	AF-P53350-F1-model_v4	P53350-F1	0.175	0.953	2	85.16989	1.603519	up_reg	3003
IL32	P24001	2	0	1	AF-P24001-F1-model_v4	P24001-F1	0.099	0.950	2	71.19002	1.544145	up_reg	628
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F10-model_v4	Q8IZT6-F10	0.434	0.949	4	62.64048	1.477836	up_reg	518
LAMA5	O15230	5	3	2	AF-O15230-F12-model_v4	O15230-F12	0.086	0.946	2	79.24314	2.198114	up_reg	155
PDE3A	Q14432	2	0	1	AF-Q14432-F1-model_v4	Q14432-F1	0.272	0.945	3	61.48643	1.816074	up_reg	371
H2BC13	Q99880	2	1475	19	AF-Q99880-F1-model_v4	Q99880-F1	0.414	0.944	2	87.44870	1.723938	up_reg	0
PTGS1	P23219	2	0	1	AF-P23219-F1-model_v4	P23219-F1	0.142	0.943	1	94.11557	1.691682	up_reg	3045
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F9-model_v4	Q9NRC6-F9	0.088	0.942	1	80.58407	1.859882	up_reg	17
H2BC3	P33778	2	269	11	AF-P33778-F1-model_v4	P33778-F1	0.423	0.941	2	87.64271	1.429227	up_reg	2
FBLN2	P98095	8	0	1	AF-P98095-F1-model_v4	P98095-F1	0.228	0.938	1	67.61607	2.431256	up_reg	74
H2BC12	O60814	2	20	10	AF-O60814-F1-model_v4	O60814-F1	0.241	0.937	1	88.05779	1.128966	up_reg	3
RAC3	P60763	2	2787	5	AF-P60763-F1-model_v4	P60763-F1	0.341	0.937	1	93.83371	1.213210	up_reg	301
NR5A2	O00482	2	5443	14	AF-O00482-F1-model_v4	O00482-F1	0.203	0.936	2	72.86144	1.943734	up_reg	569
H2BC15	Q99877	2	1247	18	AF-Q99877-F1-model_v4	Q99877-F1	0.313	0.935	1	87.69131	1.134114	up_reg	0
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F12-model_v4	Q9NYC9-F12	0.087	0.930	2	85.79432	3.112720	up_reg	75
CDC45	O75419	2	263	3	AF-O75419-F1-model_v4	O75419-F1	0.323	0.926	1	92.88743	1.483786	up_reg	603
SLC27A2	O14975	4	0	1	AF-O14975-F1-model_v4	O14975-F1	0.206	0.925	1	92.73940	1.659103	up_reg	79
CDC6	Q99741	2	2	2	AF-Q99741-F1-model_v4	Q99741-F1	0.244	0.922	2	69.83948	3.355449	up_reg	1062
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F5-model_v4	Q8WXX0-F5	0.424	0.921	2	88.31141	1.516270	up_reg	21
CENPI	Q92674	2	1240	10	AF-Q92674-F1-model_v4	Q92674-F1	0.058	0.915	3	72.79816	1.176172	up_reg	68
CENPF	P49454	2	0	3	AF-P49454-F7-model_v4	P49454-F7	0.122	0.906	1	71.41875	1.543658	up_reg	391
PBK	Q96KB5	2	0	2	AF-Q96KB5-F1-model_v4	Q96KB5-F1	0.152	0.901	1	84.90700	1.610733	up_reg	788
TOP2A	P11388	2	1844	9	AF-P11388-F1-model_v4	P11388-F1	0.045	0.897	1	76.40832	2.033427	up_reg	1351
ITGB8	P26012	5	0	2	AF-P26012-F1-model_v4	P26012-F1	0.085	0.896	1	76.46707	1.652867	up_reg	134
HEPH	Q9BQS7	6	0	1	AF-Q9BQS7-F1-model_v4	Q9BQS7-F1	0.288	0.895	2	89.66272	1.676420	up_reg	201
H2BC14	Q99879	2	766	14	AF-Q99879-F1-model_v4	Q99879-F1	0.365	0.888	2	86.12243	1.594661	up_reg	1
SPAG5	Q96R06	2	1766	5	AF-Q96R06-F1-model_v4	Q96R06-F1	0.223	0.887	2	63.81311	1.534844	up_reg	127
ANPEP	P15144	3	76	2	AF-P15144-F1-model_v4	P15144-F1	0.232	0.886	1	93.75126	6.652030	up_reg	193
HMMR	O75330	2	0	1	AF-O75330-F1-model_v4	O75330-F1	0.192	0.886	2	76.10490	1.783138	up_reg	255
ESPL1	Q14674	2	0	1	AF-Q14674-F1-model_v4	Q14674-F1	0.619	0.885	1	75.77835	1.914072	up_reg	146
ABCD1	P33897	4	0	1	AF-P33897-F1-model_v4	P33897-F1	0.179	0.884	1	81.73405	1.260959	up_reg	675
CIT	O14578	2	0	1	AF-O14578-F1-model_v4	O14578-F1	0.129	0.882	1	70.15278	1.119051	up_reg	8694
ABCC2	Q92887	3	0	2	AF-Q92887-F1-model_v4	Q92887-F1	0.256	0.879	6	81.43685	1.508199	up_reg	2209
MTTP	P55157	2	0	1	AF-P55157-F1-model_v4	P55157-F1	0.279	0.871	2	86.91982	3.185389	up_reg	434
H2BC11	P06899	2	233	10	AF-P06899-F1-model_v4	P06899-F1	0.250	0.870	2	85.69804	1.482316	up_reg	1
KIF15	Q9NS87	2	10	2	AF-Q9NS87-F1-model_v4	Q9NS87-F1	0.241	0.869	1	72.02130	1.354129	up_reg	161
SLC1A5	Q15758	2	2988	2	AF-Q15758-F1-model_v4	Q15758-F1	0.051	0.866	2	79.59138	1.291235	up_reg	544
SLC7A5	Q01650	2	260	3	AF-Q01650-F1-model_v4	Q01650-F1	0.097	0.862	2	86.24003	2.711656	up_reg	872
WDR76	Q9H967	2	4995	4	AF-Q9H967-F1-model_v4	Q9H967-F1	0.272	0.861	1	75.38044	1.087175	up_reg	22
NRCAM	Q92823	2	260	2	AF-Q92823-F1-model_v4	Q92823-F1	0.090	0.859	2	78.95628	3.487392	up_reg	325
BUB1B	O60566	2	521	5	AF-O60566-F1-model_v4	O60566-F1	0.211	0.846	2	64.72058	1.529523	up_reg	478
POLD1	P28340	2	1287	5	AF-P28340-F1-model_v4	P28340-F1	0.097	0.843	2	86.95676	1.347636	up_reg	323
SLC2A1	P11166	12	0	1	AF-P11166-F1-model_v4	P11166-F1	0.190	0.839	1	89.61531	1.425517	up_reg	3575
H2BC18	Q5QNW6	2	34	7	AF-Q5QNW6-F1-model_v4	Q5QNW6-F1	0.422	0.825	2	87.95688	1.297057	up_reg	0
GPI	P06744	2	260	2	AF-P06744-F1-model_v4	P06744-F1	0.383	0.816	2	97.84077	1.548803	up_reg	20988
CENPA	P49450	2	1242	7	AF-P49450-F1-model_v4	P49450-F1	0.140	0.815	2	82.07836	1.774299	up_reg	1099
KIF20A	O95235	2	1070	6	AF-O95235-F1-model_v4	O95235-F1	0.333	0.814	3	67.30456	1.472619	up_reg	306
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F58-model_v4	Q8WXI7-F58	0.180	0.798	1	55.96839	4.631299	up_reg	1358
BRCA2	P51587	2	769	5	AF-P51587-F12-model_v4	P51587-F12	0.083	0.796	1	65.83808	1.000504	up_reg	14413
RECQL4	O94761	2	103	6	AF-O94761-F1-model_v4	O94761-F1	0.125	0.793	1	69.03096	2.366331	up_reg	335
RTKN	Q9BST9	16	0	1	AF-Q9BST9-F1-model_v4	Q9BST9-F1	0.115	0.793	1	72.73822	1.286409	up_reg	70
FGFR4	P22455	2	0	1	AF-P22455-F1-model_v4	P22455-F1	0.145	0.792	3	74.61047	1.878331	up_reg	1205
AURKB	Q96GD4	2	0	2	AF-Q96GD4-F1-model_v4	Q96GD4-F1	0.060	0.789	2	79.85404	1.350410	up_reg	1380
CHAF1B	Q13112	2	0	1	AF-Q13112-F1-model_v4	Q13112-F1	0.173	0.789	1	75.38529	1.009863	up_reg	92
MZT2A	Q6P582	2	260	2	AF-Q6P582-F1-model_v4	Q6P582-F1	0.264	0.788	1	65.50284	1.098928	up_reg	5
ATP1A1	P05023	2	4150	3	AF-P05023-F1-model_v4	P05023-F1	0.200	0.787	1	88.69918	1.217536	up_reg	574
TGM2	P21980	2	0	1	AF-P21980-F1-model_v4	P21980-F1	0.245	0.781	1	92.78304	1.904023	up_reg	595
CDC25C	P30307	2	0	1	AF-P30307-F1-model_v4	P30307-F1	0.362	0.777	1	64.18249	1.552450	up_reg	1464
ATP1B3	P54709	2	3224	3	AF-P54709-F1-model_v4	P54709-F1	0.329	0.776	1	89.52136	1.755640	up_reg	52
TRAIP	Q9BWF2	2	0	1	AF-Q9BWF2-F1-model_v4	Q9BWF2-F1	0.303	0.770	1	74.95434	1.048263	up_reg	59
WDR62	O43379	2	260	2	AF-O43379-F1-model_v4	O43379-F1	0.088	0.770	2	61.36502	1.688680	up_reg	124
FZD2	Q14332	2	0	2	AF-Q14332-F1-model_v4	Q14332-F1	0.544	0.766	4	84.43777	1.655708	up_reg	255
LGR5	O75473	3	22	2	AF-O75473-F1-model_v4	O75473-F1	0.267	0.766	4	80.74472	3.555059	up_reg	2038
ORC1	Q13415	2	15590	8	AF-Q13415-F1-model_v4	Q13415-F1	0.154	0.765	1	67.97461	1.802587	up_reg	378
PHF19	Q5T6S3	2	430	11	AF-Q5T6S3-F1-model_v4	Q5T6S3-F1	0.257	0.765	1	69.88708	1.211096	up_reg	70
PPFIA3	O75145	2	0	1	AF-O75145-F1-model_v4	O75145-F1	0.306	0.764	3	69.92988	2.010150	up_reg	8
ANLN	Q9NQW6	2	1633	5	AF-Q9NQW6-F1-model_v4	Q9NQW6-F1	0.121	0.760	1	59.87419	1.600614	up_reg	232
LMNB1	P20700	2	260	3	AF-P20700-F1-model_v4	P20700-F1	0.275	0.754	2	82.63466	1.294937	up_reg	202
DNA2	P51530	2	3554	5	AF-P51530-F1-model_v4	P51530-F1	0.216	0.741	2	87.56204	1.114640	up_reg	607
SPTBN2	O15020	2	518	2	AF-O15020-F1-model_v4	O15020-F1	0.242	0.736	3	76.77521	2.161117	up_reg	98
CHEK1	O14757	2	260	3	AF-O14757-F1-model_v4	O14757-F1	0.067	0.732	1	78.13441	1.188158	up_reg	2110
MME	P08473	3	112	2	AF-P08473-F1-model_v4	P08473-F1	0.377	0.727	3	96.22472	2.634423	up_reg	2311
BCAM	P50895	5	0	1	AF-P50895-F1-model_v4	P50895-F1	0.182	0.725	3	84.58449	2.892853	up_reg	431
POLQ	O75417	2	0	1	AF-O75417-F1-model_v4	O75417-F1	0.104	0.717	1	59.48627	1.691706	up_reg	186
KPNA2	P52292	2	400	3	AF-P52292-F1-model_v4	P52292-F1	0.024	0.711	1	86.10732	1.245351	up_reg	315
SHCBP1	Q8NEM2	2	0	1	AF-Q8NEM2-F1-model_v4	Q8NEM2-F1	0.180	0.711	1	73.69646	1.170171	up_reg	66
SPC25	Q9HBM1	2	0	1	AF-Q9HBM1-F1-model_v4	Q9HBM1-F1	0.390	0.708	1	90.25548	1.320553	up_reg	108
FANCA	O15360	2	0	1	AF-O15360-F1-model_v4	O15360-F1	0.135	0.707	1	74.56587	1.028733	up_reg	697
RARRES1	P49788	9	0	1	AF-P49788-F1-model_v4	P49788-F1	0.423	0.702	3	79.94364	2.923580	up_reg	102
FOXM1	Q08050	2	510	4	AF-Q08050-F1-model_v4	Q08050-F1	0.173	0.701	1	51.07629	1.648781	up_reg	2285
PFKFB3	Q16875	11	1	2	AF-Q16875-F1-model_v4	Q16875-F1	0.182	0.700	1	87.13527	1.551414	up_reg	668
CCNB1	P14635	2	2056	13	AF-P14635-F1-model_v4	P14635-F1	0.078	0.699	1	77.77241	1.801033	up_reg	2303
MCM6	Q14566	2	529	7	AF-Q14566-F1-model_v4	Q14566-F1	0.032	0.695	2	77.33923	1.041344	up_reg	384
STIL	Q15468	2	0	1	AF-Q15468-F1-model_v4	Q15468-F1	0.163	0.693	1	53.64950	1.037125	up_reg	476
LDHA	P00338	11	0	1	AF-P00338-F1-model_v4	P00338-F1	0.089	0.690	1	96.06050	1.071241	up_reg	2265
ABCC4	O15439	3	57	2	AF-O15439-F1-model_v4	O15439-F1	0.139	0.684	3	83.59147	1.197058	up_reg	845
ITGA7	Q13683	5	4	3	AF-Q13683-F1-model_v4	Q13683-F1	0.119	0.684	2	79.47519	1.441251	up_reg	231
NCAPH	Q15003	2	260	2	AF-Q15003-F1-model_v4	Q15003-F1	0.198	0.683	1	60.71979	1.728427	up_reg	73
SKA3	Q8IX90	2	0	2	AF-Q8IX90-F1-model_v4	Q8IX90-F1	0.354	0.683	1	64.75869	1.526244	up_reg	99
TRIP13	Q15645	2	0	1	AF-Q15645-F1-model_v4	Q15645-F1	0.249	0.677	2	86.97940	1.912157	up_reg	205
PKMYT1	Q99640	2	280	3	AF-Q99640-F1-model_v4	Q99640-F1	0.142	0.674	1	75.59028	2.415277	up_reg	108
DLGAP5	Q15398	2	774	2	AF-Q15398-F1-model_v4	Q15398-F1	0.128	0.669	1	56.37102	1.477999	up_reg	184
RAD54L	Q92698	2	0	1	AF-Q92698-F1-model_v4	Q92698-F1	0.171	0.669	1	80.51223	1.511108	up_reg	181
BCL6	P41182	2	260	2	AF-P41182-F1-model_v4	P41182-F1	0.071	0.668	1	50.10971	1.124834	up_reg	4242
KIF4A	O95239	2	0	2	AF-O95239-F1-model_v4	O95239-F1	0.244	0.668	3	72.17122	1.626611	up_reg	229
FANCB	Q8NB91	2	0	1	AF-Q8NB91-F1-model_v4	Q8NB91-F1	0.127	0.662	3	71.98628	1.300126	up_reg	87
GPC1	P35052	2	1028	2	AF-P35052-F1-model_v4	P35052-F1	0.159	0.659	1	82.89746	2.018276	up_reg	268
XRCC2	O43543	2	0	3	AF-O43543-F1-model_v4	O43543-F1	0.516	0.659	1	87.09828	1.514626	up_reg	432
MCM4	P33991	2	366	7	AF-P33991-F1-model_v4	P33991-F1	0.217	0.658	3	73.74330	1.169478	up_reg	450
NEK2	P51955	2	0	2	AF-P51955-F1-model_v4	P51955-F1	0.136	0.658	2	78.74819	1.921272	up_reg	497
TPX2	Q9ULW0	2	518	2	AF-Q9ULW0-F1-model_v4	Q9ULW0-F1	0.402	0.656	1	64.23851	1.659036	up_reg	689
NCAPG	Q9BPX3	2	0	1	AF-Q9BPX3-F1-model_v4	Q9BPX3-F1	0.163	0.655	1	82.50230	1.672671	up_reg	258
CENPH	Q9H3R5	2	858	8	AF-Q9H3R5-F1-model_v4	Q9H3R5-F1	0.285	0.649	1	83.39197	1.363394	up_reg	90
BAMBI	Q13145	2	130	2	AF-Q13145-F1-model_v4	Q13145-F1	0.346	0.648	1	64.85375	1.519035	up_reg	578
H2BC21	Q16778	2	1	6	AF-Q16778-F1-model_v4	Q16778-F1	0.458	0.645	2	88.04314	1.311310	up_reg	2
PODXL	O00592	3	0	1	AF-O00592-F1-model_v4	O00592-F1	0.288	0.644	1	53.92824	1.533310	up_reg	212
RAD51	Q06609	2	19	3	AF-Q06609-F1-model_v4	Q06609-F1	0.282	0.640	1	91.59067	1.172608	up_reg	5877
GINS4	Q9BRT9	2	0	1	AF-Q9BRT9-F1-model_v4	Q9BRT9-F1	0.324	0.635	1	90.74832	1.344926	up_reg	38
MYBL2	P10244	2	0	1	AF-P10244-F1-model_v4	P10244-F1	0.066	0.633	1	58.45051	2.299187	up_reg	483
CLDN3	O15551	3	1	3	AF-O15551-F1-model_v4	O15551-F1	0.271	0.631	1	81.42759	4.740731	up_reg	487
H1-5	P16401	2	1287	5	AF-P16401-F1-model_v4	P16401-F1	0.282	0.629	1	64.55596	1.583736	up_reg	139
PCDHGB1	Q9Y5G3	14	0	1	AF-Q9Y5G3-F1-model_v4	Q9Y5G3-F1	0.109	0.624	2	75.21973	3.070102	up_reg	3
H3C1	P68431	2	1350	12	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.099690	up_reg	5
H3C10	P68431	2	497	6	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.831417	up_reg	0
H3C11	P68431	2	481	4	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.514423	up_reg	1
H3C12	P68431	2	4161	8	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	2.005020	up_reg	0
NUF2	Q9BZD4	2	0	1	AF-Q9BZD4-F1-model_v4	Q9BZD4-F1	0.317	0.622	2	89.42833	1.255478	up_reg	201
BLM	P54132	2	0	2	AF-P54132-F1-model_v4	P54132-F1	0.161	0.616	1	60.95775	1.054300	up_reg	5467
PFKFB4	Q16877	11	0	1	AF-Q16877-F1-model_v4	Q16877-F1	0.267	0.607	1	92.10892	1.207471	up_reg	142
PRAME	P78395	2	0	1	AF-P78395-F1-model_v4	P78395-F1	0.372	0.605	1	81.57775	2.811976	up_reg	566
IQGAP3	Q86VI3	2	0	1	AF-Q86VI3-F1-model_v4	Q86VI3-F1	0.181	0.604	2	79.62675	1.151973	up_reg	86
MZT2B	Q6NZ67	2	0	1	AF-Q6NZ67-F1-model_v4	Q6NZ67-F1	0.256	0.603	1	65.75364	1.516884	up_reg	3
NOTCH1	P46531	2	5773	6	AF-P46531-F1-model_v4	P46531-F1	0.203	0.600	2	57.49833	1.622551	up_reg	9140
CENPK	Q9BS16	2	0	8	AF-Q9BS16-F1-model_v4	Q9BS16-F1	0.253	0.599	1	81.70731	1.268209	up_reg	51
ICAM1	P05362	3	0	1	AF-P05362-F1-model_v4	P05362-F1	0.208	0.596	2	88.57488	1.791348	up_reg	31229
PHLDA1	Q8WV24	2	0	1	AF-Q8WV24-F1-model_v4	Q8WV24-F1	0.396	0.593	1	62.40043	1.124484	up_reg	193
NRARP	Q7Z6K4	2	0	1	AF-Q7Z6K4-F1-model_v4	Q7Z6K4-F1	0.142	0.584	1	82.92880	1.755765	up_reg	46
RACGAP1	Q9H0H5	2	847	6	AF-Q9H0H5-F1-model_v4	Q9H0H5-F1	0.133	0.584	2	69.86318	1.059365	up_reg	177
NUSAP1	Q9BXS6	2	257	2	AF-Q9BXS6-F1-model_v4	Q9BXS6-F1	0.144	0.583	1	63.08720	1.230911	up_reg	186
H4C1	P62805	2	847	10	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.351587	up_reg	1
H4C13	P62805	2	4	3	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.732810	up_reg	0
H4C4	P62805	2	81	8	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.036836	up_reg	19
PDZK1	Q5T2W1	3	44	4	AF-Q5T2W1-F1-model_v4	Q5T2W1-F1	0.169	0.577	2	78.65569	2.855962	up_reg	291
ERBB2	P04626	2	4747	8	AF-P04626-F1-model_v4	P04626-F1	0.179	0.572	1	74.90918	2.810506	up_reg	37036
SEMA6A	Q9H2E6	15	0	1	AF-Q9H2E6-F1-model_v4	Q9H2E6-F1	0.163	0.564	1	70.78297	2.534740	up_reg	133
E2F8	A0AVK6	2	0	1	AF-A0AVK6-F1-model_v4	A0AVK6-F1	0.140	0.562	1	53.69316	1.322877	up_reg	153
DSCC1	Q9BVC3	2	0	1	AF-Q9BVC3-F1-model_v4	Q9BVC3-F1	0.206	0.558	1	92.16572	1.280364	up_reg	21
KIF2C	Q99661	2	1267	4	AF-Q99661-F1-model_v4	Q99661-F1	0.070	0.558	2	74.65762	1.874636	up_reg	302
TK1	P04183	2	12	2	AF-P04183-F1-model_v4	P04183-F1	0.284	0.554	2	82.30998	1.559659	up_reg	784
EXO1	Q9UQ84	2	251	3	AF-Q9UQ84-F1-model_v4	Q9UQ84-F1	0.203	0.552	1	63.63935	1.723281	up_reg	931
UBE2S	Q16763	2	18196	9	AF-Q16763-F1-model_v4	Q16763-F1	0.168	0.552	1	81.85029	2.280124	up_reg	119
MCM10	Q7L590	2	412	3	AF-Q7L590-F1-model_v4	Q7L590-F1	0.080	0.549	2	66.88891	1.989976	up_reg	234
CCNA2	P20248	2	14369	7	AF-P20248-F1-model_v4	P20248-F1	0.256	0.547	2	74.74787	1.423933	up_reg	784
ERCC6L	Q2NKX8	2	0	1	AF-Q2NKX8-F1-model_v4	Q2NKX8-F1	0.048	0.546	1	62.79458	1.585961	up_reg	64
MDK	P21741	12	0	1	AF-P21741-F1-model_v4	P21741-F1	0.343	0.543	1	73.10764	1.614032	up_reg	962
NDC80	O14777	2	606	3	AF-O14777-F1-model_v4	O14777-F1	0.161	0.532	2	78.60958	1.647925	up_reg	596
MRPL12	P52815	2	0	1	AF-P52815-F1-model_v4	P52815-F1	0.472	0.530	1	69.51532	1.804467	up_reg	36
CCNE2	O96020	2	0	1	AF-O96020-F1-model_v4	O96020-F1	0.296	0.527	1	77.76399	1.400035	up_reg	308
MCM2	P49736	2	0	2	AF-P49736-F1-model_v4	P49736-F1	0.139	0.522	3	76.52259	1.728739	up_reg	1566
S100A4	P26447	16	0	1	AF-P26447-F1-model_v4	P26447-F1	0.313	0.516	1	85.18673	2.611786	up_reg	1720
CENPM	Q9NSP4	2	464	9	AF-Q9NSP4-F1-model_v4	Q9NSP4-F1	0.181	0.514	1	89.76468	1.643556	up_reg	49
ATAD2	Q6PL18	2	0	3	AF-Q6PL18-F1-model_v4	Q6PL18-F1	0.186	0.513	1	62.52127	1.359788	up_reg	168
KRT15	P19012	10	0	1	AF-P19012-F1-model_v4	P19012-F1	0.359	0.513	1	77.14245	2.098460	up_reg	232
DTL	Q9NZJ0	2	10	2	AF-Q9NZJ0-F1-model_v4	Q9NZJ0-F1	0.101	0.511	2	63.43932	1.403031	up_reg	635
DBN1	Q16643	2	147	2	AF-Q16643-F1-model_v4	Q16643-F1	0.135	0.507	1	63.03875	1.667269	up_reg	49
MED1	Q15648	2	1287	8	AF-Q15648-F1-model_v4	Q15648-F1	0.111	0.507	1	51.29562	1.306109	up_reg	1104
KIF14	Q15058	2	861	5	AF-Q15058-F1-model_v4	Q15058-F1	0.127	0.506	1	66.04636	1.571041	up_reg	164
PTTG1	O95997	2	726	4	AF-O95997-F1-model_v4	O95997-F1	0.339	0.504	1	64.54399	1.771144	up_reg	440
TMOD1	P28289	2	774	2	AF-P28289-F1-model_v4	P28289-F1	0.096	0.499	1	84.79803	2.356395	up_reg	153
KIF23	Q02241	2	0	2	AF-Q02241-F1-model_v4	Q02241-F1	0.314	0.498	1	73.07353	1.531319	up_reg	207
FGFR3	P22607	2	519	3	AF-P22607-F1-model_v4	P22607-F1	0.127	0.488	1	75.36964	1.507694	up_reg	3446
CLDN15	P56746	3	60	4	AF-P56746-F1-model_v4	P56746-F1	0.406	0.485	1	81.81001	1.946830	up_reg	38
CDCA8	Q53HL2	2	260	6	AF-Q53HL2-F1-model_v4	Q53HL2-F1	0.388	0.483	1	68.78919	1.145697	up_reg	210
CDK1	P06493	2	18044	16	AF-P06493-F1-model_v4	P06493-F1	0.514	0.471	1	89.31551	1.580437	up_reg	6002
CHTF18	Q8WVB6	2	260	2	AF-Q8WVB6-F1-model_v4	Q8WVB6-F1	0.162	0.470	1	64.97510	1.599515	up_reg	19
JAG2	Q9Y219	2	0	1	AF-Q9Y219-F1-model_v4	Q9Y219-F1	0.248	0.470	1	72.67450	2.132090	up_reg	322
DEPDC1B	Q8WUY9	2	0	1	AF-Q8WUY9-F1-model_v4	Q8WUY9-F1	0.107	0.469	1	77.36351	2.451811	up_reg	55
GLA	P06280	1	0	1	AF-P06280-F1-model_v4	P06280-F1	0.368	0.468	1	94.50382	1.121088	up_reg	12907
FBLN1	P23142	8	0	1	AF-P23142-F1-model_v4	P23142-F1	0.382	0.461	1	79.64933	5.288778	up_reg	150
TRIB3	Q96RU7	2	0	1	AF-Q96RU7-F1-model_v4	Q96RU7-F1	0.175	0.461	2	78.02088	1.928480	up_reg	514
FAM83D	Q9H4H8	2	0	2	AF-Q9H4H8-F1-model_v4	Q9H4H8-F1	0.140	0.459	1	64.42717	1.177234	up_reg	60
DPP4	P27487	3	107	3	AF-P27487-F1-model_v4	P27487-F1	0.321	0.453	1	96.40635	3.510087	up_reg	5935
DEPDC1	Q5TB30	2	0	1	AF-Q5TB30-F1-model_v4	Q5TB30-F1	0.111	0.445	1	61.05036	1.835268	up_reg	92
NEIL3	Q8TAT5	2	47	11	AF-Q8TAT5-F1-model_v4	Q8TAT5-F1	0.015	0.445	1	70.00855	1.452700	up_reg	153
KIF18B	Q86Y91	2	0	2	AF-Q86Y91-F1-model_v4	Q86Y91-F1	0.200	0.437	1	62.74387	1.922124	up_reg	78
DNM1	Q05193	2	0	1	AF-Q05193-F1-model_v4	Q05193-F1	0.166	0.433	1	79.06586	1.800731	up_reg	263
BRAT1	Q6PJG6	2	0	1	AF-Q6PJG6-F1-model_v4	Q6PJG6-F1	0.415	0.432	1	85.19003	1.099328	up_reg	53
CDH24	Q86UP0	2	260	2	AF-Q86UP0-F1-model_v4	Q86UP0-F1	0.296	0.432	1	76.24933	1.247597	up_reg	8
AURKA	O14965	2	260	6	AF-O14965-F1-model_v4	O14965-F1	0.139	0.431	1	75.90579	1.275528	up_reg	2494
CDC7	O00311	2	0	2	AF-O00311-F1-model_v4	O00311-F1	0.307	0.427	1	72.36204	1.012901	up_reg	661
PLXNA4	Q9HCM2	15	0	1	AF-Q9HCM2-F1-model_v4	Q9HCM2-F1	0.090	0.426	1	83.61456	2.486699	up_reg	108
ORC6	Q9Y5N6	2	0	2	AF-Q9Y5N6-F1-model_v4	Q9Y5N6-F1	0.216	0.425	1	81.54463	1.147588	up_reg	103
PDLIM4	P50479	2	0	1	AF-P50479-F1-model_v4	P50479-F1	0.362	0.420	1	70.90770	2.084414	up_reg	71
CDKN3	Q16667	2	0	1	AF-Q16667-F1-model_v4	Q16667-F1	0.472	0.413	1	91.05949	1.590039	up_reg	184
GAPDH	P04406	2	774	2	AF-P04406-F1-model_v4	P04406-F1	0.345	0.413	1	98.17071	1.126776	up_reg	8565
RPL19	P84098	2	519	4	AF-P84098-F1-model_v4	P84098-F1	0.402	0.406	1	94.64079	1.191137	up_reg	131
BUB1	O43683	2	519	4	AF-O43683-F1-model_v4	O43683-F1	0.138	0.403	1	64.12427	1.883874	up_reg	1290
TACC3	Q9Y6A5	2	0	1	AF-Q9Y6A5-F1-model_v4	Q9Y6A5-F1	0.259	0.400	1	58.34000	1.257585	up_reg	373
LMNB2	Q03252	2	0	1	AF-Q03252-F1-model_v4	Q03252-F1	0.194	0.394	0	80.02784	1.018836	up_reg	73
BOP1	Q14137	2	0	1	AF-Q14137-F1-model_v4	Q14137-F1	0.149	0.393	0	80.78432	1.427766	up_reg	122
IGSF8	Q969P0	3	0	1	AF-Q969P0-F1-model_v4	Q969P0-F1	0.093	0.389	0	88.38596	1.008061	up_reg	49
CEP55	Q53EZ4	2	6	2	AF-Q53EZ4-F1-model_v4	Q53EZ4-F1	0.284	0.386	0	82.79305	1.774115	up_reg	279
UBE2T	Q9NPD8	2	0	1	AF-Q9NPD8-F1-model_v4	Q9NPD8-F1	0.273	0.383	0	86.02709	1.200009	up_reg	149
KRT23	Q9C075	10	0	1	AF-Q9C075-F1-model_v4	Q9C075-F1	0.182	0.382	0	78.43096	6.327604	up_reg	48
RRM2	P31350	2	260	2	AF-P31350-F1-model_v4	P31350-F1	0.276	0.377	0	80.12601	1.559305	up_reg	923
CDCA5	Q96FF9	2	0	1	AF-Q96FF9-F1-model_v4	Q96FF9-F1	0.258	0.376	0	63.50505	1.762388	up_reg	158
KIF1A	Q12756	2	2485	9	AF-Q12756-F1-model_v4	Q12756-F1	0.106	0.373	0	71.01825	2.921797	up_reg	354
SPC24	Q8NBT2	2	0	1	AF-Q8NBT2-F1-model_v4	Q8NBT2-F1	0.345	0.372	0	91.39337	1.231117	up_reg	80
PCDHGA5	Q9Y5G8	13	0	1	AF-Q9Y5G8-F1-model_v4	Q9Y5G8-F1	0.102	0.371	0	75.39293	1.810726	up_reg	0
PIF1	Q9H611	2	0	1	AF-Q9H611-F1-model_v4	Q9H611-F1	0.062	0.368	0	77.97936	1.521154	up_reg	478
CBX2	Q14781	2	4	8	AF-Q14781-F1-model_v4	Q14781-F1	0.412	0.367	0	57.18264	2.495511	up_reg	194
CLDN4	O14493	3	21	3	AF-O14493-F1-model_v4	O14493-F1	0.511	0.360	0	84.52154	1.539998	up_reg	632
GRB7	Q14451	2	0	1	AF-Q14451-F1-model_v4	Q14451-F1	0.214	0.360	0	78.88878	3.704094	up_reg	311
CENPW	Q5EE01	2	64	9	AF-Q5EE01-F1-model_v4	Q5EE01-F1	0.310	0.353	0	89.69919	1.259111	up_reg	61
KIFC1	Q9BW19	2	1277	4	AF-Q9BW19-F1-model_v4	Q9BW19-F1	0.202	0.353	0	77.88326	1.653350	up_reg	190
NECTIN1	Q15223	2	0	1	AF-Q15223-F1-model_v4	Q15223-F1	0.115	0.351	0	75.94298	1.035554	up_reg	389
PCDHGB2	Q9Y5G2	14	0	1	AF-Q9Y5G2-F1-model_v4	Q9Y5G2-F1	0.338	0.351	0	75.75001	1.612896	up_reg	2
RUNX3	Q13761	2	260	2	AF-Q13761-F1-model_v4	Q13761-F1	0.403	0.350	0	62.21557	1.969305	up_reg	1565
ASF1B	Q9NVP2	2	0	4	AF-Q9NVP2-F1-model_v4	Q9NVP2-F1	0.391	0.346	0	85.64720	1.543374	up_reg	114
ENO1	P06733	2	0	1	AF-P06733-F1-model_v4	P06733-F1	0.465	0.346	0	97.62715	1.253482	up_reg	881
RPL39L	Q96EH5	2	0	1	AF-Q96EH5-F1-model_v4	Q96EH5-F1	0.319	0.343	0	94.09941	1.340365	up_reg	19
TONSL	Q96HA7	2	21	4	AF-Q96HA7-F1-model_v4	Q96HA7-F1	0.187	0.335	0	76.48871	1.661091	up_reg	54
FBXL19	Q6PCT2	2	0	1	AF-Q6PCT2-F1-model_v4	Q6PCT2-F1	0.073	0.327	0	67.83220	1.264427	up_reg	65
C4B	P0C0L5	2	0	1	AF-P0C0L5-F1-model_v4	P0C0L5-F1	0.182	0.325	0	83.46925	2.001316	up_reg	3359
OIP5	O43482	2	260	7	AF-O43482-F1-model_v4	O43482-F1	0.193	0.324	0	76.32641	1.591730	up_reg	272
CLSPN	Q9HAW4	2	776	6	AF-Q9HAW4-F1-model_v4	Q9HAW4-F1	0.285	0.322	0	51.81036	1.270376	up_reg	151
GINS2	Q9Y248	2	0	1	AF-Q9Y248-F1-model_v4	Q9Y248-F1	0.258	0.318	0	93.40448	1.567400	up_reg	87
EME1	Q96AY2	2	0	1	AF-Q96AY2-F1-model_v4	Q96AY2-F1	0.155	0.315	0	67.90349	1.276116	up_reg	191
SLC3A1	Q07837	2	0	1	AF-Q07837-F1-model_v4	Q07837-F1	0.216	0.312	0	87.82102	2.729605	up_reg	278
RTN4R	Q9BZR6	3	60	2	AF-Q9BZR6-F1-model_v4	Q9BZR6-F1	0.240	0.303	0	77.06296	2.208875	up_reg	341
E2F1	Q01094	2	530	5	AF-Q01094-F1-model_v4	Q01094-F1	0.159	0.295	0	63.73504	1.335481	up_reg	5151
GINS1	Q14691	2	0	1	AF-Q14691-F1-model_v4	Q14691-F1	0.241	0.287	0	93.30269	1.666886	up_reg	69
UBE2C	O00762	2	18	4	AF-O00762-F1-model_v4	O00762-F1	0.355	0.286	0	89.69871	1.857549	up_reg	444
CCNE1	P24864	2	969	6	AF-P24864-F1-model_v4	P24864-F1	0.101	0.284	0	79.97658	1.823919	up_reg	1067
SPRY1	O43609	2	0	1	AF-O43609-F1-model_v4	O43609-F1	0.224	0.267	0	61.61950	1.240669	up_reg	317
KIF18A	Q8NI77	2	0	2	AF-Q8NI77-F1-model_v4	Q8NI77-F1	0.186	0.256	0	67.74104	1.821786	up_reg	147
E2F7	Q96AV8	2	260	2	AF-Q96AV8-F1-model_v4	Q96AV8-F1	0.108	0.254	0	51.27249	1.708301	up_reg	226
PDLIM7	Q9NR12	2	519	3	AF-Q9NR12-F1-model_v4	Q9NR12-F1	0.079	0.251	0	71.03190	1.532650	up_reg	175
WDR18	Q9BV38	2	0	1	AF-Q9BV38-F1-model_v4	Q9BV38-F1	0.095	0.251	0	86.10082	1.125611	up_reg	14
GGT1	P19440	3	0	1	AF-P19440-F1-model_v4	P19440-F1	0.391	0.244	0	94.94071	1.800705	up_reg	180
PARVB	Q9HBI1	5	1	2	AF-Q9HBI1-F1-model_v4	Q9HBI1-F1	0.063	0.242	0	82.45817	1.248136	up_reg	81
RAD51AP1	Q96B01	2	614	5	AF-Q96B01-F1-model_v4	Q96B01-F1	0.122	0.242	0	58.79844	1.425452	up_reg	101
IGFBP3	P17936	2	0	1	AF-P17936-F1-model_v4	P17936-F1	0.282	0.235	0	67.73329	2.109532	up_reg	8159
KHDRBS3	O75525	9	0	1	AF-O75525-F1-model_v4	O75525-F1	0.467	0.235	0	69.77844	1.649271	up_reg	64
CDT1	Q9H211	2	260	3	AF-Q9H211-F1-model_v4	Q9H211-F1	0.393	0.234	0	74.90779	2.404285	up_reg	661
H2AC11	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.789297	up_reg	1
H2AC13	P0C0S8	2	0	2	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.687352	up_reg	1
H2AC15	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.300878	up_reg	0
H2AC16	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	2.102910	up_reg	0
H2AC12	Q96KK5	2	0	8	AF-Q96KK5-F1-model_v4	Q96KK5-F1	0.413	0.233	0	91.90792	1.694176	up_reg	0
H2AC4	P04908	2	0	1	AF-P04908-F1-model_v4	P04908-F1	0.384	0.231	0	91.08903	2.125754	up_reg	1
H2AC8	P04908	2	5209	9	AF-P04908-F1-model_v4	P04908-F1	0.384	0.231	0	91.08903	1.236545	up_reg	1
H2AC14	Q99878	2	5614	14	AF-Q99878-F1-model_v4	Q99878-F1	0.443	0.230	0	91.90550	1.611322	up_reg	0
CDC25A	P30304	2	5900	3	AF-P30304-F1-model_v4	P30304-F1	0.261	0.229	0	63.57967	1.351055	up_reg	1245
H3C13	Q71DI3	2	6617	7	AF-Q71DI3-F1-model_v4	Q71DI3-F1	0.089	0.228	0	87.30418	2.440964	up_reg	1
UHRF1	Q96T88	2	270	9	AF-Q96T88-F1-model_v4	Q96T88-F1	0.210	0.221	0	81.26714	1.647277	up_reg	703
PSMD3	O43242	2	0	1	AF-O43242-F1-model_v4	O43242-F1	0.208	0.219	0	73.48985	2.626656	up_reg	45
CDC20	Q12834	2	623	5	AF-Q12834-F1-model_v4	Q12834-F1	0.319	0.217	0	84.85435	2.104143	up_reg	1658
NHERF1	O14745	3	107	4	AF-O14745-F1-model_v4	O14745-F1	0.202	0.212	0	72.47472	1.164937	up_reg	466
PLK4	O00444	2	299	3	AF-O00444-F1-model_v4	O00444-F1	0.133	0.199	0	66.92294	1.179010	up_reg	487
EPHB2	P29323	2	260	2	AF-P29323-F1-model_v4	P29323-F1	0.129	0.198	0	80.12099	1.875976	up_reg	851
CKS2	P33552	2	0	1	AF-P33552-F1-model_v4	P33552-F1	0.368	0.194	0	92.87122	1.091549	up_reg	172
S100A9	P06702	2	0	1	AF-P06702-F1-model_v4	P06702-F1	0.328	0.187	0	94.90595	5.148571	up_reg	2221
PCDHGA4	Q9Y5G9	13	0	1	AF-Q9Y5G9-F1-model_v4	Q9Y5G9-F1	0.100	0.184	0	74.38778	2.483945	up_reg	4
ZNRF3	Q9ULT6	3	0	1	AF-Q9ULT6-F1-model_v4	Q9ULT6-F1	0.232	0.183	0	51.30892	1.455680	up_reg	160
HMGA1	P17096	2	0	1	AF-P17096-F1-model_v4	P17096-F1	0.159	0.181	0	65.46237	1.407994	up_reg	1303
H1-3	P16402	2	0	2	AF-P16402-F1-model_v4	P16402-F1	0.228	0.176	0	63.95611	1.231820	up_reg	153
H2AC21	Q8IUE6	2	777	7	AF-Q8IUE6-F1-model_v4	Q8IUE6-F1	0.379	0.174	0	91.07137	1.668757	up_reg	0
PCLAF	Q15004	2	0	1	AF-Q15004-F1-model_v4	Q15004-F1	0.264	0.167	0	66.12640	1.296453	up_reg	103
TNFRSF19	Q9NS68	3	42	2	AF-Q9NS68-F1-model_v4	Q9NS68-F1	0.228	0.160	0	60.38073	2.426988	up_reg	118
CLDN7	O95471	3	76	2	AF-O95471-F1-model_v4	O95471-F1	0.254	0.152	0	82.24946	1.355505	up_reg	303
ESPN	B1AK53	2	0	1	AF-B1AK53-F1-model_v4	B1AK53-F1	0.114	0.144	0	68.30997	2.798276	up_reg	203
PITX1	P78337	3	0	1	AF-P78337-F1-model_v4	P78337-F1	0.326	0.132	0	63.26645	1.889320	up_reg	481
USP44	Q9H0E7	2	0	1	AF-Q9H0E7-F1-model_v4	Q9H0E7-F1	0.101	0.131	0	72.70601	2.218077	up_reg	63
SPINDOC	Q9BUA3	2	0	5	AF-Q9BUA3-F1-model_v4	Q9BUA3-F1	0.062	0.118	0	51.19178	1.089261	up_reg	9
SKA1	Q96BD8	2	0	2	AF-Q96BD8-F1-model_v4	Q96BD8-F1	0.218	0.102	0	85.82242	1.714548	up_reg	115
CLDN2	P57739	3	0	3	AF-P57739-F1-model_v4	P57739-F1	0.093	0.091	0	78.67346	3.466479	up_reg	415
E2F2	Q14209	2	0	1	AF-Q14209-F1-model_v4	Q14209-F1	0.180	0.079	0	64.08260	1.719613	up_reg	642
H2AX	P16104	2	5479	14	AF-P16104-F1-model_v4	P16104-F1	0.328	0.078	0	87.32992	1.814395	up_reg	7263
CCNB2	O95067	2	259	4	AF-O95067-F1-model_v4	O95067-F1	0.089	0.073	0	80.38333	1.681702	up_reg	456
H1-10	Q92522	2	160	3	AF-Q92522-F1-model_v4	Q92522-F1	0.065	0.060	0	66.41116	1.405241	up_reg	41
CCNF	P41002	2	1	2	AF-P41002-F1-model_v4	P41002-F1	0.276	0.059	0	72.44700	1.358114	up_reg	185
A4GALT	Q9NPC4	1	0	1	AF-Q9NPC4-F1-model_v4	Q9NPC4-F1	0.089	0.056	0	89.56960	2.317881	up_reg	69
CDH3	P22223	2	0	1	AF-P22223-F1-model_v4	P22223-F1	0.256	0.053	0	76.62218	1.560149	up_reg	267
SGO1	Q5FBB7	2	0	1	AF-Q5FBB7-F1-model_v4	Q5FBB7-F1	0.108	0.050	0	55.17324	1.452157	up_reg	255
JUP	P14923	2	518	2	AF-P14923-F1-model_v4	P14923-F1	0.091	0.021	0	81.10563	2.379501	up_reg	491
MAD2L1	Q13257	2	1535	4	AF-Q13257-F1-model_v4	Q13257-F1	0.178	0.019	0	93.75853	1.487082	up_reg	687

Step 5: Functional Enrichment Analysis

Show code

##   Performing enrichment analysis...

## Warning in cluster_edge_betweenness(subnet): At
## core/community/edge_betweenness.c:493 : Membership vector will be selected
## based on the highest modularity score.

##   Enrichment is being performed by EnrichR (http://amp.pharm.mssm.edu/Enrichr) API ...
## [1] "Number of enrichment results: 27"

Tip: Hover over nodes for details!

Note: P-value represents likelihood of observing that pathway by random chance. The top 15 functional enrichment terms for each cluster are ranked according to the adjusted p-value. This is what you observe when you hover your mouse over a node in that cluster.

Tabulated format

Enrichment Results

Cluster	Term	PValue	Adjusted_Pvalue	Genes
2	regulation of cellular component size (GO:0032535)	2.853203205375592E-4	0.009653337511520754	NEB;IQGAP3;CIT
2	chromosome organization (GO:0051276)	5.309166049096651E-4	0.012679537740783767	NCAPG;NCAPH;CIT
2	regulation of anatomical structure size (GO:0090066)	7.716824091518915E-4	0.014241048096166725	NEB;IQGAP3;CIT
2	regulation of actin filament-based process (GO:0032970)	0.0010375794448162583	0.01734785921116683	NEB;ATP1A1;CIT
2	actin filament-based process (GO:0030029)	0.0016655778410991028	0.02600863859562445	TMOD1;BCL6;NEB
2	spermatogenesis (GO:0007283)	0.002573726987660608	0.03291716539476697	BCL6;DNAH9;CIT
2	male gamete generation (GO:0048232)	0.002594456385794441	0.03291716539476697	BCL6;DNAH9;CIT
2	ATP metabolic process (GO:0046034)	0.0031003034101407144	0.03702127013285677	ABCA2;DNAH9;ATP1A1
2	gamete generation (GO:0007276)	0.0034113793392660454	0.03957200033548613	BCL6;DNAH9;CIT
2	purine ribonucleoside monophosphate metabolic process (GO:0009167)	0.0037150696836296742	0.03997073687603469	ABCA2;DNAH9;ATP1A1
2	purine nucleoside monophosphate metabolic process (GO:0009126)	0.003741103451451523	0.03997073687603469	ABCA2;DNAH9;ATP1A1
2	ribonucleoside monophosphate metabolic process (GO:0009161)	0.004089837030204999	0.04257625216059563	ABCA2;DNAH9;ATP1A1
2	nucleoside monophosphate metabolic process (GO:0009123)	0.004400024649679723	0.04308207656959098	ABCA2;DNAH9;ATP1A1
2	multicellular organismal reproductive process (GO:0048609)	0.00648969504452812	0.04626047591773712	BCL6;DNAH9;CIT
2	Protein digestion and absorption Homo sapiens hsa04974	4.729605552859509E-5	0.0011351053326862821	SLC3A1;ATP1B3;ATP1A1
2	Muscle contraction Homo sapiens R-HSA-397014	1.4845023306409954E-5	4.601957224987086E-4	TMOD1;ATP1B3;NEB;ATP1A1
2	Transmembrane transport of small molecules Homo sapiens R-HSA-382551	7.56156661616401E-5	7.813618836702811E-4	ABCA2;SLC7A5;SLC3A1;ATP1B3;ATP1A1
3	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.142160251914031E-11	1.8184083505902596E-8	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)	7.928270709188758E-8	1.196869036310753E-5	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2;ICAM1
3	cell-cell adhesion (GO:0098609)	8.179059473649792E-8	1.196869036310753E-5	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2;ICAM1
3	peptide metabolic process (GO:0006518)	3.2596951610233536E-4	0.0251555384035891	MME;ANPEP;GGT1
3	cellular amide metabolic process (GO:0043603)	0.0012028947887501064	0.05867453469569964	MME;ANPEP;GGT1
3	protein processing (GO:0016485)	0.0017321782940624465	0.07347362074129819	MME;ANPEP;GGT1
3	protein maturation (GO:0051604)	0.002298885816114334	0.07347362074129819	MME;ANPEP;GGT1
3	regulation of hormone levels (GO:0010817)	0.0025104881802265897	0.07347362074129819	ABCC2;MME;ANPEP
3	response to hypoxia (GO:0001666)	0.0029006543391088256	0.07846639217384778	DPP4;CLDN3;ICAM1
3	response to decreased oxygen levels (GO:0036293)	0.0030385618837253125	0.07846639217384778	DPP4;CLDN3;ICAM1
3	response to oxygen levels (GO:0070482)	0.0035529211756350197	0.08665179978354298	DPP4;CLDN3;ICAM1
3	response to acid chemical (GO:0001101)	0.004202671713238798	0.08821989685703478	ABCC2;CD9;ICAM1
3	regulation of cell adhesion (GO:0030155)	0.007322050378773087	0.11084069366487534	DPP4;PODXL;ICAM1
3	regulation of cell projection organization (GO:0031344)	0.01106570374994887	0.11848399868847692	RTN4R;PODXL;ICAM1
3	nitrogen compound transport (GO:0071705)	0.017487230597532315	0.11991336361794784	ABCC2;SLC19A3;PDZK1
3	cellular response to cytokine stimulus (GO:0071345)	0.01819260010549322	0.11991336361794784	MME;TNFRSF19;ICAM1
3	Leukocyte transendothelial migration Homo sapiens hsa04670	4.5782720069570716E-9	1.3734816020871214E-7	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2;ICAM1
3	Cell adhesion molecules (CAMs) Homo sapiens hsa04514	1.3953383774015167E-8	2.0930075661022751E-7	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2;ICAM1
3	Hepatitis C Homo sapiens hsa05160	4.630088131976925E-7	4.323539458503561E-6	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	Tight junction Homo sapiens hsa04530	5.764719278004748E-7	4.323539458503561E-6	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	Hematopoietic cell lineage Homo sapiens hsa04640	1.558113728712707E-4	9.348682372276242E-4	MME;ANPEP;CD9
3	Tight junction interactions Homo sapiens R-HSA-420029	2.2274387911640424E-10	1.2250913351402233E-8	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	Cell-cell junction organization Homo sapiens R-HSA-421270	9.073704910877522E-9	2.4952688504913184E-7	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	Cell junction organization Homo sapiens R-HSA-446728	5.207595972810795E-8	9.547259283486457E-7	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	Cell-Cell communication Homo sapiens R-HSA-1500931	4.2940464257975363E-7	5.9043138354716125E-6	CLDN4;CLDN3;CLDN15;CLDN7;CLDN2
3	Peptide hormone metabolism Homo sapiens R-HSA-2980736	1.2181275755868715E-4	0.0013399403331455586	DPP4;MME;ANPEP
3	Metabolism of proteins Homo sapiens R-HSA-392499	0.03724500062959532	0.07315982266527651	DPP4;MME;MUC17;ANPEP
5	regulation of lipid metabolic process (GO:0019216)	3.532629898071043E-6	0.0020276563745920354	FABP1;PTGS2;APOB;FGFR4;FGFR3
5	glycolytic process (GO:0006096)	1.1032325952813076E-5	0.0020276563745920354	GPI;ENO1;GAPDH
5	gluconeogenesis (GO:0006094)	1.262892516653142E-5	0.0020276563745920354	GPI;ENO1;GAPDH
5	peptidyl-tyrosine phosphorylation (GO:0018108)	1.413101921435206E-5	0.0020276563745920354	ERBB2;EPHB2;FGFR4;FGFR3
5	peptidyl-tyrosine modification (GO:0018212)	1.4878219351708313E-5	0.0020276563745920354	ERBB2;EPHB2;FGFR4;FGFR3
5	hexose biosynthetic process (GO:0019319)	1.626462332560456E-5	0.0020276563745920354	GPI;ENO1;GAPDH
5	monosaccharide biosynthetic process (GO:0046364)	2.2915057949159607E-5	0.002448637620853055	GPI;ENO1;GAPDH
5	epidermal growth factor receptor signaling pathway (GO:0007173)	3.6082402498459696E-5	0.0028665857977365665	GRB7;ERBB2;FGFR4;FGFR3
5	ERBB signaling pathway (GO:0038127)	3.832333954193271E-5	0.0028665857977365665	GRB7;ERBB2;FGFR4;FGFR3
5	adherens junction organization (GO:0034332)	4.295479506296637E-5	0.0029170988616558464	CDH3;JUP;CDH24
5	pyruvate metabolic process (GO:0006090)	4.679837745971946E-5	0.0029170988616558464	GPI;ENO1;GAPDH
5	monocarboxylic acid metabolic process (GO:0032787)	8.370554549795593E-5	0.004012569173787809	GPI;ENO1;PTGS2;GAPDH;PTGS1
5	positive regulation of lipid metabolic process (GO:0045834)	1.4188183374609618E-4	0.005895978424559997	FABP1;PTGS2;FGFR3
5	single-organism carbohydrate catabolic process (GO:0044724)	1.8664631260868848E-4	0.006980572091564948	GPI;ENO1;GAPDH
5	regulation of lipid biosynthetic process (GO:0046890)	1.8664631260868848E-4	0.006980572091564948	PTGS2;APOB;FGFR4
5	carbohydrate catabolic process (GO:0016052)	2.228807399107775E-4	0.007397234210136392	GPI;ENO1;GAPDH
5	carbohydrate biosynthetic process (GO:0016051)	2.821222287122725E-4	0.008441097083071192	GPI;ENO1;GAPDH
5	inositol lipid-mediated signaling (GO:0048017)	3.221149859892001E-4	0.008923778130367469	ERBB2;FGFR4;FGFR3
5	phosphatidylinositol-mediated signaling (GO:0048015)	3.221149859892001E-4	0.008923778130367469	ERBB2;FGFR4;FGFR3
5	regulation of protein import into nucleus (GO:0042306)	3.731980326597169E-4	0.00949699631647679	JUP;TACC3;PTGS2
5	positive regulation of epithelial cell proliferation (GO:0050679)	3.808955741902456E-4	0.00949699631647679	CDH3;ERBB2;FGFR3
5	glucose metabolic process (GO:0006006)	4.2092079830777386E-4	0.010156411520458543	GPI;ENO1;GAPDH
5	response to inorganic substance (GO:0010035)	4.4155622119483644E-4	0.010321376670429303	FABP1;MTTP;PTGS2;APOB
5	regulation of protein localization to nucleus (GO:1900180)	4.81365021138088E-4	0.010910940479129995	JUP;TACC3;PTGS2
5	cell junction assembly (GO:0034329)	5.182801129399194E-4	0.010966186876508572	CDH3;JUP;CDH24
5	cell-cell junction organization (GO:0045216)	5.277843951260809E-4	0.010966186876508572	CDH3;JUP;CDH24
5	regulation of ERK1 and ERK2 cascade (GO:0070372)	5.277843951260809E-4	0.010966186876508572	ERBB2;FGFR4;FGFR3
5	fibroblast growth factor receptor signaling pathway (GO:0008543)	5.471274226597022E-4	0.011060846274309656	ERBB2;FGFR4;FGFR3
5	regulation of protein targeting (GO:1903533)	5.871666095682293E-4	0.011261554460436808	JUP;TACC3;PTGS2
5	response to wounding (GO:0009611)	5.871666095682293E-4	0.011261554460436808	CDH3;ERBB2;FGFR3
5	protein autophosphorylation (GO:0046777)	6.183970475611111E-4	0.011493650274394617	ERBB2;FGFR4;FGFR3
5	cellular response to organonitrogen compound (GO:0071417)	6.558308127529366E-4	0.011493650274394617	JUP;PTGS2;FGFR4;FGFR3
5	detection of external stimulus (GO:0009581)	6.727783440508361E-4	0.011493650274394617	JUP;GPC1;APOB
5	regulation of cellular ketone metabolic process (GO:0010565)	7.068287601900433E-4	0.011493650274394617	FABP1;PTGS2;FGFR4
5	regulation of nucleocytoplasmic transport (GO:0046822)	7.068287601900433E-4	0.011493650274394617	JUP;TACC3;PTGS2
5	detection of abiotic stimulus (GO:0009582)	7.068287601900433E-4	0.011493650274394617	JUP;GPC1;APOB
5	cellular response to fibroblast growth factor stimulus (GO:0044344)	7.659941735256985E-4	0.011870002139975373	ERBB2;FGFR4;FGFR3
5	response to fibroblast growth factor (GO:0071774)	8.155369061794201E-4	0.011870002139975373	ERBB2;FGFR4;FGFR3
5	hexose metabolic process (GO:0019318)	8.155369061794201E-4	0.011870002139975373	GPI;ENO1;GAPDH
5	cellular response to nitrogen compound (GO:1901699)	8.320759197187428E-4	0.011870002139975373	JUP;PTGS2;FGFR4;FGFR3
5	cell junction organization (GO:0034330)	8.410563013618914E-4	0.011870002139975373	CDH3;JUP;CDH24
5	lipid transport (GO:0006869)	8.936113232019103E-4	0.01215311399554598	FABP1;MTTP;APOB
5	learning or memory (GO:0007611)	9.621891486724228E-4	0.01285209791441022	GPI;PTGS2;EPHB2
5	regulation of intracellular protein transport (GO:0033157)	0.0012865352003956765	0.0160388054982661	JUP;TACC3;PTGS2
5	monosaccharide metabolic process (GO:0005996)	0.0013205867537506347	0.016140202331817826	GPI;ENO1;GAPDH
5	negative regulation of endopeptidase activity (GO:0010951)	0.0013378242574501407	0.016140202331817826	C4B;FABP1;GPI
5	cognition (GO:0050890)	0.0014261470872844798	0.016668094082637357	GPI;PTGS2;EPHB2
5	negative regulation of peptidase activity (GO:0010466)	0.0014808651236500755	0.01704134019215779	C4B;FABP1;GPI
5	single organismal cell-cell adhesion (GO:0016337)	0.001574974026413352	0.01705873304761835	CDH3;JUP;CDH24
5	angiogenesis (GO:0001525)	0.0015942365614235127	0.01705873304761835	GPI;PTGS2;EPHB2
5	response to hypoxia (GO:0001666)	0.0016927767302854124	0.01705873304761835	FABP1;TACC3;PTGS2
5	response to molecule of bacterial origin (GO:0002237)	0.0017332402561751263	0.01705873304761835	C4B;PTGS2;APOB
5	response to decreased oxygen levels (GO:0036293)	0.001774307403611571	0.01723612906365526	FABP1;TACC3;PTGS2
5	regulation of epithelial cell proliferation (GO:0050678)	0.0020561863499423015	0.019198273144554592	CDH3;ERBB2;FGFR3
5	single organism cell adhesion (GO:0098602)	0.0020789573859744948	0.019198273144554592	CDH3;JUP;CDH24
5	response to oxygen levels (GO:0070482)	0.0020789573859744948	0.019198273144554592	FABP1;TACC3;PTGS2
5	regulation of translation (GO:0006417)	0.002195182163156956	0.019783087446281968	GRB7;ERBB2;GAPDH
5	neurotrophin TRK receptor signaling pathway (GO:0048011)	0.0024396359602979435	0.020503906722504066	ERBB2;FGFR4;FGFR3
5	nervous system development (GO:0007399)	0.0025161381300716525	0.02066729770308194	JUP;APOB;EPHB2
5	neurotrophin signaling pathway (GO:0038179)	0.002541967097170506	0.02066729770308194	ERBB2;FGFR4;FGFR3
5	response to oxidative stress (GO:0006979)	0.00286486949283676	0.02255795014919221	FABP1;PTGS2;PTGS1
5	Fc-epsilon receptor signaling pathway (GO:0038095)	0.0030065630094240894	0.023184630217002258	ERBB2;FGFR4;FGFR3
5	negative regulation of proteolysis (GO:0045861)	0.003212119256707478	0.024026652040171938	C4B;FABP1;GPI
5	negative regulation of protein processing (GO:0010955)	0.0036488140519614744	0.02503956798960718	C4B;FABP1;GPI
5	negative regulation of protein maturation (GO:1903318)	0.0036488140519614744	0.02503956798960718	C4B;FABP1;GPI
5	response to light stimulus (GO:0009416)	0.0038465889022610495	0.02570287226249979	GPC1;PTGS2;APOB
5	Fc receptor signaling pathway (GO:0038093)	0.004933848877555198	0.030235384275764943	ERBB2;FGFR4;FGFR3
5	regulation of endopeptidase activity (GO:0052548)	0.005012282954805953	0.030235384275764943	C4B;FABP1;GPI
5	negative regulation of hydrolase activity (GO:0051346)	0.005012282954805953	0.030235384275764943	C4B;FABP1;GPI
5	single-organism behavior (GO:0044708)	0.005333607030614851	0.03092665161937913	GPI;PTGS2;EPHB2
5	neuron projection guidance (GO:0097485)	0.005540643203282556	0.031160910647032723	GPC1;ERBB2;EPHB2
5	axon guidance (GO:0007411)	0.005540643203282556	0.031160910647032723	GPC1;ERBB2;EPHB2
5	regulation of peptidase activity (GO:0052547)	0.005752494574537764	0.03177601055225785	C4B;FABP1;GPI
5	generation of precursor metabolites and energy (GO:0006091)	0.005881930009510173	0.03188176555879427	GPI;ENO1;GAPDH
5	inflammatory response (GO:0006954)	0.005925464102700178	0.031886670135393765	C4B;PTGS2;PTGS1
5	regulation of protein transport (GO:0051223)	0.006057236705553873	0.03236295039824497	JUP;TACC3;PTGS2
5	regulation of intracellular transport (GO:0032386)	0.0067426392253870215	0.03502426486520481	JUP;TACC3;PTGS2
5	positive regulation of MAPK cascade (GO:0043410)	0.006789917433024734	0.035026608551051726	ERBB2;FGFR4;FGFR3
5	cellular component morphogenesis (GO:0032989)	0.00895831548879373	0.03831102440883968	JUP;EPHB2;FGFR3
5	posttranscriptional regulation of gene expression (GO:0010608)	0.009014358684432866	0.03831102440883968	GRB7;ERBB2;GAPDH
5	regulation of establishment of protein localization (GO:0070201)	0.009240614805105705	0.03883134760797229	JUP;TACC3;PTGS2
5	response to radiation (GO:0009314)	0.009240614805105705	0.03883134760797229	GPC1;PTGS2;APOB
5	immune response-regulating cell surface receptor signaling pathway (GO:0002768)	0.009354995370616875	0.03903097009301049	ERBB2;FGFR4;FGFR3
5	cellular response to hormone stimulus (GO:0032870)	0.010422244165838453	0.04060332622941231	APOB;FGFR4;FGFR3
5	hemostasis (GO:0007599)	0.011428596751227172	0.04253030034785037	GPI;GRB7;APOB
5	behavior (GO:0007610)	0.012489883742787321	0.0437496093790254	GPI;PTGS2;EPHB2
5	Fat digestion and absorption Homo sapiens hsa04975	8.896823842210735E-6	5.338094305326441E-4	FABP1;MTTP;APOB
5	Glycolysis / Gluconeogenesis Homo sapiens hsa00010	3.932461310986922E-5	0.0011797383932960767	GPI;ENO1;GAPDH
5	HIF-1 signaling pathway Homo sapiens hsa04066	1.4188183374609618E-4	0.002799694689130327	ERBB2;ENO1;GAPDH
5	Carbon metabolism Homo sapiens hsa01200	1.8664631260868848E-4	0.002799694689130327	GPI;ENO1;GAPDH
5	Pathways in cancer Homo sapiens hsa05200	5.758057490154307E-4	0.006909668988185168	JUP;ERBB2;PTGS2;FGFR3
5	Endocytosis Homo sapiens hsa04144	0.0020789573859744948	0.012473744315846969	FGFR4;FGFR3;DNM1
5	MicroRNAs in cancer Homo sapiens hsa05206	0.003064433925941554	0.01532216962970777	ERBB2;PTGS2;FGFR3
5	Metabolic pathways Homo sapiens hsa01100	0.006416596033741906	0.027499697287465312	GPI;ENO1;PTGS2;GAPDH;PTGS1
5	Adherens junctions interactions Homo sapiens R-HSA-418990	3.775486561735298E-6	2.622943803142085E-4	CDH3;JUP;CDH24
5	Gluconeogenesis Homo sapiens R-HSA-70263	4.163402862130293E-6	2.622943803142085E-4	GPI;ENO1;GAPDH
5	Glycolysis Homo sapiens R-HSA-70171	4.163402862130293E-6	2.622943803142085E-4	GPI;ENO1;GAPDH
5	Axon guidance Homo sapiens R-HSA-422475	8.070210465669256E-6	3.584489895211002E-4	GPC1;ERBB2;EPHB2;FGFR4;FGFR3;DNM1
5	Cell-cell junction organization Homo sapiens R-HSA-421270	2.965691309905068E-5	8.007366536743683E-4	CDH3;JUP;CDH24
5	Constitutive Signaling by Aberrant PI3K in Cancer Homo sapiens R-HSA-2219530	2.965691309905068E-5	8.007366536743683E-4	ERBB2;FGFR4;FGFR3
5	Metabolism Homo sapiens R-HSA-1430728	4.0630021687749465E-5	9.598842623730811E-4	FABP1;GPI;GPC1;MTTP;ENO1;PTGS2;APOB;GAPDH;PTGS1
5	Lipid digestion, mobilization, and transport Homo sapiens R-HSA-73923	4.679837745971946E-5	9.827659266541087E-4	FABP1;MTTP;APOB
5	Glucose metabolism Homo sapiens R-HSA-70326	6.442041756915408E-5	0.001099696934546304	GPI;ENO1;GAPDH
5	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Homo sapiens R-HSA-6811558	7.465878858569353E-5	0.001099696934546304	ERBB2;FGFR4;FGFR3
5	Cell junction organization Homo sapiens R-HSA-446728	8.299850468693465E-5	0.001099696934546304	CDH3;JUP;CDH24
5	PI3K/AKT Signaling in Cancer Homo sapiens R-HSA-2219528	8.299850468693465E-5	0.001099696934546304	ERBB2;FGFR4;FGFR3
5	Developmental Biology Homo sapiens R-HSA-1266738	8.72775344878019E-5	0.001099696934546304	GPC1;ERBB2;EPHB2;FGFR4;FGFR3;DNM1
5	Negative regulation of the PI3K/AKT network Homo sapiens R-HSA-199418	9.503457079054536E-5	0.001122595867463317	ERBB2;FGFR4;FGFR3
5	Metabolism of carbohydrates Homo sapiens R-HSA-71387	1.56870264629672E-4	0.001647137778611556	GPI;GPC1;ENO1;GAPDH
5	PI-3K cascade:FGFR1 Homo sapiens R-HSA-5654689	2.340104012489108E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	PI-3K cascade:FGFR3 Homo sapiens R-HSA-5654710	2.340104012489108E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	PI3K events in ERBB4 signaling Homo sapiens R-HSA-1250342	2.340104012489108E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	PIP3 activates AKT signaling Homo sapiens R-HSA-1257604	2.340104012489108E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	PI-3K cascade:FGFR4 Homo sapiens R-HSA-5654720	2.340104012489108E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	PI-3K cascade:FGFR2 Homo sapiens R-HSA-5654695	2.340104012489108E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	GAB1 signalosome Homo sapiens R-HSA-180292	2.513709619528748E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	PI3K/AKT activation Homo sapiens R-HSA-198203	2.513709619528748E-4	0.0017813039625775443	ERBB2;FGFR4;FGFR3
5	VEGFA-VEGFR2 Pathway Homo sapiens R-HSA-4420097	2.544719946539349E-4	0.0017813039625775443	JUP;ERBB2;FGFR4;FGFR3
5	Signaling by SCF-KIT Homo sapiens R-HSA-1433557	2.6996237913954225E-4	0.0018178681370232756	GRB7;ERBB2;FGFR4;FGFR3
5	Signaling by VEGF Homo sapiens R-HSA-194138	2.795767886938573E-4	0.0018178681370232756	JUP;ERBB2;FGFR4;FGFR3
5	Cell-Cell communication Homo sapiens R-HSA-1500931	2.8855049794020246E-4	0.0018178681370232756	CDH3;JUP;CDH24
5	Downstream signal transduction Homo sapiens R-HSA-186763	3.2411329031939256E-4	0.001976045544205329	GRB7;ERBB2;FGFR4;FGFR3
5	Metabolism of lipids and lipoproteins Homo sapiens R-HSA-556833	3.929038056401208E-4	0.0023074243105139875	FABP1;MTTP;PTGS2;APOB;PTGS1
5	Metabolism of vitamins and cofactors Homo sapiens R-HSA-196854	4.1270883760580635E-4	0.0023074243105139875	GPC1;PTGS2;APOB
5	Signaling by PDGF Homo sapiens R-HSA-186797	4.150922040078073E-4	0.0023074243105139875	GRB7;ERBB2;FGFR4;FGFR3
5	NGF signalling via TRKA from the plasma membrane Homo sapiens R-HSA-187037	4.598576382487965E-4	0.0024832312465435016	ERBB2;FGFR4;FGFR3;DNM1
5	Role of LAT2/NTAL/LAB on calcium mobilization Homo sapiens R-HSA-2730905	5.373999824485817E-4	0.002745097207642755	ERBB2;FGFR4;FGFR3
5	Downstream signaling events of B Cell Receptor (BCR) Homo sapiens R-HSA-1168372	8.802817869493325E-4	0.00424225896525307	ERBB2;FGFR4;FGFR3
5	Signalling by NGF Homo sapiens R-HSA-166520	9.202783998697137E-4	0.00424225896525307	ERBB2;FGFR4;FGFR3;DNM1
5	Innate Immune System Homo sapiens R-HSA-168249	9.875255577720121E-4	0.0044438650099740545	C4B;ERBB2;FGFR4;FGFR3;DNM1
5	Signaling by the B Cell Receptor (BCR) Homo sapiens R-HSA-983705	0.0015368910135307476	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	GRB2 events in EGFR signaling Homo sapiens R-HSA-179812	0.001574974026413352	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	SHC1 events in EGFR signaling Homo sapiens R-HSA-180336	0.001574974026413352	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	SOS-mediated signalling Homo sapiens R-HSA-112412	0.001574974026413352	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	SHC1 events in ERBB4 signaling Homo sapiens R-HSA-1250347	0.001574974026413352	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	RAF/MAP kinase cascade Homo sapiens R-HSA-5673001	0.001574974026413352	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	FRS-mediated FGFR2 signaling Homo sapiens R-HSA-5654700	0.0015942365614235127	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	FRS-mediated FGFR4 signaling Homo sapiens R-HSA-5654712	0.0015942365614235127	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	FRS-mediated FGFR3 signaling Homo sapiens R-HSA-5654706	0.0015942365614235127	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	FRS-mediated FGFR1 signaling Homo sapiens R-HSA-5654693	0.0015942365614235127	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	ARMS-mediated activation Homo sapiens R-HSA-170984	0.0016529134522188442	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Signalling to p38 via RIT and RIN Homo sapiens R-HSA-187706	0.0016529134522188442	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Frs2-mediated activation Homo sapiens R-HSA-170968	0.0016727702722147627	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Signal Transduction Homo sapiens R-HSA-162582	0.0016785072376585264	0.005219506530498929	GRB7;JUP;GPC1;ERBB2;APOB;FGFR4;FGFR3;DNM1
5	MAPK1/MAPK3 signaling Homo sapiens R-HSA-5684996	0.0016927767302854124	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Prolonged ERK activation events Homo sapiens R-HSA-169893	0.0017129332509558362	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Signaling by Leptin Homo sapiens R-HSA-2586552	0.0017332402561751263	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Interleukin receptor SHC signaling Homo sapiens R-HSA-912526	0.001774307403611571	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	Signalling to RAS Homo sapiens R-HSA-167044	0.0017950683835049228	0.005219506530498929	ERBB2;FGFR4;FGFR3
5	VEGFR2 mediated cell proliferation Homo sapiens R-HSA-5218921	0.001837047238600423	0.005260635274173938	ERBB2;FGFR4;FGFR3
5	Interleukin-2 signaling Homo sapiens R-HSA-451927	0.0019228441068388843	0.005405063347983406	ERBB2;FGFR4;FGFR3
5	Signalling to ERKs Homo sapiens R-HSA-187687	0.0019446788765231304	0.005405063347983406	ERBB2;FGFR4;FGFR3
5	Interleukin-3, 5 and GM-CSF signaling Homo sapiens R-HSA-512988	0.0021249721918369076	0.005820576003727182	ERBB2;FGFR4;FGFR3
5	NCAM signaling for neurite out-growth Homo sapiens R-HSA-375165	0.0022427852305828082	0.006055520122573582	ERBB2;FGFR4;FGFR3
5	IRS-mediated signalling Homo sapiens R-HSA-112399	0.0027004133931725145	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	MAPK family signaling cascades Homo sapiens R-HSA-5683057	0.0027004133931725145	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	Insulin receptor signalling cascade Homo sapiens R-HSA-74751	0.002781885334776576	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	IGF1R signaling cascade Homo sapiens R-HSA-2428924	0.002809378219211148	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Homo sapiens R-HSA-2404192	0.002809378219211148	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	IRS-related events triggered by IGF1R Homo sapiens R-HSA-2428928	0.002809378219211148	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	Diseases of signal transduction Homo sapiens R-HSA-5663202	0.002809378219211148	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	FCERI mediated MAPK activation Homo sapiens R-HSA-2871796	0.002837039486201781	0.0067873476315460325	ERBB2;FGFR4;FGFR3
5	Signaling by Insulin receptor Homo sapiens R-HSA-74752	0.0034888959436988284	0.008242516666988482	ERBB2;FGFR4;FGFR3
5	Downstream signaling of activated FGFR2 Homo sapiens R-HSA-5654696	0.00408551033061979	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Downstream signaling of activated FGFR4 Homo sapiens R-HSA-5654716	0.00408551033061979	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Downstream signaling of activated FGFR3 Homo sapiens R-HSA-5654708	0.00408551033061979	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Signaling by ERBB4 Homo sapiens R-HSA-1236394	0.004120367234632701	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Signaling by FGFR4 Homo sapiens R-HSA-5654743	0.004190628047431229	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Downstream signaling of activated FGFR1 Homo sapiens R-HSA-5654687	0.004190628047431229	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Signaling by FGFR3 Homo sapiens R-HSA-5654741	0.0042260325595866385	0.008874668375131942	ERBB2;FGFR4;FGFR3
5	Signaling by FGFR1 Homo sapiens R-HSA-5654736	0.0043333461141719645	0.009000026544818697	ERBB2;FGFR4;FGFR3
5	DAP12 signaling Homo sapiens R-HSA-2424491	0.0046276343521876795	0.009404547231865283	ERBB2;FGFR4;FGFR3
5	Signaling by EGFR Homo sapiens R-HSA-177929	0.005051783584300124	0.010050390499291824	ERBB2;FGFR4;FGFR3
5	DAP12 interactions Homo sapiens R-HSA-2172127	0.005211683062941041	0.010168596909064808	ERBB2;FGFR4;FGFR3
5	Disease Homo sapiens R-HSA-1643685	0.005218803704652309	0.010168596909064808	GPC1;ERBB2;FGFR4;FGFR3
5	Signaling by FGFR2 Homo sapiens R-HSA-5654738	0.005292774758270837	0.010207494176665185	ERBB2;FGFR4;FGFR3
5	Signaling by FGFR Homo sapiens R-HSA-190236	0.0054988517880183016	0.010497807958944031	ERBB2;FGFR4;FGFR3
5	Adaptive Immune System Homo sapiens R-HSA-1280218	0.0062205520625708615	0.011304657113710507	ERBB2;FGFR4;FGFR3;DNM1
5	Signaling by Interleukins Homo sapiens R-HSA-449147	0.00664868009558327	0.011967624172049886	ERBB2;FGFR4;FGFR3
5	Fc epsilon receptor (FCERI) signaling Homo sapiens R-HSA-2454202	0.006789917433024734	0.01210655089473278	ERBB2;FGFR4;FGFR3
5	Gastrin-CREB signalling pathway via PKC and MAPK Homo sapiens R-HSA-881907	0.008681215412647344	0.01505274966046191	ERBB2;FGFR4;FGFR3
5	Immune System Homo sapiens R-HSA-168256	0.015988899962636114	0.023067954907925386	C4B;ERBB2;FGFR4;FGFR3;DNM1
5	Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215	0.022819311474816664	0.029540067594111985	ERBB2;FGFR4;FGFR3
5	Signaling by GPCR Homo sapiens R-HSA-372790	0.13556373711353906	0.14000844980578625	ERBB2;FGFR4;FGFR3
6	DNA replication-independent nucleosome organization (GO:0034724)	4.2040620583371935E-12	7.315067981506717E-10	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B
6	DNA replication-independent nucleosome assembly (GO:0006336)	4.2040620583371935E-12	7.315067981506717E-10	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B
6	CENP-A containing nucleosome assembly (GO:0034080)	3.9724565776745696E-11	4.608049630102501E-9	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5
6	chromatin remodeling at centromere (GO:0031055)	6.938868793643878E-11	6.036815850470174E-9	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5
6	chromatin assembly or disassembly (GO:0006333)	2.8014146825970077E-10	1.541524030585466E-8	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B
6	histone exchange (GO:0043486)	2.847237859391667E-10	1.541524030585466E-8	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5
6	nucleosome assembly (GO:0006334)	3.100766728189156E-10	1.541524030585466E-8	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B;MCM2
6	protein-DNA complex assembly (GO:0065004)	1.060235577894776E-9	4.612024763842275E-8	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B;MCM2
6	nucleosome organization (GO:0034728)	1.7145371604620082E-9	6.629543687119765E-8	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B;MCM2
6	protein-DNA complex subunit organization (GO:0071824)	4.637042173576687E-9	1.613690676404687E-7	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5;ASF1B;MCM2
6	ATP-dependent chromatin remodeling (GO:0043044)	7.519577539133215E-9	2.378920894198508E-7	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5
6	chromatin modification (GO:0016568)	8.253519978330232E-7	2.3935207937157673E-5	CENPW;CENPH;UHRF1;CENPI;CBX2;CENPK;HJURP;OIP5;ASF1B;PHF19
6	chromatin remodeling (GO:0006338)	1.053493080002432E-6	2.8201199372372798E-5	CENPW;CENPH;CENPI;CENPK;HJURP;OIP5
6	mitotic cell cycle (GO:0000278)	1.7986303019272052E-5	4.4708810362190527E-4	ERCC6L;CENPW;CENPH;CENPI;CENPK;CENPM;MCM6;MCM2
6	chromosome organization (GO:0051276)	0.02044268945320505	0.2547805986874829	CENPW;CENPH;CENPI
6	regulation of binding (GO:0051098)	0.024286838985908953	0.2547805986874829	HJURP;RARA;TRIB3
6	mitotic nuclear division (GO:0007067)	0.031065358385378723	0.2547805986874829	ERCC6L;CENPW;OIP5
6	nuclear division (GO:0000280)	0.053178748962657015	0.2762120095373827	ERCC6L;CENPW;OIP5
6	organelle fission (GO:0048285)	0.06548302234981587	0.2963411675561559	ERCC6L;CENPW;OIP5
6	DNA repair (GO:0006281)	0.107460772739999	0.3267765106070514	NEIL3;UHRF1;UBE2T
6	cellular response to hormone stimulus (GO:0032870)	0.1446349661057718	0.37774845856257355	NR5A2;RARA;TRIB3
6	Deposition of new CENPA-containing nucleosomes at the centromere Homo sapiens R-HSA-606279	1.2629638517514153E-10	7.072597569807926E-9	CENPW;CENPH;CENPI;CENPK;HJURP;CENPM;OIP5
6	Nucleosome assembly Homo sapiens R-HSA-774815	1.2629638517514153E-10	7.072597569807926E-9	CENPW;CENPH;CENPI;CENPK;HJURP;CENPM;OIP5
6	Chromosome Maintenance Homo sapiens R-HSA-73886	4.708512519024951E-9	1.7578446737693152E-7	CENPW;CENPH;CENPI;CENPK;HJURP;CENPM;OIP5
6	Cell Cycle Homo sapiens R-HSA-1640170	3.970751438085211E-6	1.111810402663859E-4	ERCC6L;CENPW;CENPH;CENPI;CENPK;HJURP;CENPM;OIP5;MCM6;MCM2
6	Resolution of Sister Chromatid Cohesion Homo sapiens R-HSA-2500257	9.16420245139553E-6	2.0527813491125985E-4	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Mitotic Prometaphase Homo sapiens R-HSA-68877	1.3387384868724032E-5	2.498978508828486E-4	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	RHO GTPases Activate Formins Homo sapiens R-HSA-5663220	1.8208899364448446E-5	2.9134238983117514E-4	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Separation of Sister Chromatids Homo sapiens R-HSA-2467813	9.7676967432523E-5	0.001367477544055322	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Mitotic Anaphase Homo sapiens R-HSA-68882	1.3300178754737025E-4	0.0015303806502591974	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Mitotic Metaphase and Anaphase Homo sapiens R-HSA-2555396	1.3664112948742836E-4	0.0015303806502591974	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	3.2702292495008603E-4	0.003329687963128149	ERCC6L;CENPH;CENPI;CENPK;CENPM;MCM6;MCM2
6	RHO GTPase Effectors Homo sapiens R-HSA-195258	7.900207207554927E-4	0.006806332363431937	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	M Phase Homo sapiens R-HSA-68886	9.869040413080417E-4	0.007895232330464333	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Signaling by Rho GTPases Homo sapiens R-HSA-194315	0.0038797971760352015	0.025561016689173092	ERCC6L;CENPH;CENPI;CENPK;CENPM
6	Generic Transcription Pathway Homo sapiens R-HSA-212436	0.4095350947952072	0.6647526176385973	NR5A2;IGFBP3;RARA
6	Gene Expression Homo sapiens R-HSA-74160	0.5010969943442228	0.7192291465659653	NR5A2;UHRF1;IGFBP3;RARA;PHF19
6	Signal Transduction Homo sapiens R-HSA-162582	0.5643431586018053	0.7192291465659653	ERCC6L;CENPH;CENPI;CENPK;RARA;CENPM;TRIB3
7	regulation of cell division (GO:0051302)	6.914326268184076E-12	2.461500151473531E-9	ASPM;UBE2C;PDE3A;KIF23;NEK2;AURKB;DLGAP5;AURKA
7	regulation of cell cycle process (GO:0010564)	5.1192904711849504E-11	9.112337038709211E-9	TOP2A;TPX2;UBE2C;PDE3A;KIF23;NEK2;AURKB;DLGAP5;AURKA
7	mitotic cell cycle (GO:0000278)	5.363383778966728E-10	5.129288909352238E-8	TOP2A;RRM2;PTTG1;UBE2C;KIF23;NEK2;AURKB;AURKA
7	mitotic nuclear division (GO:0007067)	5.763245965564312E-10	5.129288909352238E-8	ASPM;TPX2;PTTG1;NEK2;FAM83D;AURKB;AURKA
7	nuclear division (GO:0000280)	2.6007499364072385E-9	1.851733954721954E-7	ASPM;TPX2;PTTG1;NEK2;FAM83D;AURKB;AURKA
7	organelle fission (GO:0048285)	4.744163311998801E-9	2.8148702317859554E-7	ASPM;TPX2;PTTG1;NEK2;FAM83D;AURKB;AURKA
7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031145)	6.09405957169532E-9	3.099264582176477E-7	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	regulation of mitotic cell cycle (GO:0007346)	1.6994359573058137E-8	7.562490010010871E-7	TOP2A;TPX2;UBE2C;NEK2;AURKB;DLGAP5;AURKA
7	positive regulation of cell division (GO:0051781)	4.1762472319220094E-8	1.6519377939602616E-6	UBE2C;KIF23;AURKB;DLGAP5;AURKA
7	regulation of nuclear division (GO:0051783)	8.417626946895142E-8	2.996675193094671E-6	UBE2C;PDE3A;NEK2;DLGAP5;AURKA
7	regulation of spindle organization (GO:0090224)	1.1167396036693565E-7	3.6141754446026452E-6	TPX2;AURKB;AURKA
7	regulation of chromosome segregation (GO:0051983)	2.0625913934635648E-7	6.119021133941909E-6	UBE2C;NEK2;AURKB;DLGAP5
7	proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	6.031528676881893E-7	1.6517109299768876E-5	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	proteasomal protein catabolic process (GO:0010498)	7.120631649642928E-7	1.810674905194916E-5	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	positive regulation of cell cycle process (GO:0090068)	8.549892428772983E-7	2.0291744697621212E-5	UBE2C;KIF23;AURKB;DLGAP5;AURKA
7	regulation of microtubule cytoskeleton organization (GO:0070507)	1.331899620230903E-6	2.9634766550137592E-5	TPX2;NEK2;AURKB;AURKA
7	regulation of mitosis (GO:0007088)	2.096449705587833E-6	4.3902123246427564E-5	UBE2C;NEK2;DLGAP5;AURKA
7	protein catabolic process (GO:0030163)	2.2989907640461356E-6	4.546892844446802E-5	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	positive regulation of cell cycle (GO:0045787)	2.7012135878261327E-6	5.0612212487689644E-5	UBE2C;KIF23;AURKB;DLGAP5;AURKA
7	regulation of microtubule-based process (GO:0032886)	3.1468863895468516E-6	5.601457773393396E-5	TPX2;NEK2;AURKB;AURKA
7	positive regulation of mitosis (GO:0045840)	5.736541405782683E-6	9.724803525993501E-5	UBE2C;DLGAP5;AURKA
7	ubiquitin-dependent protein catabolic process (GO:0006511)	8.892574317975939E-6	1.438980207817925E-4	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	modification-dependent protein catabolic process (GO:0019941)	1.0039759235721567E-5	1.5539801251812513E-4	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	modification-dependent macromolecule catabolic process (GO:0043632)	1.0585431386697746E-5	1.5701723223601657E-4	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	positive regulation of nuclear division (GO:0051785)	1.3020489206058386E-5	1.854117662942714E-4	UBE2C;DLGAP5;AURKA
7	proteolysis involved in cellular protein catabolic process (GO:0051603)	1.4190719563269293E-5	1.9430369863553338E-4	PTTG1;UBE2C;UBE2S;AURKB;AURKA
7	negative regulation of cell division (GO:0051782)	2.2580052737559447E-5	2.97722176835969E-4	ASPM;UBE2C;AURKB
7	microtubule-based process (GO:0007017)	2.424367045129092E-5	2.9946167380132463E-4	KIF23;NEK2;AURKB;DLGAP5;AURKA
7	negative regulation of organelle organization (GO:0010639)	4.052711965490471E-5	4.8092181990486924E-4	UBE2C;NEK2;AURKB;AURKA
7	regulation of mitotic cell cycle phase transition (GO:1901990)	5.06861610043424E-5	5.797040776642031E-4	TOP2A;UBE2C;AURKB;DLGAP5
7	negative regulation of cell cycle process (GO:0010948)	5.3085049816445224E-5	5.797040776642031E-4	TOP2A;UBE2C;AURKB;AURKA
7	cellular protein complex assembly (GO:0043623)	5.472983620861784E-5	5.797040776642031E-4	UBE2C;UBE2S;KIF23;AURKB
7	chromosome segregation (GO:0007059)	5.536499618141265E-5	5.797040776642031E-4	TOP2A;PTTG1;NEK2
7	regulation of cell cycle phase transition (GO:1901987)	6.168437888351942E-5	6.274182537866547E-4	TOP2A;UBE2C;AURKB;DLGAP5
7	negative regulation of binding (GO:0051100)	6.726813167588696E-5	6.652070799059933E-4	NEK2;AURKB;AURKA
7	negative regulation of cytoskeleton organization (GO:0051494)	8.073522203341371E-5	7.768037579431157E-4	NEK2;AURKB;AURKA
7	positive regulation of mitotic cell cycle (GO:0045931)	8.558724851199656E-5	7.812579607761737E-4	UBE2C;DLGAP5;AURKA
7	mitotic cell cycle checkpoint (GO:0007093)	8.558724851199656E-5	7.812579607761737E-4	TOP2A;UBE2C;AURKB
7	regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	1.218275680350221E-4	0.0010842653555116967	UBE2C;DLGAP5;AURKA
7	positive regulation of multi-organism process (GO:0043902)	1.4492333034616422E-4	0.0012583586732496212	TOP2A;PDE3A;AURKA
7	regulation of cytoskeleton organization (GO:0051493)	1.8320406546224816E-4	0.0014366096722117471	TPX2;NEK2;AURKB;AURKA
7	regulation of proteasomal protein catabolic process (GO:0061136)	1.9082727339368242E-4	0.001445415092088318	UBE2C;DLGAP5;AURKA
7	regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	2.5021651330965595E-4	0.0017815415747647503	UBE2C;DLGAP5;AURKA
7	regulation of cellular protein catabolic process (GO:1903362)	2.866359332066321E-4	0.001962048510939006	UBE2C;DLGAP5;AURKA
7	cell cycle checkpoint (GO:0000075)	2.921027277521554E-4	0.001962048510939006	TOP2A;UBE2C;AURKB
7	protein autophosphorylation (GO:0046777)	3.758449505672523E-4	0.0023473824982796813	NEK2;AURKB;AURKA
7	negative regulation of cell cycle (GO:0045786)	4.015351914899215E-4	0.0024645953132829664	TOP2A;UBE2C;AURKB;AURKA
7	negative regulation of mitotic cell cycle phase transition (GO:1901991)	5.363288156403564E-4	0.0031771661265864635	TOP2A;UBE2C;AURKB
7	negative regulation of cellular component organization (GO:0051129)	5.801005568205622E-4	0.0031771661265864635	UBE2C;NEK2;AURKB;AURKA
7	negative regulation of cell cycle phase transition (GO:1901988)	6.040394207294829E-4	0.0032581520269650897	TOP2A;UBE2C;AURKB
7	chromosome organization (GO:0051276)	6.39855063874516E-4	0.0033498294520489364	TOP2A;PTTG1;NEK2
7	regulation of binding (GO:0051098)	7.758512070395703E-4	0.0038873893667592664	NEK2;AURKB;AURKA
7	negative regulation of mitotic cell cycle (GO:0045930)	7.862135797940089E-4	0.0038873893667592664	TOP2A;UBE2C;AURKB
7	microtubule cytoskeleton organization (GO:0000226)	0.0010874447654406513	0.004925614940437545	NEK2;AURKB;AURKA
7	regulation of protein catabolic process (GO:0042176)	0.0012903675207351448	0.005742135467271395	UBE2C;DLGAP5;AURKA
7	mitotic cell cycle phase transition (GO:0044772)	0.0015476078248931493	0.006406376577464665	RRM2;NEK2;AURKA
7	cell cycle phase transition (GO:0044770)	0.0015961049890547952	0.006456970182994399	RRM2;NEK2;AURKA
7	regulation of multi-organism process (GO:0043900)	0.002056898128592405	0.008085209012270618	TOP2A;PDE3A;AURKA
7	positive regulation of organelle organization (GO:0010638)	0.002774274610783868	0.01020228626748803	UBE2C;DLGAP5;AURKA
7	positive regulation of cell development (GO:0010720)	0.0032095551107824186	0.011541430499379203	ASPM;PDE3A;AURKA
7	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	6.60840807264996E-13	5.551062781025967E-11	TOP2A;TPX2;RRM2;PTTG1;UBE2C;KIF23;NEK2;PHLDA1;AURKB;AURKA
7	Cell Cycle Homo sapiens R-HSA-1640170	4.954898434455427E-12	2.0810573424712796E-10	TOP2A;TPX2;RRM2;PTTG1;UBE2C;KIF23;NEK2;PHLDA1;AURKB;AURKA
7	APC/C-mediated degradation of cell cycle proteins Homo sapiens R-HSA-174143	7.315087322824842E-9	1.5361683377932168E-7	PTTG1;UBE2C;NEK2;AURKB;AURKA
7	Regulation of mitotic cell cycle Homo sapiens R-HSA-453276	7.315087322824842E-9	1.5361683377932168E-7	PTTG1;UBE2C;NEK2;AURKB;AURKA
7	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Homo sapiens R-HSA-174178	3.3504839751975475E-7	5.62881307833188E-6	PTTG1;UBE2C;AURKB;AURKA
7	SUMOylation of DNA replication proteins Homo sapiens R-HSA-4615885	6.611071131028793E-6	9.25549958344031E-5	TOP2A;AURKB;AURKA
7	G2/M Transition Homo sapiens R-HSA-69275	1.178508567055491E-5	1.2948251763121365E-4	TPX2;NEK2;PHLDA1;AURKA
7	Mitotic G2-G2/M phases Homo sapiens R-HSA-453274	1.2331668345829871E-5	1.2948251763121365E-4	TPX2;NEK2;PHLDA1;AURKA
7	AURKA Activation by TPX2 Homo sapiens R-HSA-8854518	2.9336526015324558E-5	2.5324346096159615E-4	TPX2;NEK2;AURKA
7	APC/C:Cdc20 mediated degradation of mitotic proteins Homo sapiens R-HSA-176409	3.18530392992831E-5	2.5324346096159615E-4	PTTG1;UBE2C;NEK2
7	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Homo sapiens R-HSA-176814	3.316283417354235E-5	2.5324346096159615E-4	PTTG1;UBE2C;NEK2
7	Regulation of TP53 Activity through Phosphorylation Homo sapiens R-HSA-6804756	5.536499618141265E-5	3.8755497326988853E-4	TPX2;AURKB;AURKA
7	M Phase Homo sapiens R-HSA-68886	6.539418860939972E-5	4.1640968947996923E-4	PTTG1;UBE2C;KIF23;AURKB
7	SUMO E3 ligases SUMOylate target proteins Homo sapiens R-HSA-3108232	6.94016149133282E-5	4.1640968947996923E-4	TOP2A;AURKB;AURKA
7	SUMOylation Homo sapiens R-HSA-2990846	8.073522203341371E-5	4.5211724338711676E-4	TOP2A;AURKB;AURKA
7	Regulation of TP53 Activity Homo sapiens R-HSA-5633007	2.654324390270615E-4	0.0013115485222513629	TPX2;AURKB;AURKA
7	Separation of Sister Chromatids Homo sapiens R-HSA-2467813	3.263249711642773E-4	0.0015228498654332942	PTTG1;UBE2C;AURKB
7	Mitotic Anaphase Homo sapiens R-HSA-68882	3.9559413349089556E-4	0.001689756237349507	PTTG1;UBE2C;AURKB
7	Mitotic Metaphase and Anaphase Homo sapiens R-HSA-2555396	4.023229136546445E-4	0.001689756237349507	PTTG1;UBE2C;AURKB
7	Transcriptional Regulation by TP53 Homo sapiens R-HSA-3700989	0.0029628663927511625	0.010370032374629069	TPX2;AURKB;AURKA
7	Post-translational protein modification Homo sapiens R-HSA-597592	0.009103792822826808	0.029412253735286612	TOP2A;AURKB;AURKA
7	Adaptive Immune System Homo sapiens R-HSA-1280218	0.025137157024537303	0.05150051683075935	UBE2C;UBE2S;KIF23
7	Generic Transcription Pathway Homo sapiens R-HSA-212436	0.029635005932962456	0.05657592041747378	TPX2;AURKB;AURKA
7	Metabolism of proteins Homo sapiens R-HSA-392499	0.05980365214289477	0.09850013294123844	TOP2A;AURKB;AURKA
7	Immune System Homo sapiens R-HSA-168256	0.1395690544322114	0.16748286531865367	UBE2C;UBE2S;KIF23
7	Gene Expression Homo sapiens R-HSA-74160	0.1565417148762545	0.17769600067034294	TPX2;AURKB;AURKA
8	nuclear division (GO:0000280)	8.502737617770726E-11	1.8979638531736185E-8	CENPF;CCNF;NUF2;KIF2C;CDC6;MKI67;KIF20B;KIF15
8	organelle fission (GO:0048285)	1.694610583190731E-10	1.8979638531736185E-8	CENPF;CCNF;NUF2;KIF2C;CDC6;MKI67;KIF20B;KIF15
8	mitotic nuclear division (GO:0007067)	9.334802968416272E-10	6.969986216417484E-8	CENPF;CCNF;NUF2;KIF2C;CDC6;KIF20B;KIF15
8	microtubule-based process (GO:0007017)	1.7605239833872636E-9	9.858934306968676E-8	KIF18A;KIF18B;NUSAP1;KIF2C;KIF1A;KIF20B;CENPA;KIF15
8	microtubule-based movement (GO:0007018)	1.0424224529055978E-8	4.6700525890170776E-7	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	chromosome segregation (GO:0007059)	1.2746588102591177E-8	4.758726224967373E-7	CENPF;KIF18B;NUF2;NUSAP1;KIF2C
8	microtubule depolymerization (GO:0007019)	3.4176008683086065E-8	9.581581029666419E-7	KIF18A;KIF18B;KIF2C
8	mitotic cell cycle (GO:0000278)	3.421993224880864E-8	9.581581029666419E-7	CENPF;KIF18A;KIF18B;NUF2;KIF2C;CDC6;CENPA
8	microtubule polymerization or depolymerization (GO:0031109)	2.2140163717738839E-7	5.292773974279095E-6	KIF18A;KIF18B;KIF2C
8	ATP catabolic process (GO:0006200)	2.8701599136989765E-7	5.292773974279095E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	purine ribonucleoside monophosphate catabolic process (GO:0009169)	3.137781603119028E-7	5.292773974279095E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	ribonucleoside monophosphate catabolic process (GO:0009158)	3.137781603119028E-7	5.292773974279095E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	purine nucleoside monophosphate catabolic process (GO:0009128)	3.19369482376416E-7	5.292773974279095E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	nucleoside monophosphate catabolic process (GO:0009125)	3.3079837339244344E-7	5.292773974279095E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	ATP metabolic process (GO:0046034)	6.607561899194479E-7	9.67504123866639E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	protein depolymerization (GO:0051261)	6.910743741904565E-7	9.67504123866639E-6	KIF18A;KIF18B;KIF2C
8	purine ribonucleoside monophosphate metabolic process (GO:0009167)	9.611224430300576E-7	1.2135074520620533E-5	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	purine nucleoside monophosphate metabolic process (GO:0009126)	9.751399168355785E-7	1.2135074520620533E-5	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	ribonucleoside monophosphate metabolic process (GO:0009161)	1.1731767733314361E-6	1.3831136696117984E-5	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	nucleoside monophosphate metabolic process (GO:0009123)	1.3654836744909443E-6	1.5293417154298576E-5	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	regulation of cell division (GO:0051302)	1.5894333021968444E-6	1.6953955223433005E-5	CENPF;KIF18B;NUSAP1;CDC6;KIF20B
8	microtubule cytoskeleton organization (GO:0000226)	1.99174180588484E-6	2.0279552932645644E-5	KIF18A;KIF18B;NUSAP1;KIF2C;CENPA
8	regulation of mitosis (GO:0007088)	2.683818051275421E-6	2.6138054064595407E-5	CENPF;NUSAP1;CDC6;KIF20B
8	regulation of nuclear division (GO:0051783)	6.1592707170728686E-6	5.748652669268011E-5	CENPF;NUSAP1;CDC6;KIF20B
8	establishment of organelle localization (GO:0051656)	1.3407853734130344E-5	1.2013436945780789E-4	CENPF;KIF18A;NUSAP1;CENPA
8	regulation of chromosome segregation (GO:0051983)	2.3498426630815085E-5	2.0244798328086842E-4	CENPF;KIF2C;CDC6
8	chromosome organization (GO:0051276)	2.874950609744118E-5	2.3851442095654902E-4	CENPF;KIF18B;NUSAP1;CENPA
8	regulation of cell cycle process (GO:0010564)	5.2099978559123934E-5	4.024274205946125E-4	CENPF;CCNF;NUSAP1;CDC6;KIF20B
8	antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	7.550237601954301E-5	5.455655557541172E-4	KIF18A;KIF2C;KIF15
8	antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	7.794760240599194E-5	5.456332168419436E-4	KIF18A;KIF2C;KIF15
8	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504)	8.299237239090204E-5	5.633421641079412E-4	KIF18A;KIF2C;KIF15
8	cellular protein complex disassembly (GO:0043624)	1.347042039591539E-4	8.381594913014021E-4	KIF18A;KIF18B;KIF2C
8	protein complex disassembly (GO:0043241)	2.1325896706951106E-4	0.001194250215589262	KIF18A;KIF18B;KIF2C
8	macromolecular complex disassembly (GO:0032984)	2.6442978241047907E-4	0.0014102921728558883	KIF18A;KIF18B;KIF2C
8	regulation of mitotic cell cycle (GO:0007346)	3.542030366836138E-4	0.0018451507027239418	CENPF;NUSAP1;CDC6;KIF20B
8	antigen processing and presentation of exogenous peptide antigen (GO:0002478)	4.559518056764469E-4	0.0023212091925346387	KIF18A;KIF2C;KIF15
8	antigen processing and presentation of exogenous antigen (GO:0019884)	4.7170343137096436E-4	0.0023480348583799116	KIF18A;KIF2C;KIF15
8	antigen processing and presentation of peptide antigen (GO:0048002)	5.735958383276149E-4	0.0027931623431605595	KIF18A;KIF2C;KIF15
8	antigen processing and presentation (GO:0019882)	0.0010118670805575455	0.004625678082548779	KIF18A;KIF2C;KIF15
8	cellular component disassembly (GO:0022411)	0.003567010320688139	0.015365582919887367	KIF18A;KIF18B;KIF2C
8	negative regulation of cell cycle (GO:0045786)	0.006333525002660498	0.024413485185421052	CENPF;CCNF;KIF20B
8	coagulation (GO:0050817)	0.008185981489915315	0.028920597222190703	KIF18A;KIF2C;KIF15
8	blood coagulation (GO:0007596)	0.008185981489915315	0.028920597222190703	KIF18A;KIF2C;KIF15
8	hemostasis (GO:0007599)	0.008474161057902873	0.028920597222190703	KIF18A;KIF2C;KIF15
8	Kinesins Homo sapiens R-HSA-983189	1.4462546026552183E-12	8.67752761593131E-11	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	COPI-dependent Golgi-to-ER retrograde traffic Homo sapiens R-HSA-6811434	6.524133463087249E-11	1.9572400389261747E-9	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Golgi-to-ER retrograde transport Homo sapiens R-HSA-8856688	4.2419075405363095E-10	8.48381508107262E-9	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Factors involved in megakaryocyte development and platelet production Homo sapiens R-HSA-983231	1.9098432018049303E-9	2.8647648027073955E-8	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Intra-Golgi and retrograde Golgi-to-ER traffic Homo sapiens R-HSA-6811442	8.02268414998457E-9	9.627220979981482E-8	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Resolution of Sister Chromatid Cohesion Homo sapiens R-HSA-2500257	2.184525448373158E-8	2.184525448373158E-7	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Mitotic Prometaphase Homo sapiens R-HSA-68877	3.2329102164495576E-8	2.771065899813906E-7	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	RHO GTPases Activate Formins Homo sapiens R-HSA-5663220	4.447450017091974E-8	3.3355875128189807E-7	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Separation of Sister Chromatids Homo sapiens R-HSA-2467813	2.5785904316077154E-7	1.719060287738477E-6	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Mitotic Anaphase Homo sapiens R-HSA-68882	3.5741693094886665E-7	2.0061341028555016E-6	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Mitotic Metaphase and Anaphase Homo sapiens R-HSA-2555396	3.677912521901753E-7	2.0061341028555016E-6	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Membrane Trafficking Homo sapiens R-HSA-199991	1.2403490115129003E-6	6.2017450575645014E-6	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	2.156770478948215E-6	9.9543252874533E-6	CENPF;KIF18A;NUF2;KIF2C;CDC6;CENPA
8	RHO GTPase Effectors Homo sapiens R-HSA-195258	2.423476785333947E-6	1.038632908000263E-5	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	M Phase Homo sapiens R-HSA-68886	3.0914903888517906E-6	1.1636801127453313E-5	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Vesicle-mediated transport Homo sapiens R-HSA-5653656	3.1031469673208834E-6	1.1636801127453313E-5	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Hemostasis Homo sapiens R-HSA-109582	6.018129417294834E-6	2.1240456766922943E-5	KIF18A;KIF18B;KIF2C;KIF1A;KIF20B;KIF15
8	Cell Cycle Homo sapiens R-HSA-1640170	6.947591505874638E-6	2.315863835291546E-5	CENPF;KIF18A;NUF2;KIF2C;CDC6;CENPA
8	Signaling by Rho GTPases Homo sapiens R-HSA-194315	1.4247785019600996E-5	4.499300532505578E-5	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	MHC class II antigen presentation Homo sapiens R-HSA-2132295	1.0232080283081646E-4	3.0696240849244937E-4	KIF18A;KIF2C;KIF15
8	Adaptive Immune System Homo sapiens R-HSA-1280218	0.02932992911098343	0.05332714383815169	KIF18A;KIF2C;KIF15
8	Signal Transduction Homo sapiens R-HSA-162582	0.06138665879539698	0.08565580297032137	CENPF;KIF18A;NUF2;KIF2C;CENPA
8	Immune System Homo sapiens R-HSA-168256	0.15838311925021645	0.1638446061209136	KIF18A;KIF2C;KIF15
9	regulation of cell adhesion (GO:0030155)	0.0011859864650968933	0.058368661218048346	FZD7;RAC3;TGM2
9	Wnt signaling pathway Homo sapiens hsa04310	1.6569378005746647E-6	5.4678947418963934E-5	FZD2;BAMBI;FZD7;RAC3
9	Pathways in cancer Homo sapiens hsa05200	0.0019144492442412157	0.015794206264990028	FZD2;FZD7;RAC3
9	PCP/CE pathway Homo sapiens R-HSA-4086400	2.5214231178906645E-5	9.077123224406393E-4	FZD2;FZD7;RAC3
9	Beta-catenin independent WNT signaling Homo sapiens R-HSA-3858494	9.915512413058258E-5	0.0017847922343504866	FZD2;FZD7;RAC3
9	Signaling by Wnt Homo sapiens R-HSA-195721	8.141316031313405E-4	0.007327184428182065	FZD2;FZD7;RAC3
9	Signaling by Rho GTPases Homo sapiens R-HSA-194315	0.0015286720830225207	0.009172032498135124	DEPDC1B;RAC3;CYBA
9	Signal Transduction Homo sapiens R-HSA-162582	0.002760207064961412	0.012420931792326353	DEPDC1B;FZD2;BAMBI;FZD7;RAC3;CYBA
10	cell-substrate adhesion (GO:0031589)	1.1436258954687523E-8	9.263369753296894E-7	LAMA5;BCAM;ITGA7;ITGB8
10	integrin-mediated signaling pathway (GO:0007229)	7.103334166939071E-7	2.8768503376103238E-5	LAMA5;ITGA7;ITGB8
10	cell-matrix adhesion (GO:0007160)	1.2040164998000132E-6	3.250844549460036E-5	BCAM;ITGA7;ITGB8
10	extracellular matrix organization (GO:0030198)	5.583805533144255E-5	9.121087632308067E-4	LAMA5;ITGA7;ITGB8
10	extracellular structure organization (GO:0043062)	5.6303010075975725E-5	9.121087632308067E-4	LAMA5;ITGA7;ITGB8
10	Focal adhesion Homo sapiens hsa04510	5.0106975568788026E-8	6.513906823942444E-7	LAMA5;ITGA7;ITGB8;PARVB
10	ECM-receptor interaction Homo sapiens hsa04512	6.603053011041432E-7	4.291984457176931E-6	LAMA5;ITGA7;ITGB8
10	PI3K-Akt signaling pathway Homo sapiens hsa04151	4.789724876426953E-5	2.0755474464516797E-4	LAMA5;ITGA7;ITGB8
10	Extracellular matrix organization Homo sapiens R-HSA-1474244	2.744904570310974E-5	1.6469427421865845E-4	LAMA5;ITGA7;ITGB8
12	DNA replication (GO:0006260)	2.3641890331895023E-18	8.345587287158943E-16	POLQ;BLM;CDC45;DSCC1;POLD1;GINS4;CHEK1;DNA2;CHTF18;DTL;TICRR
12	DNA repair (GO:0006281)	1.6888467257675357E-16	2.9808144709797006E-14	RAD51AP1;POLQ;BLM;RAD51;EXO1;XRCC2;POLD1;CHEK1;DNA2;BRCA2;DTL;TICRR
12	DNA recombination (GO:0006310)	5.078756612303836E-12	5.976003613810848E-10	RAD51AP1;BLM;RAD51;EXO1;XRCC2;POLD1;DNA2;BRCA2
12	regulation of DNA metabolic process (GO:0051052)	5.694236378166689E-11	5.025163603732104E-9	RAD51AP1;BLM;RAD51;DSCC1;CHEK1;DNA2;BRCA2;TICRR
12	cell cycle checkpoint (GO:0000075)	7.144226845888761E-11	5.043824153197465E-9	BLM;CDC45;CCNE2;CHEK1;DNA2;DTL;TICRR
12	response to radiation (GO:0009314)	8.805053946045166E-11	5.180306738256572E-9	RAD51AP1;BLM;RAD51;XRCC2;POLD1;CHEK1;BRCA2;DTL;TICRR
12	DNA integrity checkpoint (GO:0031570)	1.3730964239094164E-10	6.9243291091432E-9	BLM;CDC45;CHEK1;DNA2;DTL;TICRR
12	response to ionizing radiation (GO:0010212)	1.4755746214006048E-9	6.510973016930168E-8	RAD51AP1;BLM;RAD51;XRCC2;BRCA2;TICRR
12	double-strand break repair via homologous recombination (GO:0000724)	2.5114338056356715E-9	9.637404950754935E-8	RAD51AP1;BLM;RAD51;XRCC2;BRCA2
12	recombinational repair (GO:0000725)	2.730143045539642E-9	9.637404950754935E-8	RAD51AP1;BLM;RAD51;XRCC2;BRCA2
12	DNA strand elongation involved in DNA replication (GO:0006271)	2.3383769242791375E-8	7.504064129732142E-7	CDC45;POLD1;GINS4;DNA2
12	DNA strand elongation (GO:0022616)	2.9885369042278254E-8	8.791279393270187E-7	CDC45;POLD1;GINS4;DNA2
12	mitotic cell cycle (GO:0000278)	5.324303418389014E-8	1.4457531589933245E-6	CDC45;CCNE2;XRCC2;POLD1;GINS4;PSMD3;DNA2
12	double-strand break repair (GO:0006302)	6.008465596989546E-8	1.5149916826695071E-6	RAD51AP1;BLM;RAD51;XRCC2;BRCA2
12	regulation of DNA replication (GO:0006275)	7.144296957776842E-8	1.6812912173968168E-6	BLM;DSCC1;DNA2;BRCA2;TICRR
12	DNA replication checkpoint (GO:0000076)	1.1934270071972324E-7	2.632998334628894E-6	CDC45;DNA2;TICRR
12	regulation of DNA recombination (GO:0000018)	1.5295495665855836E-7	3.176064688263006E-6	RAD51AP1;BLM;RAD51;CHEK1
12	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.0661417263692345E-7	4.051933496712999E-6	RAD51AP1;RAD51;CHEK1
12	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	5.87742599279441E-7	1.0919638818191718E-5	BLM;POLD1;BRCA2
12	regulation of mitotic cell cycle (GO:0007346)	1.17523205972296E-6	2.074284585411024E-5	BLM;POLD1;CHEK1;PSMD3;BRCA2;TICRR
12	DNA catabolic process, exonucleolytic (GO:0000738)	1.2717933141285084E-6	2.1378239994636354E-5	BLM;EXO1;DNA2
12	regulation of double-strand break repair (GO:2000779)	1.4526083270118207E-6	2.2294379975442292E-5	RAD51AP1;RAD51;CHEK1
12	response to X-ray (GO:0010165)	1.4526083270118207E-6	2.2294379975442292E-5	BLM;XRCC2;BRCA2
12	cellular response to alkaloid (GO:0071312)	3.212529455094768E-6	4.536091590593812E-5	BLM;RAD51;CHEK1
12	mitotic recombination (GO:0006312)	3.212529455094768E-6	4.536091590593812E-5	RAD51;POLD1;DNA2
12	response to UV (GO:0009411)	4.0282933833237015E-6	5.382016957573961E-5	POLD1;CHEK1;BRCA2;DTL
12	G2 DNA damage checkpoint (GO:0031572)	4.269021949350451E-6	5.382016957573961E-5	BLM;CHEK1;DTL
12	regulation of DNA-dependent DNA replication (GO:0090329)	4.269021949350451E-6	5.382016957573961E-5	BLM;BRCA2;TICRR
12	cellular response to radiation (GO:0071478)	5.409193637765766E-6	6.584294324590743E-5	RAD51AP1;BLM;RAD51;CHEK1
12	cellular response to ionizing radiation (GO:0071479)	1.0056706502888636E-5	1.1833391318398963E-4	RAD51AP1;BLM;RAD51
12	ATP catabolic process (GO:0006200)	1.0913928650707053E-5	1.2372252709199217E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	purine ribonucleoside monophosphate catabolic process (GO:0009169)	1.1745106762664561E-5	1.2372252709199217E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	ribonucleoside monophosphate catabolic process (GO:0009158)	1.1745106762664561E-5	1.2372252709199217E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	purine nucleoside monophosphate catabolic process (GO:0009128)	1.1917133583397819E-5	1.2372252709199217E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	nucleoside monophosphate catabolic process (GO:0009125)	1.2267106085608288E-5	1.2372252709199217E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	DNA biosynthetic process (GO:0071897)	1.748442782548463E-5	1.7144452839989096E-4	POLQ;POLD1;DTL
12	DNA duplex unwinding (GO:0032508)	1.848205796311634E-5	1.7632882326973156E-4	BLM;RAD51;DNA2
12	regulation of DNA repair (GO:0006282)	2.058840388329684E-5	1.8635145053343035E-4	RAD51AP1;RAD51;CHEK1
12	DNA geometric change (GO:0032392)	2.058840388329684E-5	1.8635145053343035E-4	BLM;RAD51;DNA2
12	ATP metabolic process (GO:0046034)	2.1674128932006943E-5	1.9127418782496127E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	telomere maintenance (GO:0000723)	2.653185030832442E-5	2.2843275997167122E-4	BLM;POLD1;DNA2
12	telomere organization (GO:0032200)	2.7841738818141377E-5	2.340031857810454E-4	BLM;POLD1;DNA2
12	meiotic nuclear division (GO:0007126)	2.919348937927407E-5	2.3410838949993956E-4	RAD51;XRCC2;BRCA2
12	purine ribonucleoside monophosphate metabolic process (GO:0009167)	2.949095457444476E-5	2.3410838949993956E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	purine nucleoside monophosphate metabolic process (GO:0009126)	2.9843845686961135E-5	2.3410838949993956E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	ribonucleoside monophosphate metabolic process (GO:0009161)	3.473814488294868E-5	2.6090564135491245E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	nucleoside monophosphate metabolic process (GO:0009123)	3.934890338375554E-5	2.893783936347022E-4	POLQ;BLM;RAD51;XRCC2;DNA2
12	negative regulation of mitotic cell cycle (GO:0045930)	4.7647184911630624E-5	3.432542096695022E-4	BLM;CHEK1;PSMD3;TICRR
12	DNA damage checkpoint (GO:0000077)	5.085723386971308E-5	3.5905207112017437E-4	BLM;CHEK1;DTL
12	nucleic acid phosphodiester bond hydrolysis (GO:0090305)	5.7659385677811226E-5	3.990933949856346E-4	BLM;EXO1;POLD1;DNA2
12	cellular response to abiotic stimulus (GO:0071214)	5.963292231051635E-5	4.0481579953100525E-4	RAD51AP1;BLM;RAD51;CHEK1
12	regulation of cell cycle process (GO:0010564)	6.931462267574252E-5	4.531122556395761E-4	BLM;CHEK1;PSMD3;BRCA2;TICRR
12	negative regulation of cell cycle process (GO:0010948)	8.474131041544852E-5	5.341729031545237E-4	BLM;CHEK1;PSMD3;TICRR
12	DNA conformation change (GO:0071103)	1.0761876633780606E-4	6.664811318815007E-4	BLM;RAD51;DNA2
12	DNA catabolic process (GO:0006308)	1.1759661871827767E-4	6.968546762757068E-4	BLM;EXO1;DNA2
12	mitotic cell cycle phase transition (GO:0044772)	1.1844555404119661E-4	6.968546762757068E-4	CDC45;CCNE2;CHEK1;PSMD3
12	cell cycle phase transition (GO:0044770)	1.2346619643657247E-4	7.144847105263948E-4	CDC45;CCNE2;CHEK1;PSMD3
12	response to alkaloid (GO:0043279)	1.5110201089851824E-4	8.603066104383377E-4	BLM;RAD51;CHEK1
12	nuclear division (GO:0000280)	1.5690421001740253E-4	8.79161684700684E-4	RAD51;XRCC2;BRCA2;CEP55
12	regulation of response to DNA damage stimulus (GO:2001020)	2.0961727220472853E-4	0.0011124061383535277	RAD51AP1;RAD51;CHEK1
12	response to light stimulus (GO:0009416)	2.1113657583480552E-4	0.0011124061383535277	POLD1;CHEK1;BRCA2;DTL
12	organelle fission (GO:0048285)	2.187573865312979E-4	0.0011356081977286494	RAD51;XRCC2;BRCA2;CEP55
12	cell cycle G1/S phase transition (GO:0044843)	3.81377856892256E-4	0.001844197034013238	CDC45;CCNE2;PSMD3
12	G1/S transition of mitotic cell cycle (GO:0000082)	3.81377856892256E-4	0.001844197034013238	CDC45;CCNE2;PSMD3
12	negative regulation of cell cycle (GO:0045786)	6.320370567796434E-4	0.0029356458032001854	BLM;CHEK1;PSMD3;TICRR
12	negative regulation of mitotic cell cycle phase transition (GO:1901991)	7.535424835157474E-4	0.003370738496812468	BLM;PSMD3;TICRR
12	negative regulation of cell cycle phase transition (GO:1901988)	8.481701801219675E-4	0.0036963465874451174	BLM;PSMD3;TICRR
12	chromosome organization (GO:0051276)	8.981935111747552E-4	0.0038666135298132754	BLM;POLD1;DNA2
12	anatomical structure homeostasis (GO:0060249)	9.500595868737623E-4	0.004040614869475157	BLM;POLD1;DNA2
12	regulation of cell division (GO:0051302)	0.0013339337721972287	0.005605697876019306	BLM;CHEK1;BRCA2
12	regulation of mitotic cell cycle phase transition (GO:1901990)	0.0016310137971720373	0.006694742679089875	BLM;PSMD3;TICRR
12	regulation of cell cycle phase transition (GO:1901987)	0.0018841610160105565	0.007390098207241404	BLM;PSMD3;TICRR
12	cellular response to organic cyclic compound (GO:0071407)	0.002485481809481908	0.009434140631689394	BLM;RAD51;CHEK1
12	regulation of cellular response to stress (GO:0080135)	0.00623298848167587	0.021361601301277497	RAD51AP1;RAD51;CHEK1
12	cellular response to organonitrogen compound (GO:0071417)	0.006535964053905135	0.02218457029835108	BLM;RAD51;CHEK1
12	cellular response to nitrogen compound (GO:1901699)	0.0077870130352825076	0.02521849175646537	BLM;RAD51;CHEK1
12	Homologous recombination Homo sapiens hsa03440	5.1074438765575355E-11	1.2257865303738085E-9	BLM;RAD51;XRCC2;POLD1;BRCA2
12	Fanconi anemia pathway Homo sapiens hsa03460	1.6522976208808423E-5	1.9827571450570106E-4	BLM;RAD51;BRCA2
12	Cell cycle Homo sapiens hsa04110	2.0961727220472853E-4	0.001282555885268284	CDC45;CCNE2;CHEK1
12	Pathways in cancer Homo sapiens hsa05200	0.005938679553569067	0.0178160386607072	RAD51;CCNE2;BRCA2
12	HDR through Homologous Recombination (HRR) Homo sapiens R-HSA-5685942	1.76076841667676E-18	3.606721495269847E-16	RAD51AP1;BLM;RAD51;EXO1;XRCC2;POLD1;CHEK1;DNA2;BRCA2
12	Homology Directed Repair Homo sapiens R-HSA-5693538	3.0565436400591925E-18	3.606721495269847E-16	RAD51AP1;POLQ;BLM;RAD51;EXO1;XRCC2;POLD1;CHEK1;DNA2;BRCA2
12	Homologous DNA Pairing and Strand Exchange Homo sapiens R-HSA-5693579	1.3828005659835481E-17	1.087803111907058E-15	RAD51AP1;BLM;RAD51;EXO1;XRCC2;CHEK1;DNA2;BRCA2
12	DNA Double-Strand Break Repair Homo sapiens R-HSA-5693532	2.5569848150322936E-17	1.5086210408690532E-15	RAD51AP1;POLQ;BLM;RAD51;EXO1;XRCC2;POLD1;CHEK1;DNA2;BRCA2
12	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Homo sapiens R-HSA-5693554	1.2926594217684004E-16	6.10135247074685E-15	RAD51AP1;BLM;RAD51;EXO1;XRCC2;DNA2;BRCA2
12	DNA Repair Homo sapiens R-HSA-73894	2.7702819659999645E-16	1.0896442399599861E-14	RAD51AP1;POLQ;BLM;RAD51;EXO1;XRCC2;POLD1;CHEK1;DNA2;BRCA2;DTL
12	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) Homo sapiens R-HSA-5693567	3.438177605360678E-16	1.1591570212358857E-14	RAD51AP1;BLM;RAD51;EXO1;XRCC2;POLD1;CHEK1;DNA2;BRCA2
12	Resolution of D-loop Structures through Holliday Junction Intermediates Homo sapiens R-HSA-5693568	6.59386348190484E-16	1.9451897271619275E-14	RAD51AP1;BLM;RAD51;EXO1;XRCC2;DNA2;BRCA2
12	Resolution of D-Loop Structures Homo sapiens R-HSA-5693537	8.364801110733722E-16	2.1934367357035092E-14	RAD51AP1;BLM;RAD51;EXO1;XRCC2;DNA2;BRCA2
12	Presynaptic phase of homologous DNA pairing and strand exchange Homo sapiens R-HSA-5693616	3.002271863068285E-15	7.085361596841152E-14	BLM;RAD51;EXO1;XRCC2;CHEK1;DNA2;BRCA2
12	Cell Cycle Homo sapiens R-HSA-1640170	5.213185097363822E-13	1.1184651663435108E-11	BLM;CDC45;RAD51;CCNE2;EXO1;POLD1;GINS4;CHEK1;PSMD3;DNA2;BRCA2
12	Cell Cycle Checkpoints Homo sapiens R-HSA-69620	2.1144633799542303E-10	4.15844464724332E-9	BLM;CDC45;CCNE2;EXO1;CHEK1;PSMD3;DNA2
12	S Phase Homo sapiens R-HSA-69242	1.2767867054193363E-9	2.317858942145872E-8	CDC45;CCNE2;POLD1;GINS4;PSMD3;DNA2
12	G2/M Checkpoints Homo sapiens R-HSA-69481	4.028875747783985E-9	6.79153340340729E-8	BLM;CDC45;EXO1;CHEK1;PSMD3;DNA2
12	DNA strand elongation Homo sapiens R-HSA-69190	2.0561673965553656E-8	3.235036703913775E-7	CDC45;POLD1;GINS4;DNA2
12	Synthesis of DNA Homo sapiens R-HSA-69239	2.664026941574688E-8	3.929439738822665E-7	CDC45;POLD1;GINS4;PSMD3;DNA2
12	HDR through Single Strand Annealing (SSA) Homo sapiens R-HSA-5685938	3.76512050106061E-8	5.208973109717766E-7	BLM;RAD51;EXO1;DNA2
12	DNA Replication Homo sapiens R-HSA-69306	3.972945592157618E-8	5.208973109717766E-7	CDC45;POLD1;GINS4;PSMD3;DNA2
12	G2/M DNA damage checkpoint Homo sapiens R-HSA-69473	7.93430757794137E-7	9.855245202074543E-6	BLM;EXO1;CHEK1;DNA2
12	Processing of DNA double-strand break ends Homo sapiens R-HSA-5693607	9.237688898207063E-7	1.0900472899884334E-5	BLM;EXO1;CHEK1;DNA2
12	Regulation of TP53 Activity through Phosphorylation Homo sapiens R-HSA-6804756	1.3491825734356798E-6	1.5162242253848592E-5	BLM;EXO1;CHEK1;DNA2
12	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	3.0908764300111116E-6	3.315667443102828E-5	CDC45;CCNE2;POLD1;GINS4;PSMD3;DNA2
12	Regulation of TP53 Activity Homo sapiens R-HSA-5633007	1.1079314289290838E-5	1.136833987944625E-4	BLM;EXO1;CHEK1;DNA2
12	Transcriptional Regulation by TP53 Homo sapiens R-HSA-3700989	1.4742798771316542E-5	1.4497085458461267E-4	BLM;CCNE2;EXO1;CHEK1;DNA2
12	Meiotic recombination Homo sapiens R-HSA-912446	1.748442782548463E-5	1.650529986725749E-4	BLM;RAD51;BRCA2
12	G1/S DNA Damage Checkpoints Homo sapiens R-HSA-69615	3.058772550952114E-5	2.7764243154796114E-4	CCNE2;CHEK1;PSMD3
12	Meiosis Homo sapiens R-HSA-1500620	6.834065620830301E-5	5.376131621719837E-4	BLM;RAD51;BRCA2
12	G1/S Transition Homo sapiens R-HSA-69206	1.5516765092196469E-4	0.0010172101560439906	CDC45;CCNE2;PSMD3
12	Mitotic G1-G1/S phases Homo sapiens R-HSA-453279	2.7516346281573526E-4	0.001665091723705475	CDC45;CCNE2;PSMD3
12	Generic Transcription Pathway Homo sapiens R-HSA-212436	7.876214422300502E-4	0.004322759543402136	BLM;CCNE2;EXO1;CHEK1;DNA2
12	Gene Expression Homo sapiens R-HSA-74160	0.0031240420319376032	0.012934630167320604	BLM;CCNE2;EXO1;CHEK1;PSMD3;DNA2
12	Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility Homo sapiens h atrbrcaPathway	1.1065692812769088E-6	6.6394156876614524E-6	RAD51;CHEK1;BRCA2
13	DNA conformation change (GO:0071103)	2.953123716576546E-8	1.2107807237963839E-5	RECQL4;CDCA5;HMGA1;CDK1;MCM4
13	mitotic metaphase plate congression (GO:0007080)	2.0661417263692345E-7	4.235590539056931E-5	CENPE;CDCA5;CDCA8
13	metaphase plate congression (GO:0051310)	4.900783719307984E-7	6.697737749720912E-5	CENPE;CDCA5;CDCA8
13	chromosome organization (GO:0051276)	1.0880886143983551E-6	8.508134486783521E-5	CENPE;CDCA5;CDK1;CDCA8;RAD54L
13	DNA repair (GO:0006281)	1.4010491614719665E-6	8.508134486783521E-5	RECQL4;CDCA5;FANCA;HMGA1;CDK1;RAD54L
13	mitotic cell cycle (GO:0000278)	1.4213680685939449E-6	8.508134486783521E-5	CENPE;CDCA5;CDK1;CDCA8;MCM4;KIF20A
13	establishment of chromosome localization (GO:0051303)	1.4526083270118207E-6	8.508134486783521E-5	CENPE;CDCA5;CDCA8
13	nuclear division (GO:0000280)	6.957058856883572E-6	3.5654926641528307E-4	CDCA5;FANCA;CDK1;CKS2;RAD54L
13	organelle fission (GO:0048285)	1.0594675901521849E-5	4.238622278176082E-4	CDCA5;FANCA;CDK1;CKS2;RAD54L
13	cell cycle G1/S phase transition (GO:0044843)	1.1371913429252904E-5	4.238622278176082E-4	CDCA5;CDK1;MCM4;CDKN3
13	G1/S transition of mitotic cell cycle (GO:0000082)	1.1371913429252904E-5	4.238622278176082E-4	CDCA5;CDK1;MCM4;CDKN3
13	establishment of organelle localization (GO:0051656)	1.6872257959853277E-5	5.764688136283202E-4	CENPE;CDCA5;CDCA8;SPRY1
13	DNA duplex unwinding (GO:0032508)	1.848205796311634E-5	5.828956742213615E-4	RECQL4;HMGA1;MCM4
13	DNA geometric change (GO:0032392)	2.058840388329684E-5	6.029461137251217E-4	RECQL4;HMGA1;MCM4
13	meiotic nuclear division (GO:0007126)	2.919348937927407E-5	7.48083165343898E-4	FANCA;CKS2;RAD54L
13	mitotic cell cycle phase transition (GO:0044772)	1.1844555404119661E-4	0.002664270554683932	CDCA5;CDK1;MCM4;CDKN3
13	cell cycle phase transition (GO:0044770)	1.2346619643657247E-4	0.002664270554683932	CDCA5;CDK1;MCM4;CDKN3
13	cellular component disassembly (GO:0022411)	2.9021988581025553E-4	0.005949507659110238	HMGA1;CDK1;LMNB1;RPL19
13	regulation of protein serine/threonine kinase activity (GO:0071900)	5.580977113240431E-4	0.009948698332298158	CDK1;CKS2;SPRY1;CDKN3
13	microtubule-based process (GO:0007017)	6.715141143061233E-4	0.011270144975989525	CENPE;CDK1;SPRY1;KIF20A
13	DNA replication (GO:0006260)	6.872039619505809E-4	0.011270144975989525	RECQL4;CDK1;MCM4
13	microtubule cytoskeleton organization (GO:0000226)	0.0015218443536020405	0.02373195624886995	CDK1;SPRY1;KIF20A
13	ATP catabolic process (GO:0006200)	0.0034553405427599866	0.045947653945757505	RECQL4;CENPE;KIF20A
13	purine ribonucleoside monophosphate catabolic process (GO:0009169)	0.003605948442487928	0.045947653945757505	RECQL4;CENPE;KIF20A
13	ribonucleoside monophosphate catabolic process (GO:0009158)	0.003605948442487928	0.045947653945757505	RECQL4;CENPE;KIF20A
13	purine nucleoside monophosphate catabolic process (GO:0009128)	0.0036365476258091037	0.045947653945757505	RECQL4;CENPE;KIF20A
13	nucleoside monophosphate catabolic process (GO:0009125)	0.0036982258053902383	0.045947653945757505	RECQL4;CENPE;KIF20A
13	ATP metabolic process (GO:0046034)	0.005144902029237037	0.0605520869933886	RECQL4;CENPE;KIF20A
13	purine ribonucleoside monophosphate metabolic process (GO:0009167)	0.0061480189647302565	0.06859649485363965	RECQL4;CENPE;KIF20A
13	purine nucleoside monophosphate metabolic process (GO:0009126)	0.006190415389230895	0.06859649485363965	RECQL4;CENPE;KIF20A
13	ribonucleoside monophosphate metabolic process (GO:0009161)	0.0067577199447910324	0.07220744261963474	RECQL4;CENPE;KIF20A
13	nucleoside monophosphate metabolic process (GO:0009123)	0.007261393608071594	0.07395630963296951	RECQL4;CENPE;KIF20A
13	multicellular organismal development (GO:0007275)	0.008539567003330355	0.07611353198620534	RECQL4;CENPE;SPRY1
13	regulation of cell cycle process (GO:0010564)	0.010056657962820416	0.07898564217969757	CENPE;CDCA5;CDK1
13	M Phase Homo sapiens R-HSA-68886	1.2829520782440717E-7	1.0698298540436692E-5	CENPE;CDCA5;CDK1;CDCA8;KIF20A;LMNB1
13	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	1.328981185147415E-7	1.0698298540436692E-5	CENPE;CDCA5;CDK1;CDCA8;MCM4;KIF20A;LMNB1
13	Cell Cycle Homo sapiens R-HSA-1640170	5.251002196542368E-7	2.8180378454777375E-5	CENPE;CDCA5;CDK1;CDCA8;MCM4;KIF20A;LMNB1
13	Resolution of Sister Chromatid Cohesion Homo sapiens R-HSA-2500257	2.0676451094097657E-6	8.322271565374306E-5	CENPE;CDCA5;CDK1;CDCA8
13	Mitotic Prometaphase Homo sapiens R-HSA-68877	2.8209582509501543E-6	9.083485568059497E-5	CENPE;CDCA5;CDK1;CDCA8
13	Mitotic Anaphase Homo sapiens R-HSA-68882	1.8935137766892787E-5	4.4548728243457833E-4	CENPE;CDCA5;CDCA8;LMNB1
13	Mitotic Metaphase and Anaphase Homo sapiens R-HSA-2555396	1.9369012279764276E-5	4.4548728243457833E-4	CENPE;CDCA5;CDCA8;LMNB1
13	Separation of Sister Chromatids Homo sapiens R-HSA-2467813	4.5951375945292214E-4	0.007398171527192047	CENPE;CDCA5;CDCA8
13	Signaling by Rho GTPases Homo sapiens R-HSA-194315	0.004773770969406874	0.03618356417897611	CENPE;PLEKHG2;CDCA8
13	Signal Transduction Homo sapiens R-HSA-162582	0.07517818764039524	0.11639825443451238	CENPE;PLEKHG2;CDK1;CDCA8;SPRY1
13	Gene Expression Homo sapiens R-HSA-74160	0.1984108789401828	0.21879555828335226	BOP1;CDK1;RPL19
14	negative regulation of chromosome organization (GO:2001251)	2.3675765296439405E-11	1.0668018000459721E-8	PIF1;ESPL1;BUB1B;TTK;BRCA1;BUB1;MAD2L1
14	negative regulation of organelle organization (GO:0010639)	4.5589820514785134E-11	1.0668018000459721E-8	PIF1;SPTBN5;ESPL1;BUB1B;TTK;BRCA1;BUB1;SPTBN2;MAD2L1
14	regulation of chromosome segregation (GO:0051983)	4.2821851638974144E-10	6.680208855679967E-8	RACGAP1;ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of cellular component organization (GO:0051129)	9.991526648145308E-10	1.169008617833001E-7	PIF1;SPTBN5;ESPL1;KIF14;BUB1B;TTK;BRCA1;BUB1;SPTBN2;MAD2L1
14	negative regulation of chromosome segregation (GO:0051985)	1.951157917393385E-9	1.8262838106802084E-7	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	chromosome segregation (GO:0007059)	3.5656357002595473E-9	2.275163686996918E-7	ESPL1;KIFC1;BRCA1;BUB1;MAD2L1;SPC25
14	regulation of mitotic sister chromatid separation (GO:0010965)	4.375314782686381E-9	2.275163686996918E-7	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	regulation of sister chromatid segregation (GO:0033045)	4.375314782686381E-9	2.275163686996918E-7	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	regulation of mitotic sister chromatid segregation (GO:0033047)	4.375314782686381E-9	2.275163686996918E-7	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	regulation of chromosome organization (GO:0033044)	5.3035097056461205E-9	2.3715451075288063E-7	PIF1;ESPL1;BUB1B;TTK;BRCA1;BUB1;MAD2L1
14	regulation of mitotic metaphase/anaphase transition (GO:0030071)	5.574144483507878E-9	2.3715451075288063E-7	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	6.264388549878888E-9	2.4431115344527664E-7	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	microtubule-based process (GO:0007017)	9.957428457621291E-9	3.584674244743665E-7	PLK4;RACGAP1;ESPL1;KIFC1;PRC1;KIF4A;KIF14;TTK;SPC25
14	mitotic spindle assembly checkpoint (GO:0007094)	1.4360311528322117E-7	4.552263619379627E-6	BUB1B;TTK;BUB1;MAD2L1
14	spindle assembly checkpoint (GO:0071173)	1.632407804022222E-7	4.552263619379627E-6	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	1.8481412129960026E-7	4.552263619379627E-6	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of sister chromatid segregation (GO:0033046)	1.8481412129960026E-7	4.552263619379627E-6	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of mitotic sister chromatid separation (GO:2000816)	1.8481412129960026E-7	4.552263619379627E-6	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of mitotic sister chromatid segregation (GO:0033048)	1.8481412129960026E-7	4.552263619379627E-6	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.084444326282279E-7	4.8775997235005326E-6	BUB1B;TTK;BUB1;MAD2L1
14	mitotic spindle checkpoint (GO:0071174)	2.3425646887914085E-7	5.220572735020853E-6	BUB1B;TTK;BUB1;MAD2L1
14	regulation of cell cycle process (GO:0010564)	3.8802337988158446E-7	8.152330078573262E-6	PLK4;RACGAP1;ESPL1;BUB1B;TTK;BRCA1;BUB1;MAD2L1
14	spindle checkpoint (GO:0031577)	4.00648700442703E-7	8.152330078573262E-6	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of mitosis (GO:0045839)	5.353919390998616E-7	1.04401428124473E-5	BUB1B;TTK;BUB1;MAD2L1
14	regulation of mitosis (GO:0007088)	6.414541976547399E-7	1.200802258009673E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	7.637064250337031E-7	1.3746715650606657E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)	1.0588769183046295E-6	1.835386658394691E-5	BUB1B;TTK;BUB1;MAD2L1
14	regulation of cell division (GO:0051302)	1.1292189003458527E-6	1.887408733435211E-5	RACGAP1;ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of nuclear division (GO:0051784)	1.2343718066518857E-6	1.9920207086658015E-5	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of proteasomal protein catabolic process (GO:1901799)	1.3298019838740273E-6	2.0744910948434825E-5	BUB1B;TTK;BUB1;MAD2L1
14	regulation of proteasomal protein catabolic process (GO:0061136)	1.6184302408375712E-6	2.4433075893934947E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	mitotic cell cycle (GO:0000278)	1.7754536959148628E-6	2.5031861165754868E-5	PLK4;ESPL1;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	regulation of nuclear division (GO:0051783)	1.8037478772957199E-6	2.5031861165754868E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of cell cycle process (GO:0010948)	1.8185540163155245E-6	2.5031861165754868E-5	ESPL1;BUB1B;TTK;BRCA1;BUB1;MAD2L1
14	negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)	2.0221019465985852E-6	2.7038391743089655E-5	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of cellular protein catabolic process (GO:1903363)	2.454308946367664E-6	3.190601630277963E-5	BUB1B;TTK;BUB1;MAD2L1
14	regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	2.5452345695736795E-6	3.2193777798931946E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of cell division (GO:0051782)	2.7781889874226016E-6	3.421559068720467E-5	BUB1B;TTK;BUB1;MAD2L1
14	regulation of cellular protein catabolic process (GO:1903362)	3.1934202560507915E-6	3.83210430726095E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	cell cycle checkpoint (GO:0000075)	3.2957200223887285E-6	3.855992426194812E-5	BUB1B;TTK;BRCA1;BUB1;MAD2L1
14	mitotic sister chromatid segregation (GO:0000070)	3.412288311774752E-6	3.8950022680745945E-5	ESPL1;KIFC1;MAD2L1
14	spindle organization (GO:0007051)	4.398619001279921E-6	4.9013183157119117E-5	ESPL1;KIFC1;TTK;SPC25
14	nuclear division (GO:0000280)	4.5717159282573625E-6	4.9757280335452224E-5	CDCA2;BUB1B;TRIP13;BUB1;SPC24;SPC25
14	sister chromatid segregation (GO:0000819)	5.284966899503806E-6	5.621282974926776E-5	ESPL1;KIFC1;MAD2L1
14	organelle fission (GO:0048285)	7.512287727025896E-6	7.812779236106931E-5	CDCA2;BUB1B;TRIP13;BUB1;SPC24;SPC25
14	chromosome organization (GO:0051276)	1.2172236313033847E-5	1.238392737934748E-4	PIF1;ESPL1;KIFC1;TRIP13;MAD2L1
14	negative regulation of protein catabolic process (GO:0042177)	1.2932327768264672E-5	1.2877296586272057E-4	BUB1B;TTK;BUB1;MAD2L1
14	mitotic cell cycle checkpoint (GO:0007093)	1.639950769981478E-5	1.598952000731941E-4	BUB1B;TTK;BUB1;MAD2L1
14	positive regulation of cell cycle process (GO:0090068)	1.7524404193284213E-5	1.6737594209095943E-4	PLK4;RACGAP1;ESPL1;BRCA1;MAD2L1
14	mitotic nuclear division (GO:0007067)	2.661800993247766E-5	2.491445729679909E-4	CDCA2;BUB1B;BUB1;SPC24;SPC25
14	microtubule cytoskeleton organization (GO:0000226)	2.9380152531364336E-5	2.696061055819315E-4	ESPL1;KIFC1;PRC1;TTK;SPC25
14	regulation of mitotic cell cycle phase transition (GO:1901990)	3.298354799248735E-5	2.968519319323862E-4	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of cell cycle (GO:0045786)	3.6552836036745236E-5	3.227684389659768E-4	ESPL1;BUB1B;TTK;BRCA1;BUB1;MAD2L1
14	regulation of protein catabolic process (GO:0042176)	3.9022538284250974E-5	3.3819533179684175E-4	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	regulation of cell cycle phase transition (GO:1901987)	4.1967033515505265E-5	3.5710130336829936E-4	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	positive regulation of cell cycle (GO:0045787)	5.365289303625452E-5	4.4838489180298424E-4	PLK4;RACGAP1;ESPL1;BRCA1;MAD2L1
14	negative regulation of cellular catabolic process (GO:0031330)	6.272706112131803E-5	5.150221860487165E-4	BUB1B;TTK;BUB1;MAD2L1
14	regulation of cytoskeleton organization (GO:0051493)	1.5857875499494133E-4	0.0012369142889605423	PLK4;SPTBN5;RACGAP1;BRCA1;SPTBN2
14	microtubule-based movement (GO:0007018)	1.676769450993752E-4	0.001286439513221436	RACGAP1;KIFC1;KIF4A;KIF14
14	negative regulation of catabolic process (GO:0009895)	1.7823342023816168E-4	0.001345374849539672	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of mitotic cell cycle phase transition (GO:1901991)	1.8553291808050555E-4	0.001378244534312327	BUB1B;TTK;BUB1;MAD2L1
14	DNA recombination (GO:0006310)	2.0077706577381437E-4	0.0014681822934710176	PIF1;EME1;BRCA1;TRIP13
14	negative regulation of cell cycle phase transition (GO:1901988)	2.1690636844734666E-4	0.001561725852820896	BUB1B;TTK;BUB1;MAD2L1
14	cytokinesis (GO:0000910)	2.229938888345761E-4	0.0015812293935542668	RACGAP1;ESPL1;PRC1
14	regulation of mitotic cell cycle (GO:0007346)	2.651327287130875E-4	0.001851971896085447	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	DNA repair (GO:0006281)	3.0477680344657174E-4	0.00207915977263808	PIF1;EME1;BRCA1;FANCB;TRIP13
14	negative regulation of mitotic cell cycle (GO:0045930)	3.065427869915118E-4	0.00207915977263808	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of protein complex assembly (GO:0031333)	3.384449276305524E-4	0.002262746087587122	SPTBN5;KIF14;SPTBN2
14	antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	3.607851781524913E-4	0.002378133286976985	RACGAP1;KIF4A;SPTBN2
14	antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	3.723028623192989E-4	0.0024199686050754426	RACGAP1;KIF4A;SPTBN2
14	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504)	3.9604353236937927E-4	0.0025390188102584863	RACGAP1;KIF4A;SPTBN2
14	regulation of microtubule cytoskeleton organization (GO:0070507)	4.4640250260442E-4	0.002785551616251581	PLK4;RACGAP1;BRCA1
14	negative regulation of cytoskeleton organization (GO:0051494)	4.596033945902726E-4	0.002830189324582205	SPTBN5;BRCA1;SPTBN2
14	regulation of microtubule-based process (GO:0032886)	8.35654521880821E-4	0.004950459699243345	PLK4;RACGAP1;BRCA1
14	negative regulation of proteolysis (GO:0045861)	0.0010246310094324917	0.00584789405383422	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of protein processing (GO:0010955)	0.0012115848365007512	0.006750258374789899	BUB1B;TTK;BUB1;MAD2L1
14	negative regulation of protein maturation (GO:1903318)	0.0012115848365007512	0.006750258374789899	BUB1B;TTK;BUB1;MAD2L1
14	ATP catabolic process (GO:0006200)	0.001374393472735406	0.007567248767531411	PIF1;KIFC1;KIF4A;KIF14
14	purine ribonucleoside monophosphate catabolic process (GO:0009169)	0.0014532376696596966	0.00781442174961269	PIF1;KIFC1;KIF4A;KIF14
14	ribonucleoside monophosphate catabolic process (GO:0009158)	0.0014532376696596966	0.00781442174961269	PIF1;KIFC1;KIF4A;KIF14
14	purine nucleoside monophosphate catabolic process (GO:0009128)	0.001469378448645121	0.00781442174961269	PIF1;KIFC1;KIF4A;KIF14
14	nucleoside monophosphate catabolic process (GO:0009125)	0.0015020361396401994	0.007898347341029363	PIF1;KIFC1;KIF4A;KIF14
14	neuron projection guidance (GO:0097485)	0.002096080413269802	0.010476096537246954	SPTBN5;KIF4A;NRCAM;SPTBN2
14	axon guidance (GO:0007411)	0.002096080413269802	0.010476096537246954	SPTBN5;KIF4A;NRCAM;SPTBN2
14	antigen processing and presentation of exogenous peptide antigen (GO:0002478)	0.0021041732361137045	0.010476096537246954	RACGAP1;KIF4A;SPTBN2
14	antigen processing and presentation of exogenous antigen (GO:0019884)	0.0021749280124979207	0.010714382208937126	RACGAP1;KIF4A;SPTBN2
14	ATP metabolic process (GO:0046034)	0.0023109296533766173	0.01126578206021101	PIF1;KIFC1;KIF4A;KIF14
14	antigen processing and presentation of peptide antigen (GO:0048002)	0.002630648654235842	0.0124357936382058	RACGAP1;KIF4A;SPTBN2
14	purine ribonucleoside monophosphate metabolic process (GO:0009167)	0.0029139346324348753	0.013489832501443247	PIF1;KIFC1;KIF4A;KIF14
14	purine nucleoside monophosphate metabolic process (GO:0009126)	0.0029400916990325026	0.013489832501443247	PIF1;KIFC1;KIF4A;KIF14
14	ribonucleoside monophosphate metabolic process (GO:0009161)	0.003294985715344298	0.01482743571904934	PIF1;KIFC1;KIF4A;KIF14
14	nucleoside monophosphate metabolic process (GO:0009123)	0.003617369639824234	0.016123133251788015	PIF1;KIFC1;KIF4A;KIF14
14	regulation of protein ubiquitination (GO:0031396)	0.0038605585243045716	0.017044730088439052	BUB1B;BRCA1;MAD2L1
14	antigen processing and presentation (GO:0019882)	0.004558956971627986	0.01939628966110816	RACGAP1;KIF4A;SPTBN2
14	regulation of protein modification by small protein conjugation or removal (GO:1903320)	0.004730295291890646	0.01994394771716056	BUB1B;BRCA1;MAD2L1
14	regulation of protein complex assembly (GO:0043254)	0.005710062720887285	0.02303714959806249	SPTBN5;KIF14;SPTBN2
14	regulation of DNA metabolic process (GO:0051052)	0.0071691345249754726	0.027501270144987877	PIF1;BRCA1;KPNA2
14	embryo development (GO:0009790)	0.008014081447539801	0.030492602580883144	STIL;RACGAP1;BRCA1
14	negative regulation of transferase activity (GO:0051348)	0.008664144974046736	0.03243855878283098	PIF1;BUB1B;MAD2L1
14	positive regulation of organelle organization (GO:0010638)	0.014078870489991553	0.04414115404445695	PLK4;ESPL1;BRCA1
14	negative regulation of protein modification process (GO:0031400)	0.022616327470476875	0.058477576001012034	BUB1B;BRCA1;MAD2L1
14	coagulation (GO:0050817)	0.03309201740763605	0.07374792450844606	RACGAP1;KIFC1;KIF4A
14	blood coagulation (GO:0007596)	0.03309201740763605	0.07374792450844606	RACGAP1;KIFC1;KIF4A
14	hemostasis (GO:0007599)	0.03416786252976883	0.07472224142024213	RACGAP1;KIFC1;KIF4A
14	Cell cycle Homo sapiens hsa04110	1.0631567766814593E-6	1.2757881320177512E-5	ESPL1;BUB1B;TTK;BUB1;MAD2L1
14	Fanconi anemia pathway Homo sapiens hsa03460	6.781809629974968E-5	4.0690857779849805E-4	EME1;BRCA1;FANCB
14	Oocyte meiosis Homo sapiens hsa04114	8.162606481688431E-4	0.0032650425926753724	ESPL1;BUB1;MAD2L1
14	Signaling by Rho GTPases Homo sapiens R-HSA-194315	4.8997293300569604E-8	6.195583689917158E-6	RACGAP1;PRC1;KIF14;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	RHO GTPase Effectors Homo sapiens R-HSA-195258	7.994357246012987E-8	6.195583689917158E-6	PRC1;KIF14;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Separation of Sister Chromatids Homo sapiens R-HSA-2467813	1.3009718145048995E-7	6.195583689917158E-6	ESPL1;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Mitotic Anaphase Homo sapiens R-HSA-68882	1.91927033724845E-7	6.195583689917158E-6	ESPL1;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Mitotic Metaphase and Anaphase Homo sapiens R-HSA-2555396	1.9857640031785762E-7	6.195583689917158E-6	ESPL1;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Resolution of Sister Chromatid Cohesion Homo sapiens R-HSA-2500257	3.466561526999802E-7	9.013059970199486E-6	BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Mitotic Prometaphase Homo sapiens R-HSA-68877	5.109713367799578E-7	1.1387361219667631E-5	BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	RHO GTPases Activate Formins Homo sapiens R-HSA-5663220	7.004747789931983E-7	1.3659258190367367E-5	BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Cell Cycle Homo sapiens R-HSA-1640170	1.3223231581788597E-6	2.2920268075100232E-5	PLK4;ESPL1;BUB1B;BRCA1;BUB1;SPC24;MAD2L1;SPC25
14	M Phase Homo sapiens R-HSA-68886	2.480846404586938E-6	3.8701203911556234E-5	ESPL1;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	4.308561409931453E-6	6.110323454084606E-5	PLK4;ESPL1;BUB1B;BUB1;SPC24;MAD2L1;SPC25
14	Interaction between L1 and Ankyrins Homo sapiens R-HSA-445095	1.0838203563114573E-5	1.4089664632048945E-4	SPTBN5;NRCAM;SPTBN2
14	L1CAM interactions Homo sapiens R-HSA-373760	1.2411938626861606E-5	1.4894326352233927E-4	SPTBN5;KIF4A;NRCAM;SPTBN2
14	Kinesins Homo sapiens R-HSA-983189	3.869184698386548E-5	4.311377235345011E-4	RACGAP1;KIFC1;KIF4A
14	MHC class II antigen presentation Homo sapiens R-HSA-2132295	4.8675237961089157E-4	0.0039964932220683735	RACGAP1;KIF4A;SPTBN2
14	DNA Repair Homo sapiens R-HSA-73894	8.261799589108794E-4	0.006137336837623676	EME1;BRCA1;FANCB;KPNA2
14	Factors involved in megakaryocyte development and platelet production Homo sapiens R-HSA-983231	0.0012112983795461213	0.007830801787406406	RACGAP1;KIFC1;KIF4A
14	DNA Double-Strand Break Repair Homo sapiens R-HSA-5693532	0.0013128137028807422	0.007876882217284453	EME1;BRCA1;KPNA2
14	Signal Transduction Homo sapiens R-HSA-162582	0.002301459293892251	0.013297320364710782	SPTBN5;RACGAP1;PRC1;KIF14;BUB1B;BUB1;SPC24;SPTBN2;MAD2L1;SPC25
14	Cell Cycle Checkpoints Homo sapiens R-HSA-69620	0.002511640590524396	0.01399342614720735	BUB1B;BRCA1;MAD2L1
14	Membrane Trafficking Homo sapiens R-HSA-199991	0.003409834341721469	0.01834255714857066	SPTBN5;RACGAP1;KIF4A;SPTBN2
14	Vesicle-mediated transport Homo sapiens R-HSA-5653656	0.005970994535695177	0.02560791676133642	SPTBN5;RACGAP1;KIF4A;SPTBN2
14	Axon guidance Homo sapiens R-HSA-422475	0.007003055662665278	0.026697314418456294	SPTBN5;KIF4A;NRCAM;SPTBN2
14	Developmental Biology Homo sapiens R-HSA-1266738	0.028812810488516066	0.08813330267075502	SPTBN5;KIF4A;NRCAM;SPTBN2
14	Post-translational protein modification Homo sapiens R-HSA-597592	0.04241052277396299	0.11139270764640662	SPTBN5;BRCA1;SPTBN2
14	Hemostasis Homo sapiens R-HSA-109582	0.0489249807902943	0.11139270764640662	RACGAP1;KIFC1;KIF4A
14	Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215	0.06484024381245929	0.1177770160016146	SPTBN5;KPNA2;SPTBN2
14	Immune System Homo sapiens R-HSA-168256	0.07788508199419669	0.12686431787234942	SPTBN5;RACGAP1;KIF4A;KPNA2;SPTBN2
14	Adaptive Immune System Homo sapiens R-HSA-1280218	0.10472046146416486	0.1328161950277213	RACGAP1;KIF4A;SPTBN2
14	Metabolism of proteins Homo sapiens R-HSA-392499	0.21649750074925847	0.23453895914503	SPTBN5;BRCA1;SPTBN2
15	mitotic cell cycle (GO:0000278)	3.456813231212911E-18	2.554584977866341E-15	CDT1;FOXM1;PKMYT1;CDC25C;CDC25A;NDC80;CDC20;CCNA2;CCNB2;CCNB1;CCNE1;E2F1;E2F2;MYBL2;E2F8
15	mitotic cell cycle phase transition (GO:0044772)	1.275816275212061E-13	3.5364987158292356E-11	CCNA2;CCNB2;CDT1;CCNB1;CCNE1;E2F1;MYBL2;FOXM1;PKMYT1;CDC25C;CDC25A
15	cell cycle phase transition (GO:0044770)	1.435655770972626E-13	3.5364987158292356E-11	CCNA2;CCNB2;CDT1;CCNB1;CCNE1;E2F1;MYBL2;FOXM1;PKMYT1;CDC25C;CDC25A
15	mitotic nuclear division (GO:0007067)	1.2490669708491581E-12	2.3076512286438196E-10	CDC20;CCNA2;CCNB2;USP44;KIF11;PKMYT1;SKA3;CDC25C;CDC25A;NDC80
15	nuclear division (GO:0000280)	1.070895643234459E-11	1.5827837607005306E-9	CDC20;CCNA2;CCNB2;USP44;KIF11;PKMYT1;SKA3;CDC25C;CDC25A;NDC80
15	G2/M transition of mitotic cell cycle (GO:0000086)	2.2847412097625875E-11	2.3267486267549584E-9	CCNA2;CCNB2;CCNB1;MYBL2;FOXM1;PKMYT1;CDC25C;CDC25A
15	cell cycle G2/M phase transition (GO:0044839)	2.2847412097625875E-11	2.3267486267549584E-9	CCNA2;CCNB2;CCNB1;MYBL2;FOXM1;PKMYT1;CDC25C;CDC25A
15	organelle fission (GO:0048285)	2.5188077150256654E-11	2.3267486267549584E-9	CDC20;CCNA2;CCNB2;USP44;KIF11;PKMYT1;SKA3;CDC25C;CDC25A;NDC80
15	regulation of cell cycle process (GO:0010564)	5.024729177705481E-11	3.760700263797762E-9	CDC20;CCNA2;CDT1;CCNB1;USP44;E2F1;FOXM1;PKMYT1;CDC25C;E2F7;E2F8
15	regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	5.08890428118777E-11	3.760700263797762E-9	CCNA2;CCNB2;CCNB1;CCNE1;PKMYT1;CDC25C;CDC25A
15	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	6.007467015815436E-8	4.035925567897825E-6	CDT1;CCNE1;E2F1;E2F7
15	regulation of mitotic cell cycle (GO:0007346)	7.979915275018153E-8	4.7046746178479534E-6	CDC20;CCNA2;CCNB1;USP44;E2F1;PKMYT1;CDC25C;E2F7
15	cell cycle G1/S phase transition (GO:0044843)	8.91278006087569E-8	4.7046746178479534E-6	CDT1;CCNB1;CCNE1;E2F1;PKMYT1;CDC25A
15	G1/S transition of mitotic cell cycle (GO:0000082)	8.91278006087569E-8	4.7046746178479534E-6	CDT1;CCNB1;CCNE1;E2F1;PKMYT1;CDC25A
15	negative regulation of cell cycle (GO:0045786)	1.6534813364229117E-7	8.146151384110212E-6	CDC20;CCNA2;CCNB1;USP44;GAS2L1;RUNX3;E2F7;E2F8
15	regulation of cell division (GO:0051302)	1.1292189003458527E-6	5.215579795972407E-5	CDC20;USP44;PKMYT1;CDC25C;E2F7;E2F8
15	regulation of mitotic cell cycle phase transition (GO:1901990)	1.6974740202873007E-6	7.379019417601854E-5	CDC20;CCNA2;CCNB1;USP44;E2F1;E2F7
15	negative regulation of cell cycle process (GO:0010948)	1.8185540163155245E-6	7.46617454476207E-5	CDC20;CCNA2;CCNB1;USP44;E2F7;E2F8
15	regulation of protein serine/threonine kinase activity (GO:0071900)	2.1559803557542754E-6	8.385628857381102E-5	CCNA2;CCNB2;CCNB1;CCNE1;PKMYT1;CDC25C;CDC25A
15	regulation of cell cycle phase transition (GO:1901987)	2.2742544565178793E-6	8.403370216833564E-5	CDC20;CCNA2;CCNB1;USP44;E2F1;E2F7
15	negative regulation of cell division (GO:0051782)	2.7781889874226016E-6	9.776579341453822E-5	CDC20;USP44;E2F7;E2F8
15	cell cycle checkpoint (GO:0000075)	3.2957200223887285E-6	1.1070623166114866E-4	CDC20;CCNA2;CDT1;CCNB1;E2F1
15	sprouting angiogenesis (GO:0002040)	6.033858309199734E-6	1.9387049089124363E-4	NOTCH1;E2F7;E2F8
15	negative regulation of mitotic cell cycle phase transition (GO:1901991)	9.074418672492803E-6	2.794164749571742E-4	CDC20;CCNA2;CCNB1;USP44;E2F7
15	negative regulation of cell cycle phase transition (GO:1901988)	1.105992394212401E-5	3.2693135172918574E-4	CDC20;CCNA2;CCNB1;USP44;E2F7
15	mitotic spindle organization (GO:0007052)	1.330577067114537E-5	3.781909433067857E-4	MYBL2;KIF11;NDC80
15	negative regulation of mitotic cell cycle (GO:0045930)	1.714402730155179E-5	4.660909237848889E-4	CDC20;CCNA2;CCNB1;USP44;E2F7
15	regulation of DNA-dependent DNA replication (GO:0090329)	1.765973730172786E-5	4.660909237848889E-4	CDT1;E2F7;E2F8
15	regulation of mitosis (GO:0007088)	2.282268914634782E-5	5.815850785914151E-4	CDC20;USP44;PKMYT1;CDC25C
15	cell division (GO:0051301)	4.221223573947962E-5	0.0010042574490177533	CCNB2;CCNB1;NOTCH1;CCNE1
15	regulation of DNA metabolic process (GO:0051052)	4.272939511390879E-5	0.0010042574490177533	CDT1;CCNB1;FOXM1;E2F7;E2F8
15	signal transduction by p53 class mediator (GO:0072331)	4.3486114165856703E-5	0.0010042574490177533	E2F1;E2F2;FOXM1;E2F7
15	regulation of nuclear division (GO:0051783)	5.1729033356397294E-5	0.0011584168378902303	CDC20;USP44;PKMYT1;CDC25C
15	regulation of microtubule polymerization or depolymerization (GO:0031110)	6.404406787341007E-5	0.001314682393290279	CCNB1;SKA3;GAS2L1
15	regulation of chromosome segregation (GO:0051983)	1.1380645743939195E-4	0.0021564864627618115	CDC20;CCNB1;USP44
15	spindle organization (GO:0007051)	1.8372253598191246E-4	0.0031574640486193794	MYBL2;KIF11;NDC80
15	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.1474269730937482E-4	0.003526552295813955	CDC20;CCNB1;USP44
15	DNA integrity checkpoint (GO:0031570)	2.865529734338402E-4	0.0043112205011436215	CCNA2;CDT1;E2F1
15	cell-type specific apoptotic process (GO:0097285)	2.865529734338402E-4	0.0043112205011436215	JAG2;E2F1;E2F2
15	liver development (GO:0001889)	2.865529734338402E-4	0.0043112205011436215	NOTCH1;TK1;FOXM1
15	gland development (GO:0048732)	3.118950113775969E-4	0.0044866717757046665	CCNB2;NOTCH1;TK1;FOXM1
15	chromosome segregation (GO:0007059)	3.1701780928996323E-4	0.0044866717757046665	KIF11;SKA3;NDC80
15	in utero embryonic development (GO:0001701)	3.22800537684735E-4	0.0044866717757046665	JAG2;CCNB2;CCNB1;NOTCH1
15	chordate embryonic development (GO:0043009)	3.454296946027603E-4	0.004641318987480725	JAG2;CCNB2;CCNB1;NOTCH1
15	embryo development ending in birth or egg hatching (GO:0009792)	3.691760418829627E-4	0.00487180526699124	JAG2;CCNB2;CCNB1;NOTCH1
15	negative regulation of organelle organization (GO:0010639)	4.1351620583025063E-4	0.005268766829457848	CDC20;CCNB1;USP44;GAS2L1
15	cellular response to hypoxia (GO:0071456)	4.334480544214506E-4	0.005429120546058508	CCNB1;NOTCH1;E2F1
15	regulation of microtubule cytoskeleton organization (GO:0070507)	4.4640250260442E-4	0.005439325865442397	CCNB1;SKA3;GAS2L1
15	cellular response to decreased oxygen levels (GO:0036294)	4.596033945902726E-4	0.005439325865442397	CCNB1;NOTCH1;E2F1
15	microtubule cytoskeleton organization (GO:0000226)	4.6872006949113046E-4	0.005439325865442397	MYBL2;KIF11;GAS2L1;NDC80
15	regulation of ubiquitin-protein transferase activity (GO:0051438)	4.8675237961089157E-4	0.005439325865442397	CDC20;CCNB1;USP44
15	mitotic cell cycle checkpoint (GO:0007093)	4.8675237961089157E-4	0.005439325865442397	CDC20;CCNA2;CCNB1
15	regulation of ligase activity (GO:0051340)	5.590743369471263E-4	0.005902227642913233	CDC20;CCNB1;USP44
15	cellular response to oxygen levels (GO:0071453)	5.743168995676725E-4	0.005977749137753661	CCNB1;NOTCH1;E2F1
15	regulation of DNA replication (GO:0006275)	7.23596787971595E-4	0.007101153454579193	CDT1;E2F7;E2F8
15	embryo development (GO:0009790)	7.329832874236017E-4	0.007101153454579193	JAG2;CCNB2;CCNB1;NOTCH1
15	multicellular organismal reproductive process (GO:0048609)	7.495128138798066E-4	0.007101153454579193	JAG2;CCNB1;E2F1;TK1;CDC25C
15	positive regulation of DNA metabolic process (GO:0051054)	8.35654521880821E-4	0.007719358645874085	FOXM1;E2F7;E2F8
15	regulation of microtubule-based process (GO:0032886)	8.35654521880821E-4	0.007719358645874085	CCNB1;SKA3;GAS2L1
15	Notch signaling pathway (GO:0007219)	9.7966142379343E-4	0.008618688002182675	JAG2;NOTCH1;E2F1
15	cell fate commitment (GO:0045165)	0.0010458927310065167	0.009014581101095957	JAG2;TEAD4;NOTCH1
15	spermatogenesis (GO:0007283)	0.0018191825098402455	0.012447924766406864	JAG2;CCNB1;E2F1;CDC25C
15	male gamete generation (GO:0048232)	0.001838062351025192	0.012461725480803825	JAG2;CCNB1;E2F1;CDC25C
15	tube development (GO:0035295)	0.0018679317590660574	0.012549105181361967	CCNB1;NOTCH1;TK1
15	regulation of chromosome organization (GO:0033044)	0.0021393678401347206	0.013765283561487571	CDC20;CCNB1;USP44
15	gamete generation (GO:0007276)	0.0026124418531259363	0.015695890483415176	JAG2;CCNB1;E2F1;CDC25C
15	DNA replication (GO:0006260)	0.0026710814079758632	0.01589324542070585	CDT1;CDC25C;CDC25A
15	transcription initiation from RNA polymerase II promoter (GO:0006367)	0.0027118979556317114	0.01589324542070585	TEAD4;NOTCH1;E2F2
15	proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	0.003513608535328855	0.019377288862746447	CDC20;CCNB1;USP44
15	proteasomal protein catabolic process (GO:0010498)	0.0038605585243045716	0.02052483992418042	CDC20;CCNB1;USP44
15	regulation of protein ubiquitination (GO:0031396)	0.0038605585243045716	0.02052483992418042	CDC20;CCNB1;USP44
15	microtubule-based process (GO:0007017)	0.003928600533214382	0.020737398528895917	MYBL2;KIF11;GAS2L1;NDC80
15	DNA-templated transcription, initiation (GO:0006352)	0.004281920964915018	0.02228408164135351	TEAD4;NOTCH1;E2F2
15	regulation of protein modification by small protein conjugation or removal (GO:1903320)	0.004730295291890646	0.023937789140584406	CDC20;CCNB1;USP44
15	angiogenesis (GO:0001525)	0.005206184019009681	0.025469003673808763	NOTCH1;E2F7;E2F8
15	negative regulation of cellular component organization (GO:0051129)	0.005238550146710328	0.025469003673808763	CDC20;CCNB1;USP44;GAS2L1
15	response to hypoxia (GO:0001666)	0.00551779904692122	0.026138804459453727	CCNB1;NOTCH1;E2F1
15	response to decreased oxygen levels (GO:0036293)	0.0057750382613765165	0.0268412155670267	CCNB1;NOTCH1;E2F1
15	regulation of epithelial cell proliferation (GO:0050678)	0.006660538167884845	0.029968771987659792	NOTCH1;NRARP;RUNX3
15	response to oxygen levels (GO:0070482)	0.006731821583154973	0.029968771987659792	CCNB1;NOTCH1;E2F1
15	protein catabolic process (GO:0030163)	0.007469885318433551	0.03305536078037362	CDC20;CCNB1;USP44
15	positive regulation of cell cycle (GO:0045787)	0.008173772995862418	0.03564159710673015	CCNB1;E2F7;E2F8
15	morphogenesis of an epithelium (GO:0002009)	0.009696172692694108	0.04118087137874107	JAG2;NOTCH1;NRARP
15	epithelial cell differentiation (GO:0030855)	0.010330088947389014	0.04288727939393529	NOTCH1;E2F7;E2F8
15	negative regulation of immune system process (GO:0002683)	0.011083637154860174	0.04525308208531309	NOTCH1;NRARP;GAS2L1
15	growth (GO:0040007)	0.01289373752984227	0.04789255952442875	CCNB2;CCNB1;NOTCH1
15	regulation of cell adhesion (GO:0030155)	0.013640937528724298	0.04820271311730809	JAG2;NOTCH1;NRARP
15	regulation of cytoskeleton organization (GO:0051493)	0.015208746125871878	0.050400284246723395	CCNB1;SKA3;GAS2L1
15	ubiquitin-dependent protein catabolic process (GO:0006511)	0.01579253028978255	0.05058798742209223	CDC20;CCNB1;USP44
15	tissue morphogenesis (GO:0048729)	0.016148852019976016	0.05058798742209223	JAG2;NOTCH1;NRARP
15	modification-dependent protein catabolic process (GO:0019941)	0.016875143105299837	0.051624006588941056	CDC20;CCNB1;USP44
15	modification-dependent macromolecule catabolic process (GO:0043632)	0.017369467075100332	0.05236626729605408	CDC20;CCNB1;USP44
15	proteolysis involved in cellular protein catabolic process (GO:0051603)	0.0203697772679535	0.05693862138293802	CDC20;CCNB1;USP44
15	negative regulation of protein modification process (GO:0031400)	0.022616327470476875	0.059478526692819965	CDC20;CCNB1;USP44
15	negative regulation of phosphorus metabolic process (GO:0010563)	0.030653017597559305	0.07123452831634065	CCNB1;FOXM1;PKMYT1
15	negative regulation of phosphate metabolic process (GO:0045936)	0.030653017597559305	0.07123452831634065	CCNB1;FOXM1;PKMYT1
15	Cell cycle Homo sapiens hsa04110	1.568494099019451E-15	5.0191811168622433E-14	CDC20;CCNA2;CCNB2;CCNB1;CCNE1;E2F1;E2F2;PKMYT1;CDC25C;CDC25A
15	Progesterone-mediated oocyte maturation Homo sapiens hsa04914	6.399191334496773E-9	1.0238706135194837E-7	CCNA2;CCNB2;CCNB1;PKMYT1;CDC25C;CDC25A
15	Oocyte meiosis Homo sapiens hsa04114	2.5176195746285213E-8	2.685460879603756E-7	CDC20;CCNB2;CCNB1;CCNE1;PKMYT1;CDC25C
15	MicroRNAs in cancer Homo sapiens hsa05206	4.4843096395067785E-6	3.587447711605423E-5	NOTCH1;CCNE1;E2F1;E2F2;CDC25C;CDC25A
15	HTLV-I infection Homo sapiens hsa05166	3.761181994937796E-5	2.4071564767601898E-4	CDC20;CCNB2;E2F1;E2F2;MYBL2
15	Hepatitis B Homo sapiens hsa05161	6.442697562858618E-5	3.436105366857929E-4	CCNA2;CCNE1;E2F1;E2F2
15	p53 signaling pathway Homo sapiens hsa04115	1.492461826251745E-4	6.822682634293691E-4	CCNB2;CCNB1;CCNE1
15	Small cell lung cancer Homo sapiens hsa05222	2.865529734338402E-4	0.0011271744330309803	CCNE1;E2F1;E2F2
15	Prostate cancer Homo sapiens hsa05215	3.1701780928996323E-4	0.0011271744330309803	CCNE1;E2F1;E2F2
15	Viral carcinogenesis Homo sapiens hsa05203	0.003513608535328855	0.008648882548501798	CDC20;CCNA2;CCNE1
15	Pathways in cancer Homo sapiens hsa05200	0.021196875009034832	0.03570000001521656	CCNE1;E2F1;E2F2
15	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	2.5647757920672636E-17	4.744835215324438E-15	CDT1;HMMR;FOXM1;PKMYT1;CDC25C;CDC25A;NDC80;CDC20;CCNA2;CCNB2;CCNB1;CCNE1;E2F1;E2F2;MYBL2
15	Polo-like kinase mediated events Homo sapiens R-HSA-156711	9.091136533349247E-17	8.409301293348054E-15	CCNB2;CCNB1;MYBL2;PKMYT1;FOXM1;CDC25C;CDC25A
15	Cell Cycle Homo sapiens R-HSA-1640170	5.220240863514239E-16	3.219148532500447E-14	CDT1;HMMR;FOXM1;PKMYT1;CDC25C;CDC25A;NDC80;CDC20;CCNA2;CCNB2;CCNB1;CCNE1;E2F1;E2F2;MYBL2
15	Cyclin A/B1 associated events during G2/M transition Homo sapiens R-HSA-69273	1.3472342480881219E-15	6.230958397407563E-14	CCNA2;CCNB2;CCNB1;PKMYT1;FOXM1;CDC25C;CDC25A
15	Mitotic G2-G2/M phases Homo sapiens R-HSA-453274	5.2416857881966974E-14	1.939423741632778E-12	CCNA2;CCNB2;CCNB1;E2F1;MYBL2;HMMR;FOXM1;PKMYT1;CDC25C;CDC25A
15	Mitotic G1-G1/S phases Homo sapiens R-HSA-453279	3.0131531629142893E-13	9.290555585652391E-12	CCNA2;CDT1;CCNB1;CCNE1;E2F1;E2F2;MYBL2;PKMYT1;CDC25A
15	G2/M Transition Homo sapiens R-HSA-69275	2.6907574213008946E-12	7.111287470580935E-11	CCNA2;CCNB2;CCNB1;MYBL2;HMMR;FOXM1;PKMYT1;CDC25C;CDC25A
15	TP53 Regulates Transcription of Cell Cycle Genes Homo sapiens R-HSA-6791312	7.85417043006692E-11	1.8162769119529752E-9	CCNA2;CCNB1;CCNE1;E2F1;CDC25C;E2F7
15	Cell Cycle Checkpoints Homo sapiens R-HSA-69620	1.9874353998629634E-10	4.085283877496092E-9	CDC20;CCNA2;CCNB2;CCNB1;CCNE1;PKMYT1;CDC25C;CDC25A
15	G1/S Transition Homo sapiens R-HSA-69206	2.6143292311066597E-10	4.677825417597172E-9	CCNA2;CDT1;CCNB1;CCNE1;E2F1;PKMYT1;CDC25A
15	G0 and Early G1 Homo sapiens R-HSA-1538133	2.781409707760481E-10	4.677825417597172E-9	CCNA2;CCNE1;E2F1;MYBL2;CDC25A
15	E2F mediated regulation of DNA replication Homo sapiens R-HSA-113510	1.2321931561146552E-9	1.89963111567676E-8	CDT1;CCNB1;CCNE1;E2F1;CDC25A
15	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Homo sapiens R-HSA-6804116	2.9121206035881377E-9	4.1441716281831185E-8	CCNA2;CCNE1;E2F1;E2F7
15	G1/S-Specific Transcription Homo sapiens R-HSA-69205	9.653432274050774E-9	1.275632121928138E-7	CDT1;CCNE1;E2F1;CDC25A
15	Cyclin B2 mediated events Homo sapiens R-HSA-157881	3.038857528973556E-8	3.5136790178756743E-7	CCNB2;CDC25C;CDC25A
15	G2/M DNA replication checkpoint Homo sapiens R-HSA-69478	3.038857528973556E-8	3.5136790178756743E-7	CCNB2;CCNB1;PKMYT1
15	Association of licensing factors with the pre-replicative complex Homo sapiens R-HSA-69298	1.368820740245418E-6	1.489599040855308E-5	CDT1;E2F1;E2F2
15	G2/M Checkpoints Homo sapiens R-HSA-69481	2.7187426681573077E-6	2.7942632978283443E-5	CCNB2;CCNB1;PKMYT1;CDC25C;CDC25A
15	Cyclin E associated events during G1/S transition Homo sapiens R-HSA-69202	3.132721179505126E-6	3.050281148465517E-5	CCNA2;CCNE1;PKMYT1;CDC25A
15	Regulation of DNA replication Homo sapiens R-HSA-69304	4.641598921588559E-6	4.293479002469417E-5	CCNA2;CDT1;E2F1;E2F2
15	Transcriptional Regulation by TP53 Homo sapiens R-HSA-3700989	1.1090052835901934E-5	9.769808450675515E-5	CCNA2;CCNB1;CCNE1;E2F1;CDC25C;E2F7
15	Resolution of Sister Chromatid Cohesion Homo sapiens R-HSA-2500257	1.4021132937600505E-5	1.179049815207315E-4	CDC20;CCNB2;CCNB1;NDC80
15	DNA Replication Homo sapiens R-HSA-69306	1.7694107271212756E-5	1.4106172786129725E-4	CCNA2;CDT1;E2F1;E2F2
15	Generic Transcription Pathway Homo sapiens R-HSA-212436	1.8835009953224868E-5	1.4106172786129725E-4	TEAD4;CCNA2;CCNB1;NOTCH1;CCNE1;E2F1;CDC25C;E2F7
15	Mitotic Prometaphase Homo sapiens R-HSA-68877	1.906239565693206E-5	1.4106172786129725E-4	CDC20;CCNB2;CCNB1;NDC80
15	S Phase Homo sapiens R-HSA-69242	3.404536817554152E-5	2.2494261115982788E-4	CCNA2;CDT1;CCNE1;CDC25A
15	Cellular Senescence Homo sapiens R-HSA-2559583	9.416140358294387E-5	5.443706144638942E-4	CCNA2;CCNE1;E2F1;E2F2
15	G1/S DNA Damage Checkpoints Homo sapiens R-HSA-69615	1.2492821606665156E-4	6.419922214536261E-4	CCNA2;CCNE1;CDC25A
15	Assembly of the pre-replicative complex Homo sapiens R-HSA-68867	1.3673529054239328E-4	6.836764527119665E-4	CDT1;E2F1;E2F2
15	Cyclin A:Cdk2-associated events at S phase entry Homo sapiens R-HSA-69656	1.492461826251745E-4	7.079626611706995E-4	CCNA2;CCNE1;CDC25A
15	APC/C:Cdc20 mediated degradation of mitotic proteins Homo sapiens R-HSA-176409	1.8372253598191246E-4	8.420650822193454E-4	CDC20;CCNA2;CCNB1
15	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Homo sapiens R-HSA-176814	1.9118429543333874E-4	8.420650822193454E-4	CDC20;CCNA2;CCNB1
15	Regulation of APC/C activators between G1/S and early anaphase Homo sapiens R-HSA-176408	2.229938888345761E-4	9.07401506598517E-4	CDC20;CCNA2;CCNB1
15	DNA Replication Pre-Initiation Homo sapiens R-HSA-69002	2.4897322259531435E-4	9.595842954194407E-4	CDT1;E2F1;E2F2
15	M/G1 Transition Homo sapiens R-HSA-68874	2.4897322259531435E-4	9.595842954194407E-4	CDT1;E2F1;E2F2
15	APC/C-mediated degradation of cell cycle proteins Homo sapiens R-HSA-174143	2.768365480614746E-4	0.001024295227827456	CDC20;CCNA2;CCNB1
15	Regulation of mitotic cell cycle Homo sapiens R-HSA-453276	2.768365480614746E-4	0.001024295227827456	CDC20;CCNA2;CCNB1
15	Gene Expression Homo sapiens R-HSA-74160	4.611345819904699E-4	0.0016405749551584024	TEAD4;CCNA2;CCNB1;NOTCH1;CCNE1;WDR18;E2F1;CDC25C;E2F7
15	M Phase Homo sapiens R-HSA-68886	6.566357697279698E-4	0.002249585507401378	CDC20;CCNB2;CCNB1;NDC80
15	Signaling by NOTCH Homo sapiens R-HSA-157118	7.971561739033456E-4	0.0026813434940385263	JAG2;NOTCH1;E2F1
15	Cellular responses to stress Homo sapiens R-HSA-2262752	0.002096080413269802	0.006155156769125608	CCNA2;CCNE1;E2F1;E2F2
15	RHO GTPase Effectors Homo sapiens R-HSA-195258	0.006449419162720483	0.01437521138678662	CDC20;CDC25C;NDC80
15	Signaling by Rho GTPases Homo sapiens R-HSA-194315	0.017245125328038614	0.03158760579888261	CDC20;CDC25C;NDC80
15	Signal Transduction Homo sapiens R-HSA-162582	0.06805448076687834	0.09486061405563491	CDC20;JAG2;NOTCH1;CCNE1;E2F1;CDC25C;NDC80
15	Metabolism Homo sapiens R-HSA-1430728	0.5554766674075969	0.5709065748355857	TEAD4;HMMR;TK1
15	Cyclins and Cell Cycle Regulation Homo sapiens h cellcyclePathway	3.569365942328552E-8	7.495668478889959E-7	CCNB1;CCNE1;E2F1;CDC25A
15	Cell Cycle: G1/S Check Point Homo sapiens h g1Pathway	7.735344501697224E-6	8.122111726782085E-5	CCNE1;E2F1;CDC25A
15	IL-2 Receptor Beta Chain in T cell Activation Homo sapiens h il2rbPathway	5.355353443650065E-5	3.7487474105550453E-4	CCNB1;CCNE1;E2F1
16	mitotic cell cycle (GO:0000278)	5.363383778966728E-10	1.9415449279859554E-7	GINS1;GINS2;ORC6;ORC1;PLK1;CDC7;MCM10;SKA1
16	DNA replication (GO:0006260)	6.782203659787625E-9	1.2275788624215601E-6	GINS2;ORC6;ORC1;CDC7;MCM10;CLSPN
16	mitotic cell cycle phase transition (GO:0044772)	2.65396762671939E-6	2.531912976717398E-4	ORC6;ORC1;PLK1;CDC7;MCM10
16	cell cycle phase transition (GO:0044770)	2.7976938969253015E-6	2.531912976717398E-4	ORC6;ORC1;PLK1;CDC7;MCM10
16	cell cycle G1/S phase transition (GO:0044843)	7.065912564612966E-6	4.263100580649823E-4	ORC6;ORC1;CDC7;MCM10
16	G1/S transition of mitotic cell cycle (GO:0000082)	7.065912564612966E-6	4.263100580649823E-4	ORC6;ORC1;CDC7;MCM10
16	positive regulation of cell cycle process (GO:0090068)	3.029990489501328E-5	0.001566937938856401	MED1;PLK1;CDC7;GTSE1
16	regulation of cell cycle process (GO:0010564)	3.8384111658690524E-5	0.0017368810525557462	MED1;PLK1;CDC7;CLSPN;GTSE1
16	regulation of mitotic cell cycle phase transition (GO:1901990)	5.06861610043424E-5	0.002004212861767138	PLK1;CDC7;CLSPN;GTSE1
16	chromosome segregation (GO:0007059)	5.536499618141265E-5	0.002004212861767138	SPAG5;PLK1;SKA1
16	regulation of cell cycle phase transition (GO:1901987)	6.168437888351942E-5	0.002029976832348548	PLK1;CDC7;CLSPN;GTSE1
16	positive regulation of cell cycle (GO:0045787)	7.538089293027666E-5	0.002273990270063346	MED1;PLK1;CDC7;GTSE1
16	cell division (GO:0051301)	1.7460923476053026E-4	0.00421390286555413	SPAG5;CDC7;SKA1
16	regulation of mitotic cell cycle (GO:0007346)	2.797873827185E-4	0.006330189534006062	PLK1;CDC7;CLSPN;GTSE1
16	negative regulation of mitotic cell cycle phase transition (GO:1901991)	5.363288156403564E-4	0.008441349185296045	PLK1;CLSPN;GTSE1
16	negative regulation of cell cycle phase transition (GO:1901988)	6.040394207294829E-4	0.008746490812162912	PLK1;CLSPN;GTSE1
16	negative regulation of mitotic cell cycle (GO:0045930)	7.862135797940089E-4	0.010946512149439662	PLK1;CLSPN;GTSE1
16	negative regulation of cell cycle process (GO:0010948)	0.0012065495831392787	0.016176701818385885	PLK1;CLSPN;GTSE1
16	negative regulation of cell cycle (GO:0045786)	0.005362524875422807	0.05246578391629882	PLK1;CLSPN;GTSE1
16	microtubule-based process (GO:0007017)	0.005608647741434197	0.05342974953682051	SPAG5;PLK1;GTSE1
16	Cell cycle Homo sapiens hsa04110	3.1468863895468516E-6	2.2028204726827962E-5	ORC6;ORC1;PLK1;CDC7
16	Cell Cycle Homo sapiens R-HSA-1640170	4.954898434455427E-12	5.252192340522753E-10	GINS1;GINS2;ORC6;ORC1;PLK1;CDC7;MCM10;CLSPN;GTSE1;SKA1
16	Cell Cycle, Mitotic Homo sapiens R-HSA-69278	3.5756596737663405E-11	1.8950996270961605E-9	GINS1;GINS2;ORC6;ORC1;PLK1;CDC7;MCM10;GTSE1;SKA1
16	Activation of ATR in response to replication stress Homo sapiens R-HSA-176187	9.956742714010659E-11	3.5180490922837664E-9	ORC6;ORC1;CDC7;MCM10;CLSPN
16	DNA Replication Homo sapiens R-HSA-69306	2.139393153087557E-10	5.669391855682026E-9	GINS1;GINS2;ORC6;ORC1;CDC7;MCM10
16	G2/M Checkpoints Homo sapiens R-HSA-69481	1.8605845258372106E-9	3.9444391947748865E-8	ORC6;ORC1;CDC7;MCM10;CLSPN;GTSE1
16	Cell Cycle Checkpoints Homo sapiens R-HSA-69620	5.953322022158057E-9	1.0517535572479236E-7	ORC6;ORC1;CDC7;MCM10;CLSPN;GTSE1
16	Activation of the pre-replicative complex Homo sapiens R-HSA-68962	9.653432274050774E-9	1.4618054586419743E-7	ORC6;ORC1;CDC7;MCM10
16	DNA Replication Pre-Initiation Homo sapiens R-HSA-69002	5.996857535784158E-7	7.062965542145786E-6	ORC6;ORC1;CDC7;MCM10
16	M/G1 Transition Homo sapiens R-HSA-68874	5.996857535784158E-7	7.062965542145786E-6	ORC6;ORC1;CDC7;MCM10
16	Synthesis of DNA Homo sapiens R-HSA-69239	1.1787217874989481E-6	1.249445094748885E-5	GINS1;GINS2;ORC6;ORC1
16	G1/S Transition Homo sapiens R-HSA-69206	2.096449705587833E-6	2.0202151708391845E-5	ORC6;ORC1;CDC7;MCM10
16	S Phase Homo sapiens R-HSA-69242	3.1468863895468516E-6	2.7797496440997192E-5	GINS1;GINS2;ORC6;ORC1
16	Mitotic G1-G1/S phases Homo sapiens R-HSA-453279	4.544876498222592E-6	3.7058223754738055E-5	ORC6;ORC1;CDC7;MCM10
16	Removal of licensing factors from origins Homo sapiens R-HSA-69300	2.9336526015324558E-5	2.019151566416155E-4	ORC6;ORC1;MCM10
16	Regulation of DNA replication Homo sapiens R-HSA-69304	3.316283417354235E-5	2.067800248467935E-4	ORC6;ORC1;MCM10
16	Organelle biogenesis and maintenance Homo sapiens R-HSA-1852241	0.0024626180169185024	0.009668055918272639	MED1;PLK1;MRPL12
22	glycolytic process (GO:0006096)	9.932881677176064E-9	1.7879187018916915E-7	LDHA;PFKFB4;PFKFB3
22	pyruvate metabolic process (GO:0006090)	4.286679719818701E-8	3.858011747836831E-7	LDHA;PFKFB4;PFKFB3
22	single-organism carbohydrate catabolic process (GO:0044724)	1.7560808157589119E-7	9.47870368535238E-7	LDHA;PFKFB4;PFKFB3
22	carbohydrate catabolic process (GO:0016052)	2.1063785967449734E-7	9.47870368535238E-7	LDHA;PFKFB4;PFKFB3
22	cellular carbohydrate metabolic process (GO:0044262)	5.51375608783252E-7	1.984952191619707E-6	LDHA;PFKFB4;PFKFB3
22	generation of precursor metabolites and energy (GO:0006091)	6.539692835817004E-6	1.4714308880588258E-5	LDHA;PFKFB4;PFKFB3
22	monocarboxylic acid metabolic process (GO:0032787)	1.3145377008683472E-5	2.6290754017366943E-5	LDHA;PFKFB4;PFKFB3
22	Metabolism Homo sapiens R-HSA-1430728	8.669954642734368E-4	0.0015172420624785144	LDHA;PFKFB4;PFKFB3

Weighted Gene Ranking

In this table the genes are ordered by their combined rank score which is a normalised score with the following contributions:

• Betweeness: 10%
• Citation score: 20%
• Degree centrality: 30%
• Druggability: 40%

Ordered by Combined Rank Score

external_gene_name	uniprot_gn_id	cluster	betweenness	degree_centrality	file_id	ID	pocket	druggability	num_drug_pockets	struct_score	logFC	regulation	citation_score	combined_score
H2BC13	Q99880	2	1475	19	AF-Q99880-F1-model_v4	Q99880-F1	0.414	0.944	2	87.44870	1.723938	up_reg	0	0.6857062
H2BC15	Q99877	2	1247	18	AF-Q99877-F1-model_v4	Q99877-F1	0.313	0.935	1	87.69131	1.134114	up_reg	0	0.6641865
H2BC6	P62807	2	4200	13	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.513907	up_reg	0	0.6090820
H2BC7	P62807	2	2530	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.650740	up_reg	0	0.5832375
H2BC10	P62807	2	288	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.200574	up_reg	0	0.5709161
H2BC14	Q99879	2	766	14	AF-Q99879-F1-model_v4	Q99879-F1	0.365	0.888	2	86.12243	1.594661	up_reg	1	0.5630336
H2BC8	P62807	2	801	12	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.316050	up_reg	1	0.5606927
H2BC3	P33778	2	269	11	AF-P33778-F1-model_v4	P33778-F1	0.423	0.941	2	87.64271	1.429227	up_reg	2	0.5238728
H2BC4	P62807	2	213	9	AF-P62807-F1-model_v4	P62807-F1	0.291	0.965	1	87.82973	1.124252	up_reg	0	0.5205039
H2BC17	P23527	2	260	9	AF-P23527-F1-model_v4	P23527-F1	0.371	0.957	2	88.00099	1.844521	up_reg	0	0.5175622
RARA	P10276	2	5107	16	AF-P10276-F1-model_v4	P10276-F1	0.362	0.958	1	79.41892	1.490980	up_reg	4411	0.5033553
NR5A2	O00482	2	5443	14	AF-O00482-F1-model_v4	O00482-F1	0.203	0.936	2	72.86144	1.943734	up_reg	569	0.5015759
H2BC12	O60814	2	20	10	AF-O60814-F1-model_v4	O60814-F1	0.241	0.937	1	88.05779	1.128966	up_reg	3	0.4988244
H2BC11	P06899	2	233	10	AF-P06899-F1-model_v4	P06899-F1	0.250	0.870	2	85.69804	1.482316	up_reg	1	0.4862378
CENPI	Q92674	2	1240	10	AF-Q92674-F1-model_v4	Q92674-F1	0.058	0.915	3	72.79816	1.176172	up_reg	68	0.4431428
H2BC18	Q5QNW6	2	34	7	AF-Q5QNW6-F1-model_v4	Q5QNW6-F1	0.422	0.825	2	87.95688	1.297057	up_reg	0	0.4301869
H3C1	P68431	2	1350	12	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.099690	up_reg	5	0.4062376
ORC1	Q13415	2	15590	8	AF-Q13415-F1-model_v4	Q13415-F1	0.154	0.765	1	67.97461	1.802587	up_reg	378	0.3966200
PLK1	P53350	2	2733	10	AF-P53350-F1-model_v4	P53350-F1	0.175	0.953	2	85.16989	1.603519	up_reg	3003	0.3955413
PHF19	Q5T6S3	2	430	11	AF-Q5T6S3-F1-model_v4	Q5T6S3-F1	0.257	0.765	1	69.88708	1.211096	up_reg	70	0.3948203
H3C12	P68431	2	4161	8	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	2.005020	up_reg	0	0.3887343
H4C1	P62805	2	847	10	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.351587	up_reg	1	0.3740121
CDK1	P06493	2	18044	16	AF-P06493-F1-model_v4	P06493-F1	0.514	0.471	1	89.31551	1.580437	up_reg	6002	0.3738591
TOP2A	P11388	2	1844	9	AF-P11388-F1-model_v4	P11388-F1	0.045	0.897	1	76.40832	2.033427	up_reg	1351	0.3666115
UBE2S	Q16763	2	18196	9	AF-Q16763-F1-model_v4	Q16763-F1	0.168	0.552	1	81.85029	2.280124	up_reg	119	0.3640486
WDR76	Q9H967	2	4995	4	AF-Q9H967-F1-model_v4	Q9H967-F1	0.272	0.861	1	75.38044	1.087175	up_reg	22	0.3628515
RAC3	P60763	2	2787	5	AF-P60763-F1-model_v4	P60763-F1	0.341	0.937	1	93.83371	1.213210	up_reg	301	0.3493319
CCNB1	P14635	2	2056	13	AF-P14635-F1-model_v4	P14635-F1	0.078	0.699	1	77.77241	1.801033	up_reg	2303	0.3452128
SPAG5	Q96R06	2	1766	5	AF-Q96R06-F1-model_v4	Q96R06-F1	0.223	0.887	2	63.81311	1.534844	up_reg	127	0.3398729
H2AC14	Q99878	2	5614	14	AF-Q99878-F1-model_v4	Q99878-F1	0.443	0.230	0	91.90550	1.611322	up_reg	0	0.3395196
H3C10	P68431	2	497	6	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.831417	up_reg	0	0.3352647
CD9	P21926	3	194	6	AF-P21926-F1-model_v4	P21926-F1	0.063	0.994	1	88.11915	1.203438	up_reg	2729	0.3331208
ABCA2	Q9BZC7	2	3430	2	AF-Q9BZC7-F1-model_v4	Q9BZC7-F1	0.258	0.976	5	72.33891	1.262028	up_reg	138	0.3330665
DNAH3	Q8TD57	7	0	1	AF-Q8TD57-F4-model_v4	Q8TD57-F4	0.164	0.960	4	85.66639	2.305663	up_reg	16	0.3306883
KIF20B	Q96Q89	2	0	2	AF-Q96Q89-F1-model_v4	Q96Q89-F1	0.232	0.971	4	63.74834	1.021659	up_reg	57	0.3286626
FZD7	O75084	2	776	4	AF-O75084-F1-model_v4	O75084-F1	0.435	0.953	3	84.14906	1.548584	up_reg	390	0.3231533
SPTBN5	Q9NRC6	2	0	1	AF-Q9NRC6-F9-model_v4	Q9NRC6-F9	0.088	0.942	1	80.58407	1.859882	up_reg	17	0.3224128
H2BC21	Q16778	2	1	6	AF-Q16778-F1-model_v4	Q16778-F1	0.458	0.645	2	88.04314	1.311310	up_reg	2	0.3206666
KIF11	P52732	2	48	4	AF-P52732-F1-model_v4	P52732-F1	0.141	0.991	1	74.76864	1.239185	up_reg	827	0.3202342
SPAG4	Q9NPE6	2	0	1	AF-Q9NPE6-F1-model_v4	Q9NPE6-F1	0.378	0.975	1	71.56424	1.521158	up_reg	51	0.3156507
ASPM	Q8IZT6	2	639	4	AF-Q8IZT6-F10-model_v4	Q8IZT6-F10	0.434	0.949	4	62.64048	1.477836	up_reg	518	0.3154716
MUC17	Q685J3	3	0	1	AF-Q685J3-F5-model_v4	Q685J3-F5	0.317	1.000	7	50.38741	2.932704	up_reg	99	0.3133459
DNAH7	Q8WXX0	7	0	1	AF-Q8WXX0-F5-model_v4	Q8WXX0-F5	0.424	0.921	2	88.31141	1.516270	up_reg	21	0.3102368
KIF20A	O95235	2	1070	6	AF-O95235-F1-model_v4	O95235-F1	0.333	0.814	3	67.30456	1.472619	up_reg	306	0.3070534
POLD1	P28340	2	1287	5	AF-P28340-F1-model_v4	P28340-F1	0.097	0.843	2	86.95676	1.347636	up_reg	323	0.3021652
CENPA	P49450	2	1242	7	AF-P49450-F1-model_v4	P49450-F1	0.140	0.815	2	82.07836	1.774299	up_reg	1099	0.3010511
LAMA5	O15230	5	3	2	AF-O15230-F12-model_v4	O15230-F12	0.086	0.946	2	79.24314	2.198114	up_reg	155	0.3000616
MZT2A	Q6P582	2	260	2	AF-Q6P582-F1-model_v4	Q6P582-F1	0.264	0.788	1	65.50284	1.098928	up_reg	5	0.2995806
XPR1	Q9UBH6	2	0	1	AF-Q9UBH6-F1-model_v4	Q9UBH6-F1	0.207	0.993	3	83.73372	1.318176	up_reg	180	0.2993815
CENPH	Q9H3R5	2	858	8	AF-Q9H3R5-F1-model_v4	Q9H3R5-F1	0.285	0.649	1	83.39197	1.363394	up_reg	90	0.2961025
TTK	P33981	2	1031	4	AF-P33981-F1-model_v4	P33981-F1	0.087	0.956	1	63.95435	1.457472	up_reg	2071	0.2943767
FBLN2	P98095	8	0	1	AF-P98095-F1-model_v4	P98095-F1	0.228	0.938	1	67.61607	2.431256	up_reg	74	0.2939591
H4C4	P62805	2	81	8	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.036836	up_reg	19	0.2931420
CYBA	P13498	2	1284	3	AF-P13498-F1-model_v4	P13498-F1	0.480	0.957	1	77.02989	1.275871	up_reg	1045	0.2923625
BUB1B	O60566	2	521	5	AF-O60566-F1-model_v4	O60566-F1	0.211	0.846	2	64.72058	1.529523	up_reg	478	0.2917989
RECQL4	O94761	2	103	6	AF-O94761-F1-model_v4	O94761-F1	0.125	0.793	1	69.03096	2.366331	up_reg	335	0.2916406
DNAH9	Q9NYC9	2	0	1	AF-Q9NYC9-F12-model_v4	Q9NYC9-F12	0.087	0.930	2	85.79432	3.112720	up_reg	75	0.2905099
H3C11	P68431	2	481	4	AF-P68431-F1-model_v4	P68431-F1	0.351	0.623	1	87.28692	1.514423	up_reg	1	0.2888007
SLC27A2	O14975	4	0	1	AF-O14975-F1-model_v4	O14975-F1	0.206	0.925	1	92.73940	1.659103	up_reg	79	0.2875447
ATP1B3	P54709	2	3224	3	AF-P54709-F1-model_v4	P54709-F1	0.329	0.776	1	89.52136	1.755640	up_reg	52	0.2867437
CDC45	O75419	2	263	3	AF-O75419-F1-model_v4	O75419-F1	0.323	0.926	1	92.88743	1.483786	up_reg	603	0.2846846
CENPE	Q02224	2	0	1	AF-Q02224-F6-model_v4	Q02224-F6	0.135	0.997	5	72.55249	1.272231	up_reg	439	0.2842670
SLC19A3	Q9BZV2	3	0	1	AF-Q9BZV2-F1-model_v4	Q9BZV2-F1	0.137	0.955	2	82.16840	3.205348	up_reg	180	0.2841815
CENPF	P49454	2	0	3	AF-P49454-F7-model_v4	P49454-F7	0.122	0.906	1	71.41875	1.543658	up_reg	391	0.2833739
ITGB8	P26012	5	0	2	AF-P26012-F1-model_v4	P26012-F1	0.085	0.896	1	76.46707	1.652867	up_reg	134	0.2827656
TEAD4	Q15561	2	0	1	AF-Q15561-F1-model_v4	Q15561-F1	0.243	0.986	2	76.58312	1.597999	up_reg	388	0.2821852
CENPK	Q9BS16	2	0	8	AF-Q9BS16-F1-model_v4	Q9BS16-F1	0.253	0.599	1	81.70731	1.268209	up_reg	51	0.2819173
ANLN	Q9NQW6	2	1633	5	AF-Q9NQW6-F1-model_v4	Q9NQW6-F1	0.121	0.760	1	59.87419	1.600614	up_reg	232	0.2770706
MELK	Q14680	2	0	1	AF-Q14680-F1-model_v4	Q14680-F1	0.159	0.993	1	70.64372	1.755936	up_reg	669	0.2747545
ANPEP	P15144	3	76	2	AF-P15144-F1-model_v4	P15144-F1	0.232	0.886	1	93.75126	6.652030	up_reg	193	0.2723607
CCNA2	P20248	2	14369	7	AF-P20248-F1-model_v4	P20248-F1	0.256	0.547	2	74.74787	1.423933	up_reg	784	0.2723418
MCM6	Q14566	2	529	7	AF-Q14566-F1-model_v4	Q14566-F1	0.032	0.695	2	77.33923	1.041344	up_reg	384	0.2688869
KIF15	Q9NS87	2	10	2	AF-Q9NS87-F1-model_v4	Q9NS87-F1	0.241	0.869	1	72.02130	1.354129	up_reg	161	0.2685899
CENPM	Q9NSP4	2	464	9	AF-Q9NSP4-F1-model_v4	Q9NSP4-F1	0.181	0.514	1	89.76468	1.643556	up_reg	49	0.2678720
PDE3A	Q14432	2	0	1	AF-Q14432-F1-model_v4	Q14432-F1	0.272	0.945	3	61.48643	1.816074	up_reg	371	0.2666260
H4C13	P62805	2	4	3	AF-P62805-F1-model_v4	P62805-F1	0.336	0.581	1	90.43752	1.732810	up_reg	0	0.2657553
FABP1	P07148	2	0	1	AF-P07148-F1-model_v4	P07148-F1	-0.023	0.981	1	94.95010	7.464763	up_reg	900	0.2643805
PPFIA3	O75145	2	0	1	AF-O75145-F1-model_v4	O75145-F1	0.306	0.764	3	69.92988	2.010150	up_reg	8	0.2642555
DNA2	P51530	2	3554	5	AF-P51530-F1-model_v4	P51530-F1	0.216	0.741	2	87.56204	1.114640	up_reg	607	0.2619801
SLC1A5	Q15758	2	2988	2	AF-Q15758-F1-model_v4	Q15758-F1	0.051	0.866	2	79.59138	1.291235	up_reg	544	0.2609279
ESPL1	Q14674	2	0	1	AF-Q14674-F1-model_v4	Q14674-F1	0.619	0.885	1	75.77835	1.914072	up_reg	146	0.2600966
IL32	P24001	2	0	1	AF-P24001-F1-model_v4	P24001-F1	0.099	0.950	2	71.19002	1.544145	up_reg	628	0.2587428
HEPH	Q9BQS7	6	0	1	AF-Q9BQS7-F1-model_v4	Q9BQS7-F1	0.288	0.895	2	89.66272	1.676420	up_reg	201	0.2581160
CDC6	Q99741	2	2	2	AF-Q99741-F1-model_v4	Q99741-F1	0.244	0.922	2	69.83948	3.355449	up_reg	1062	0.2543469
NRCAM	Q92823	2	260	2	AF-Q92823-F1-model_v4	Q92823-F1	0.090	0.859	2	78.95628	3.487392	up_reg	325	0.2528053
SLC7A5	Q01650	2	260	3	AF-Q01650-F1-model_v4	Q01650-F1	0.097	0.862	2	86.24003	2.711656	up_reg	872	0.2521368
PRC1	O43663	2	0	1	AF-O43663-F1-model_v4	O43663-F1	0.226	0.975	2	80.11427	1.458330	up_reg	1534	0.2519554
PBK	Q96KB5	2	0	2	AF-Q96KB5-F1-model_v4	Q96KB5-F1	0.152	0.901	1	84.90700	1.610733	up_reg	788	0.2515449
ATP1A1	P05023	2	4150	3	AF-P05023-F1-model_v4	P05023-F1	0.200	0.787	1	88.69918	1.217536	up_reg	574	0.2513723
MCM4	P33991	2	366	7	AF-P33991-F1-model_v4	P33991-F1	0.217	0.658	3	73.74330	1.169478	up_reg	450	0.2502138
NEIL3	Q8TAT5	2	47	11	AF-Q8TAT5-F1-model_v4	Q8TAT5-F1	0.015	0.445	1	70.00855	1.452700	up_reg	153	0.2501462
HMMR	O75330	2	0	1	AF-O75330-F1-model_v4	O75330-F1	0.192	0.886	2	76.10490	1.783138	up_reg	255	0.2500581
H2AC8	P04908	2	5209	9	AF-P04908-F1-model_v4	P04908-F1	0.384	0.231	0	91.08903	1.236545	up_reg	1	0.2413178
RTKN	Q9BST9	16	0	1	AF-Q9BST9-F1-model_v4	Q9BST9-F1	0.115	0.793	1	72.73822	1.286409	up_reg	70	0.2369905
LMNB1	P20700	2	260	3	AF-P20700-F1-model_v4	P20700-F1	0.275	0.754	2	82.63466	1.294937	up_reg	202	0.2363852
WDR62	O43379	2	260	2	AF-O43379-F1-model_v4	O43379-F1	0.088	0.770	2	61.36502	1.688680	up_reg	124	0.2352427
MTTP	P55157	2	0	1	AF-P55157-F1-model_v4	P55157-F1	0.279	0.871	2	86.91982	3.185389	up_reg	434	0.2340821
H1-5	P16401	2	1287	5	AF-P16401-F1-model_v4	P16401-F1	0.282	0.629	1	64.55596	1.583736	up_reg	139	0.2323543
ABCD1	P33897	4	0	1	AF-P33897-F1-model_v4	P33897-F1	0.179	0.884	1	81.73405	1.260959	up_reg	675	0.2309868
TRAIP	Q9BWF2	2	0	1	AF-Q9BWF2-F1-model_v4	Q9BWF2-F1	0.303	0.770	1	74.95434	1.048263	up_reg	59	0.2309580
CHAF1B	Q13112	2	0	1	AF-Q13112-F1-model_v4	Q13112-F1	0.173	0.789	1	75.38529	1.009863	up_reg	92	0.2303115
SPTBN2	O15020	2	518	2	AF-O15020-F1-model_v4	O15020-F1	0.242	0.736	3	76.77521	2.161117	up_reg	98	0.2274485
PTGS1	P23219	2	0	1	AF-P23219-F1-model_v4	P23219-F1	0.142	0.943	1	94.11557	1.691682	up_reg	3045	0.2262603
RACGAP1	Q9H0H5	2	847	6	AF-Q9H0H5-F1-model_v4	Q9H0H5-F1	0.133	0.584	2	69.86318	1.059365	up_reg	177	0.2240842
PCDHGB1	Q9Y5G3	14	0	1	AF-Q9Y5G3-F1-model_v4	Q9Y5G3-F1	0.109	0.624	2	75.21973	3.070102	up_reg	3	0.2235145
ABCC2	Q92887	3	0	2	AF-Q92887-F1-model_v4	Q92887-F1	0.256	0.879	6	81.43685	1.508199	up_reg	2209	0.2233641
FZD2	Q14332	2	0	2	AF-Q14332-F1-model_v4	Q14332-F1	0.544	0.766	4	84.43777	1.655708	up_reg	255	0.2187248
PKMYT1	Q99640	2	280	3	AF-Q99640-F1-model_v4	Q99640-F1	0.142	0.674	1	75.59028	2.415277	up_reg	108	0.2161965
MZT2B	Q6NZ67	2	0	1	AF-Q6NZ67-F1-model_v4	Q6NZ67-F1	0.256	0.603	1	65.75364	1.516884	up_reg	3	0.2151145
H3C13	Q71DI3	2	6617	7	AF-Q71DI3-F1-model_v4	Q71DI3-F1	0.089	0.228	0	87.30418	2.440964	up_reg	1	0.2145224
PTGS2	P35354	2	260	2	AF-P35354-F1-model_v4	P35354-F1	0.262	0.987	1	93.32770	2.338946	up_reg	41309	0.2128956
KPNA2	P52292	2	400	3	AF-P52292-F1-model_v4	P52292-F1	0.024	0.711	1	86.10732	1.245351	up_reg	315	0.2116276
NCAPH	Q15003	2	260	2	AF-Q15003-F1-model_v4	Q15003-F1	0.198	0.683	1	60.71979	1.728427	up_reg	73	0.2103073
H2AC12	Q96KK5	2	0	8	AF-Q96KK5-F1-model_v4	Q96KK5-F1	0.413	0.233	0	91.90792	1.694176	up_reg	0	0.2098667
BRCA2	P51587	2	769	5	AF-P51587-F12-model_v4	P51587-F12	0.083	0.796	1	65.83808	1.000504	up_reg	14413	0.2091051
SHCBP1	Q8NEM2	2	0	1	AF-Q8NEM2-F1-model_v4	Q8NEM2-F1	0.180	0.711	1	73.69646	1.170171	up_reg	66	0.2052816
ITGA7	Q13683	5	4	3	AF-Q13683-F1-model_v4	Q13683-F1	0.119	0.684	2	79.47519	1.441251	up_reg	231	0.2044657
SKA3	Q8IX90	2	0	2	AF-Q8IX90-F1-model_v4	Q8IX90-F1	0.354	0.683	1	64.75869	1.526244	up_reg	99	0.2032126
MUC16	Q8WXI7	2	260	2	AF-Q8WXI7-F58-model_v4	Q8WXI7-F58	0.180	0.798	1	55.96839	4.631299	up_reg	1358	0.2015424
CENPW	Q5EE01	2	64	9	AF-Q5EE01-F1-model_v4	Q5EE01-F1	0.310	0.353	0	89.69919	1.259111	up_reg	61	0.1972260
AURKB	Q96GD4	2	0	2	AF-Q96GD4-F1-model_v4	Q96GD4-F1	0.060	0.789	2	79.85404	1.350410	up_reg	1380	0.1962114
SPC25	Q9HBM1	2	0	1	AF-Q9HBM1-F1-model_v4	Q9HBM1-F1	0.390	0.708	1	90.25548	1.320553	up_reg	108	0.1949243
MED1	Q15648	2	1287	8	AF-Q15648-F1-model_v4	Q15648-F1	0.111	0.507	1	51.29562	1.306109	up_reg	1104	0.1946798
RARRES1	P49788	9	0	1	AF-P49788-F1-model_v4	P49788-F1	0.423	0.702	3	79.94364	2.923580	up_reg	102	0.1935897
TGM2	P21980	2	0	1	AF-P21980-F1-model_v4	P21980-F1	0.245	0.781	1	92.78304	1.904023	up_reg	595	0.1921568
DLGAP5	Q15398	2	774	2	AF-Q15398-F1-model_v4	Q15398-F1	0.128	0.669	1	56.37102	1.477999	up_reg	184	0.1902905
POLQ	O75417	2	0	1	AF-O75417-F1-model_v4	O75417-F1	0.104	0.717	1	59.48627	1.691706	up_reg	186	0.1883678
FOXM1	Q08050	2	510	4	AF-Q08050-F1-model_v4	Q08050-F1	0.173	0.701	1	51.07629	1.648781	up_reg	2285	0.1876640
KIF1A	Q12756	2	2485	9	AF-Q12756-F1-model_v4	Q12756-F1	0.106	0.373	0	71.01825	2.921797	up_reg	354	0.1856963
GINS4	Q9BRT9	2	0	1	AF-Q9BRT9-F1-model_v4	Q9BRT9-F1	0.324	0.635	1	90.74832	1.344926	up_reg	38	0.1850639
CHEK1	O14757	2	260	3	AF-O14757-F1-model_v4	O14757-F1	0.067	0.732	1	78.13441	1.188158	up_reg	2110	0.1835220
NOTCH1	P46531	2	5773	6	AF-P46531-F1-model_v4	P46531-F1	0.203	0.600	2	57.49833	1.622551	up_reg	9140	0.1834420
FGFR4	P22455	2	0	1	AF-P22455-F1-model_v4	P22455-F1	0.145	0.792	3	74.61047	1.878331	up_reg	1205	0.1832943
XRCC2	O43543	2	0	3	AF-O43543-F1-model_v4	O43543-F1	0.516	0.659	1	87.09828	1.514626	up_reg	432	0.1827021
CIT	O14578	2	0	1	AF-O14578-F1-model_v4	O14578-F1	0.129	0.882	1	70.15278	1.119051	up_reg	8694	0.1821231
SLC2A1	P11166	12	0	1	AF-P11166-F1-model_v4	P11166-F1	0.190	0.839	1	89.61531	1.425517	up_reg	3575	0.1816418
KIF4A	O95239	2	0	2	AF-O95239-F1-model_v4	O95239-F1	0.244	0.668	3	72.17122	1.626611	up_reg	229	0.1815400
GPC1	P35052	2	1028	2	AF-P35052-F1-model_v4	P35052-F1	0.159	0.659	1	82.89746	2.018276	up_reg	268	0.1806423
FANCB	Q8NB91	2	0	1	AF-Q8NB91-F1-model_v4	Q8NB91-F1	0.127	0.662	3	71.98628	1.300126	up_reg	87	0.1805513
LGR5	O75473	3	22	2	AF-O75473-F1-model_v4	O75473-F1	0.267	0.766	4	80.74472	3.555059	up_reg	2038	0.1798003
KIF14	Q15058	2	861	5	AF-Q15058-F1-model_v4	Q15058-F1	0.127	0.506	1	66.04636	1.571041	up_reg	164	0.1777215
CDCA8	Q53HL2	2	260	6	AF-Q53HL2-F1-model_v4	Q53HL2-F1	0.388	0.483	1	68.78919	1.145697	up_reg	210	0.1772579
BCAM	P50895	5	0	1	AF-P50895-F1-model_v4	P50895-F1	0.182	0.725	3	84.58449	2.892853	up_reg	431	0.1758123
CLDN15	P56746	3	60	4	AF-P56746-F1-model_v4	P56746-F1	0.406	0.485	1	81.81001	1.946830	up_reg	38	0.1753936
PFKFB3	Q16875	11	1	2	AF-Q16875-F1-model_v4	Q16875-F1	0.182	0.700	1	87.13527	1.551414	up_reg	668	0.1742548
PDZK1	Q5T2W1	3	44	4	AF-Q5T2W1-F1-model_v4	Q5T2W1-F1	0.169	0.577	2	78.65569	2.855962	up_reg	291	0.1742241
H2AC21	Q8IUE6	2	777	7	AF-Q8IUE6-F1-model_v4	Q8IUE6-F1	0.379	0.174	0	91.07137	1.668757	up_reg	0	0.1738702
CDC25C	P30307	2	0	1	AF-P30307-F1-model_v4	P30307-F1	0.362	0.777	1	64.18249	1.552450	up_reg	1464	0.1736336
ERBB2	P04626	2	4747	8	AF-P04626-F1-model_v4	P04626-F1	0.179	0.572	1	74.90918	2.810506	up_reg	37036	0.1736094
KIF2C	Q99661	2	1267	4	AF-Q99661-F1-model_v4	Q99661-F1	0.070	0.558	2	74.65762	1.874636	up_reg	302	0.1726495
TRIP13	Q15645	2	0	1	AF-Q15645-F1-model_v4	Q15645-F1	0.249	0.677	2	86.97940	1.912157	up_reg	205	0.1705470
RAD54L	Q92698	2	0	1	AF-Q92698-F1-model_v4	Q92698-F1	0.171	0.669	1	80.51223	1.511108	up_reg	181	0.1696778
CLDN3	O15551	3	1	3	AF-O15551-F1-model_v4	O15551-F1	0.271	0.631	1	81.42759	4.740731	up_reg	487	0.1692576
DSCC1	Q9BVC3	2	0	1	AF-Q9BVC3-F1-model_v4	Q9BVC3-F1	0.206	0.558	1	92.16572	1.280364	up_reg	21	0.1650368
CBX2	Q14781	2	4	8	AF-Q14781-F1-model_v4	Q14781-F1	0.412	0.367	0	57.18264	2.495511	up_reg	194	0.1642682
ABCC4	O15439	3	57	2	AF-O15439-F1-model_v4	O15439-F1	0.139	0.684	3	83.59147	1.197058	up_reg	845	0.1637456
NEK2	P51955	2	0	2	AF-P51955-F1-model_v4	P51955-F1	0.136	0.658	2	78.74819	1.921272	up_reg	497	0.1630037
MME	P08473	3	112	2	AF-P08473-F1-model_v4	P08473-F1	0.377	0.727	3	96.22472	2.634423	up_reg	2311	0.1623306
NRARP	Q7Z6K4	2	0	1	AF-Q7Z6K4-F1-model_v4	Q7Z6K4-F1	0.142	0.584	1	82.92880	1.755765	up_reg	46	0.1611530
STIL	Q15468	2	0	1	AF-Q15468-F1-model_v4	Q15468-F1	0.163	0.693	1	53.64950	1.037125	up_reg	476	0.1611477
FANCA	O15360	2	0	1	AF-O15360-F1-model_v4	O15360-F1	0.135	0.707	1	74.56587	1.028733	up_reg	697	0.1595842
TPX2	Q9ULW0	2	518	2	AF-Q9ULW0-F1-model_v4	Q9ULW0-F1	0.402	0.656	1	64.23851	1.659036	up_reg	689	0.1589145
IQGAP3	Q86VI3	2	0	1	AF-Q86VI3-F1-model_v4	Q86VI3-F1	0.181	0.604	2	79.62675	1.151973	up_reg	86	0.1575664
NCAPG	Q9BPX3	2	0	1	AF-Q9BPX3-F1-model_v4	Q9BPX3-F1	0.163	0.655	1	82.50230	1.672671	up_reg	258	0.1574389
GPI	P06744	2	260	2	AF-P06744-F1-model_v4	P06744-F1	0.383	0.816	2	97.84077	1.548803	up_reg	20988	0.1572365
BAMBI	Q13145	2	130	2	AF-Q13145-F1-model_v4	Q13145-F1	0.346	0.648	1	64.85375	1.519035	up_reg	578	0.1568824
PODXL	O00592	3	0	1	AF-O00592-F1-model_v4	O00592-F1	0.288	0.644	1	53.92824	1.533310	up_reg	212	0.1567182
NUSAP1	Q9BXS6	2	257	2	AF-Q9BXS6-F1-model_v4	Q9BXS6-F1	0.144	0.583	1	63.08720	1.230911	up_reg	186	0.1528469
MCM10	Q7L590	2	412	3	AF-Q7L590-F1-model_v4	Q7L590-F1	0.080	0.549	2	66.88891	1.989976	up_reg	234	0.1524662
CHTF18	Q8WVB6	2	260	2	AF-Q8WVB6-F1-model_v4	Q8WVB6-F1	0.162	0.470	1	64.97510	1.599515	up_reg	19	0.1497258
CDH24	Q86UP0	2	260	2	AF-Q86UP0-F1-model_v4	Q86UP0-F1	0.296	0.432	1	76.24933	1.247597	up_reg	8	0.1495511
PFKFB4	Q16877	11	0	1	AF-Q16877-F1-model_v4	Q16877-F1	0.267	0.607	1	92.10892	1.207471	up_reg	142	0.1494157
NUF2	Q9BZD4	2	0	1	AF-Q9BZD4-F1-model_v4	Q9BZD4-F1	0.317	0.622	2	89.42833	1.255478	up_reg	201	0.1489160
PCDHGA5	Q9Y5G8	13	0	1	AF-Q9Y5G8-F1-model_v4	Q9Y5G8-F1	0.102	0.371	0	75.39293	1.810726	up_reg	0	0.1484000
DBN1	Q16643	2	147	2	AF-Q16643-F1-model_v4	Q16643-F1	0.135	0.507	1	63.03875	1.667269	up_reg	49	0.1466632
MRPL12	P52815	2	0	1	AF-P52815-F1-model_v4	P52815-F1	0.472	0.530	1	69.51532	1.804467	up_reg	36	0.1440545
ATAD2	Q6PL18	2	0	3	AF-Q6PL18-F1-model_v4	Q6PL18-F1	0.186	0.513	1	62.52127	1.359788	up_reg	168	0.1420056
PTTG1	O95997	2	726	4	AF-O95997-F1-model_v4	O95997-F1	0.339	0.504	1	64.54399	1.771144	up_reg	440	0.1410142
ERCC6L	Q2NKX8	2	0	1	AF-Q2NKX8-F1-model_v4	Q2NKX8-F1	0.048	0.546	1	62.79458	1.585961	up_reg	64	0.1398518
PHLDA1	Q8WV24	2	0	1	AF-Q8WV24-F1-model_v4	Q8WV24-F1	0.396	0.593	1	62.40043	1.124484	up_reg	193	0.1380763
MYBL2	P10244	2	0	1	AF-P10244-F1-model_v4	P10244-F1	0.066	0.633	1	58.45051	2.299187	up_reg	483	0.1368736
SEMA6A	Q9H2E6	15	0	1	AF-Q9H2E6-F1-model_v4	Q9H2E6-F1	0.163	0.564	1	70.78297	2.534740	up_reg	133	0.1334388
LDHA	P00338	11	0	1	AF-P00338-F1-model_v4	P00338-F1	0.089	0.690	1	96.06050	1.071241	up_reg	2265	0.1306265
E2F8	A0AVK6	2	0	1	AF-A0AVK6-F1-model_v4	A0AVK6-F1	0.140	0.562	1	53.69316	1.322877	up_reg	153	0.1300212
NDC80	O14777	2	606	3	AF-O14777-F1-model_v4	O14777-F1	0.161	0.532	2	78.60958	1.647925	up_reg	596	0.1291890
BCL6	P41182	2	260	2	AF-P41182-F1-model_v4	P41182-F1	0.071	0.668	1	50.10971	1.124834	up_reg	4242	0.1281192
EXO1	Q9UQ84	2	251	3	AF-Q9UQ84-F1-model_v4	Q9UQ84-F1	0.203	0.552	1	63.63935	1.723281	up_reg	931	0.1268568
RAD51	Q06609	2	19	3	AF-Q06609-F1-model_v4	Q06609-F1	0.282	0.640	1	91.59067	1.172608	up_reg	5877	0.1261282
TMOD1	P28289	2	774	2	AF-P28289-F1-model_v4	P28289-F1	0.096	0.499	1	84.79803	2.356395	up_reg	153	0.1257416
OIP5	O43482	2	260	7	AF-O43482-F1-model_v4	O43482-F1	0.193	0.324	0	76.32641	1.591730	up_reg	272	0.1254772
RPL19	P84098	2	519	4	AF-P84098-F1-model_v4	P84098-F1	0.402	0.406	1	94.64079	1.191137	up_reg	131	0.1233741
FAM83D	Q9H4H8	2	0	2	AF-Q9H4H8-F1-model_v4	Q9H4H8-F1	0.140	0.459	1	64.42717	1.177234	up_reg	60	0.1229136
PRAME	P78395	2	0	1	AF-P78395-F1-model_v4	P78395-F1	0.372	0.605	1	81.57775	2.811976	up_reg	566	0.1226954
CLSPN	Q9HAW4	2	776	6	AF-Q9HAW4-F1-model_v4	Q9HAW4-F1	0.285	0.322	0	51.81036	1.270376	up_reg	151	0.1218652
PCDHGB2	Q9Y5G2	14	0	1	AF-Q9Y5G2-F1-model_v4	Q9Y5G2-F1	0.338	0.351	0	75.75001	1.612896	up_reg	2	0.1197277
KIF23	Q02241	2	0	2	AF-Q02241-F1-model_v4	Q02241-F1	0.314	0.498	1	73.07353	1.531319	up_reg	207	0.1154318
TK1	P04183	2	12	2	AF-P04183-F1-model_v4	P04183-F1	0.284	0.554	2	82.30998	1.559659	up_reg	784	0.1129065
DEPDC1B	Q8WUY9	2	0	1	AF-Q8WUY9-F1-model_v4	Q8WUY9-F1	0.107	0.469	1	77.36351	2.451811	up_reg	55	0.1118562
H2AX	P16104	2	5479	14	AF-P16104-F1-model_v4	P16104-F1	0.328	0.078	0	87.32992	1.814395	up_reg	7263	0.1106844
AURKA	O14965	2	260	6	AF-O14965-F1-model_v4	O14965-F1	0.139	0.431	1	75.90579	1.275528	up_reg	2494	0.1099772
KIF18B	Q86Y91	2	0	2	AF-Q86Y91-F1-model_v4	Q86Y91-F1	0.200	0.437	1	62.74387	1.922124	up_reg	78	0.1092481
TONSL	Q96HA7	2	21	4	AF-Q96HA7-F1-model_v4	Q96HA7-F1	0.187	0.335	0	76.48871	1.661091	up_reg	54	0.1087106
CCNE2	O96020	2	0	1	AF-O96020-F1-model_v4	O96020-F1	0.296	0.527	1	77.76399	1.400035	up_reg	308	0.1029175
KRT15	P19012	10	0	1	AF-P19012-F1-model_v4	P19012-F1	0.359	0.513	1	77.14245	2.098460	up_reg	232	0.1026295
BLM	P54132	2	0	2	AF-P54132-F1-model_v4	P54132-F1	0.161	0.616	1	60.95775	1.054300	up_reg	5467	0.1011176
UHRF1	Q96T88	2	270	9	AF-Q96T88-F1-model_v4	Q96T88-F1	0.210	0.221	0	81.26714	1.647277	up_reg	703	0.0998403
DTL	Q9NZJ0	2	10	2	AF-Q9NZJ0-F1-model_v4	Q9NZJ0-F1	0.101	0.511	2	63.43932	1.403031	up_reg	635	0.0996561
KIFC1	Q9BW19	2	1277	4	AF-Q9BW19-F1-model_v4	Q9BW19-F1	0.202	0.353	0	77.88326	1.653350	up_reg	190	0.0993876
ORC6	Q9Y5N6	2	0	2	AF-Q9Y5N6-F1-model_v4	Q9Y5N6-F1	0.216	0.425	1	81.54463	1.147588	up_reg	103	0.0992746
ASF1B	Q9NVP2	2	0	4	AF-Q9NVP2-F1-model_v4	Q9NVP2-F1	0.391	0.346	0	85.64720	1.543374	up_reg	114	0.0991161
BRAT1	Q6PJG6	2	0	1	AF-Q6PJG6-F1-model_v4	Q6PJG6-F1	0.415	0.432	1	85.19003	1.099328	up_reg	53	0.0977405
H2AC13	P0C0S8	2	0	2	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.687352	up_reg	1	0.0972239
H2AC15	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.300878	up_reg	0	0.0936000
H2AC16	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	2.102910	up_reg	0	0.0936000
DEPDC1	Q5TB30	2	0	1	AF-Q5TB30-F1-model_v4	Q5TB30-F1	0.111	0.445	1	61.05036	1.835268	up_reg	92	0.0927115
FBLN1	P23142	8	0	1	AF-P23142-F1-model_v4	P23142-F1	0.382	0.461	1	79.64933	5.288778	up_reg	150	0.0899914
MDK	P21741	12	0	1	AF-P21741-F1-model_v4	P21741-F1	0.343	0.543	1	73.10764	1.614032	up_reg	962	0.0879283
PDLIM4	P50479	2	0	1	AF-P50479-F1-model_v4	P50479-F1	0.362	0.420	1	70.90770	2.084414	up_reg	71	0.0875273
MCM2	P49736	2	0	2	AF-P49736-F1-model_v4	P49736-F1	0.139	0.522	3	76.52259	1.728739	up_reg	1566	0.0870338
PLXNA4	Q9HCM2	15	0	1	AF-Q9HCM2-F1-model_v4	Q9HCM2-F1	0.090	0.426	1	83.61456	2.486699	up_reg	108	0.0821243
IGSF8	Q969P0	3	0	1	AF-Q969P0-F1-model_v4	Q969P0-F1	0.093	0.389	0	88.38596	1.008061	up_reg	49	0.0819887
RPL39L	Q96EH5	2	0	1	AF-Q96EH5-F1-model_v4	Q96EH5-F1	0.319	0.343	0	94.09941	1.340365	up_reg	19	0.0808302
H2AC11	P0C0S8	2	0	1	AF-P0C0S8-F1-model_v4	P0C0S8-F1	0.416	0.234	0	91.30357	1.789297	up_reg	1	0.0805573
RAD51AP1	Q96B01	2	614	5	AF-Q96B01-F1-model_v4	Q96B01-F1	0.122	0.242	0	58.79844	1.425452	up_reg	101	0.0798143
KRT23	Q9C075	10	0	1	AF-Q9C075-F1-model_v4	Q9C075-F1	0.182	0.382	0	78.43096	6.327604	up_reg	48	0.0795688
H2AC4	P04908	2	0	1	AF-P04908-F1-model_v4	P04908-F1	0.384	0.231	0	91.08903	2.125754	up_reg	1	0.0793573
JAG2	Q9Y219	2	0	1	AF-Q9Y219-F1-model_v4	Q9Y219-F1	0.248	0.470	1	72.67450	2.132090	up_reg	322	0.0792837
BUB1	O43683	2	519	4	AF-O43683-F1-model_v4	O43683-F1	0.138	0.403	1	64.12427	1.883874	up_reg	1290	0.0792651
FGFR3	P22607	2	519	3	AF-P22607-F1-model_v4	P22607-F1	0.127	0.488	1	75.36964	1.507694	up_reg	3446	0.0781188
LMNB2	Q03252	2	0	1	AF-Q03252-F1-model_v4	Q03252-F1	0.194	0.394	0	80.02784	1.018836	up_reg	73	0.0766117
CCNE1	P24864	2	969	6	AF-P24864-F1-model_v4	P24864-F1	0.101	0.284	0	79.97658	1.823919	up_reg	1067	0.0710397
SPINDOC	Q9BUA3	2	0	5	AF-Q9BUA3-F1-model_v4	Q9BUA3-F1	0.062	0.118	0	51.19178	1.089261	up_reg	9	0.0705396
DNM1	Q05193	2	0	1	AF-Q05193-F1-model_v4	Q05193-F1	0.166	0.433	1	79.06586	1.800731	up_reg	263	0.0682791
CDKN3	Q16667	2	0	1	AF-Q16667-F1-model_v4	Q16667-F1	0.472	0.413	1	91.05949	1.590039	up_reg	184	0.0669702
TRIB3	Q96RU7	2	0	1	AF-Q96RU7-F1-model_v4	Q96RU7-F1	0.175	0.461	2	78.02088	1.928480	up_reg	514	0.0669054
BOP1	Q14137	2	0	1	AF-Q14137-F1-model_v4	Q14137-F1	0.149	0.393	0	80.78432	1.427766	up_reg	122	0.0666506
S100A4	P26447	16	0	1	AF-P26447-F1-model_v4	P26447-F1	0.313	0.516	1	85.18673	2.611786	up_reg	1720	0.0662032
SPC24	Q8NBT2	2	0	1	AF-Q8NBT2-F1-model_v4	Q8NBT2-F1	0.345	0.372	0	91.39337	1.231117	up_reg	80	0.0661110
CDC7	O00311	2	0	2	AF-O00311-F1-model_v4	O00311-F1	0.307	0.427	1	72.36204	1.012901	up_reg	661	0.0652472
CEP55	Q53EZ4	2	6	2	AF-Q53EZ4-F1-model_v4	Q53EZ4-F1	0.284	0.386	0	82.79305	1.774115	up_reg	279	0.0650715
UBE2T	Q9NPD8	2	0	1	AF-Q9NPD8-F1-model_v4	Q9NPD8-F1	0.273	0.383	0	86.02709	1.200009	up_reg	149	0.0589164
CLDN4	O14493	3	21	3	AF-O14493-F1-model_v4	O14493-F1	0.511	0.360	0	84.52154	1.539998	up_reg	632	0.0560722
CDCA5	Q96FF9	2	0	1	AF-Q96FF9-F1-model_v4	Q96FF9-F1	0.258	0.376	0	63.50505	1.762388	up_reg	158	0.0550200
FBXL19	Q6PCT2	2	0	1	AF-Q6PCT2-F1-model_v4	Q6PCT2-F1	0.073	0.327	0	67.83220	1.264427	up_reg	65	0.0519646
DPP4	P27487	3	107	3	AF-P27487-F1-model_v4	P27487-F1	0.321	0.453	1	96.40635	3.510087	up_reg	5935	0.0516271
UBE2C	O00762	2	18	4	AF-O00762-F1-model_v4	O00762-F1	0.355	0.286	0	89.69871	1.857549	up_reg	444	0.0497533
WDR18	Q9BV38	2	0	1	AF-Q9BV38-F1-model_v4	Q9BV38-F1	0.095	0.251	0	86.10082	1.125611	up_reg	14	0.0494434
TACC3	Q9Y6A5	2	0	1	AF-Q9Y6A5-F1-model_v4	Q9Y6A5-F1	0.259	0.400	1	58.34000	1.257585	up_reg	373	0.0485251
ICAM1	P05362	3	0	1	AF-P05362-F1-model_v4	P05362-F1	0.208	0.596	2	88.57488	1.791348	up_reg	31229	0.0436635
PCDHGA4	Q9Y5G9	13	0	1	AF-Q9Y5G9-F1-model_v4	Q9Y5G9-F1	0.100	0.184	0	74.38778	2.483945	up_reg	4	0.0433157
GINS2	Q9Y248	2	0	1	AF-Q9Y248-F1-model_v4	Q9Y248-F1	0.258	0.318	0	93.40448	1.567400	up_reg	87	0.0429513
RRM2	P31350	2	260	2	AF-P31350-F1-model_v4	P31350-F1	0.276	0.377	0	80.12601	1.559305	up_reg	923	0.0404018
PDLIM7	Q9NR12	2	519	3	AF-Q9NR12-F1-model_v4	Q9NR12-F1	0.079	0.251	0	71.03190	1.532650	up_reg	175	0.0392942
GRB7	Q14451	2	0	1	AF-Q14451-F1-model_v4	Q14451-F1	0.214	0.360	0	78.88878	3.704094	up_reg	311	0.0359357
GINS1	Q14691	2	0	1	AF-Q14691-F1-model_v4	Q14691-F1	0.241	0.287	0	93.30269	1.666886	up_reg	69	0.0348574
PIF1	Q9H611	2	0	1	AF-Q9H611-F1-model_v4	Q9H611-F1	0.062	0.368	0	77.97936	1.521154	up_reg	478	0.0310690
PARVB	Q9HBI1	5	1	2	AF-Q9HBI1-F1-model_v4	Q9HBI1-F1	0.063	0.242	0	82.45817	1.248136	up_reg	81	0.0305523
RTN4R	Q9BZR6	3	60	2	AF-Q9BZR6-F1-model_v4	Q9BZR6-F1	0.240	0.303	0	77.06296	2.208875	up_reg	341	0.0284046
NECTIN1	Q15223	2	0	1	AF-Q15223-F1-model_v4	Q15223-F1	0.115	0.351	0	75.94298	1.035554	up_reg	389	0.0281368
EME1	Q96AY2	2	0	1	AF-Q96AY2-F1-model_v4	Q96AY2-F1	0.155	0.315	0	67.90349	1.276116	up_reg	191	0.0270713
E2F1	Q01094	2	530	5	AF-Q01094-F1-model_v4	Q01094-F1	0.159	0.295	0	63.73504	1.335481	up_reg	5151	0.0267505
KIF18A	Q8NI77	2	0	2	AF-Q8NI77-F1-model_v4	Q8NI77-F1	0.186	0.256	0	67.74104	1.821786	up_reg	147	0.0250357
CDC25A	P30304	2	5900	3	AF-P30304-F1-model_v4	P30304-F1	0.261	0.229	0	63.57967	1.351055	up_reg	1245	0.0232384
NHERF1	O14745	3	107	4	AF-O14745-F1-model_v4	O14745-F1	0.202	0.212	0	72.47472	1.164937	up_reg	466	0.0197344
RUNX3	Q13761	2	260	2	AF-Q13761-F1-model_v4	Q13761-F1	0.403	0.350	0	62.21557	1.969305	up_reg	1565	0.0196747
SLC3A1	Q07837	2	0	1	AF-Q07837-F1-model_v4	Q07837-F1	0.216	0.312	0	87.82102	2.729605	up_reg	278	0.0188392
E2F7	Q96AV8	2	260	2	AF-Q96AV8-F1-model_v4	Q96AV8-F1	0.108	0.254	0	51.27249	1.708301	up_reg	226	0.0176159
CDC20	Q12834	2	623	5	AF-Q12834-F1-model_v4	Q12834-F1	0.319	0.217	0	84.85435	2.104143	up_reg	1658	0.0173841
GAPDH	P04406	2	774	2	AF-P04406-F1-model_v4	P04406-F1	0.345	0.413	1	98.17071	1.126776	up_reg	8565	0.0157247
PSMD3	O43242	2	0	1	AF-O43242-F1-model_v4	O43242-F1	0.208	0.219	0	73.48985	2.626656	up_reg	45	0.0155576
KHDRBS3	O75525	9	0	1	AF-O75525-F1-model_v4	O75525-F1	0.467	0.235	0	69.77844	1.649271	up_reg	64	0.0154518
ENO1	P06733	2	0	1	AF-P06733-F1-model_v4	P06733-F1	0.465	0.346	0	97.62715	1.253482	up_reg	881	0.0107816
GLA	P06280	1	0	1	AF-P06280-F1-model_v4	P06280-F1	0.368	0.468	1	94.50382	1.121088	up_reg	12907	0.0090887
CDT1	Q9H211	2	260	3	AF-Q9H211-F1-model_v4	Q9H211-F1	0.393	0.234	0	74.90779	2.404285	up_reg	661	0.0061428
GGT1	P19440	3	0	1	AF-P19440-F1-model_v4	P19440-F1	0.391	0.244	0	94.94071	1.800705	up_reg	180	-0.0002185
SPRY1	O43609	2	0	1	AF-O43609-F1-model_v4	O43609-F1	0.224	0.267	0	61.61950	1.240669	up_reg	317	-0.0016228
PLK4	O00444	2	299	3	AF-O00444-F1-model_v4	O00444-F1	0.133	0.199	0	66.92294	1.179010	up_reg	487	-0.0019047
H1-3	P16402	2	0	2	AF-P16402-F1-model_v4	P16402-F1	0.228	0.176	0	63.95611	1.231820	up_reg	153	-0.0077121
TNFRSF19	Q9NS68	3	42	2	AF-Q9NS68-F1-model_v4	Q9NS68-F1	0.228	0.160	0	60.38073	2.426988	up_reg	118	-0.0090298
H1-10	Q92522	2	160	3	AF-Q92522-F1-model_v4	Q92522-F1	0.065	0.060	0	66.41116	1.405241	up_reg	41	-0.0121179
CKS2	P33552	2	0	1	AF-P33552-F1-model_v4	P33552-F1	0.368	0.194	0	92.87122	1.091549	up_reg	172	-0.0193679
PCLAF	Q15004	2	0	1	AF-Q15004-F1-model_v4	Q15004-F1	0.264	0.167	0	66.12640	1.296453	up_reg	103	-0.0205921
ZNRF3	Q9ULT6	3	0	1	AF-Q9ULT6-F1-model_v4	Q9ULT6-F1	0.232	0.183	0	51.30892	1.455680	up_reg	160	-0.0224152
C4B	P0C0L5	2	0	1	AF-P0C0L5-F1-model_v4	P0C0L5-F1	0.182	0.325	0	83.46925	2.001316	up_reg	3359	-0.0227858
USP44	Q9H0E7	2	0	1	AF-Q9H0E7-F1-model_v4	Q9H0E7-F1	0.101	0.131	0	72.70601	2.218077	up_reg	63	-0.0258564
EPHB2	P29323	2	260	2	AF-P29323-F1-model_v4	P29323-F1	0.129	0.198	0	80.12099	1.875976	up_reg	851	-0.0296717
CLDN7	O95471	3	76	2	AF-O95471-F1-model_v4	O95471-F1	0.254	0.152	0	82.24946	1.355505	up_reg	303	-0.0296912
SKA1	Q96BD8	2	0	2	AF-Q96BD8-F1-model_v4	Q96BD8-F1	0.218	0.102	0	85.82242	1.714548	up_reg	115	-0.0319802
CCNB2	O95067	2	259	4	AF-O95067-F1-model_v4	O95067-F1	0.089	0.073	0	80.38333	1.681702	up_reg	456	-0.0346229
ESPN	B1AK53	2	0	1	AF-B1AK53-F1-model_v4	B1AK53-F1	0.114	0.144	0	68.30997	2.798276	up_reg	203	-0.0424694
CLDN2	P57739	3	0	3	AF-P57739-F1-model_v4	P57739-F1	0.093	0.091	0	78.67346	3.466479	up_reg	415	-0.0437442
MAD2L1	Q13257	2	1535	4	AF-Q13257-F1-model_v4	Q13257-F1	0.178	0.019	0	93.75853	1.487082	up_reg	687	-0.0569084
A4GALT	Q9NPC4	1	0	1	AF-Q9NPC4-F1-model_v4	Q9NPC4-F1	0.089	0.056	0	89.56960	2.317881	up_reg	69	-0.0575426
CCNF	P41002	2	1	2	AF-P41002-F1-model_v4	P41002-F1	0.276	0.059	0	72.44700	1.358114	up_reg	185	-0.0580591
HMGA1	P17096	2	0	1	AF-P17096-F1-model_v4	P17096-F1	0.159	0.181	0	65.46237	1.407994	up_reg	1303	-0.0625758
PITX1	P78337	3	0	1	AF-P78337-F1-model_v4	P78337-F1	0.326	0.132	0	63.26645	1.889320	up_reg	481	-0.0634485
S100A9	P06702	2	0	1	AF-P06702-F1-model_v4	P06702-F1	0.328	0.187	0	94.90595	5.148571	up_reg	2221	-0.0702045
IGFBP3	P17936	2	0	1	AF-P17936-F1-model_v4	P17936-F1	0.282	0.235	0	67.73329	2.109532	up_reg	8159	-0.0754819
CDH3	P22223	2	0	1	AF-P22223-F1-model_v4	P22223-F1	0.256	0.053	0	76.62218	1.560149	up_reg	267	-0.0840039
SGO1	Q5FBB7	2	0	1	AF-Q5FBB7-F1-model_v4	Q5FBB7-F1	0.108	0.050	0	55.17324	1.452157	up_reg	255	-0.0843419
JUP	P14923	2	518	2	AF-P14923-F1-model_v4	P14923-F1	0.091	0.021	0	81.10563	2.379501	up_reg	491	-0.0887214
E2F2	Q14209	2	0	1	AF-Q14209-F1-model_v4	Q14209-F1	0.180	0.079	0	64.08260	1.719613	up_reg	642	-0.0900715

Gene subset progression

## Raw gene list = 14889 --> Initial subset (>1 in >=0.5) = 14868

## Initial subset = 14868 --> EdgeR hits (only dif exp genes) = 790

## EdgeR hits = 790 --> ensembl gene converted = 764

## ensembl gene converted = 764 --> Cytoscape/STRING = 718

## Cytoscape/STRING = 718 --> PCSF subnet = 318

## PCSF subnet = 318 --> Druggability CrossRef = 420

## Druggability CrossRef = 420 --> Unique IDs = 302

Score correlations

Alternative Rank Testing

Rank Sensitivity

Rank Sensitivity

external_gene_name	description	count	counts_when_betweeness_0	counts_when_centrality_0	counts_when_citation_0	counts_when_druggability_0
H2BC6	H2B clustered histone 6	250	2	7	4	0
H2BC13	H2B clustered histone 13	228	1	3	3	0
H2BC15	H2B clustered histone 15	221	2	4	6	0
H2BC7	H2B clustered histone 7	216	1	3	3	0
H2BC10	H2B clustered histone 10	160	2	4	3	0
H2BC8	H2B clustered histone 8	142	1	2	2	0
H2BC14	H2B clustered histone 14	139	1	2	2	0
CDK1	cyclin dependent kinase 1	121	1	1	1	0
NR5A2	nuclear receptor subfamily 5 group A member 2	117	1	1	1	0
RARA	retinoic acid receptor alpha	115	1	15	9	0
UBE2S	ubiquitin conjugating enzyme E2 S	108	61	39	47	52
ORC1	origin recognition complex subunit 1	101	20	13	60	22
H2BC4	H2B clustered histone 4	96	61	38	44	50
H2BC17	H2B clustered histone 17	92	61	58	55	56
H2AC14	H2A clustered histone 14	88	59	33	19	25
H2BC3	H2B clustered histone 3	74	58	51	40	36
CCNA2	cyclin A2	67	53	26	21	14
H3C12	H3 clustered histone 12	37	19	18	60	22
H3C13	H3 clustered histone 13	32	40	31	1	9
H2AC8	H2A clustered histone 8	25	38	10	7	4
WDR76	WD repeat domain 76	21	1	3	12	0
H2AX	H2A.X variant histone	18	50	9	23	29
H2BC18	H2B clustered histone 18	16	8	23	46	41
ABCA2	ATP binding cassette subfamily A member 2	15	14	13	16	61
PLK1	polo like kinase 1	12	2	0	5	3
H2BC12	H2B clustered histone 12	7	37	31	0	10
MUC17	mucin 17, cell surface associated	7	3	1	13	16
NOTCH1	notch receptor 1	7	4	6	0	0
CD9	CD9 molecule	6	2	0	0	4
H3C10	H3 clustered histone 10	6	9	12	0	1
CCNB1	cyclin B1	5	4	19	0	19
H3C1	H3 clustered histone 1	5	2	6	0	4
H2AC21	H2A clustered histone 21	4	0	4	0	4
XPR1	xenotropic and polytropic retrovirus receptor 1	4	1	0	0	2
CDC25A	cell division cycle 25A	3	0	11	0	22
CENPE	centromere protein E	3	0	30	36	28
MELK	maternal embryonic leucine zipper kinase	3	0	31	33	35
H2AC12	H2A clustered histone 12	2	0	22	26	23
KIF11	kinesin family member 11	2	0	15	5	21
PTGS2	prostaglandin-endoperoxide synthase 2	2	0	1	1	0
FABP1	fatty acid binding protein 1	1	0	4	7	2
RAC3	Rac family small GTPase 3	1	0	3	2	2
TEAD4	TEA domain transcription factor 4	1	0	17	7	3

Rank Sensitivity w/ Num Drug Pockets

Rank Sensitivity

external_gene_name	description	count	counts_when_betweeness_0	counts_when_centrality_0	counts_when_citation_0	counts_when_druggability_0	counts_when_num_drug_pockets_0
H2BC13	H2B clustered histone 13	718	120	164	137	97	7
H2BC6	H2B clustered histone 6	643	77	103	110	67	0
H2BC15	H2B clustered histone 15	579	78	117	100	52	3
H2BC7	H2B clustered histone 7	481	87	166	138	80	15
H2BC14	H2B clustered histone 14	458	66	103	63	37	0
NR5A2	nuclear receptor subfamily 5 group A member 2	376	75	120	56	43	0
MUC17	mucin 17, cell surface associated	372	55	76	80	32	0
CDK1	cyclin dependent kinase 1	358	18	29	27	18	0
H2BC10	H2B clustered histone 10	358	28	37	27	23	0
ABCA2	ATP binding cassette subfamily A member 2	329	23	40	26	1	4
UBE2S	ubiquitin conjugating enzyme E2 S	322	6	16	15	0	0
H2BC17	H2B clustered histone 17	310	3	6	6	0	0
ORC1	origin recognition complex subunit 1	286	3	5	5	0	1
RARA	retinoic acid receptor alpha	285	3	6	8	0	6
H2BC8	H2B clustered histone 8	257	2	4	4	0	3
CCNA2	cyclin A2	232	1	2	2	0	2
H2BC3	H2B clustered histone 3	229	1	2	2	0	2
ABCC2	ATP binding cassette subfamily C member 2	228	1	1	1	0	1
H2AC14	H2A clustered histone 14	224	49	10	61	30	0
CENPE	centromere protein E	217	229	134	169	204	228
DNAH3	dynein axonemal heavy chain 3	187	74	51	207	99	117
KIF20B	kinesin family member 20B	165	63	22	174	70	115
H2BC4	H2B clustered histone 4	163	192	76	128	164	221
ASPM	assembly factor for spindle microtubules	141	179	147	128	171	250
CENPI	centromere protein I	110	163	74	34	73	160
H3C12	H3 clustered histone 12	94	151	114	63	105	216
H2BC18	H2B clustered histone 18	93	110	33	36	30	142
H3C13	H3 clustered histone 13	67	79	65	1	17	96
FZD2	frizzled class receptor 2	61	181	40	89	131	139
H2BC11	H2B clustered histone 11	60	130	27	22	38	74
LGR5	leucine rich repeat containing G protein-coupled receptor 5	44	1	3	22	0	12
XPR1	xenotropic and polytropic retrovirus receptor 1	42	25	74	158	143	121
H2AC8	H2A clustered histone 8	40	9	0	19	11	5
H2AX	H2A.X variant histone	36	38	35	42	162	88
WDR76	WD repeat domain 76	33	6	2	31	34	18
NOTCH1	notch receptor 1	27	11	20	0	11	0
PLK1	polo like kinase 1	22	137	118	0	67	92
PPFIA3	PTPRF interacting protein alpha 3	20	4	6	0	0	7
CCNB1	cyclin B1	19	39	12	0	29	0
FZD7	frizzled class receptor 7	17	45	59	0	37	16
H3C10	H3 clustered histone 10	15	2	0	0	4	5
CD9	CD9 molecule	8	6	15	0	11	6
H2BC12	H2B clustered histone 12	7	9	52	0	58	37
PDE3A	phosphodiesterase 3A	6	1	0	0	2	2
CDC25A	cell division cycle 25A	5	0	96	118	94	101
H3C1	H3 clustered histone 1	5	0	87	102	98	67
TEAD4	TEA domain transcription factor 4	5	0	4	0	4	4
H2AC21	H2A clustered histone 21	4	0	19	0	37	25
MELK	maternal embryonic leucine zipper kinase	4	0	102	116	125	108
H2AC12	H2A clustered histone 12	2	0	29	11	4	21
KIF11	kinesin family member 11	2	0	36	12	48	32
PTGS2	prostaglandin-endoperoxide synthase 2	2	0	1	1	0	1
FABP1	fatty acid binding protein 1	1	0	15	25	15	7
RAC3	Rac family small GTPase 3	1	0	5	4	4	3

RRA

Robust Rank Aggregation

external_gene_name	description	ID	Score
H2BC13	H2B clustered histone 13	Q99880-F1	0.0005445
H2BC15	H2B clustered histone 15	Q99877-F1	0.0013639
H2AC14	H2A clustered histone 14	Q99878-F1	0.0021947
CDK1	cyclin dependent kinase 1	P06493-F1	0.0025859
RARA	retinoic acid receptor alpha	P10276-F1	0.0051316
H2BC14	H2B clustered histone 14	Q99879-F1	0.0066718
H2BC17	H2B clustered histone 17	P23527-F1	0.0098844
H2BC10	H2B clustered histone 10	P62807-F1	0.0110876
H2BC4	H2B clustered histone 4	P62807-F1	0.0110876
H2BC6	H2B clustered histone 6	P62807-F1	0.0110876
H2BC7	H2B clustered histone 7	P62807-F1	0.0110876
H2BC8	H2B clustered histone 8	P62807-F1	0.0110876
PLK1	polo like kinase 1	P53350-F1	0.0110876
CENPI	centromere protein I	Q92674-F1	0.0167426
H2AX	H2A.X variant histone	P16104-F1	0.0226259
H2BC3	H2B clustered histone 3	P33778-F1	0.0242382
NR5A2	nuclear receptor subfamily 5 group A member 2	O00482-F1	0.0278012
H2BC12	H2B clustered histone 12	O60814-F1	0.0286071
PHF19	PHD finger protein 19	Q5T6S3-F1	0.0386814
WDR76	WD repeat domain 76	Q9H967-F1	0.0404295
MUC17	mucin 17, cell surface associated	Q685J3-F5	0.0554584
UBE2S	ubiquitin conjugating enzyme E2 S	Q16763-F1	0.0554584
H3C13	H3 clustered histone 13	Q71DI3-F1	0.0616390
TOP2A	DNA topoisomerase II alpha	P11388-F1	0.0654621
H2AC21	H2A clustered histone 21	Q8IUE6-F1	0.0778155
ATP1B3	ATPase Na+/K+ transporting subunit beta 3	P54709-F1	0.0802098
SPAG5	sperm associated antigen 5	Q96R06-F1	0.0832220
H2BC11	H2B clustered histone 11	P06899-F1	0.0961272
ABCA2	ATP binding cassette subfamily A member 2	Q9BZC7-F1	0.0961311
CENPE	centromere protein E	Q02224-F6	0.1103382
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	Q99640-F1	0.1104780
SPTBN2	spectrin beta, non-erythrocytic 2	O15020-F1	0.1306086
WDR62	WD repeat domain 62	O43379-F1	0.1439370
RAC3	Rac family small GTPase 3	P60763-F1	0.1542998
CENPH	centromere protein H	Q9H3R5-F1	0.1582604
BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	O60566-F1	0.1610230
CD9	CD9 molecule	P21926-F1	0.1646433
ORC1	origin recognition complex subunit 1	Q13415-F1	0.1646433
POLD1	DNA polymerase delta 1, catalytic subunit	P28340-F1	0.1679217
CCNB1	cyclin B1	P14635-F1	0.1739839
H2BC18	H2B clustered histone 18	Q5QNW6-F1	0.1822507
KIF1A	kinesin family member 1A	Q12756-F1	0.1867062
CENPA	centromere protein A	P49450-F1	0.1972964
H1-5	H1.5 linker histone, cluster member	P16401-F1	0.2016917
KIF20A	kinesin family member 20A	O95235-F1	0.2050906
CCNA2	cyclin A2	P20248-F1	0.2183777
MELK	maternal embryonic leucine zipper kinase	Q14680-F1	0.2183777
BRCA2	BRCA2 DNA repair associated	P51587-F12	0.2212272
H3C1	H3 clustered histone 1	P68431-F1	0.2330284
H3C10	H3 clustered histone 10	P68431-F1	0.2330284
H3C11	H3 clustered histone 11	P68431-F1	0.2330284
H3C12	H3 clustered histone 12	P68431-F1	0.2330284
FZD7	frizzled class receptor 7	O75084-F1	0.2381009
CENPM	centromere protein M	Q9NSP4-F1	0.2468163
ANPEP	alanyl aminopeptidase, membrane	P15144-F1	0.2535026
ERBB2	erb-b2 receptor tyrosine kinase 2	P04626-F1	0.2558631
TTK	TTK protein kinase	P33981-F1	0.2648086
XPR1	xenotropic and polytropic retrovirus receptor 1	Q9UBH6-F1	0.2715456
LAMA5	laminin subunit alpha 5	O15230-F12	0.2828650
LMNB1	lamin B1	P20700-F1	0.2905879
H2BC21	H2B clustered histone 21	Q16778-F1	0.3147073
NCAPH	non-SMC condensin I complex subunit H	Q15003-F1	0.3147073
CYBA	cytochrome b-245 alpha chain	P13498-F1	0.3174329
DLGAP5	DLG associated protein 5	Q15398-F1	0.3230711
RACGAP1	Rac GTPase activating protein 1	Q9H0H5-F1	0.3230711
CDC25A	cell division cycle 25A	P30304-F1	0.3241508
KIF11	kinesin family member 11	P52732-F1	0.3241508
MED1	mediator complex subunit 1	Q15648-F1	0.3336367
ASPM	assembly factor for spindle microtubules	Q8IZT6-F10	0.3443609
H2AC12	H2A clustered histone 12	Q96KK5-F1	0.3501517
H4C1	H4 clustered histone 1	P62805-F1	0.3582045
H4C13	H4 clustered histone 13	P62805-F1	0.3582045
H4C4	H4 clustered histone 4	P62805-F1	0.3582045
ITGA7	integrin subunit alpha 7	Q13683-F1	0.3582045
MZT2A	mitotic spindle organizing protein 2A	Q6P582-F1	0.3674183
NOTCH1	notch receptor 1	P46531-F1	0.3761974
PTGS2	prostaglandin-endoperoxide synthase 2	P35354-F1	0.3761974
ANLN	anillin, actin binding protein	Q9NQW6-F1	0.3768087
DNAH3	dynein axonemal heavy chain 3	Q8TD57-F4	0.4014994
SPTBN5	spectrin beta, non-erythrocytic 5	Q9NRC6-F9	0.4191947
DNA2	DNA replication helicase/nuclease 2	P51530-F1	0.4240664
TEAD4	TEA domain transcription factor 4	Q15561-F1	0.4276894
CHEK1	checkpoint kinase 1	O14757-F1	0.4485848
RAD51AP1	RAD51 associated protein 1	Q96B01-F1	0.4485848
GPC1	glypican 1	P35052-F1	0.4585622
MCM10	minichromosome maintenance 10 replication initiation factor	Q7L590-F1	0.4585622
DNAH7	dynein axonemal heavy chain 7	Q8WXX0-F5	0.4739298
FABP1	fatty acid binding protein 1	P07148-F1	0.4786306
CDC45	cell division cycle 45	O75419-F1	0.4868190
KIF4A	kinesin family member 4A	O95239-F1	0.4924114
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1	P05023-F1	0.4999519
PDZK1	PDZ domain containing 1	Q5T2W1-F1	0.5041002
KIF2C	kinesin family member 2C	Q99661-F1	0.5281008
NUSAP1	nucleolar and spindle associated protein 1	Q9BXS6-F1	0.5281008
FOXM1	forkhead box M1	Q08050-F1	0.5685194
PRC1	protein regulator of cytokinesis 1	O43663-F1	0.5788767
KPNA2	karyopherin subunit alpha 2	P52292-F1	0.5918510
KIF15	kinesin family member 15	Q9NS87-F1	0.6052636
MCM6	minichromosome maintenance complex component 6	Q14566-F1	0.6119711
SPAG4	sperm associated antigen 4	Q9NPE6-F1	0.6281893
CCNE1	cyclin E1	P24864-F1	0.6308928
DBN1	drebrin 1	Q16643-F1	0.6327712
RPL19	ribosomal protein L19	P84098-F1	0.6418947
KIF14	kinesin family member 14	Q15058-F1	0.6468714
NRCAM	neuronal cell adhesion molecule	Q92823-F1	0.6468714
SLC7A5	solute carrier family 7 member 5	Q01650-F1	0.6571416
E2F8	E2F transcription factor 8	A0AVK6-F1	0.6612060
RECQL4	RecQ like helicase 4	O94761-F1	0.6612060
TMOD1	tropomodulin 1	P28289-F1	0.6757775
KIF20B	kinesin family member 20B	Q96Q89-F1	0.6769670
PODXL	podocalyxin like	O00592-F1	0.6905885
CLDN15	claudin 15	P56746-F1	0.7209395
SLC27A2	solute carrier family 27 member 2	O14975-F1	0.7209395
CENPK	centromere protein K	Q9BS16-F1	0.7360780
H1-10	H1.10 linker histone	Q92522-F1	0.7362009
CDCA8	cell division cycle associated 8	Q53HL2-F1	0.7364848
CLSPN	claspin	Q9HAW4-F1	0.7576871
CHTF18	chromosome transmission fidelity factor 18	Q8WVB6-F1	0.7683283
PPFIA3	PTPRF interacting protein alpha 3	O75145-F1	0.8011933
HMMR	hyaluronan mediated motility receptor	O75330-F1	0.8180157
SLC1A5	solute carrier family 1 member 5	Q15758-F1	0.8235568
POLQ	DNA polymerase theta	O75417-F1	0.8351016
NEIL3	nei like DNA glycosylase 3	Q8TAT5-F1	0.8668047
PCDHGA5	protocadherin gamma subfamily A, 5	Q9Y5G8-F1	0.8668047
CCNE2	cyclin E2	O96020-F1	0.8700750
XRCC2	X-ray repair cross complementing 2	O43543-F1	0.8700750
MCM4	minichromosome maintenance complex component 4	P33991-F1	0.8722866
ITGB8	integrin subunit beta 8	P26012-F1	0.9061355
CENPW	centromere protein W	Q5EE01-F1	0.9081023
E2F1	E2F transcription factor 1	Q01094-F1	0.9136089
PTTG1	PTTG1 regulator of sister chromatid separation, securin	O95997-F1	0.9245805
CDC20	cell division cycle 20	Q12834-F1	0.9364832
H2AC4	H2A clustered histone 4	P04908-F1	0.9586137
H2AC8	H2A clustered histone 8	P04908-F1	0.9586137
ABCC4	ATP binding cassette subfamily C member 4	O15439-F1	0.9631328
CENPF	centromere protein F	P49454-F7	0.9816075
A4GALT	alpha 1,4-galactosyltransferase (P blood group)	Q9NPC4-F1	1.0000000
ABCC2	ATP binding cassette subfamily C member 2	Q92887-F1	1.0000000
ABCD1	ATP binding cassette subfamily D member 1	P33897-F1	1.0000000
ASF1B	anti-silencing function 1B histone chaperone	Q9NVP2-F1	1.0000000
ATAD2	ATPase family AAA domain containing 2	Q6PL18-F1	1.0000000
AURKA	aurora kinase A	O14965-F1	1.0000000
AURKB	aurora kinase B	Q96GD4-F1	1.0000000
BAMBI	BMP and activin membrane bound inhibitor	Q13145-F1	1.0000000
BCAM	basal cell adhesion molecule (Lutheran blood group)	P50895-F1	1.0000000
BCL6	BCL6 transcription repressor	P41182-F1	1.0000000
BLM	BLM RecQ like helicase	P54132-F1	1.0000000
BOP1	BOP1 ribosomal biogenesis factor	Q14137-F1	1.0000000
BRAT1	BRCA1 associated ATM activator 1	Q6PJG6-F1	1.0000000
BUB1	BUB1 mitotic checkpoint serine/threonine kinase	O43683-F1	1.0000000
C4B	complement C4B (Chido blood group)	P0C0L5-F1	1.0000000
CBX2	chromobox 2	Q14781-F1	1.0000000
CCNB2	cyclin B2	O95067-F1	1.0000000
CCNF	cyclin F	P41002-F1	1.0000000
CDC25C	cell division cycle 25C	P30307-F1	1.0000000
CDC6	cell division cycle 6	Q99741-F1	1.0000000
CDC7	cell division cycle 7	O00311-F1	1.0000000
CDCA5	cell division cycle associated 5	Q96FF9-F1	1.0000000
CDH24	cadherin 24	Q86UP0-F1	1.0000000
CDH3	cadherin 3	P22223-F1	1.0000000
CDKN3	cyclin dependent kinase inhibitor 3	Q16667-F1	1.0000000
CDT1	chromatin licensing and DNA replication factor 1	Q9H211-F1	1.0000000
CEP55	centrosomal protein 55	Q53EZ4-F1	1.0000000
CHAF1B	chromatin assembly factor 1 subunit B	Q13112-F1	1.0000000
CIT	citron rho-interacting serine/threonine kinase	O14578-F1	1.0000000
CLDN2	claudin 2	P57739-F1	1.0000000
CLDN3	claudin 3	O15551-F1	1.0000000
CLDN4	claudin 4	O14493-F1	1.0000000
CLDN7	claudin 7	O95471-F1	1.0000000
DEPDC1	DEP domain containing 1	Q5TB30-F1	1.0000000
DEPDC1B	DEP domain containing 1B	Q8WUY9-F1	1.0000000
DNAH9	dynein axonemal heavy chain 9	Q9NYC9-F12	1.0000000
DNM1	dynamin 1	Q05193-F1	1.0000000
DPP4	dipeptidyl peptidase 4	P27487-F1	1.0000000
DSCC1	DNA replication and sister chromatid cohesion 1	Q9BVC3-F1	1.0000000
DTL	denticleless E3 ubiquitin protein ligase homolog	Q9NZJ0-F1	1.0000000
E2F2	E2F transcription factor 2	Q14209-F1	1.0000000
E2F7	E2F transcription factor 7	Q96AV8-F1	1.0000000
EME1	essential meiotic structure-specific endonuclease 1	Q96AY2-F1	1.0000000
ENO1	enolase 1	P06733-F1	1.0000000
EPHB2	EPH receptor B2	P29323-F1	1.0000000
ERCC6L	ERCC excision repair 6 like, spindle assembly checkpoint helicase	Q2NKX8-F1	1.0000000
ESPL1	extra spindle pole bodies like 1, separase	Q14674-F1	1.0000000
ESPN	espin	B1AK53-F1	1.0000000
EXO1	exonuclease 1	Q9UQ84-F1	1.0000000
FAM83D	family with sequence similarity 83 member D	Q9H4H8-F1	1.0000000
FANCA	FA complementation group A	O15360-F1	1.0000000
FANCB	FA complementation group B	Q8NB91-F1	1.0000000
FBLN1	fibulin 1	P23142-F1	1.0000000
FBLN2	fibulin 2	P98095-F1	1.0000000
FBXL19	F-box and leucine rich repeat protein 19	Q6PCT2-F1	1.0000000
FGFR3	fibroblast growth factor receptor 3	P22607-F1	1.0000000
FGFR4	fibroblast growth factor receptor 4	P22455-F1	1.0000000
FZD2	frizzled class receptor 2	Q14332-F1	1.0000000
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	P04406-F1	1.0000000
GGT1	gamma-glutamyltransferase 1	P19440-F1	1.0000000
GINS1	GINS complex subunit 1	Q14691-F1	1.0000000
GINS2	GINS complex subunit 2	Q9Y248-F1	1.0000000
GINS4	GINS complex subunit 4	Q9BRT9-F1	1.0000000
GLA	galactosidase alpha	P06280-F1	1.0000000
GPI	glucose-6-phosphate isomerase	P06744-F1	1.0000000
GRB7	growth factor receptor bound protein 7	Q14451-F1	1.0000000
H1-3	H1.3 linker histone, cluster member	P16402-F1	1.0000000
H2AC11	H2A clustered histone 11	P0C0S8-F1	1.0000000
H2AC13	H2A clustered histone 13	P0C0S8-F1	1.0000000
H2AC15	H2A clustered histone 15	P0C0S8-F1	1.0000000
H2AC16	H2A clustered histone 16	P0C0S8-F1	1.0000000
HEPH	hephaestin	Q9BQS7-F1	1.0000000
HMGA1	high mobility group AT-hook 1	P17096-F1	1.0000000
ICAM1	intercellular adhesion molecule 1	P05362-F1	1.0000000
IGFBP3	insulin like growth factor binding protein 3	P17936-F1	1.0000000
IGSF8	immunoglobulin superfamily member 8	Q969P0-F1	1.0000000
IL32	interleukin 32	P24001-F1	1.0000000
IQGAP3	IQ motif containing GTPase activating protein 3	Q86VI3-F1	1.0000000
JAG2	jagged canonical Notch ligand 2	Q9Y219-F1	1.0000000
JUP	junction plakoglobin	P14923-F1	1.0000000
KHDRBS3	KH RNA binding domain containing, signal transduction associated 3	O75525-F1	1.0000000
KIF18A	kinesin family member 18A	Q8NI77-F1	1.0000000
KIF18B	kinesin family member 18B	Q86Y91-F1	1.0000000
KIF23	kinesin family member 23	Q02241-F1	1.0000000
KIFC1	kinesin family member C1	Q9BW19-F1	1.0000000
KRT15	keratin 15	P19012-F1	1.0000000
KRT23	keratin 23	Q9C075-F1	1.0000000
LDHA	lactate dehydrogenase A	P00338-F1	1.0000000
LGR5	leucine rich repeat containing G protein-coupled receptor 5	O75473-F1	1.0000000
LMNB2	lamin B2	Q03252-F1	1.0000000
MAD2L1	mitotic arrest deficient 2 like 1	Q13257-F1	1.0000000
MCM2	minichromosome maintenance complex component 2	P49736-F1	1.0000000
MDK	midkine	P21741-F1	1.0000000
MME	membrane metalloendopeptidase	P08473-F1	1.0000000
MRPL12	mitochondrial ribosomal protein L12	P52815-F1	1.0000000
MTTP	microsomal triglyceride transfer protein	P55157-F1	1.0000000
MUC16	mucin 16, cell surface associated	Q8WXI7-F58	1.0000000
MYBL2	MYB proto-oncogene like 2	P10244-F1	1.0000000
MZT2B	mitotic spindle organizing protein 2B	Q6NZ67-F1	1.0000000
NCAPG	non-SMC condensin I complex subunit G	Q9BPX3-F1	1.0000000
NDC80	NDC80 kinetochore complex component	O14777-F1	1.0000000
NECTIN1	nectin cell adhesion molecule 1	Q15223-F1	1.0000000
NEK2	NIMA related kinase 2	P51955-F1	1.0000000
NHERF1	NHERF family PDZ scaffold protein 1	O14745-F1	1.0000000
NRARP	NOTCH regulated ankyrin repeat protein	Q7Z6K4-F1	1.0000000
NUF2	NUF2 component of NDC80 kinetochore complex	Q9BZD4-F1	1.0000000
OIP5	Opa interacting protein 5	O43482-F1	1.0000000
ORC6	origin recognition complex subunit 6	Q9Y5N6-F1	1.0000000
PARVB	parvin beta	Q9HBI1-F1	1.0000000
PBK	PDZ binding kinase	Q96KB5-F1	1.0000000
PCDHGA4	protocadherin gamma subfamily A, 4	Q9Y5G9-F1	1.0000000
PCDHGB1	protocadherin gamma subfamily B, 1	Q9Y5G3-F1	1.0000000
PCDHGB2	protocadherin gamma subfamily B, 2	Q9Y5G2-F1	1.0000000
PCLAF	PCNA clamp associated factor	Q15004-F1	1.0000000
PDE3A	phosphodiesterase 3A	Q14432-F1	1.0000000
PDLIM4	PDZ and LIM domain 4	P50479-F1	1.0000000
PDLIM7	PDZ and LIM domain 7	Q9NR12-F1	1.0000000
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Q16875-F1	1.0000000
PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Q16877-F1	1.0000000
PHLDA1	pleckstrin homology like domain family A member 1	Q8WV24-F1	1.0000000
PIF1	PIF1 5’-to-3’ DNA helicase	Q9H611-F1	1.0000000
PITX1	paired like homeodomain 1	P78337-F1	1.0000000
PLK4	polo like kinase 4	O00444-F1	1.0000000
PLXNA4	plexin A4	Q9HCM2-F1	1.0000000
PRAME	PRAME nuclear receptor transcriptional regulator	P78395-F1	1.0000000
PSMD3	proteasome 26S subunit, non-ATPase 3	O43242-F1	1.0000000
PTGS1	prostaglandin-endoperoxide synthase 1	P23219-F1	1.0000000
RAD51	RAD51 recombinase	Q06609-F1	1.0000000
RAD54L	RAD54 like	Q92698-F1	1.0000000
RARRES1	retinoic acid receptor responder 1	P49788-F1	1.0000000
RRM2	ribonucleotide reductase regulatory subunit M2	P31350-F1	1.0000000
RTKN	rhotekin	Q9BST9-F1	1.0000000
RTN4R	reticulon 4 receptor	Q9BZR6-F1	1.0000000
RUNX3	RUNX family transcription factor 3	Q13761-F1	1.0000000
S100A4	S100 calcium binding protein A4	P26447-F1	1.0000000
S100A9	S100 calcium binding protein A9	P06702-F1	1.0000000
SEMA6A	semaphorin 6A	Q9H2E6-F1	1.0000000
SGO1	shugoshin 1	Q5FBB7-F1	1.0000000
SHCBP1	SHC binding and spindle associated 1	Q8NEM2-F1	1.0000000
SKA1	spindle and kinetochore associated complex subunit 1	Q96BD8-F1	1.0000000
SKA3	spindle and kinetochore associated complex subunit 3	Q8IX90-F1	1.0000000
SLC19A3	solute carrier family 19 member 3	Q9BZV2-F1	1.0000000
SLC2A1	solute carrier family 2 member 1	P11166-F1	1.0000000
SLC3A1	solute carrier family 3 member 1	Q07837-F1	1.0000000
SPC24	SPC24 component of NDC80 kinetochore complex	Q8NBT2-F1	1.0000000
SPC25	SPC25 component of NDC80 kinetochore complex	Q9HBM1-F1	1.0000000
SPINDOC	spindlin interactor and repressor of chromatin binding	Q9BUA3-F1	1.0000000
SPRY1	sprouty RTK signaling antagonist 1	O43609-F1	1.0000000
STIL	STIL centriolar assembly protein	Q15468-F1	1.0000000
TACC3	transforming acidic coiled-coil containing protein 3	Q9Y6A5-F1	1.0000000
TGM2	transglutaminase 2	P21980-F1	1.0000000
TK1	thymidine kinase 1	P04183-F1	1.0000000
TNFRSF19	TNF receptor superfamily member 19	Q9NS68-F1	1.0000000
TONSL	tonsoku like, DNA repair protein	Q96HA7-F1	1.0000000
TPX2	TPX2 microtubule nucleation factor	Q9ULW0-F1	1.0000000
TRAIP	TRAF interacting protein	Q9BWF2-F1	1.0000000
TRIB3	tribbles pseudokinase 3	Q96RU7-F1	1.0000000
TRIP13	thyroid hormone receptor interactor 13	Q15645-F1	1.0000000
UBE2C	ubiquitin conjugating enzyme E2 C	O00762-F1	1.0000000
UBE2T	ubiquitin conjugating enzyme E2 T	Q9NPD8-F1	1.0000000
UHRF1	ubiquitin like with PHD and ring finger domains 1	Q96T88-F1	1.0000000
USP44	ubiquitin specific peptidase 44	Q9H0E7-F1	1.0000000
WDR18	WD repeat domain 18	Q9BV38-F1	1.0000000
ZNRF3	zinc and ring finger 3	Q9ULT6-F1	1.0000000

RRA w/ Num drug Pockets

Robust Rank Aggregation

external_gene_name	description	ID	Score
MUC17	mucin 17, cell surface associated	Q685J3-F5	0.0006028
H2BC13	H2B clustered histone 13	Q99880-F1	0.0031089
H2BC14	H2B clustered histone 14	Q99879-F1	0.0034668
CENPI	centromere protein I	Q92674-F1	0.0053232
CDK1	cyclin dependent kinase 1	P06493-F1	0.0053499
CENPE	centromere protein E	Q02224-F6	0.0053499
H2AC14	H2A clustered histone 14	Q99878-F1	0.0065904
NR5A2	nuclear receptor subfamily 5 group A member 2	O00482-F1	0.0068694
H2BC15	H2B clustered histone 15	Q99877-F1	0.0075978
H2BC17	H2B clustered histone 17	P23527-F1	0.0075978
H2BC3	H2B clustered histone 3	P33778-F1	0.0101236
ABCA2	ATP binding cassette subfamily A member 2	Q9BZC7-F1	0.0131048
RARA	retinoic acid receptor alpha	P10276-F1	0.0152011
PLK1	polo like kinase 1	P53350-F1	0.0156249
H2BC10	H2B clustered histone 10	P62807-F1	0.0323059
H2BC4	H2B clustered histone 4	P62807-F1	0.0323059
H2BC6	H2B clustered histone 6	P62807-F1	0.0323059
H2BC7	H2B clustered histone 7	P62807-F1	0.0323059
H2BC8	H2B clustered histone 8	P62807-F1	0.0323059
SPAG5	sperm associated antigen 5	Q96R06-F1	0.0395087
H2BC11	H2B clustered histone 11	P06899-F1	0.0397680
H2AX	H2A.X variant histone	P16104-F1	0.0461571
BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	O60566-F1	0.0570549
POLD1	DNA polymerase delta 1, catalytic subunit	P28340-F1	0.0603852
H2BC18	H2B clustered histone 18	Q5QNW6-F1	0.0674591
SPTBN2	spectrin beta, non-erythrocytic 2	O15020-F1	0.0694000
CENPA	centromere protein A	P49450-F1	0.0751051
WDR62	WD repeat domain 62	O43379-F1	0.0783629
KIF20A	kinesin family member 20A	O95235-F1	0.0791505
H2BC12	H2B clustered histone 12	O60814-F1	0.0810451
UBE2S	ubiquitin conjugating enzyme E2 S	Q16763-F1	0.0865031
KIF20B	kinesin family member 20B	Q96Q89-F1	0.0936054
FZD7	frizzled class receptor 7	O75084-F1	0.0968897
ATP1B3	ATPase Na+/K+ transporting subunit beta 3	P54709-F1	0.1029035
DNAH3	dynein axonemal heavy chain 3	Q8TD57-F4	0.1163206
H1-5	H1.5 linker histone, cluster member	P16401-F1	0.1194690
CCNA2	cyclin A2	P20248-F1	0.1243169
ANPEP	alanyl aminopeptidase, membrane	P15144-F1	0.1589912
ASPM	assembly factor for spindle microtubules	Q8IZT6-F10	0.1599069
H3C13	H3 clustered histone 13	Q71DI3-F1	0.1691844
H3C1	H3 clustered histone 1	P68431-F1	0.1703432
H3C10	H3 clustered histone 10	P68431-F1	0.1703432
H3C11	H3 clustered histone 11	P68431-F1	0.1703432
H3C12	H3 clustered histone 12	P68431-F1	0.1703432
ABCC2	ATP binding cassette subfamily C member 2	Q92887-F1	0.1718048
TOP2A	DNA topoisomerase II alpha	P11388-F1	0.1791541
PHF19	PHD finger protein 19	Q5T6S3-F1	0.1811086
LAMA5	laminin subunit alpha 5	O15230-F12	0.1823346
LMNB1	lamin B1	P20700-F1	0.1885784
WDR76	WD repeat domain 76	Q9H967-F1	0.1885887
H2BC21	H2B clustered histone 21	Q16778-F1	0.2083428
H2AC21	H2A clustered histone 21	Q8IUE6-F1	0.2110966
DNA2	DNA replication helicase/nuclease 2	P51530-F1	0.2123088
RACGAP1	Rac GTPase activating protein 1	Q9H0H5-F1	0.2152869
CHEK1	checkpoint kinase 1	O14757-F1	0.2292177
H4C1	H4 clustered histone 1	P62805-F1	0.2449395
H4C13	H4 clustered histone 13	P62805-F1	0.2449395
H4C4	H4 clustered histone 4	P62805-F1	0.2449395
ITGA7	integrin subunit alpha 7	Q13683-F1	0.2449395
NOTCH1	notch receptor 1	P46531-F1	0.2461254
CD9	CD9 molecule	P21926-F1	0.2559176
ORC1	origin recognition complex subunit 1	Q13415-F1	0.2559176
CDC45	cell division cycle 45	O75419-F1	0.2562813
NCAPH	non-SMC condensin I complex subunit H	Q15003-F1	0.2609433
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1	P05023-F1	0.2657669
DLGAP5	DLG associated protein 5	Q15398-F1	0.2777729
CYBA	cytochrome b-245 alpha chain	P13498-F1	0.3061033
XPR1	xenotropic and polytropic retrovirus receptor 1	Q9UBH6-F1	0.3175122
DNAH7	dynein axonemal heavy chain 7	Q8WXX0-F5	0.3255704
GPC1	glypican 1	P35052-F1	0.3335361
MCM10	minichromosome maintenance 10 replication initiation factor	Q7L590-F1	0.3335361
MELK	maternal embryonic leucine zipper kinase	Q14680-F1	0.3388541
CCNB1	cyclin B1	P14635-F1	0.3389418
MCM6	minichromosome maintenance complex component 6	Q14566-F1	0.3503939
SLC1A5	solute carrier family 1 member 5	Q15758-F1	0.3548516
KIF4A	kinesin family member 4A	O95239-F1	0.3645903
KIF1A	kinesin family member 1A	Q12756-F1	0.3649864
PDZK1	PDZ domain containing 1	Q5T2W1-F1	0.3754405
SLC7A5	solute carrier family 7 member 5	Q01650-F1	0.3863012
RAC3	Rac family small GTPase 3	P60763-F1	0.3865474
KIF2C	kinesin family member 2C	Q99661-F1	0.3979157
MZT2A	mitotic spindle organizing protein 2A	Q6P582-F1	0.4095498
LGR5	leucine rich repeat containing G protein-coupled receptor 5	O75473-F1	0.4206265
PDE3A	phosphodiesterase 3A	Q14432-F1	0.4408128
PRC1	protein regulator of cytokinesis 1	O43663-F1	0.4408128
KPNA2	karyopherin subunit alpha 2	P52292-F1	0.4588392
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	Q99640-F1	0.4652972
ERBB2	erb-b2 receptor tyrosine kinase 2	P04626-F1	0.4942267
DBN1	drebrin 1	Q16643-F1	0.4988310
CDC25A	cell division cycle 25A	P30304-F1	0.5012473
FZD2	frizzled class receptor 2	Q14332-F1	0.5012473
KIF11	kinesin family member 11	P52732-F1	0.5012473
KIF14	kinesin family member 14	Q15058-F1	0.5127639
NRCAM	neuronal cell adhesion molecule	Q92823-F1	0.5127639
TTK	TTK protein kinase	P33981-F1	0.5234588
E2F8	E2F transcription factor 8	A0AVK6-F1	0.5270065
RECQL4	RecQ like helicase 4	O94761-F1	0.5270065
TMOD1	tropomodulin 1	P28289-F1	0.5415638
PODXL	podocalyxin like	O00592-F1	0.5564411
BRCA2	BRCA2 DNA repair associated	P51587-F12	0.5597816
MCM4	minichromosome maintenance complex component 4	P33991-F1	0.5700499
PTGS2	prostaglandin-endoperoxide synthase 2	P35354-F1	0.5807286
CLDN15	claudin 15	P56746-F1	0.5871763
SLC27A2	solute carrier family 27 member 2	O14975-F1	0.5871763
CDCA8	cell division cycle associated 8	Q53HL2-F1	0.6030451
CENPM	centromere protein M	Q9NSP4-F1	0.6187067
CHTF18	chromosome transmission fidelity factor 18	Q8WVB6-F1	0.6358117
CENPH	centromere protein H	Q9H3R5-F1	0.6362124
MED1	mediator complex subunit 1	Q15648-F1	0.6367529
PPFIA3	PTPRF interacting protein alpha 3	O75145-F1	0.6367529
ABCC4	ATP binding cassette subfamily C member 4	O15439-F1	0.6534839
TEAD4	TEA domain transcription factor 4	Q15561-F1	0.6590825
H2AC12	H2A clustered histone 12	Q96KK5-F1	0.6666634
HMMR	hyaluronan mediated motility receptor	O75330-F1	0.6876177
GPI	glucose-6-phosphate isomerase	P06744-F1	0.6889125
POLQ	DNA polymerase theta	O75417-F1	0.7056172
MME	membrane metalloendopeptidase	P08473-F1	0.7070718
DNAH9	dynein axonemal heavy chain 9	Q9NYC9-F12	0.7235081
IL32	interleukin 32	P24001-F1	0.7277579
FABP1	fatty acid binding protein 1	P07148-F1	0.7363210
CCNE2	cyclin E2	O96020-F1	0.7427470
XRCC2	X-ray repair cross complementing 2	O43543-F1	0.7427470
NUSAP1	nucleolar and spindle associated protein 1	Q9BXS6-F1	0.7618889
ITGB8	integrin subunit beta 8	P26012-F1	0.7814235
SPTBN5	spectrin beta, non-erythrocytic 5	Q9NRC6-F9	0.7904444
NEIL3	nei like DNA glycosylase 3	Q8TAT5-F1	0.8013568
PTTG1	PTTG1 regulator of sister chromatid separation, securin	O95997-F1	0.8013568
BUB1	BUB1 mitotic checkpoint serine/threonine kinase	O43683-F1	0.8130967
CENPF	centromere protein F	P49454-F7	0.8636094
AURKA	aurora kinase A	O14965-F1	0.8835142
CDH24	cadherin 24	Q86UP0-F1	0.8851986
ANLN	anillin, actin binding protein	Q9NQW6-F1	0.9296722
BCL6	BCL6 transcription repressor	P41182-F1	0.9484264
SPAG4	sperm associated antigen 4	Q9NPE6-F1	0.9614637
KIF15	kinesin family member 15	Q9NS87-F1	0.9759156
MYBL2	MYB proto-oncogene like 2	P10244-F1	0.9997173
A4GALT	alpha 1,4-galactosyltransferase (P blood group)	Q9NPC4-F1	1.0000000
ABCD1	ATP binding cassette subfamily D member 1	P33897-F1	1.0000000
ASF1B	anti-silencing function 1B histone chaperone	Q9NVP2-F1	1.0000000
ATAD2	ATPase family AAA domain containing 2	Q6PL18-F1	1.0000000
AURKB	aurora kinase B	Q96GD4-F1	1.0000000
BAMBI	BMP and activin membrane bound inhibitor	Q13145-F1	1.0000000
BCAM	basal cell adhesion molecule (Lutheran blood group)	P50895-F1	1.0000000
BLM	BLM RecQ like helicase	P54132-F1	1.0000000
BOP1	BOP1 ribosomal biogenesis factor	Q14137-F1	1.0000000
BRAT1	BRCA1 associated ATM activator 1	Q6PJG6-F1	1.0000000
C4B	complement C4B (Chido blood group)	P0C0L5-F1	1.0000000
CBX2	chromobox 2	Q14781-F1	1.0000000
CCNB2	cyclin B2	O95067-F1	1.0000000
CCNE1	cyclin E1	P24864-F1	1.0000000
CCNF	cyclin F	P41002-F1	1.0000000
CDC20	cell division cycle 20	Q12834-F1	1.0000000
CDC25C	cell division cycle 25C	P30307-F1	1.0000000
CDC6	cell division cycle 6	Q99741-F1	1.0000000
CDC7	cell division cycle 7	O00311-F1	1.0000000
CDCA5	cell division cycle associated 5	Q96FF9-F1	1.0000000
CDH3	cadherin 3	P22223-F1	1.0000000
CDKN3	cyclin dependent kinase inhibitor 3	Q16667-F1	1.0000000
CDT1	chromatin licensing and DNA replication factor 1	Q9H211-F1	1.0000000
CENPK	centromere protein K	Q9BS16-F1	1.0000000
CENPW	centromere protein W	Q5EE01-F1	1.0000000
CEP55	centrosomal protein 55	Q53EZ4-F1	1.0000000
CHAF1B	chromatin assembly factor 1 subunit B	Q13112-F1	1.0000000
CIT	citron rho-interacting serine/threonine kinase	O14578-F1	1.0000000
CLDN2	claudin 2	P57739-F1	1.0000000
CLDN3	claudin 3	O15551-F1	1.0000000
CLDN4	claudin 4	O14493-F1	1.0000000
CLDN7	claudin 7	O95471-F1	1.0000000
CLSPN	claspin	Q9HAW4-F1	1.0000000
DEPDC1	DEP domain containing 1	Q5TB30-F1	1.0000000
DEPDC1B	DEP domain containing 1B	Q8WUY9-F1	1.0000000
DNM1	dynamin 1	Q05193-F1	1.0000000
DPP4	dipeptidyl peptidase 4	P27487-F1	1.0000000
DSCC1	DNA replication and sister chromatid cohesion 1	Q9BVC3-F1	1.0000000
DTL	denticleless E3 ubiquitin protein ligase homolog	Q9NZJ0-F1	1.0000000
E2F1	E2F transcription factor 1	Q01094-F1	1.0000000
E2F2	E2F transcription factor 2	Q14209-F1	1.0000000
E2F7	E2F transcription factor 7	Q96AV8-F1	1.0000000
EME1	essential meiotic structure-specific endonuclease 1	Q96AY2-F1	1.0000000
ENO1	enolase 1	P06733-F1	1.0000000
EPHB2	EPH receptor B2	P29323-F1	1.0000000
ERCC6L	ERCC excision repair 6 like, spindle assembly checkpoint helicase	Q2NKX8-F1	1.0000000
ESPL1	extra spindle pole bodies like 1, separase	Q14674-F1	1.0000000
ESPN	espin	B1AK53-F1	1.0000000
EXO1	exonuclease 1	Q9UQ84-F1	1.0000000
FAM83D	family with sequence similarity 83 member D	Q9H4H8-F1	1.0000000
FANCA	FA complementation group A	O15360-F1	1.0000000
FANCB	FA complementation group B	Q8NB91-F1	1.0000000
FBLN1	fibulin 1	P23142-F1	1.0000000
FBLN2	fibulin 2	P98095-F1	1.0000000
FBXL19	F-box and leucine rich repeat protein 19	Q6PCT2-F1	1.0000000
FGFR3	fibroblast growth factor receptor 3	P22607-F1	1.0000000
FGFR4	fibroblast growth factor receptor 4	P22455-F1	1.0000000
FOXM1	forkhead box M1	Q08050-F1	1.0000000
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	P04406-F1	1.0000000
GGT1	gamma-glutamyltransferase 1	P19440-F1	1.0000000
GINS1	GINS complex subunit 1	Q14691-F1	1.0000000
GINS2	GINS complex subunit 2	Q9Y248-F1	1.0000000
GINS4	GINS complex subunit 4	Q9BRT9-F1	1.0000000
GLA	galactosidase alpha	P06280-F1	1.0000000
GRB7	growth factor receptor bound protein 7	Q14451-F1	1.0000000
H1-10	H1.10 linker histone	Q92522-F1	1.0000000
H1-3	H1.3 linker histone, cluster member	P16402-F1	1.0000000
H2AC11	H2A clustered histone 11	P0C0S8-F1	1.0000000
H2AC13	H2A clustered histone 13	P0C0S8-F1	1.0000000
H2AC15	H2A clustered histone 15	P0C0S8-F1	1.0000000
H2AC16	H2A clustered histone 16	P0C0S8-F1	1.0000000
H2AC4	H2A clustered histone 4	P04908-F1	1.0000000
H2AC8	H2A clustered histone 8	P04908-F1	1.0000000
HEPH	hephaestin	Q9BQS7-F1	1.0000000
HMGA1	high mobility group AT-hook 1	P17096-F1	1.0000000
ICAM1	intercellular adhesion molecule 1	P05362-F1	1.0000000
IGFBP3	insulin like growth factor binding protein 3	P17936-F1	1.0000000
IGSF8	immunoglobulin superfamily member 8	Q969P0-F1	1.0000000
IQGAP3	IQ motif containing GTPase activating protein 3	Q86VI3-F1	1.0000000
JAG2	jagged canonical Notch ligand 2	Q9Y219-F1	1.0000000
JUP	junction plakoglobin	P14923-F1	1.0000000
KHDRBS3	KH RNA binding domain containing, signal transduction associated 3	O75525-F1	1.0000000
KIF18A	kinesin family member 18A	Q8NI77-F1	1.0000000
KIF18B	kinesin family member 18B	Q86Y91-F1	1.0000000
KIF23	kinesin family member 23	Q02241-F1	1.0000000
KIFC1	kinesin family member C1	Q9BW19-F1	1.0000000
KRT15	keratin 15	P19012-F1	1.0000000
KRT23	keratin 23	Q9C075-F1	1.0000000
LDHA	lactate dehydrogenase A	P00338-F1	1.0000000
LMNB2	lamin B2	Q03252-F1	1.0000000
MAD2L1	mitotic arrest deficient 2 like 1	Q13257-F1	1.0000000
MCM2	minichromosome maintenance complex component 2	P49736-F1	1.0000000
MDK	midkine	P21741-F1	1.0000000
MRPL12	mitochondrial ribosomal protein L12	P52815-F1	1.0000000
MTTP	microsomal triglyceride transfer protein	P55157-F1	1.0000000
MUC16	mucin 16, cell surface associated	Q8WXI7-F58	1.0000000
MZT2B	mitotic spindle organizing protein 2B	Q6NZ67-F1	1.0000000
NCAPG	non-SMC condensin I complex subunit G	Q9BPX3-F1	1.0000000
NDC80	NDC80 kinetochore complex component	O14777-F1	1.0000000
NECTIN1	nectin cell adhesion molecule 1	Q15223-F1	1.0000000
NEK2	NIMA related kinase 2	P51955-F1	1.0000000
NHERF1	NHERF family PDZ scaffold protein 1	O14745-F1	1.0000000
NRARP	NOTCH regulated ankyrin repeat protein	Q7Z6K4-F1	1.0000000
NUF2	NUF2 component of NDC80 kinetochore complex	Q9BZD4-F1	1.0000000
OIP5	Opa interacting protein 5	O43482-F1	1.0000000
ORC6	origin recognition complex subunit 6	Q9Y5N6-F1	1.0000000
PARVB	parvin beta	Q9HBI1-F1	1.0000000
PBK	PDZ binding kinase	Q96KB5-F1	1.0000000
PCDHGA4	protocadherin gamma subfamily A, 4	Q9Y5G9-F1	1.0000000
PCDHGA5	protocadherin gamma subfamily A, 5	Q9Y5G8-F1	1.0000000
PCDHGB1	protocadherin gamma subfamily B, 1	Q9Y5G3-F1	1.0000000
PCDHGB2	protocadherin gamma subfamily B, 2	Q9Y5G2-F1	1.0000000
PCLAF	PCNA clamp associated factor	Q15004-F1	1.0000000
PDLIM4	PDZ and LIM domain 4	P50479-F1	1.0000000
PDLIM7	PDZ and LIM domain 7	Q9NR12-F1	1.0000000
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Q16875-F1	1.0000000
PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Q16877-F1	1.0000000
PHLDA1	pleckstrin homology like domain family A member 1	Q8WV24-F1	1.0000000
PIF1	PIF1 5’-to-3’ DNA helicase	Q9H611-F1	1.0000000
PITX1	paired like homeodomain 1	P78337-F1	1.0000000
PLK4	polo like kinase 4	O00444-F1	1.0000000
PLXNA4	plexin A4	Q9HCM2-F1	1.0000000
PRAME	PRAME nuclear receptor transcriptional regulator	P78395-F1	1.0000000
PSMD3	proteasome 26S subunit, non-ATPase 3	O43242-F1	1.0000000
PTGS1	prostaglandin-endoperoxide synthase 1	P23219-F1	1.0000000
RAD51	RAD51 recombinase	Q06609-F1	1.0000000
RAD51AP1	RAD51 associated protein 1	Q96B01-F1	1.0000000
RAD54L	RAD54 like	Q92698-F1	1.0000000
RARRES1	retinoic acid receptor responder 1	P49788-F1	1.0000000
RPL19	ribosomal protein L19	P84098-F1	1.0000000
RRM2	ribonucleotide reductase regulatory subunit M2	P31350-F1	1.0000000
RTKN	rhotekin	Q9BST9-F1	1.0000000
RTN4R	reticulon 4 receptor	Q9BZR6-F1	1.0000000
RUNX3	RUNX family transcription factor 3	Q13761-F1	1.0000000
S100A4	S100 calcium binding protein A4	P26447-F1	1.0000000
S100A9	S100 calcium binding protein A9	P06702-F1	1.0000000
SEMA6A	semaphorin 6A	Q9H2E6-F1	1.0000000
SGO1	shugoshin 1	Q5FBB7-F1	1.0000000
SHCBP1	SHC binding and spindle associated 1	Q8NEM2-F1	1.0000000
SKA1	spindle and kinetochore associated complex subunit 1	Q96BD8-F1	1.0000000
SKA3	spindle and kinetochore associated complex subunit 3	Q8IX90-F1	1.0000000
SLC19A3	solute carrier family 19 member 3	Q9BZV2-F1	1.0000000
SLC2A1	solute carrier family 2 member 1	P11166-F1	1.0000000
SLC3A1	solute carrier family 3 member 1	Q07837-F1	1.0000000
SPC24	SPC24 component of NDC80 kinetochore complex	Q8NBT2-F1	1.0000000
SPC25	SPC25 component of NDC80 kinetochore complex	Q9HBM1-F1	1.0000000
SPINDOC	spindlin interactor and repressor of chromatin binding	Q9BUA3-F1	1.0000000
SPRY1	sprouty RTK signaling antagonist 1	O43609-F1	1.0000000
STIL	STIL centriolar assembly protein	Q15468-F1	1.0000000
TACC3	transforming acidic coiled-coil containing protein 3	Q9Y6A5-F1	1.0000000
TGM2	transglutaminase 2	P21980-F1	1.0000000
TK1	thymidine kinase 1	P04183-F1	1.0000000
TNFRSF19	TNF receptor superfamily member 19	Q9NS68-F1	1.0000000
TONSL	tonsoku like, DNA repair protein	Q96HA7-F1	1.0000000
TPX2	TPX2 microtubule nucleation factor	Q9ULW0-F1	1.0000000
TRAIP	TRAF interacting protein	Q9BWF2-F1	1.0000000
TRIB3	tribbles pseudokinase 3	Q96RU7-F1	1.0000000
TRIP13	thyroid hormone receptor interactor 13	Q15645-F1	1.0000000
UBE2C	ubiquitin conjugating enzyme E2 C	O00762-F1	1.0000000
UBE2T	ubiquitin conjugating enzyme E2 T	Q9NPD8-F1	1.0000000
UHRF1	ubiquitin like with PHD and ring finger domains 1	Q96T88-F1	1.0000000
USP44	ubiquitin specific peptidase 44	Q9H0E7-F1	1.0000000
WDR18	WD repeat domain 18	Q9BV38-F1	1.0000000
ZNRF3	zinc and ring finger 3	Q9ULT6-F1	1.0000000

Rank Sensitivity w/ all factors

Rank Sensitivity

external_gene_name	description	count	counts_when_betweeness_0	counts_when_centrality_0	counts_when_citation_0	counts_when_druggability_0	counts_when_num_drug_pockets_0	counts_when_cryptic_pockets_0	counts_when_num_cryp_pockets_0
H2BC13	H2B clustered histone 13	5030	1101	1278	1148	1090	1123	821	9
ASPM	assembly factor for spindle microtubules	3454	1231	1461	1251	1240	971	1005	77
H2BC6	H2B clustered histone 6	3389	465	460	467	614	472	378	0
NR5A2	nuclear receptor subfamily 5 group A member 2	3115	1487	1688	1816	1163	862	1095	769
CENPE	centromere protein E	2967	1095	1421	798	698	1116	589	298
ORC1	origin recognition complex subunit 1	2952	428	470	454	189	422	379	0
SPTBN2	spectrin beta, non-erythrocytic 2	2878	296	266	177	474	379	146	2
POLQ	DNA polymerase theta	2589	1328	1642	1498	912	471	1062	803
H2BC7	H2B clustered histone 7	2503	217	295	85	261	214	76	3
H2BC15	H2B clustered histone 15	2327	162	145	124	118	27	118	0
SPTBN5	spectrin beta, non-erythrocytic 5	2298	581	623	728	566	753	78	291
UBE2S	ubiquitin conjugating enzyme E2 S	2066	912	963	1153	717	733	256	437
POLD1	DNA polymerase delta 1, catalytic subunit	2004	45	28	71	72	50	0	11
H2BC10	H2B clustered histone 10	1949	4	5	1	5	5	0	0
CDK1	cyclin dependent kinase 1	1919	24	32	8	39	28	0	31
MUC17	mucin 17, cell surface associated	1771	182	204	236	252	1	25	102
H2BC14	H2B clustered histone 14	1472	15	21	32	30	20	0	30
H2BC8	H2B clustered histone 8	1398	179	210	227	32	203	0	217
ANLN	anillin, actin binding protein	1354	82	80	84	113	98	0	168
CCNA2	cyclin A2	1182	18	19	29	10	24	0	31
H2BC3	H2B clustered histone 3	1105	29	35	39	53	5	0	44
ABCA2	ATP binding cassette subfamily A member 2	1100	24	2	28	42	37	0	40
KIF14	kinesin family member 14	1017	2042	1286	1535	1812	2005	1811	2303
RARA	retinoic acid receptor alpha	974	484	549	597	125	109	109	437
H2BC4	H2B clustered histone 4	936	761	930	769	589	13	843	856
FZD7	frizzled class receptor 7	890	76	40	90	57	0	0	101
H2AC14	H2A clustered histone 14	839	350	411	441	295	0	482	395
CENPF	centromere protein F	826	360	645	525	324	24	678	560
H2BC17	H2B clustered histone 17	810	85	109	116	78	0	74	99
ABCC2	ATP binding cassette subfamily C member 2	802	326	464	203	174	0	347	380
DNAH3	dynein axonemal heavy chain 3	654	57	76	53	54	0	94	66
H2BC18	H2B clustered histone 18	635	235	312	195	99	0	295	263
TONSL	tonsoku like, DNA repair protein	576	9	12	1	3	12	0	14
H2AX	H2A.X variant histone	503	43	46	35	0	12	12	1
KIF20B	kinesin family member 20B	458	40	66	45	0	5	54	52
PCDHGA5	protocadherin gamma subfamily A, 5	421	44	65	60	0	48	1	65
PCDHGB1	protocadherin gamma subfamily B, 1	406	13	14	14	0	1	0	14
H3C12	H3 clustered histone 12	374	90	113	146	0	120	52	17
ERCC6L	ERCC excision repair 6 like, spindle assembly checkpoint helicase	363	24	38	36	0	12	8	30
CDC45	cell division cycle 45	340	878	490	1755	1053	1242	1081	1390
H2AC8	H2A clustered histone 8	328	5	9	9	0	0	9	6
MCM2	minichromosome maintenance complex component 2	321	24	33	11	0	30	3	23
H2AC12	H2A clustered histone 12	318	12	12	1	0	11	3	3
CENPI	centromere protein I	232	11	13	19	0	17	11	15
ITGA7	integrin subunit alpha 7	219	4	6	6	0	5	5	5
H3C13	H3 clustered histone 13	214	2	3	3	0	3	3	2
H2BC21	H2B clustered histone 21	213	1	2	2	0	2	2	2
CDH24	cadherin 24	186	54	0	83	27	25	0	81
H1-5	H1.5 linker histone, cluster member	186	133	10	140	75	0	165	158
TTK	TTK protein kinase	163	707	146	132	228	394	390	742
LGR5	leucine rich repeat containing G protein-coupled receptor 5	154	1166	770	753	1105	1620	1460	1755
CCNB1	cyclin B1	140	271	49	708	277	456	656	443
PCDHGA4	protocadherin gamma subfamily A, 4	137	1067	429	210	505	985	791	1063
KIF20A	kinesin family member 20A	123	994	611	355	680	1256	1047	1376
NOTCH1	notch receptor 1	111	720	196	209	249	786	528	834
FZD2	frizzled class receptor 2	108	984	181	612	783	1069	1367	1069
CDC25A	cell division cycle 25A	97	520	374	5	150	544	338	558
H2BC11	H2B clustered histone 11	91	37	1146	1440	1215	1301	1062	1021
CENPA	centromere protein A	87	755	60	324	516	519	976	726
FABP1	fatty acid binding protein 1	76	1	4	35	0	21	30	27
BUB1	BUB1 mitotic checkpoint serine/threonine kinase	74	114	25	396	423	281	115	245
XPR1	xenotropic and polytropic retrovirus receptor 1	68	165	117	1	284	206	18	187
PPFIA3	PTPRF interacting protein alpha 3	61	150	458	1050	960	814	939	840
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1	58	77	0	140	94	61	47	77
WDR76	WD repeat domain 76	58	178	117	145	661	470	579	352
NDC80	NDC80 kinetochore complex component	54	2	0	1	1	2	0	2
MTTP	microsomal triglyceride transfer protein	46	224	346	0	263	108	119	48
OIP5	Opa interacting protein 5	46	98	142	0	161	103	8	62
KIF18B	kinesin family member 18B	41	34	61	0	38	0	25	50
TEAD4	TEA domain transcription factor 4	38	432	343	0	172	271	615	423
PLK1	polo like kinase 1	35	4	6	0	0	7	7	7
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	34	129	124	0	144	49	2	175
SPAG4	sperm associated antigen 4	33	62	20	0	45	0	91	60
CHEK1	checkpoint kinase 1	32	209	310	0	315	257	124	72
H3C10	H3 clustered histone 10	32	67	107	0	134	96	11	35
H3C1	H3 clustered histone 1	27	350	367	0	262	183	172	421
CD9	CD9 molecule	19	8	141	22	300	221	84	210
CDC6	cell division cycle 6	15	17	0	0	26	20	15	11
SKA3	spindle and kinetochore associated complex subunit 3	14	13	13	0	13	4	13	5
H4C13	H4 clustered histone 13	13	5	5	0	5	5	5	1
SLC27A2	solute carrier family 27 member 2	12	33	219	0	240	189	197	213
PDE3A	phosphodiesterase 3A	9	4	4	0	4	4	4	1
H2BC12	H2B clustered histone 12	7	15	32	0	25	14	20	23
H2AC21	H2A clustered histone 21	6	0	6	0	6	6	6	4
MELK	maternal embryonic leucine zipper kinase	6	0	783	906	999	887	821	958
H2AC15	H2A clustered histone 15	5	0	129	38	169	127	154	102
SEMA6A	semaphorin 6A	5	0	496	613	604	455	553	573
H2AC16	H2A clustered histone 16	4	0	50	42	12	41	0	48
KIF11	kinesin family member 11	3	0	1	1	0	1	1	1
PHF19	PHD finger protein 19	2	0	64	106	66	36	44	76
PTGS2	prostaglandin-endoperoxide synthase 2	2	0	74	73	82	64	21	47
RAC3	Rac family small GTPase 3	1	0	52	19	9	37	55	36

RRA w/ all factors

Robust Rank Aggregation

external_gene_name	description	ID	Score
MUC17	mucin 17, cell surface associated	Q685J3-F5	0.0004242
H2BC13	H2B clustered histone 13	Q99880-F1	0.0016747
H2BC14	H2B clustered histone 14	Q99879-F1	0.0023325
CENPI	centromere protein I	Q92674-F1	0.0035146
NR5A2	nuclear receptor subfamily 5 group A member 2	O00482-F1	0.0036697
CDK1	cyclin dependent kinase 1	P06493-F1	0.0037747
CENPE	centromere protein E	Q02224-F6	0.0037747
H2AC14	H2A clustered histone 14	Q99878-F1	0.0037842
H2BC15	H2B clustered histone 15	Q99877-F1	0.0040540
H2BC17	H2B clustered histone 17	P23527-F1	0.0040540
H2BC3	H2B clustered histone 3	P33778-F1	0.0053829
ABCA2	ATP binding cassette subfamily A member 2	Q9BZC7-F1	0.0075323
PLK1	polo like kinase 1	P53350-F1	0.0082606
RARA	retinoic acid receptor alpha	P10276-F1	0.0087396
H2BC10	H2B clustered histone 10	P62807-F1	0.0186075
H2BC4	H2B clustered histone 4	P62807-F1	0.0186075
H2BC6	H2B clustered histone 6	P62807-F1	0.0186075
H2BC7	H2B clustered histone 7	P62807-F1	0.0186075
H2BC8	H2B clustered histone 8	P62807-F1	0.0186075
H2BC11	H2B clustered histone 11	P06899-F1	0.0207254
SPAG5	sperm associated antigen 5	Q96R06-F1	0.0232089
BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	O60566-F1	0.0295475
POLD1	DNA polymerase delta 1, catalytic subunit	P28340-F1	0.0312399
H2AX	H2A.X variant histone	P16104-F1	0.0328303
H2BC18	H2B clustered histone 18	Q5QNW6-F1	0.0348281
CENPA	centromere protein A	P49450-F1	0.0386972
SPTBN2	spectrin beta, non-erythrocytic 2	O15020-F1	0.0390188
KIF20A	kinesin family member 20A	O95235-F1	0.0407407
WDR62	WD repeat domain 62	O43379-F1	0.0436086
H2BC12	H2B clustered histone 12	O60814-F1	0.0468560
FZD7	frizzled class receptor 7	O75084-F1	0.0496748
ATP1B3	ATPase Na+/K+ transporting subunit beta 3	P54709-F1	0.0559006
H1-5	H1.5 linker histone, cluster member	P16401-F1	0.0640030
KIF20B	kinesin family member 20B	Q96Q89-F1	0.0669500
DNAH3	dynein axonemal heavy chain 3	Q8TD57-F4	0.0674009
CCNA2	cyclin A2	P20248-F1	0.0720687
ASPM	assembly factor for spindle microtubules	Q8IZT6-F10	0.0811421
ANPEP	alanyl aminopeptidase, membrane	P15144-F1	0.0828162
UBE2S	ubiquitin conjugating enzyme E2 S	Q16763-F1	0.0830499
H3C1	H3 clustered histone 1	P68431-F1	0.0881030
H3C10	H3 clustered histone 10	P68431-F1	0.0881030
H3C11	H3 clustered histone 11	P68431-F1	0.0881030
H3C12	H3 clustered histone 12	P68431-F1	0.0881030
PHF19	PHD finger protein 19	Q5T6S3-F1	0.0916561
LAMA5	laminin subunit alpha 5	O15230-F12	0.0936371
WDR76	WD repeat domain 76	Q9H967-F1	0.0953584
LMNB1	lamin B1	P20700-F1	0.0964991
H3C13	H3 clustered histone 13	Q71DI3-F1	0.0983281
TOP2A	DNA topoisomerase II alpha	P11388-F1	0.1041784
H2BC21	H2B clustered histone 21	Q16778-F1	0.1054756
DNA2	DNA replication helicase/nuclease 2	P51530-F1	0.1070765
RACGAP1	Rac GTPase activating protein 1	Q9H0H5-F1	0.1086008
CHEK1	checkpoint kinase 1	O14757-F1	0.1154110
H4C1	H4 clustered histone 1	P62805-F1	0.1217911
H4C13	H4 clustered histone 13	P62805-F1	0.1217911
H4C4	H4 clustered histone 4	P62805-F1	0.1217911
ITGA7	integrin subunit alpha 7	Q13683-F1	0.1217911
H2AC21	H2A clustered histone 21	Q8IUE6-F1	0.1229589
CDC45	cell division cycle 45	O75419-F1	0.1287216
NCAPH	non-SMC condensin I complex subunit H	Q15003-F1	0.1288123
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1	P05023-F1	0.1333792
DLGAP5	DLG associated protein 5	Q15398-F1	0.1361271
NOTCH1	notch receptor 1	P46531-F1	0.1436167
CYBA	cytochrome b-245 alpha chain	P13498-F1	0.1531449
GPC1	glypican 1	P35052-F1	0.1599051
MCM10	minichromosome maintenance 10 replication initiation factor	Q7L590-F1	0.1599051
ABCC2	ATP binding cassette subfamily C member 2	Q92887-F1	0.1652538
CCNB1	cyclin B1	P14635-F1	0.1691944
KIF4A	kinesin family member 4A	O95239-F1	0.1728700
MCM6	minichromosome maintenance complex component 6	Q14566-F1	0.1747837
PDZK1	PDZ domain containing 1	Q5T2W1-F1	0.1773569
RAC3	Rac family small GTPase 3	P60763-F1	0.1819280
KIF2C	kinesin family member 2C	Q99661-F1	0.1865842
DNAH7	dynein axonemal heavy chain 7	Q8WXX0-F5	0.1907046
MZT2A	mitotic spindle organizing protein 2A	Q6P582-F1	0.1913263
SLC7A5	solute carrier family 7 member 5	Q01650-F1	0.1922851
SLC1A5	solute carrier family 1 member 5	Q15758-F1	0.2081411
KPNA2	karyopherin subunit alpha 2	P52292-F1	0.2111720
CD9	CD9 molecule	P21926-F1	0.2173714
DBN1	drebrin 1	Q16643-F1	0.2270021
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	Q99640-F1	0.2306832
XPR1	xenotropic and polytropic retrovirus receptor 1	Q9UBH6-F1	0.2311216
KIF14	kinesin family member 14	Q15058-F1	0.2324636
NRCAM	neuronal cell adhesion molecule	Q92823-F1	0.2324636
E2F8	E2F transcription factor 8	A0AVK6-F1	0.2380189
RECQL4	RecQ like helicase 4	O94761-F1	0.2380189
TMOD1	tropomodulin 1	P28289-F1	0.2436690
ORC1	origin recognition complex subunit 1	Q13415-F1	0.2466189
PODXL	podocalyxin like	O00592-F1	0.2494147
TTK	TTK protein kinase	P33981-F1	0.2588822
CLDN15	claudin 15	P56746-F1	0.2611962
SLC27A2	solute carrier family 27 member 2	O14975-F1	0.2611962
KIF1A	kinesin family member 1A	Q12756-F1	0.2664931
CDCA8	cell division cycle associated 8	Q53HL2-F1	0.2672338
CHTF18	chromosome transmission fidelity factor 18	Q8WVB6-F1	0.2796067
MCM4	minichromosome maintenance complex component 4	P33991-F1	0.2814383
PPFIA3	PTPRF interacting protein alpha 3	O75145-F1	0.2923824
HMMR	hyaluronan mediated motility receptor	O75330-F1	0.2989233
BRCA2	BRCA2 DNA repair associated	P51587-F12	0.3052255
POLQ	DNA polymerase theta	O75417-F1	0.3055674
CENPH	centromere protein H	Q9H3R5-F1	0.3134318
CCNE2	cyclin E2	O96020-F1	0.3191684
XRCC2	X-ray repair cross complementing 2	O43543-F1	0.3191684
ABCC4	ATP binding cassette subfamily C member 4	O15439-F1	0.3217780
PDE3A	phosphodiesterase 3A	Q14432-F1	0.3233614
PRC1	protein regulator of cytokinesis 1	O43663-F1	0.3233614
NUSAP1	nucleolar and spindle associated protein 1	Q9BXS6-F1	0.3261269
MELK	maternal embryonic leucine zipper kinase	Q14680-F1	0.3271523
KIF11	kinesin family member 11	P52732-F1	0.3302648
ITGB8	integrin subunit beta 8	P26012-F1	0.3331918
GPI	glucose-6-phosphate isomerase	P06744-F1	0.3388929
NEIL3	nei like DNA glycosylase 3	Q8TAT5-F1	0.3403639
PTTG1	PTTG1 regulator of sister chromatid separation, securin	O95997-F1	0.3403639
MME	membrane metalloendopeptidase	P08473-F1	0.3476630
CENPF	centromere protein F	P49454-F7	0.3625314
ERBB2	erb-b2 receptor tyrosine kinase 2	P04626-F1	0.3636897
CENPM	centromere protein M	Q9NSP4-F1	0.3672084
CDH24	cadherin 24	Q86UP0-F1	0.3701401
LGR5	leucine rich repeat containing G protein-coupled receptor 5	O75473-F1	0.3748316
ANLN	anillin, actin binding protein	Q9NQW6-F1	0.3856918
KIF15	kinesin family member 15	Q9NS87-F1	0.4016938
MYBL2	MYB proto-oncogene like 2	P10244-F1	0.4098656
CLDN3	claudin 3	O15551-F1	0.4265545
DNAH9	dynein axonemal heavy chain 9	Q9NYC9-F12	0.4313668
RPL19	ribosomal protein L19	P84098-F1	0.4350729
PTGS2	prostaglandin-endoperoxide synthase 2	P35354-F1	0.4433080
KRT15	keratin 15	P19012-F1	0.4437083
NEK2	NIMA related kinase 2	P51955-F1	0.4437083
BCL6	BCL6 transcription repressor	P41182-F1	0.4641985
MED1	mediator complex subunit 1	Q15648-F1	0.4723631
KIF23	kinesin family member 23	Q02241-F1	0.4794336
CDC25A	cell division cycle 25A	P30304-F1	0.4857525
FZD2	frizzled class receptor 2	Q14332-F1	0.4857525
BUB1	BUB1 mitotic checkpoint serine/threonine kinase	O43683-F1	0.4866633
H2AC12	H2A clustered histone 12	Q96KK5-F1	0.4953639
FBLN1	fibulin 1	P23142-F1	0.4980158
BAMBI	BMP and activin membrane bound inhibitor	Q13145-F1	0.5074892
TGM2	transglutaminase 2	P21980-F1	0.5170848
NDC80	NDC80 kinetochore complex component	O14777-F1	0.5268034
AURKA	aurora kinase A	O14965-F1	0.5304246
IL32	interleukin 32	P24001-F1	0.5425538
RAD51	RAD51 recombinase	Q06609-F1	0.5537475
RARRES1	retinoic acid receptor responder 1	P49788-F1	0.5567031
FOXM1	forkhead box M1	Q08050-F1	0.5656199
PDLIM4	PDZ and LIM domain 4	P50479-F1	0.5669196
BCAM	basal cell adhesion molecule (Lutheran blood group)	P50895-F1	0.5772621
DTL	denticleless E3 ubiquitin protein ligase homolog	Q9NZJ0-F1	0.5772621
CLDN4	claudin 4	O14493-F1	0.5877311
MRPL12	mitochondrial ribosomal protein L12	P52815-F1	0.5877311
SPTBN5	spectrin beta, non-erythrocytic 5	Q9NRC6-F9	0.5912651
CDC7	cell division cycle 7	O00311-F1	0.5983272
MTTP	microsomal triglyceride transfer protein	P55157-F1	0.5983272
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Q16875-F1	0.6199027
PRAME	PRAME nuclear receptor transcriptional regulator	P78395-F1	0.6199027
FBLN2	fibulin 2	P98095-F1	0.6308833
RAD51AP1	RAD51 associated protein 1	Q96B01-F1	0.6400240
TEAD4	TEA domain transcription factor 4	Q15561-F1	0.6411105
ABCD1	ATP binding cassette subfamily D member 1	P33897-F1	0.6419931
DNM1	dynamin 1	Q05193-F1	0.6646022
TPX2	TPX2 microtubule nucleation factor	Q9ULW0-F1	0.6646022
FANCA	FA complementation group A	O15360-F1	0.6761025
CHAF1B	chromatin assembly factor 1 subunit B	Q13112-F1	0.6877340
TK1	thymidine kinase 1	P04183-F1	0.6994971
FABP1	fatty acid binding protein 1	P07148-F1	0.7175911
OIP5	Opa interacting protein 5	O43482-F1	0.7234199
ESPL1	extra spindle pole bodies like 1, separase	Q14674-F1	0.7478743
ATAD2	ATPase family AAA domain containing 2	Q6PL18-F1	0.7728635
ENO1	enolase 1	P06733-F1	0.7855596
KIF18B	kinesin family member 18B	Q86Y91-F1	0.8113566
RRM2	ribonucleotide reductase regulatory subunit M2	P31350-F1	0.8113566
STIL	STIL centriolar assembly protein	Q15468-F1	0.8113566
CDC6	cell division cycle 6	Q99741-F1	0.8201290
EXO1	exonuclease 1	Q9UQ84-F1	0.8244582
SKA3	spindle and kinetochore associated complex subunit 3	Q8IX90-F1	0.8244582
UBE2C	ubiquitin conjugating enzyme E2 C	O00762-F1	0.8244582
MDK	midkine	P21741-F1	0.8376956
TRIP13	thyroid hormone receptor interactor 13	Q15645-F1	0.8376956
CDKN3	cyclin dependent kinase inhibitor 3	Q16667-F1	0.8510690
LMNB2	lamin B2	Q03252-F1	0.8510690
SPRY1	sprouty RTK signaling antagonist 1	O43609-F1	0.8510690
PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Q16877-F1	0.8645789
SLC3A1	solute carrier family 3 member 1	Q07837-F1	0.8645789
CCNE1	cyclin E1	P24864-F1	0.8782254
ERCC6L	ERCC excision repair 6 like, spindle assembly checkpoint helicase	Q2NKX8-F1	0.8782254
DEPDC1	DEP domain containing 1	Q5TB30-F1	0.9059295
FGFR4	fibroblast growth factor receptor 4	P22455-F1	0.9199875
GGT1	gamma-glutamyltransferase 1	P19440-F1	0.9199875
FGFR3	fibroblast growth factor receptor 3	P22607-F1	0.9280393
BOP1	BOP1 ribosomal biogenesis factor	Q14137-F1	0.9341832
MZT2B	mitotic spindle organizing protein 2B	Q6NZ67-F1	0.9341832
SPAG4	sperm associated antigen 4	Q9NPE6-F1	0.9423212
BRAT1	BRCA1 associated ATM activator 1	Q6PJG6-F1	0.9629881
GRB7	growth factor receptor bound protein 7	Q14451-F1	0.9629881
KHDRBS3	KH RNA binding domain containing, signal transduction associated 3	O75525-F1	0.9629881
GINS1	GINS complex subunit 1	Q14691-F1	0.9775978
NRARP	NOTCH regulated ankyrin repeat protein	Q7Z6K4-F1	0.9775978
CBX2	chromobox 2	Q14781-F1	0.9923458
IQGAP3	IQ motif containing GTPase activating protein 3	Q86VI3-F1	0.9923458
MUC16	mucin 16, cell surface associated	Q8WXI7-F58	0.9923458
A4GALT	alpha 1,4-galactosyltransferase (P blood group)	Q9NPC4-F1	1.0000000
ASF1B	anti-silencing function 1B histone chaperone	Q9NVP2-F1	1.0000000
AURKB	aurora kinase B	Q96GD4-F1	1.0000000
BLM	BLM RecQ like helicase	P54132-F1	1.0000000
C4B	complement C4B (Chido blood group)	P0C0L5-F1	1.0000000
CCNB2	cyclin B2	O95067-F1	1.0000000
CCNF	cyclin F	P41002-F1	1.0000000
CDC20	cell division cycle 20	Q12834-F1	1.0000000
CDC25C	cell division cycle 25C	P30307-F1	1.0000000
CDCA5	cell division cycle associated 5	Q96FF9-F1	1.0000000
CDH3	cadherin 3	P22223-F1	1.0000000
CDT1	chromatin licensing and DNA replication factor 1	Q9H211-F1	1.0000000
CENPK	centromere protein K	Q9BS16-F1	1.0000000
CENPW	centromere protein W	Q5EE01-F1	1.0000000
CEP55	centrosomal protein 55	Q53EZ4-F1	1.0000000
CIT	citron rho-interacting serine/threonine kinase	O14578-F1	1.0000000
CLDN2	claudin 2	P57739-F1	1.0000000
CLDN7	claudin 7	O95471-F1	1.0000000
CLSPN	claspin	Q9HAW4-F1	1.0000000
DEPDC1B	DEP domain containing 1B	Q8WUY9-F1	1.0000000
DPP4	dipeptidyl peptidase 4	P27487-F1	1.0000000
DSCC1	DNA replication and sister chromatid cohesion 1	Q9BVC3-F1	1.0000000
E2F1	E2F transcription factor 1	Q01094-F1	1.0000000
E2F2	E2F transcription factor 2	Q14209-F1	1.0000000
E2F7	E2F transcription factor 7	Q96AV8-F1	1.0000000
EME1	essential meiotic structure-specific endonuclease 1	Q96AY2-F1	1.0000000
EPHB2	EPH receptor B2	P29323-F1	1.0000000
ESPN	espin	B1AK53-F1	1.0000000
FAM83D	family with sequence similarity 83 member D	Q9H4H8-F1	1.0000000
FANCB	FA complementation group B	Q8NB91-F1	1.0000000
FBXL19	F-box and leucine rich repeat protein 19	Q6PCT2-F1	1.0000000
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	P04406-F1	1.0000000
GINS2	GINS complex subunit 2	Q9Y248-F1	1.0000000
GINS4	GINS complex subunit 4	Q9BRT9-F1	1.0000000
GLA	galactosidase alpha	P06280-F1	1.0000000
H1-10	H1.10 linker histone	Q92522-F1	1.0000000
H1-3	H1.3 linker histone, cluster member	P16402-F1	1.0000000
H2AC11	H2A clustered histone 11	P0C0S8-F1	1.0000000
H2AC13	H2A clustered histone 13	P0C0S8-F1	1.0000000
H2AC15	H2A clustered histone 15	P0C0S8-F1	1.0000000
H2AC16	H2A clustered histone 16	P0C0S8-F1	1.0000000
H2AC4	H2A clustered histone 4	P04908-F1	1.0000000
H2AC8	H2A clustered histone 8	P04908-F1	1.0000000
HEPH	hephaestin	Q9BQS7-F1	1.0000000
HMGA1	high mobility group AT-hook 1	P17096-F1	1.0000000
ICAM1	intercellular adhesion molecule 1	P05362-F1	1.0000000
IGFBP3	insulin like growth factor binding protein 3	P17936-F1	1.0000000
IGSF8	immunoglobulin superfamily member 8	Q969P0-F1	1.0000000
JAG2	jagged canonical Notch ligand 2	Q9Y219-F1	1.0000000
JUP	junction plakoglobin	P14923-F1	1.0000000
KIF18A	kinesin family member 18A	Q8NI77-F1	1.0000000
KIFC1	kinesin family member C1	Q9BW19-F1	1.0000000
KRT23	keratin 23	Q9C075-F1	1.0000000
LDHA	lactate dehydrogenase A	P00338-F1	1.0000000
MAD2L1	mitotic arrest deficient 2 like 1	Q13257-F1	1.0000000
MCM2	minichromosome maintenance complex component 2	P49736-F1	1.0000000
NCAPG	non-SMC condensin I complex subunit G	Q9BPX3-F1	1.0000000
NECTIN1	nectin cell adhesion molecule 1	Q15223-F1	1.0000000
NHERF1	NHERF family PDZ scaffold protein 1	O14745-F1	1.0000000
NUF2	NUF2 component of NDC80 kinetochore complex	Q9BZD4-F1	1.0000000
ORC6	origin recognition complex subunit 6	Q9Y5N6-F1	1.0000000
PARVB	parvin beta	Q9HBI1-F1	1.0000000
PBK	PDZ binding kinase	Q96KB5-F1	1.0000000
PCDHGA4	protocadherin gamma subfamily A, 4	Q9Y5G9-F1	1.0000000
PCDHGA5	protocadherin gamma subfamily A, 5	Q9Y5G8-F1	1.0000000
PCDHGB1	protocadherin gamma subfamily B, 1	Q9Y5G3-F1	1.0000000
PCDHGB2	protocadherin gamma subfamily B, 2	Q9Y5G2-F1	1.0000000
PCLAF	PCNA clamp associated factor	Q15004-F1	1.0000000
PDLIM7	PDZ and LIM domain 7	Q9NR12-F1	1.0000000
PHLDA1	pleckstrin homology like domain family A member 1	Q8WV24-F1	1.0000000
PIF1	PIF1 5’-to-3’ DNA helicase	Q9H611-F1	1.0000000
PITX1	paired like homeodomain 1	P78337-F1	1.0000000
PLK4	polo like kinase 4	O00444-F1	1.0000000
PLXNA4	plexin A4	Q9HCM2-F1	1.0000000
PSMD3	proteasome 26S subunit, non-ATPase 3	O43242-F1	1.0000000
PTGS1	prostaglandin-endoperoxide synthase 1	P23219-F1	1.0000000
RAD54L	RAD54 like	Q92698-F1	1.0000000
RTKN	rhotekin	Q9BST9-F1	1.0000000
RTN4R	reticulon 4 receptor	Q9BZR6-F1	1.0000000
RUNX3	RUNX family transcription factor 3	Q13761-F1	1.0000000
S100A4	S100 calcium binding protein A4	P26447-F1	1.0000000
S100A9	S100 calcium binding protein A9	P06702-F1	1.0000000
SEMA6A	semaphorin 6A	Q9H2E6-F1	1.0000000
SGO1	shugoshin 1	Q5FBB7-F1	1.0000000
SHCBP1	SHC binding and spindle associated 1	Q8NEM2-F1	1.0000000
SKA1	spindle and kinetochore associated complex subunit 1	Q96BD8-F1	1.0000000
SLC19A3	solute carrier family 19 member 3	Q9BZV2-F1	1.0000000
SLC2A1	solute carrier family 2 member 1	P11166-F1	1.0000000
SPC24	SPC24 component of NDC80 kinetochore complex	Q8NBT2-F1	1.0000000
SPC25	SPC25 component of NDC80 kinetochore complex	Q9HBM1-F1	1.0000000
SPINDOC	spindlin interactor and repressor of chromatin binding	Q9BUA3-F1	1.0000000
TACC3	transforming acidic coiled-coil containing protein 3	Q9Y6A5-F1	1.0000000
TNFRSF19	TNF receptor superfamily member 19	Q9NS68-F1	1.0000000
TONSL	tonsoku like, DNA repair protein	Q96HA7-F1	1.0000000
TRAIP	TRAF interacting protein	Q9BWF2-F1	1.0000000
TRIB3	tribbles pseudokinase 3	Q96RU7-F1	1.0000000
UBE2T	ubiquitin conjugating enzyme E2 T	Q9NPD8-F1	1.0000000
UHRF1	ubiquitin like with PHD and ring finger domains 1	Q96T88-F1	1.0000000
USP44	ubiquitin specific peptidase 44	Q9H0E7-F1	1.0000000
WDR18	WD repeat domain 18	Q9BV38-F1	1.0000000
ZNRF3	zinc and ring finger 3	Q9ULT6-F1	1.0000000

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